hexamethonium has been researched along with Bradyarrhythmia in 12 studies
Hexamethonium: A nicotinic cholinergic antagonist often referred to as the prototypical ganglionic blocker. It is poorly absorbed from the gastrointestinal tract and does not cross the blood-brain barrier. It has been used for a variety of therapeutic purposes including hypertension but, like the other ganglionic blockers, it has been replaced by more specific drugs for most purposes, although it is widely used a research tool.
| Excerpt | Relevance | Reference |
|---|---|---|
| "The present study investigated the bradycardiac responses to brain ischemia for approximately 30s before and after intravenous administration of hexamethonium (C6, 15 mg/kg) in urethane-anesthetized spontaneously breathing rabbits." | 7.68 | Effects of hexamethonium on bradycardiac responses to brain ischemia in the rabbit. ( Kanno, T; Matsumoto, S; Nagayama, T; Shimizu, T; Yamasaki, M, 1992) |
| "Previous studies from this laboratory have established that electrical stimulation of non-myelinated axons in the rabbit vagus nerve produces a bradycardia which is unaffected by the nicotinic ganglion blocker hexamethonium." | 7.68 | The effect of supranodose vagotomy on the hexamethonium-resistant bradycardia in the anaesthetized rabbit. ( McWilliam, PN; Woolley, DC, 1990) |
| "Nicotine (200 mg/kg) was administered as a single bolus, as infusions lasting 7." | 5.30 | Tachyphylaxis and sensitization to nicotine-induced tachycardiac and pressor effects after nicotine infusions. ( Cruz, SL; Vidrio, H, 1997) |
| "After saline pretreatment, response to 5-HT consisted of immediate and brief apnea, bradycardia, and hypotension, followed by sustained tachypnea, tachycardia, pulmonary hypertension, and hypocapnic hypoxemia." | 3.69 | Parasympathetic component of 5-hydroxytryptamine-induced pulmonary dysfunctions in healthy calves. ( Amory, H; Desmecht, DJ; Lekeux, PM; Linden, AS, 1996) |
| "The present study investigated the bradycardiac responses to brain ischemia for approximately 30s before and after intravenous administration of hexamethonium (C6, 15 mg/kg) in urethane-anesthetized spontaneously breathing rabbits." | 3.68 | Effects of hexamethonium on bradycardiac responses to brain ischemia in the rabbit. ( Kanno, T; Matsumoto, S; Nagayama, T; Shimizu, T; Yamasaki, M, 1992) |
| "Previous studies from this laboratory have established that electrical stimulation of non-myelinated axons in the rabbit vagus nerve produces a bradycardia which is unaffected by the nicotinic ganglion blocker hexamethonium." | 3.68 | The effect of supranodose vagotomy on the hexamethonium-resistant bradycardia in the anaesthetized rabbit. ( McWilliam, PN; Woolley, DC, 1990) |
| "Pretreatment with methyllycaconitine citrate, a selective alpha7 nicotinic receptor antagonist, significantly attenuated cytisine-induced sympathetic response with little effect on the parasympathetic response." | 1.36 | Cytisine induces autonomic cardiovascular responses via activations of different nicotinic receptors. ( Freeling, J; Lacroix, C; Li, YF, 2010) |
| "Cardiac hypertrophy was observed in both treated groups (P<0." | 1.33 | Effects of chronic anabolic steroid treatment on tonic and reflex cardiovascular control in male rats. ( Bergamaschi, CT; Beutel, A; Campos, RR, 2005) |
| "Nicotine (200 mg/kg) was administered as a single bolus, as infusions lasting 7." | 1.30 | Tachyphylaxis and sensitization to nicotine-induced tachycardiac and pressor effects after nicotine infusions. ( Cruz, SL; Vidrio, H, 1997) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 0 (0.00) | 18.7374 |
| 1990's | 4 (33.33) | 18.2507 |
| 2000's | 5 (41.67) | 29.6817 |
| 2010's | 3 (25.00) | 24.3611 |
| 2020's | 0 (0.00) | 2.80 |
| Authors | Studies |
|---|---|
| Stoyek, MR | 1 |
| Quinn, TA | 1 |
| Croll, RP | 1 |
| Smith, FM | 1 |
| Richer, LP | 1 |
| Vinet, A | 1 |
| Kus, T | 1 |
| Cardinal, R | 1 |
| Ardell, JL | 2 |
| Armour, JA | 2 |
| Li, YF | 1 |
| Lacroix, C | 1 |
| Freeling, J | 1 |
| Gibbons, DD | 1 |
| Southerland, EM | 1 |
| Hoover, DB | 1 |
| Beaumont, E | 1 |
| Lahlou, S | 1 |
| Beutel, A | 1 |
| Bergamaschi, CT | 1 |
| Campos, RR | 1 |
| Ciriello, J | 1 |
| Solano-Flores, LP | 1 |
| Rosas-Arellano, MP | 1 |
| Kirouac, GJ | 1 |
| Babic, T | 1 |
| Linden, AS | 1 |
| Desmecht, DJ | 1 |
| Amory, H | 1 |
| Lekeux, PM | 1 |
| Cruz, SL | 1 |
| Vidrio, H | 1 |
| Markos, F | 1 |
| Snow, HM | 1 |
| Kidd, C | 1 |
| Conlon, K | 1 |
| Matsumoto, S | 1 |
| Yamasaki, M | 1 |
| Kanno, T | 1 |
| Nagayama, T | 1 |
| Shimizu, T | 1 |
| McWilliam, PN | 1 |
| Woolley, DC | 1 |
12 other studies available for hexamethonium and Bradyarrhythmia
| Article | Year |
|---|---|
Zebrafish heart as a model to study the integrative autonomic control of pacemaker function.
Topics: Adrenergic beta-Antagonists; Animals; Atrioventricular Node; Atropine; Autonomic Nervous System; Bra | 2016 |
Alpha-adrenoceptor blockade modifies neurally induced atrial arrhythmias.
Topics: Adrenergic alpha-1 Receptor Antagonists; Adrenergic alpha-2 Receptor Antagonists; Adrenergic alpha-A | 2008 |
Cytisine induces autonomic cardiovascular responses via activations of different nicotinic receptors.
Topics: Aconitine; Adrenergic alpha-Antagonists; Alkaloids; Analysis of Variance; Animals; Atropine; Azocine | 2010 |
Neuromodulation targets intrinsic cardiac neurons to attenuate neuronally mediated atrial arrhythmias.
Topics: Animals; Atrial Fibrillation; Autonomic Pathways; Bradycardia; Dogs; Electric Stimulation; Female; G | 2012 |
Mechanisms underlying the cardiovascular responses to spinal dopamine receptor stimulation by apomorphine in anesthetized rats.
Topics: Adrenalectomy; Adrenergic beta-Antagonists; Animals; Anti-Arrhythmia Agents; Apomorphine; Atenolol; | 2003 |
Effects of chronic anabolic steroid treatment on tonic and reflex cardiovascular control in male rats.
Topics: Anabolic Agents; Animals; Baroreflex; Blood Pressure; Body Weight; Bradycardia; Cardiac Output; Card | 2005 |
Medullary pathways mediating the parasubthalamic nucleus depressor response.
Topics: Animals; Atropine Derivatives; Baroreflex; Blood Pressure; Bradycardia; Cobalt; Glutamic Acid; Heart | 2008 |
Parasympathetic component of 5-hydroxytryptamine-induced pulmonary dysfunctions in healthy calves.
Topics: Aging; Animals; Apnea; Atropine; Bradycardia; Cattle; Cattle Diseases; Cholinergic Agents; Ganglioni | 1996 |
Tachyphylaxis and sensitization to nicotine-induced tachycardiac and pressor effects after nicotine infusions.
Topics: Animals; Blood Pressure; Bradycardia; Decerebrate State; Drug Administration Schedule; Ganglionic Bl | 1997 |
Nitric oxide facilitates vagal control of heart rate via actions in the cardiac parasympathetic ganglia of the anaesthetised dog.
Topics: Anesthesia; Animals; Bradycardia; Dogs; Electrocardiography; Enzyme Inhibitors; Ganglia, Parasympath | 2002 |
Effects of hexamethonium on bradycardiac responses to brain ischemia in the rabbit.
Topics: Animals; Bradycardia; Brain Ischemia; Electric Stimulation; Evoked Potentials; Ganglionic Blockers; | 1992 |
The effect of supranodose vagotomy on the hexamethonium-resistant bradycardia in the anaesthetized rabbit.
Topics: Action Potentials; Anesthesia; Animals; Bradycardia; Cardiovascular Physiological Phenomena; Cardiov | 1990 |