hexamethonium has been researched along with Arrhythmia in 15 studies
Hexamethonium: A nicotinic cholinergic antagonist often referred to as the prototypical ganglionic blocker. It is poorly absorbed from the gastrointestinal tract and does not cross the blood-brain barrier. It has been used for a variety of therapeutic purposes including hypertension but, like the other ganglionic blockers, it has been replaced by more specific drugs for most purposes, although it is widely used a research tool.
| Excerpt | Relevance | Reference |
|---|---|---|
| " To investigate the mechanisms by which bupivacaine may act within the CNS to produce cardiovascular toxicity, we studied four groups of halothane-anesthetized rabbits in which infusion of intracerebroventricular (icv) bupivacaine or intravenous (iv) phenylephrine resulted in dysrhythmias and hypertension." | 7.68 | Hexamethonium and midazolam terminate dysrhythmias and hypertension caused by intracerebroventricular bupivacaine in rabbits. ( Artu, AA; Bernards, CM, 1991) |
| " To investigate the mechanisms by which bupivacaine may act within the CNS to produce cardiovascular toxicity, we studied four groups of halothane-anesthetized rabbits in which infusion of intracerebroventricular (icv) bupivacaine or intravenous (iv) phenylephrine resulted in dysrhythmias and hypertension." | 3.68 | Hexamethonium and midazolam terminate dysrhythmias and hypertension caused by intracerebroventricular bupivacaine in rabbits. ( Artu, AA; Bernards, CM, 1991) |
| "Ventricular arrhythmias, including Torsades de pointes in monkeys, were prevented in both species when HF oscillations were suppressed by autonomic blockade." | 1.42 | Short-term variability in QT interval and ventricular arrhythmias induced by dofetilide are dependent on high-frequency autonomic oscillations. ( Champeroux, P; Fowler, JS; Judé, S; Laigot-Barbé, C; Le Guennec, JY; Maurin, A; Richard, S; Sola, ML; Thireau, J, 2015) |
| "In many species arrhythmias induced by myocardial ischaemia appear to be in part dependent upon cardiac sympathetic nerves." | 1.30 | Cardiac transplantation does not effect ischaemia-induced arrhythmias in rats. ( Guo, P; Pugsley, MK; Walker, MJ; Yong, SL, 1999) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 3 (20.00) | 18.7374 |
| 1990's | 8 (53.33) | 18.2507 |
| 2000's | 3 (20.00) | 29.6817 |
| 2010's | 1 (6.67) | 24.3611 |
| 2020's | 0 (0.00) | 2.80 |
| Authors | Studies |
|---|---|
| Champeroux, P | 1 |
| Thireau, J | 1 |
| Judé, S | 1 |
| Laigot-Barbé, C | 1 |
| Maurin, A | 1 |
| Sola, ML | 1 |
| Fowler, JS | 1 |
| Richard, S | 1 |
| Le Guennec, JY | 1 |
| Richer, LP | 1 |
| Vinet, A | 1 |
| Kus, T | 1 |
| Cardinal, R | 1 |
| Ardell, JL | 1 |
| Armour, JA | 1 |
| OHYAMA, Y | 1 |
| AOKI, Y | 1 |
| TAMURA, K | 1 |
| KAWABE, A | 1 |
| IMAI, T | 1 |
| KIKUTA, R | 1 |
| EGUCHI, A | 1 |
| MASHIMA, T | 1 |
| OGURO, C | 1 |
| BIRCHER, RP | 1 |
| CHAI, CY | 1 |
| WANG, SC | 1 |
| Lobanov, AV | 1 |
| Rzhevskii, DI | 1 |
| Korshunov, VA | 1 |
| Murashev, AN | 1 |
| Onuaguluchi, G | 1 |
| Igbo, IN | 1 |
| Bernards, CM | 2 |
| Artru, AA | 1 |
| Lishmanov, YB | 1 |
| Maslov, LN | 4 |
| Ugdyzhekova, DS | 3 |
| Smagin, GN | 1 |
| Lishmanov, IB | 1 |
| Krylatov, AV | 1 |
| Lishmanov, IuB | 2 |
| Maĭmeskulova, LA | 2 |
| Krasnov, EA | 1 |
| Guo, P | 1 |
| Pugsley, MK | 1 |
| Yong, SL | 1 |
| Walker, MJ | 2 |
| Davydova, YG | 1 |
| Mechoulam, R | 1 |
| Artu, AA | 1 |
| Abraham, S | 1 |
| Beatch, GN | 1 |
15 other studies available for hexamethonium and Arrhythmia
| Article | Year |
|---|---|
Short-term variability in QT interval and ventricular arrhythmias induced by dofetilide are dependent on high-frequency autonomic oscillations.
Topics: Animals; Anti-Arrhythmia Agents; Arrhythmias, Cardiac; Autonomic Nervous System; Dogs; Electrophysio | 2015 |
Alpha-adrenoceptor blockade modifies neurally induced atrial arrhythmias.
Topics: Adrenergic alpha-1 Receptor Antagonists; Adrenergic alpha-2 Receptor Antagonists; Adrenergic alpha-A | 2008 |
A CASE OF ACUTE MYOCARDIAL INFARCTION WITH INITIAL ST SEGMENT DEPRESSIN.
Topics: Abscess; Alanine Transaminase; Anal Canal; Arrhythmias, Cardiac; Aspartate Aminotransferases; Blood | 1964 |
EFFECTS OF HEXAMETHONIUM AND TETRAETHYLAMMONIUM ON CARDIAC ARRHYTHMIAS PRODUCED BY PENTYLENETETRAZOL, PICROTOXIN AND DESLANOSIDE IN DOGS.
Topics: Animals; Arrhythmias, Cardiac; Autonomic Nervous System; Central Nervous System; Deslanoside; Dogs; | 1965 |
Effect of cholinergic and adrenergic receptor blockade on arrhythmogenic activity of endothelin-1 during inhibition of nitric oxide synthesis in awake mice.
Topics: Adrenergic Antagonists; Animals; Arrhythmias, Cardiac; Atenolol; Atropine; Cholinergic Antagonists; | 2004 |
Effect of levamisole hydrochloride on the guinea-pig atrium.
Topics: Animals; Arrhythmias, Cardiac; Atropine; Disease Models, Animal; Drug Antagonism; Drug Evaluation, P | 1993 |
Effect of intracerebroventricular picrotoxin and muscimol on intravenous bupivacaine toxicity. Evidence supporting central nervous system involvement in bupivacaine cardiovascular toxicity.
Topics: Animals; Antihypertensive Agents; Arrhythmias, Cardiac; Blood Pressure; Bupivacaine; Central Nervous | 1993 |
Participation of central kappa-opioid receptor in arrhythmogenesis.
Topics: 3,4-Dichloro-N-methyl-N-(2-(1-pyrrolidinyl)-cyclohexyl)-benzeneacetamide, (trans)-Isomer; Animals; A | 1997 |
[Central K1-opiate receptors and mechanisms of arrhythmogenesis].
Topics: Animals; Arrhythmias, Cardiac; Blood-Brain Barrier; Brain; Dynorphins; Ganglionic Blockers; Heart; H | 1997 |
[The anti-arrhythmic effect of the mu-opiate receptor agonists in adrenal arrhythmia: the role of the autonomic nervous system].
Topics: Animals; Anti-Arrhythmia Agents; Arrhythmias, Cardiac; Atropine; Autonomic Nervous System; Electroca | 1996 |
[Mechanism of the anti-arrhythmic effect of Rhodiola rosea extract].
Topics: Animals; Anti-Arrhythmia Agents; Arrhythmias, Cardiac; Atropine; Atropine Derivatives; Epinephrine; | 1998 |
Cardiac transplantation does not effect ischaemia-induced arrhythmias in rats.
Topics: Acetylcholine; Adrenergic alpha-Agonists; Adrenergic beta-Antagonists; Animals; Arrhythmias, Cardiac | 1999 |
Involvement of central and peripheral cannabinoid receptors in the regulation of heart resistance to arrhythmogenic effects of epinephrine.
Topics: Animals; Arrhythmias, Cardiac; Cannabinoids; Disease Models, Animal; Dronabinol; Epinephrine; Gangli | 2000 |
Hexamethonium and midazolam terminate dysrhythmias and hypertension caused by intracerebroventricular bupivacaine in rabbits.
Topics: Animals; Arrhythmias, Cardiac; Autonomic Nervous System; Blood Pressure; Brain; Bupivacaine; Halotha | 1991 |
Effects of inhibition of ventricular sodium channel conductance by tetrodotoxin on the occurrence of occlusion induced arrhythmia in the rat.
Topics: Animals; Arrhythmias, Cardiac; Blood Pressure; Coronary Vessels; Heart Rate; Hexamethonium; Hexameth | 1988 |