Page last updated: 2024-10-28

hexamethonium and Bronchial Spasm

hexamethonium has been researched along with Bronchial Spasm in 4 studies

Hexamethonium: A nicotinic cholinergic antagonist often referred to as the prototypical ganglionic blocker. It is poorly absorbed from the gastrointestinal tract and does not cross the blood-brain barrier. It has been used for a variety of therapeutic purposes including hypertension but, like the other ganglionic blockers, it has been replaced by more specific drugs for most purposes, although it is widely used a research tool.

Bronchial Spasm: Spasmodic contraction of the smooth muscle of the bronchi.

Research Excerpts

ExcerptRelevanceReference
"In hexamethonium-treated animals, MEN 10,376 still abolished the increase in insufflation pressure induced by [beta-Ala8]NKA-(4-10) and reduced the increase elicited by capsaicin."5.28Effects of selective tachykinin receptor antagonists on capsaicin- and tachykinin-induced bronchospasm in anaesthetized guinea-pigs. ( Ballati, L; Evangelista, S; Maggi, CA; Manzini, S, 1992)
"In hexamethonium-treated animals, MEN 10,376 still abolished the increase in insufflation pressure induced by [beta-Ala8]NKA-(4-10) and reduced the increase elicited by capsaicin."1.28Effects of selective tachykinin receptor antagonists on capsaicin- and tachykinin-induced bronchospasm in anaesthetized guinea-pigs. ( Ballati, L; Evangelista, S; Maggi, CA; Manzini, S, 1992)
" The latter interventions, when imposed between successive dose-response curves generated by intravenous 5HT in animals pretreated with atropine and propranolol, did not alter the positions or slopes of the curves."1.27Reflex activation of the nonadrenergic noncholinergic inhibitory nervous system in feline airways. ( Altiere, RJ; Diamond, L; Gillespie, MN; Szarek, JL, 1986)

Research

Studies (4)

TimeframeStudies, this research(%)All Research%
pre-19902 (50.00)18.7374
1990's1 (25.00)18.2507
2000's0 (0.00)29.6817
2010's1 (25.00)24.3611
2020's0 (0.00)2.80

Authors

AuthorsStudies
Streck, E1
Jörres, RA1
Huber, RM1
Bergner, A1
Ballati, L1
Evangelista, S1
Maggi, CA1
Manzini, S1
Hartiala, JJ1
Mapp, C1
Mitchell, RA1
Gold, WM1
Szarek, JL1
Gillespie, MN1
Altiere, RJ1
Diamond, L1

Other Studies

4 other studies available for hexamethonium and Bronchial Spasm

ArticleYear
Effects of cigarette smoke extract and nicotine on bronchial tone and acetylcholine-induced airway contraction in mouse lung slices.
    Journal of investigational allergology & clinical immunology, 2010, Volume: 20, Issue:4

    Topics: Acetylcholine; Animals; Bronchial Hyperreactivity; Bronchial Spasm; Cells, Cultured; Complex Mixture

2010
Effects of selective tachykinin receptor antagonists on capsaicin- and tachykinin-induced bronchospasm in anaesthetized guinea-pigs.
    European journal of pharmacology, 1992, Apr-22, Volume: 214, Issue:2-3

    Topics: Anesthesia; Animals; Atropine; Biphenyl Compounds; Bronchial Spasm; Capsaicin; Guinea Pigs; Hexameth

1992
Nicotine-induced respiratory effects of cigarette smoke in dogs.
    Journal of applied physiology (Bethesda, Md. : 1985), 1985, Volume: 59, Issue:1

    Topics: Animals; Blood; Bronchial Spasm; Dogs; Female; Hexamethonium; Hexamethonium Compounds; Male; Mecamyl

1985
Reflex activation of the nonadrenergic noncholinergic inhibitory nervous system in feline airways.
    The American review of respiratory disease, 1986, Volume: 133, Issue:6

    Topics: Airway Resistance; Animals; Autonomic Nerve Block; Bronchial Spasm; Cats; Cold Temperature; Dose-Res

1986