hexamethonium has been researched along with Arrhythmias, Cardiac in 15 studies
Hexamethonium: A nicotinic cholinergic antagonist often referred to as the prototypical ganglionic blocker. It is poorly absorbed from the gastrointestinal tract and does not cross the blood-brain barrier. It has been used for a variety of therapeutic purposes including hypertension but, like the other ganglionic blockers, it has been replaced by more specific drugs for most purposes, although it is widely used a research tool.
Arrhythmias, Cardiac: Any disturbances of the normal rhythmic beating of the heart or MYOCARDIAL CONTRACTION. Cardiac arrhythmias can be classified by the abnormalities in HEART RATE, disorders of electrical impulse generation, or impulse conduction.
| Excerpt | Relevance | Reference |
|---|---|---|
| " To investigate the mechanisms by which bupivacaine may act within the CNS to produce cardiovascular toxicity, we studied four groups of halothane-anesthetized rabbits in which infusion of intracerebroventricular (icv) bupivacaine or intravenous (iv) phenylephrine resulted in dysrhythmias and hypertension." | 7.68 | Hexamethonium and midazolam terminate dysrhythmias and hypertension caused by intracerebroventricular bupivacaine in rabbits. ( Artu, AA; Bernards, CM, 1991) |
| " To investigate the mechanisms by which bupivacaine may act within the CNS to produce cardiovascular toxicity, we studied four groups of halothane-anesthetized rabbits in which infusion of intracerebroventricular (icv) bupivacaine or intravenous (iv) phenylephrine resulted in dysrhythmias and hypertension." | 3.68 | Hexamethonium and midazolam terminate dysrhythmias and hypertension caused by intracerebroventricular bupivacaine in rabbits. ( Artu, AA; Bernards, CM, 1991) |
| "Ventricular arrhythmias, including Torsades de pointes in monkeys, were prevented in both species when HF oscillations were suppressed by autonomic blockade." | 1.42 | Short-term variability in QT interval and ventricular arrhythmias induced by dofetilide are dependent on high-frequency autonomic oscillations. ( Champeroux, P; Fowler, JS; Judé, S; Laigot-Barbé, C; Le Guennec, JY; Maurin, A; Richard, S; Sola, ML; Thireau, J, 2015) |
| "In many species arrhythmias induced by myocardial ischaemia appear to be in part dependent upon cardiac sympathetic nerves." | 1.30 | Cardiac transplantation does not effect ischaemia-induced arrhythmias in rats. ( Guo, P; Pugsley, MK; Walker, MJ; Yong, SL, 1999) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 3 (20.00) | 18.7374 |
| 1990's | 8 (53.33) | 18.2507 |
| 2000's | 3 (20.00) | 29.6817 |
| 2010's | 1 (6.67) | 24.3611 |
| 2020's | 0 (0.00) | 2.80 |
| Authors | Studies |
|---|---|
| Champeroux, P | 1 |
| Thireau, J | 1 |
| Judé, S | 1 |
| Laigot-Barbé, C | 1 |
| Maurin, A | 1 |
| Sola, ML | 1 |
| Fowler, JS | 1 |
| Richard, S | 1 |
| Le Guennec, JY | 1 |
| Richer, LP | 1 |
| Vinet, A | 1 |
| Kus, T | 1 |
| Cardinal, R | 1 |
| Ardell, JL | 1 |
| Armour, JA | 1 |
| OHYAMA, Y | 1 |
| AOKI, Y | 1 |
| TAMURA, K | 1 |
| KAWABE, A | 1 |
| IMAI, T | 1 |
| KIKUTA, R | 1 |
| EGUCHI, A | 1 |
| MASHIMA, T | 1 |
| OGURO, C | 1 |
| BIRCHER, RP | 1 |
| CHAI, CY | 1 |
| WANG, SC | 1 |
| Lobanov, AV | 1 |
| Rzhevskii, DI | 1 |
| Korshunov, VA | 1 |
| Murashev, AN | 1 |
| Onuaguluchi, G | 1 |
| Igbo, IN | 1 |
| Bernards, CM | 2 |
| Artru, AA | 1 |
| Lishmanov, YB | 1 |
| Maslov, LN | 4 |
| Ugdyzhekova, DS | 3 |
| Smagin, GN | 1 |
| Lishmanov, IB | 1 |
| Krylatov, AV | 1 |
| Lishmanov, IuB | 2 |
| Maĭmeskulova, LA | 2 |
| Krasnov, EA | 1 |
| Guo, P | 1 |
| Pugsley, MK | 1 |
| Yong, SL | 1 |
| Walker, MJ | 2 |
| Davydova, YG | 1 |
| Mechoulam, R | 1 |
| Artu, AA | 1 |
| Abraham, S | 1 |
| Beatch, GN | 1 |
15 other studies available for hexamethonium and Arrhythmias, Cardiac
| Article | Year |
|---|---|
Short-term variability in QT interval and ventricular arrhythmias induced by dofetilide are dependent on high-frequency autonomic oscillations.
Topics: Animals; Anti-Arrhythmia Agents; Arrhythmias, Cardiac; Autonomic Nervous System; Dogs; Electrophysio | 2015 |
Alpha-adrenoceptor blockade modifies neurally induced atrial arrhythmias.
Topics: Adrenergic alpha-1 Receptor Antagonists; Adrenergic alpha-2 Receptor Antagonists; Adrenergic alpha-A | 2008 |
A CASE OF ACUTE MYOCARDIAL INFARCTION WITH INITIAL ST SEGMENT DEPRESSIN.
Topics: Abscess; Alanine Transaminase; Anal Canal; Arrhythmias, Cardiac; Aspartate Aminotransferases; Blood | 1964 |
EFFECTS OF HEXAMETHONIUM AND TETRAETHYLAMMONIUM ON CARDIAC ARRHYTHMIAS PRODUCED BY PENTYLENETETRAZOL, PICROTOXIN AND DESLANOSIDE IN DOGS.
Topics: Animals; Arrhythmias, Cardiac; Autonomic Nervous System; Central Nervous System; Deslanoside; Dogs; | 1965 |
Effect of cholinergic and adrenergic receptor blockade on arrhythmogenic activity of endothelin-1 during inhibition of nitric oxide synthesis in awake mice.
Topics: Adrenergic Antagonists; Animals; Arrhythmias, Cardiac; Atenolol; Atropine; Cholinergic Antagonists; | 2004 |
Effect of levamisole hydrochloride on the guinea-pig atrium.
Topics: Animals; Arrhythmias, Cardiac; Atropine; Disease Models, Animal; Drug Antagonism; Drug Evaluation, P | 1993 |
Effect of intracerebroventricular picrotoxin and muscimol on intravenous bupivacaine toxicity. Evidence supporting central nervous system involvement in bupivacaine cardiovascular toxicity.
Topics: Animals; Antihypertensive Agents; Arrhythmias, Cardiac; Blood Pressure; Bupivacaine; Central Nervous | 1993 |
Participation of central kappa-opioid receptor in arrhythmogenesis.
Topics: 3,4-Dichloro-N-methyl-N-(2-(1-pyrrolidinyl)-cyclohexyl)-benzeneacetamide, (trans)-Isomer; Animals; A | 1997 |
[Central K1-opiate receptors and mechanisms of arrhythmogenesis].
Topics: Animals; Arrhythmias, Cardiac; Blood-Brain Barrier; Brain; Dynorphins; Ganglionic Blockers; Heart; H | 1997 |
[The anti-arrhythmic effect of the mu-opiate receptor agonists in adrenal arrhythmia: the role of the autonomic nervous system].
Topics: Animals; Anti-Arrhythmia Agents; Arrhythmias, Cardiac; Atropine; Autonomic Nervous System; Electroca | 1996 |
[Mechanism of the anti-arrhythmic effect of Rhodiola rosea extract].
Topics: Animals; Anti-Arrhythmia Agents; Arrhythmias, Cardiac; Atropine; Atropine Derivatives; Epinephrine; | 1998 |
Cardiac transplantation does not effect ischaemia-induced arrhythmias in rats.
Topics: Acetylcholine; Adrenergic alpha-Agonists; Adrenergic beta-Antagonists; Animals; Arrhythmias, Cardiac | 1999 |
Involvement of central and peripheral cannabinoid receptors in the regulation of heart resistance to arrhythmogenic effects of epinephrine.
Topics: Animals; Arrhythmias, Cardiac; Cannabinoids; Disease Models, Animal; Dronabinol; Epinephrine; Gangli | 2000 |
Hexamethonium and midazolam terminate dysrhythmias and hypertension caused by intracerebroventricular bupivacaine in rabbits.
Topics: Animals; Arrhythmias, Cardiac; Autonomic Nervous System; Blood Pressure; Brain; Bupivacaine; Halotha | 1991 |
Effects of inhibition of ventricular sodium channel conductance by tetrodotoxin on the occurrence of occlusion induced arrhythmia in the rat.
Topics: Animals; Arrhythmias, Cardiac; Blood Pressure; Coronary Vessels; Heart Rate; Hexamethonium; Hexameth | 1988 |