hexamethonium has been researched along with Bradycardia in 12 studies
Hexamethonium: A nicotinic cholinergic antagonist often referred to as the prototypical ganglionic blocker. It is poorly absorbed from the gastrointestinal tract and does not cross the blood-brain barrier. It has been used for a variety of therapeutic purposes including hypertension but, like the other ganglionic blockers, it has been replaced by more specific drugs for most purposes, although it is widely used a research tool.
Bradycardia: Cardiac arrhythmias that are characterized by excessively slow HEART RATE, usually below 50 beats per minute in human adults. They can be classified broadly into SINOATRIAL NODE dysfunction and ATRIOVENTRICULAR BLOCK.
| Excerpt | Relevance | Reference |
|---|---|---|
| "The present study investigated the bradycardiac responses to brain ischemia for approximately 30s before and after intravenous administration of hexamethonium (C6, 15 mg/kg) in urethane-anesthetized spontaneously breathing rabbits." | 7.68 | Effects of hexamethonium on bradycardiac responses to brain ischemia in the rabbit. ( Kanno, T; Matsumoto, S; Nagayama, T; Shimizu, T; Yamasaki, M, 1992) |
| "Previous studies from this laboratory have established that electrical stimulation of non-myelinated axons in the rabbit vagus nerve produces a bradycardia which is unaffected by the nicotinic ganglion blocker hexamethonium." | 7.68 | The effect of supranodose vagotomy on the hexamethonium-resistant bradycardia in the anaesthetized rabbit. ( McWilliam, PN; Woolley, DC, 1990) |
| "Nicotine (200 mg/kg) was administered as a single bolus, as infusions lasting 7." | 5.30 | Tachyphylaxis and sensitization to nicotine-induced tachycardiac and pressor effects after nicotine infusions. ( Cruz, SL; Vidrio, H, 1997) |
| "After saline pretreatment, response to 5-HT consisted of immediate and brief apnea, bradycardia, and hypotension, followed by sustained tachypnea, tachycardia, pulmonary hypertension, and hypocapnic hypoxemia." | 3.69 | Parasympathetic component of 5-hydroxytryptamine-induced pulmonary dysfunctions in healthy calves. ( Amory, H; Desmecht, DJ; Lekeux, PM; Linden, AS, 1996) |
| "The present study investigated the bradycardiac responses to brain ischemia for approximately 30s before and after intravenous administration of hexamethonium (C6, 15 mg/kg) in urethane-anesthetized spontaneously breathing rabbits." | 3.68 | Effects of hexamethonium on bradycardiac responses to brain ischemia in the rabbit. ( Kanno, T; Matsumoto, S; Nagayama, T; Shimizu, T; Yamasaki, M, 1992) |
| "Previous studies from this laboratory have established that electrical stimulation of non-myelinated axons in the rabbit vagus nerve produces a bradycardia which is unaffected by the nicotinic ganglion blocker hexamethonium." | 3.68 | The effect of supranodose vagotomy on the hexamethonium-resistant bradycardia in the anaesthetized rabbit. ( McWilliam, PN; Woolley, DC, 1990) |
| "Pretreatment with methyllycaconitine citrate, a selective alpha7 nicotinic receptor antagonist, significantly attenuated cytisine-induced sympathetic response with little effect on the parasympathetic response." | 1.36 | Cytisine induces autonomic cardiovascular responses via activations of different nicotinic receptors. ( Freeling, J; Lacroix, C; Li, YF, 2010) |
| "Cardiac hypertrophy was observed in both treated groups (P<0." | 1.33 | Effects of chronic anabolic steroid treatment on tonic and reflex cardiovascular control in male rats. ( Bergamaschi, CT; Beutel, A; Campos, RR, 2005) |
| "Nicotine (200 mg/kg) was administered as a single bolus, as infusions lasting 7." | 1.30 | Tachyphylaxis and sensitization to nicotine-induced tachycardiac and pressor effects after nicotine infusions. ( Cruz, SL; Vidrio, H, 1997) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 0 (0.00) | 18.7374 |
| 1990's | 4 (33.33) | 18.2507 |
| 2000's | 5 (41.67) | 29.6817 |
| 2010's | 3 (25.00) | 24.3611 |
| 2020's | 0 (0.00) | 2.80 |
| Authors | Studies |
|---|---|
| Stoyek, MR | 1 |
| Quinn, TA | 1 |
| Croll, RP | 1 |
| Smith, FM | 1 |
| Richer, LP | 1 |
| Vinet, A | 1 |
| Kus, T | 1 |
| Cardinal, R | 1 |
| Ardell, JL | 2 |
| Armour, JA | 2 |
| Li, YF | 1 |
| Lacroix, C | 1 |
| Freeling, J | 1 |
| Gibbons, DD | 1 |
| Southerland, EM | 1 |
| Hoover, DB | 1 |
| Beaumont, E | 1 |
| Lahlou, S | 1 |
| Beutel, A | 1 |
| Bergamaschi, CT | 1 |
| Campos, RR | 1 |
| Ciriello, J | 1 |
| Solano-Flores, LP | 1 |
| Rosas-Arellano, MP | 1 |
| Kirouac, GJ | 1 |
| Babic, T | 1 |
| Linden, AS | 1 |
| Desmecht, DJ | 1 |
| Amory, H | 1 |
| Lekeux, PM | 1 |
| Cruz, SL | 1 |
| Vidrio, H | 1 |
| Markos, F | 1 |
| Snow, HM | 1 |
| Kidd, C | 1 |
| Conlon, K | 1 |
| Matsumoto, S | 1 |
| Yamasaki, M | 1 |
| Kanno, T | 1 |
| Nagayama, T | 1 |
| Shimizu, T | 1 |
| McWilliam, PN | 1 |
| Woolley, DC | 1 |
12 other studies available for hexamethonium and Bradycardia
| Article | Year |
|---|---|
Zebrafish heart as a model to study the integrative autonomic control of pacemaker function.
Topics: Adrenergic beta-Antagonists; Animals; Atrioventricular Node; Atropine; Autonomic Nervous System; Bra | 2016 |
Alpha-adrenoceptor blockade modifies neurally induced atrial arrhythmias.
Topics: Adrenergic alpha-1 Receptor Antagonists; Adrenergic alpha-2 Receptor Antagonists; Adrenergic alpha-A | 2008 |
Cytisine induces autonomic cardiovascular responses via activations of different nicotinic receptors.
Topics: Aconitine; Adrenergic alpha-Antagonists; Alkaloids; Analysis of Variance; Animals; Atropine; Azocine | 2010 |
Neuromodulation targets intrinsic cardiac neurons to attenuate neuronally mediated atrial arrhythmias.
Topics: Animals; Atrial Fibrillation; Autonomic Pathways; Bradycardia; Dogs; Electric Stimulation; Female; G | 2012 |
Mechanisms underlying the cardiovascular responses to spinal dopamine receptor stimulation by apomorphine in anesthetized rats.
Topics: Adrenalectomy; Adrenergic beta-Antagonists; Animals; Anti-Arrhythmia Agents; Apomorphine; Atenolol; | 2003 |
Effects of chronic anabolic steroid treatment on tonic and reflex cardiovascular control in male rats.
Topics: Anabolic Agents; Animals; Baroreflex; Blood Pressure; Body Weight; Bradycardia; Cardiac Output; Card | 2005 |
Medullary pathways mediating the parasubthalamic nucleus depressor response.
Topics: Animals; Atropine Derivatives; Baroreflex; Blood Pressure; Bradycardia; Cobalt; Glutamic Acid; Heart | 2008 |
Parasympathetic component of 5-hydroxytryptamine-induced pulmonary dysfunctions in healthy calves.
Topics: Aging; Animals; Apnea; Atropine; Bradycardia; Cattle; Cattle Diseases; Cholinergic Agents; Ganglioni | 1996 |
Tachyphylaxis and sensitization to nicotine-induced tachycardiac and pressor effects after nicotine infusions.
Topics: Animals; Blood Pressure; Bradycardia; Decerebrate State; Drug Administration Schedule; Ganglionic Bl | 1997 |
Nitric oxide facilitates vagal control of heart rate via actions in the cardiac parasympathetic ganglia of the anaesthetised dog.
Topics: Anesthesia; Animals; Bradycardia; Dogs; Electrocardiography; Enzyme Inhibitors; Ganglia, Parasympath | 2002 |
Effects of hexamethonium on bradycardiac responses to brain ischemia in the rabbit.
Topics: Animals; Bradycardia; Brain Ischemia; Electric Stimulation; Evoked Potentials; Ganglionic Blockers; | 1992 |
The effect of supranodose vagotomy on the hexamethonium-resistant bradycardia in the anaesthetized rabbit.
Topics: Action Potentials; Anesthesia; Animals; Bradycardia; Cardiovascular Physiological Phenomena; Cardiov | 1990 |