hexamethonium has been researched along with Colitis in 9 studies
Hexamethonium: A nicotinic cholinergic antagonist often referred to as the prototypical ganglionic blocker. It is poorly absorbed from the gastrointestinal tract and does not cross the blood-brain barrier. It has been used for a variety of therapeutic purposes including hypertension but, like the other ganglionic blockers, it has been replaced by more specific drugs for most purposes, although it is widely used a research tool.
Colitis: Inflammation of the COLON section of the large intestine (INTESTINE, LARGE), usually with symptoms such as DIARRHEA (often with blood and mucus), ABDOMINAL PAIN, and FEVER.
| Excerpt | Relevance | Reference |
|---|---|---|
| " Treatment with hexamethonium before smoking reversed the effect of the smoke on the colitis, improving all parameters." | 3.70 | Cigarette smoke aggravates experimental colitis in rats. ( Blennerhassett, PA; Collins, SM; Galeazzi, F; O'Byrne, PM; Qiu, B, 1999) |
| "Colitis was induced 72 h prior to experiments using trinitrobenzene sulphate (TNBS) instillation." | 1.34 | Acute distal colitis impairs gastric emptying in rats via an extrinsic neuronal reflex pathway involving the pelvic nerve. ( De Man, JG; De Schepper, HU; De Winter, BY; Herman, AG; Pelckmans, PA; Timmermans, JP; Van Nassauw, L, 2007) |
| "Muscarine was infused close-intra-arterially in seven conscious dogs during normal and experimental colitis states." | 1.31 | Inflammation inhibits muscarinic signaling in in vivo canine colonic circular smooth muscle cells. ( Jadcherla, SR, 2002) |
| "Colitis was induced in male Sprague-Dawley rats by intrarectal administration of trinitrobenzenesulphonic acid in ethanol." | 1.30 | Progressive alterations in circular smooth muscle contractility in TNBS-induced colitis in rats. ( Bossone, C; Goldhill, JM; Hosseini, JM; Piñeiro-Carrero, V; Shea-Donohue, T, 1999) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 1 (11.11) | 18.7374 |
| 1990's | 2 (22.22) | 18.2507 |
| 2000's | 5 (55.56) | 29.6817 |
| 2010's | 1 (11.11) | 24.3611 |
| 2020's | 0 (0.00) | 2.80 |
| Authors | Studies |
|---|---|
| Yokoyama, S | 1 |
| Hiramoto, K | 1 |
| Koyama, M | 1 |
| Ooi, K | 1 |
| Jadcherla, SR | 1 |
| HURLEY, JW | 1 |
| KNOWLTON, NP | 1 |
| WALL, ED | 1 |
| Gülpinar, MA | 1 |
| Ozbeyli, D | 1 |
| Arbak, S | 1 |
| Yeğen, BC | 1 |
| Saunders, PR | 1 |
| Miceli, P | 1 |
| Vallance, BA | 1 |
| Wang, L | 1 |
| Pinto, S | 1 |
| Tougas, G | 1 |
| Kamath, M | 1 |
| Jacobson, K | 1 |
| De Schepper, HU | 1 |
| De Man, JG | 1 |
| Van Nassauw, L | 1 |
| Timmermans, JP | 1 |
| Herman, AG | 1 |
| Pelckmans, PA | 1 |
| De Winter, BY | 1 |
| Galeazzi, F | 1 |
| Blennerhassett, PA | 1 |
| Qiu, B | 1 |
| O'Byrne, PM | 1 |
| Collins, SM | 1 |
| Hosseini, JM | 1 |
| Goldhill, JM | 1 |
| Bossone, C | 1 |
| Piñeiro-Carrero, V | 1 |
| Shea-Donohue, T | 1 |
| Sayer, B | 1 |
| Lu, J | 1 |
| Green, C | 1 |
| Söderholm, JD | 1 |
| Akhtar, M | 1 |
| McKay, DM | 1 |
9 other studies available for hexamethonium and Colitis
| Article | Year |
|---|---|
Impairment of skin barrier function via cholinergic signal transduction in a dextran sulphate sodium-induced colitis mouse model.
Topics: Animals; Antibodies, Monoclonal; Atropine; Cell Count; Colitis; Colon; Dextran Sulfate; Disease Mode | 2015 |
Inflammation inhibits muscarinic signaling in in vivo canine colonic circular smooth muscle cells.
Topics: Animals; Cholinergic Agents; Colitis; Dogs; Female; Ganglionic Blockers; Hexamethonium; Infusions, I | 2002 |
Hexamethonium in the treatment of ulcerative colitis: report of a case.
Topics: Colitis; Colitis, Ulcerative; Hexamethonium; Humans; Muscle Relaxants, Central | 1954 |
Anti-inflammatory effect of acute stress on experimental colitis is mediated by cholecystokinin-B receptors.
Topics: Acute Disease; Animals; Colitis; Colon; Disease Models, Animal; Electric Stimulation; Ganglionic Blo | 2004 |
Noradrenergic and cholinergic neural pathways mediate stress-induced reactivation of colitis in the rat.
Topics: Acute Disease; Animals; Atropine; Autonomic Pathways; Bretylium Tosylate; CD3 Complex; Colitis; Colo | 2006 |
Acute distal colitis impairs gastric emptying in rats via an extrinsic neuronal reflex pathway involving the pelvic nerve.
Topics: Acute Disease; Analgesics, Non-Narcotic; Animals; Capsaicin; Colitis; Ganglia, Spinal; Ganglionic Bl | 2007 |
Cigarette smoke aggravates experimental colitis in rats.
Topics: Animals; Colitis; Colon; Dinitrofluorobenzene; Ganglionic Blockers; Hexamethonium; Male; Nicotine; P | 1999 |
Progressive alterations in circular smooth muscle contractility in TNBS-induced colitis in rats.
Topics: Acetylcholine; Animals; Atropine; Colitis; Dose-Response Relationship, Drug; Gastrointestinal Motili | 1999 |
Dextran sodium sulphate-induced colitis perturbs muscarinic cholinergic control of colonic epithelial ion transport.
Topics: Animals; Atropine; Carbachol; Cholinergic Agonists; Colitis; Dextran Sulfate; Disease Models, Animal | 2002 |