hexamethonium has been researched along with Chronic Disease in 7 studies
Hexamethonium: A nicotinic cholinergic antagonist often referred to as the prototypical ganglionic blocker. It is poorly absorbed from the gastrointestinal tract and does not cross the blood-brain barrier. It has been used for a variety of therapeutic purposes including hypertension but, like the other ganglionic blockers, it has been replaced by more specific drugs for most purposes, although it is widely used a research tool.
Chronic Disease: Diseases which have one or more of the following characteristics: they are permanent, leave residual disability, are caused by nonreversible pathological alteration, require special training of the patient for rehabilitation, or may be expected to require a long period of supervision, observation, or care (Dictionary of Health Services Management, 2d ed). For epidemiological studies chronic disease often includes HEART DISEASES; STROKE; CANCER; and diabetes (DIABETES MELLITUS, TYPE 2).
| Excerpt | Relevance | Reference |
|---|---|---|
| " To test this hypothesis, we have used a novel approach to effectively "clamp" the sympathetic nervous system at a fixed level through chronic administration of the ganglionic blocking agent hexamethonium (15 mg/kg/h) and the alpha agonist phenylephrine (2." | 1.33 | Role of a responsive sympathetic nervous system in the chronic hypotensive effects of losartan in normal rats. ( Collister, JP; Osborn, JW, 2005) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 1 (14.29) | 18.7374 |
| 1990's | 1 (14.29) | 18.2507 |
| 2000's | 4 (57.14) | 29.6817 |
| 2010's | 1 (14.29) | 24.3611 |
| 2020's | 0 (0.00) | 2.80 |
| Authors | Studies |
|---|---|
| Gulliford, M | 1 |
| Charlton, J | 1 |
| Bhattarai, N | 1 |
| Rudisill, C | 1 |
| Collister, JP | 1 |
| Osborn, JW | 1 |
| Zoccal, DB | 1 |
| Bonagamba, LG | 1 |
| Oliveira, FR | 1 |
| Antunes-Rodrigues, J | 1 |
| Machado, BH | 1 |
| Kontani, H | 1 |
| Hayashi, K | 1 |
| De Man, JG | 1 |
| Moreels, TG | 1 |
| De Winter, BY | 1 |
| Bogers, JJ | 1 |
| Van Marck, EA | 1 |
| Herman, AG | 1 |
| Pelckmans, PA | 1 |
| Ferrari, AU | 1 |
| Radaelli, A | 1 |
| Mori, T | 1 |
| Mircoli, L | 1 |
| Perlini, S | 1 |
| Meregalli, P | 1 |
| Fedele, L | 1 |
| Mancia, G | 1 |
| Sweet, WD | 1 |
| Freeman, RH | 1 |
| Davis, JO | 1 |
| Vari, RC | 1 |
7 other studies available for hexamethonium and Chronic Disease
| Article | Year |
|---|---|
Social and material deprivation and the cost-effectiveness of an intervention to promote physical activity: cohort study and Markov model.
Topics: Adult; Cardiovascular Diseases; Chronic Disease; Cohort Studies; Cost-Benefit Analysis; Cultural Dep | 2014 |
Role of a responsive sympathetic nervous system in the chronic hypotensive effects of losartan in normal rats.
Topics: Angiotensin II Type 1 Receptor Blockers; Animals; Blood Pressure; Chronic Disease; Ganglionic Blocke | 2005 |
Increased sympathetic activity in rats submitted to chronic intermittent hypoxia.
Topics: Angiotensin II Type 1 Receptor Blockers; Animals; Blood Pressure; Chronic Disease; Disease Models, A | 2007 |
Urinary bladder response to hypogastric nerve stimulation after bilateral resection of the pelvic nerve or spinal cord injury in rats.
Topics: Animals; Atropine; Chronic Disease; Electric Stimulation; Hexamethonium; Hypogastric Plexus; Nicotin | 1997 |
Disturbance of the prejunctional modulation of cholinergic neurotransmission during chronic granulomatous inflammation of the mouse ileum.
Topics: Adrenergic Agonists; Adrenergic alpha-2 Receptor Agonists; Adrenergic alpha-2 Receptor Antagonists; | 2001 |
Nitric oxide-dependent vasodilation and the regulation of arterial blood pressure.
Topics: Animals; Aorta; Blood Pressure; Chronic Disease; Denervation; Ganglionic Blockers; Hexamethonium; Ni | 2001 |
Ganglionic blockade in conscious dogs with chronic caval constriction.
Topics: Animals; Chronic Disease; Consciousness; Constriction, Pathologic; Dogs; Epinephrine; Female; Gangli | 1985 |