hexamethonium has been researched along with Brain Injuries in 1 studies
Hexamethonium: A nicotinic cholinergic antagonist often referred to as the prototypical ganglionic blocker. It is poorly absorbed from the gastrointestinal tract and does not cross the blood-brain barrier. It has been used for a variety of therapeutic purposes including hypertension but, like the other ganglionic blockers, it has been replaced by more specific drugs for most purposes, although it is widely used a research tool.
Brain Injuries: Acute and chronic (see also BRAIN INJURIES, CHRONIC) injuries to the brain, including the cerebral hemispheres, CEREBELLUM, and BRAIN STEM. Clinical manifestations depend on the nature of injury. Diffuse trauma to the brain is frequently associated with DIFFUSE AXONAL INJURY or COMA, POST-TRAUMATIC. Localized injuries may be associated with NEUROBEHAVIORAL MANIFESTATIONS; HEMIPARESIS, or other focal neurologic deficits.
| Excerpt | Relevance | Reference |
|---|---|---|
| "Pretreatment with hexamethonium prevented neither acute nor more enduring behavioral deficits observed after TBI." | 1.28 | Blockade of acute hypertensive response does not prevent changes in behavior or in CSF acetylcholine (ACH) content following traumatic brain injury (TBI). ( Enters, EK; Kapasi, MZ; McDowell, KP; Pascua, JR; Povlishock, JT; Robinson, SE, 1992) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 0 (0.00) | 18.7374 |
| 1990's | 1 (100.00) | 18.2507 |
| 2000's | 0 (0.00) | 29.6817 |
| 2010's | 0 (0.00) | 24.3611 |
| 2020's | 0 (0.00) | 2.80 |
| Authors | Studies |
|---|---|
| Enters, EK | 1 |
| Pascua, JR | 1 |
| McDowell, KP | 1 |
| Kapasi, MZ | 1 |
| Povlishock, JT | 1 |
| Robinson, SE | 1 |
1 other study available for hexamethonium and Brain Injuries
| Article | Year |
|---|---|
Blockade of acute hypertensive response does not prevent changes in behavior or in CSF acetylcholine (ACH) content following traumatic brain injury (TBI).
Topics: Acetylcholine; Analysis of Variance; Animals; Axonal Transport; Behavior, Animal; Blood Pressure; Br | 1992 |