hexamethonium has been researched along with Asthma in 18 studies
Hexamethonium: A nicotinic cholinergic antagonist often referred to as the prototypical ganglionic blocker. It is poorly absorbed from the gastrointestinal tract and does not cross the blood-brain barrier. It has been used for a variety of therapeutic purposes including hypertension but, like the other ganglionic blockers, it has been replaced by more specific drugs for most purposes, although it is widely used a research tool.
Asthma: A form of bronchial disorder with three distinct components: airway hyper-responsiveness (RESPIRATORY HYPERSENSITIVITY), airway INFLAMMATION, and intermittent AIRWAY OBSTRUCTION. It is characterized by spasmodic contraction of airway smooth muscle, WHEEZING, and dyspnea (DYSPNEA, PAROXYSMAL).
| Excerpt | Relevance | Reference |
|---|---|---|
| "The degree of protection against inhaled histamine achieved by inhalation of the ganglion blocker hexamethonium bromide plus placebo, hexamethonium plus atropine sulphate, and placebo plus placebo was examined in six atopic subjects, four of whom had current asthma." | 5.05 | The effect of inhaled hexamethonium bromide and atropine sulphate on airway responsiveness to histamine. ( Daniel, EE; Hargreave, FE; Latimer, KM; Morris, MM; O'Byrne, PM; Roberts, RS; Thomson, NC, 1985) |
| "Brown-Norway rats (n=113) sensitized and challenged with nDer f 1 allergen were used to examine the contribution of lung sensory nerves to ozone (O(3)) exacerbation of asthma." | 3.78 | Vagal afferents contribute to exacerbated airway responses following ozone and allergen challenge. ( Schelegle, ES; Walby, WF, 2012) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 2 (11.11) | 18.7374 |
| 1990's | 1 (5.56) | 18.2507 |
| 2000's | 14 (77.78) | 29.6817 |
| 2010's | 1 (5.56) | 24.3611 |
| 2020's | 0 (0.00) | 2.80 |
| Authors | Studies |
|---|---|
| Schelegle, ES | 1 |
| Walby, WF | 1 |
| Kolata, G | 2 |
| Glanz, J | 2 |
| Maloney, DM | 2 |
| Boushey, HA | 1 |
| Smaglik, P | 1 |
| Marshall, E | 2 |
| Josefson, D | 1 |
| Begley, S | 1 |
| Bonetta, L | 1 |
| Savulescu, J | 1 |
| Spriggs, M | 1 |
| Steinbrook, R | 1 |
| Inoue, H | 1 |
| Aizawa, H | 1 |
| Miyazaki, N | 1 |
| Ikeda, T | 1 |
| Shigematsu, N | 1 |
| O'Byrne, PM | 1 |
| Thomson, NC | 1 |
| Latimer, KM | 1 |
| Roberts, RS | 1 |
| Morris, MM | 1 |
| Daniel, EE | 1 |
| Hargreave, FE | 1 |
1 trial available for hexamethonium and Asthma
| Article | Year |
|---|---|
The effect of inhaled hexamethonium bromide and atropine sulphate on airway responsiveness to histamine.
Topics: Adult; Asthma; Atropine; Blood Pressure; Drug Interactions; Female; Forced Expiratory Volume; Heart | 1985 |
17 other studies available for hexamethonium and Asthma
| Article | Year |
|---|---|
Vagal afferents contribute to exacerbated airway responses following ozone and allergen challenge.
Topics: Air Pollutants; Airway Resistance; Allergens; Animals; Asthma; Bronchoconstriction; Capsaicin; Gangl | 2012 |
Johns Hopkins admits fault in fatal experiment.
Topics: Academic Medical Centers; Asthma; Controlled Clinical Trials as Topic; Ethics Committees, Research; | 2001 |
Johns Hopkins death brings halt to U.S.-financed human studies.
Topics: Asthma; Controlled Clinical Trials as Topic; Fatal Outcome; Female; Financing, Government; Governmen | 2001 |
1978 study had troubles like fatal Hopkins test.
Topics: Asthma; Controlled Clinical Trials as Topic; Fatal Outcome; Female; Hexamethonium; Hospitals, Univer | 2001 |
Clues of asthma study risks may have been overlooked.
Topics: Asthma; Controlled Clinical Trials as Topic; Ethics Committees, Research; Hexamethonium; Humans; Non | 2001 |
Death of a research subject and a halt to all federally-funded research.
Topics: Asthma; Consent Forms; Ethics Committees, Research; Fatal Outcome; Federal Government; Government Re | 2004 |
Why wasn't an investigational new drug (IND) application required before appropriate study?
Topics: Asthma; Baltimore; Controlled Clinical Trials as Topic; Drugs, Investigational; Ethics Committees, R | 2004 |
The role of the parasympathetic system in the regulation of bronchial smooth muscle.
Topics: Airway Resistance; Asthma; Atropine; Bronchi; Bronchodilator Agents; Hexamethonium; Hexamethonium Co | 1984 |
Asthma study death spurs inquiry.
Topics: Administration, Inhalation; Asthma; Baltimore; Controlled Clinical Trials as Topic; Fatal Outcome; F | 2001 |
Human subjects. Volunteer's death prompts review.
Topics: Academic Medical Centers; Adult; Asthma; Baltimore; Controlled Clinical Trials as Topic; Fatal Outco | 2001 |
Clinical research. Procedures faulted in fatal asthma trial.
Topics: Academic Medical Centers; Administration, Inhalation; Adult; Asthma; Baltimore; Clinical Protocols; | 2001 |
Second US institute investigates use of drug in asthma trial.
Topics: Administration, Inhalation; Asthma; Bronchoconstrictor Agents; Hexamethonium; Human Experimentation; | 2001 |
Medicine. Dying for science.
Topics: Adult; Anti-Asthmatic Agents; Asthma; Baltimore; Clinical Trials as Topic; Fatal Outcome; Female; He | 2001 |
Johns Hopkins troubles raise trial questions.
Topics: Academies and Institutes; Adult; Asthma; Baltimore; Clinical Trials as Topic; Ethics Committees, Res | 2001 |
The hexamethonium asthma study and the death of a normal volunteer in research.
Topics: Administration, Inhalation; Asthma; Baltimore; Controlled Clinical Trials as Topic; Ethics Committee | 2002 |
Protecting research subjects--the crisis at Johns Hopkins.
Topics: Academic Medical Centers; Adult; Asthma; Baltimore; Clinical Trials as Topic; Ethics Committees, Res | 2002 |
Possible roles of the peripheral vagal nerve in histamine-induced bronchoconstriction in guinea-pigs.
Topics: Animals; Asthma; Atropine; Bronchoconstriction; Female; Ganglionic Blockers; Guinea Pigs; Hexamethon | 1991 |