hexamethonium has been researched along with Anesthesia in 47 studies
Hexamethonium: A nicotinic cholinergic antagonist often referred to as the prototypical ganglionic blocker. It is poorly absorbed from the gastrointestinal tract and does not cross the blood-brain barrier. It has been used for a variety of therapeutic purposes including hypertension but, like the other ganglionic blockers, it has been replaced by more specific drugs for most purposes, although it is widely used a research tool.
Anesthesia: A state characterized by loss of feeling or sensation. This depression of nerve function is usually the result of pharmacologic action and is induced to allow performance of surgery or other painful procedures.
| Excerpt | Relevance | Reference |
|---|---|---|
| "This study was designed to evaluate the importance of sympathoadrenal activation in the acute cardiovascular response to apneas and the role of hypoxemia in this response." | 7.70 | Mechanisms of acute cardiovascular response to periodic apneas in sedated pigs. ( Chen, L; Scharf, SM; Sica, AL, 1999) |
| " Under pentobarbital anesthesia, HQR was decreased significantly (p less than 0." | 7.68 | Sympathetic vasoconstrictor tone induced by pentobarbital anesthesia in hindquarters of rats. ( Iriuchijima, J; Teranishi, Y, 1992) |
| "Previous studies from this laboratory have established that electrical stimulation of non-myelinated axons in the rabbit vagus nerve produces a bradycardia which is unaffected by the nicotinic ganglion blocker hexamethonium." | 7.68 | The effect of supranodose vagotomy on the hexamethonium-resistant bradycardia in the anaesthetized rabbit. ( McWilliam, PN; Woolley, DC, 1990) |
| "In hexamethonium-treated animals, MEN 10,376 still abolished the increase in insufflation pressure induced by [beta-Ala8]NKA-(4-10) and reduced the increase elicited by capsaicin." | 5.28 | Effects of selective tachykinin receptor antagonists on capsaicin- and tachykinin-induced bronchospasm in anaesthetized guinea-pigs. ( Ballati, L; Evangelista, S; Maggi, CA; Manzini, S, 1992) |
| "This study was designed to evaluate the importance of sympathoadrenal activation in the acute cardiovascular response to apneas and the role of hypoxemia in this response." | 3.70 | Mechanisms of acute cardiovascular response to periodic apneas in sedated pigs. ( Chen, L; Scharf, SM; Sica, AL, 1999) |
| " Under pentobarbital anesthesia, HQR was decreased significantly (p less than 0." | 3.68 | Sympathetic vasoconstrictor tone induced by pentobarbital anesthesia in hindquarters of rats. ( Iriuchijima, J; Teranishi, Y, 1992) |
| "Previous studies from this laboratory have established that electrical stimulation of non-myelinated axons in the rabbit vagus nerve produces a bradycardia which is unaffected by the nicotinic ganglion blocker hexamethonium." | 3.68 | The effect of supranodose vagotomy on the hexamethonium-resistant bradycardia in the anaesthetized rabbit. ( McWilliam, PN; Woolley, DC, 1990) |
| "Pretreatment with hexamethonium bromide, a ganglionic transmission blocker, suppressed the HDR-induced drop of ABP, suggesting that the ABP drop was induced by an inhibition of autonomic neural outflows." | 1.35 | Vestibular control of arterial blood pressure during head-down postural change in anesthetized rabbits. ( Hosogai, M; Kawai, Y; Matsuo, S; Nakamura, Y, 2009) |
| "Oxytocin was administered in anesthetized female rats either intrathecally at the lumbosacral or thoracolumbar spinal cord levels or intravenously." | 1.32 | Spinal effects of oxytocin on uterine motility in anesthetized rats. ( Benoussaidh, A; Maurin, Y; Rampin, O, 2004) |
| "Pretreatment with indomethacin, a cyclooxygenase inhibitor, further reduced the first increase and abolished the second increase." | 1.32 | Cholecystokinin and prostaglandins inhibit responses of vagal afferent activity to systemic administration of nicotine in anesthetized rats. ( Kurosawa, M; Taniguchi, T; Yoneda, M, 2004) |
| "Nicotine responses were completely blocked by prior sequential microinjections of alpha-BT and mecamylamine into the NTS." | 1.31 | Receptor subtypes mediating depressor responses to microinjections of nicotine into medial NTS of the rat. ( Dhar, S; McIntosh, JM; Nagy, F; Sapru, HN, 2000) |
| "In atropine-treated animals (6 micromol kg(-1), i." | 1.30 | The role of tachykinin NK1 and NK2 receptors in atropine-resistant colonic propulsion in anaesthetized guinea-pigs. ( Giorgio, RD; Giuliani, S; Lecci, A; Maggi, CA; Tramontana, M, 1998) |
| " At the lowest dose studied (20 microgram/kg iv), the inhibitory effects of candesartan were competitive, whereas at the highest dose (100 microgram/kg iv) the dose-response curve for angiotensin II was shifted to the right in a nonparallel manner with inhibitory effects that could not be surmounted." | 1.30 | Role of AT(1) receptors and autonomic nervous system in mediating acute pressor responses to ANG II in anesthetized mice. ( Bivalacqua, TJ; Champion, HC; Dalal, A; Kadowitz, PJ, 1999) |
| "Hexamethonium pretreatment induced significantly less QRS widening and QTc lengthening than was seen in group 1 but worsened the bupivacaine effects on bradycardia, atria-His and PR intervals, mean aortic pressure, and first derivative of left ventricular pressure." | 1.29 | Mechanisms of the putative cardioprotective effect of hexamethonium in anesthetized dogs given a large dose of bupivacaine. ( Bassoul, B; Bruelle, P; de La Coussaye, JE; Desch, G; Eledjam, JJ; Lefrant, JY; Peray, PA; Sassine, A, 1994) |
| "PD 145065 was without effect." | 1.29 | Roles of endothelin receptors in the regional and systemic vascular responses to ET-1 in the anaesthetized ganglion-blocked rat: use of selective antagonists. ( Allcock, GH; Vane, JR; Warner, TD, 1995) |
| " Bilateral pupillary and nictitating membrane (NM) dose-response curves in response to i." | 1.29 | Analysis of miosis produced by McN-A-343 in anesthetized cats. ( Koss, MC; Wally, JR, 1995) |
| "In hexamethonium-treated animals, MEN 10,376 still abolished the increase in insufflation pressure induced by [beta-Ala8]NKA-(4-10) and reduced the increase elicited by capsaicin." | 1.28 | Effects of selective tachykinin receptor antagonists on capsaicin- and tachykinin-induced bronchospasm in anaesthetized guinea-pigs. ( Ballati, L; Evangelista, S; Maggi, CA; Manzini, S, 1992) |
| "Pretreatment with metoclopramide (5 mg/kg i." | 1.27 | Mechanism of the pressor action of LY171555, a specific dopamine D2 receptor agonist, in the conscious rat. ( Chen, YF; Lindheimer, MD; Nagahama, S; Oparil, S, 1986) |
| "Propranolol pretreatment abolished yohimbine-induced tachycardia, but had little effect on the pressor response." | 1.26 | Presynaptic alpha receptors in relation to the cardiovascular effect of yohimbine in the anesthetized cat. ( Rahman, AR; Sharabi, FM, 1981) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 17 (36.17) | 18.7374 |
| 1990's | 20 (42.55) | 18.2507 |
| 2000's | 10 (21.28) | 29.6817 |
| 2010's | 0 (0.00) | 24.3611 |
| 2020's | 0 (0.00) | 2.80 |
| Authors | Studies |
|---|---|
| Nakamura, Y | 1 |
| Matsuo, S | 1 |
| Hosogai, M | 1 |
| Kawai, Y | 1 |
| Sun, Y | 1 |
| Fihn, BM | 1 |
| Jodal, M | 3 |
| Sjövall, H | 1 |
| LANE, R | 1 |
| STEVEN, RJ | 1 |
| TOVELL, RM | 1 |
| GRIFFITHS, JA | 1 |
| MANDOW, GA | 1 |
| ARDEN, GP | 1 |
| STONEHAM, FJ | 1 |
| GUIDETTI, B | 1 |
| ALVISI, C | 1 |
| PARMA, A | 1 |
| DE SANDO, T | 1 |
| HUGHES, G | 1 |
| Benoussaidh, A | 1 |
| Maurin, Y | 1 |
| Rampin, O | 1 |
| Kurosawa, M | 1 |
| Taniguchi, T | 1 |
| Yoneda, M | 1 |
| Rahman, AR | 1 |
| Sharabi, FM | 1 |
| Billingsley, ML | 1 |
| Suria, A | 1 |
| Haxhiu, MA | 1 |
| Van Lunteren, E | 1 |
| Van de Graaff, WB | 1 |
| Strohl, KP | 1 |
| Bruce, EN | 1 |
| Mitra, J | 1 |
| Cherniack, NS | 1 |
| de La Coussaye, JE | 1 |
| Eledjam, JJ | 1 |
| Bruelle, P | 1 |
| Lefrant, JY | 1 |
| Bassoul, B | 1 |
| Peray, PA | 1 |
| Desch, G | 1 |
| Sassine, A | 1 |
| Allcock, GH | 1 |
| Warner, TD | 1 |
| Vane, JR | 1 |
| Koss, MC | 1 |
| Wally, JR | 1 |
| Yamashita, T | 1 |
| Suzuki, H | 1 |
| Harasawa, S | 1 |
| Miwa, T | 1 |
| Hirose, M | 2 |
| Furukawa, Y | 2 |
| Nagashima, Y | 2 |
| Yamazaki, K | 1 |
| Hoyano, Y | 1 |
| Chiba, S | 2 |
| Sudoh, K | 1 |
| Masuda, N | 1 |
| Uchida, W | 1 |
| Lakhe, M | 1 |
| Jaup, EA | 1 |
| Timar Peregrin, A | 2 |
| Lundgren, O | 2 |
| Lecci, A | 1 |
| Giuliani, S | 2 |
| Tramontana, M | 1 |
| Giorgio, RD | 1 |
| Maggi, CA | 4 |
| Niijima, A | 1 |
| Zhang, C | 1 |
| Kuroyangi, M | 1 |
| Tan, BK | 1 |
| Chen, L | 1 |
| Sica, AL | 1 |
| Scharf, SM | 1 |
| Svensson, M | 1 |
| Ahlman, H | 1 |
| Bivalacqua, TJ | 1 |
| Dalal, A | 1 |
| Champion, HC | 1 |
| Kadowitz, PJ | 1 |
| Ullman, J | 1 |
| Dhar, S | 1 |
| Nagy, F | 1 |
| McIntosh, JM | 1 |
| Sapru, HN | 1 |
| Teranishi, Y | 2 |
| Tsuru, H | 1 |
| Shimomura, H | 1 |
| Amano, T | 1 |
| Matsubayashi, H | 1 |
| Pedersen, NL | 1 |
| Nagain-Domaine, C | 1 |
| Mahé, S | 1 |
| Chariot, J | 1 |
| Rozé, C | 1 |
| Tomé, D | 1 |
| Uchida, S | 1 |
| Kagitani, F | 1 |
| Suzuki, A | 1 |
| Aikawa, Y | 1 |
| Markos, F | 1 |
| Snow, HM | 1 |
| Kidd, C | 1 |
| Conlon, K | 1 |
| LaForte, AJ | 1 |
| Lee, LP | 1 |
| Rich, GF | 1 |
| Skalak, TC | 1 |
| Lee, JS | 1 |
| Ballati, L | 1 |
| Evangelista, S | 1 |
| Manzini, S | 1 |
| Iriuchijima, J | 1 |
| Conte, B | 1 |
| Parlani, M | 1 |
| Giachetti, A | 1 |
| Yamazaki, R | 1 |
| Tsuchida, K | 1 |
| Otomo, S | 1 |
| McWilliam, PN | 1 |
| Woolley, DC | 1 |
| Salido, GM | 1 |
| Pedrosa, F | 1 |
| Esteller, A | 1 |
| Lopez, MA | 1 |
| Sloan, JW | 1 |
| Martin, WR | 1 |
| Bostwick, M | 1 |
| Meli, A | 1 |
| Nagahama, S | 1 |
| Chen, YF | 1 |
| Lindheimer, MD | 1 |
| Oparil, S | 1 |
| Holloway, RH | 1 |
| Blank, EL | 1 |
| Takahashi, I | 1 |
| Dodds, WJ | 1 |
| Dent, J | 1 |
| Sarna, SK | 1 |
| Watanabe, K | 1 |
| Yano, S | 1 |
| Lin, WC | 1 |
| Bass, AS | 1 |
| Kohli, JD | 1 |
| Lubbers, N | 1 |
| Goldberg, LI | 1 |
47 other studies available for hexamethonium and Anesthesia
| Article | Year |
|---|---|
Vestibular control of arterial blood pressure during head-down postural change in anesthetized rabbits.
Topics: Analysis of Variance; Anesthesia; Anesthetics, Intravenous; Animals; Baroreflex; Blood Pressure; Gan | 2009 |
Effects of nicotinic receptor blockade on the colonic mucosal response to luminal bile acids in anaesthetized rats.
Topics: Amiloride; Anesthesia; Animals; Biological Transport; Colon; Deoxycholic Acid; Electrophysiology; Ep | 2003 |
The uses of hexamethonium.
Topics: Anesthesia; Cardiovascular Agents; Gastrointestinal Diseases; Hexamethonium; Humans; Hypertension; M | 1952 |
Hexamethonium salts as an aid to the orthopedic surgeon.
Topics: Anesthesia; Anesthesiology; Hexamethonium; Muscle Relaxants, Central; Salts; Surgeons | 1954 |
The effects of general anaesthesia, and hexamethonium, on the blood-sugar in non-diabetic and diabetic surgical patients.
Topics: Anesthesia; Anesthesia, General; Blood Glucose; Diabetes Complications; Diabetes Mellitus; Hexametho | 1953 |
Hypotension induced with hexamethonium bromide during anaesthesia.
Topics: Anesthesia; Hexamethonium; Humans; Hypotension; Hypotension, Controlled; Muscle Relaxants, Central | 1954 |
[Hexamethonium in neurosurgery and neurology].
Topics: Analgesia; Anesthesia; Anesthesia and Analgesia; Brain; Brain Neoplasms; Hexamethonium; Hypotension; | 1954 |
[Hexamethonium and sparteine as protectors of the heart in cardiac surgery].
Topics: Analgesia; Anesthesia; Anesthesia and Analgesia; Cardiac Surgical Procedures; Hexamethonium; Hexamet | 1956 |
The investigation of cerebral blood flow during anaesthesia with hypotension induced by the use of hexamethonium bromide and posture.
Topics: Anesthesia; Anesthesiology; Brain; Cerebrovascular Circulation; Hexamethonium; Hibernation; Humans; | 1955 |
Spinal effects of oxytocin on uterine motility in anesthetized rats.
Topics: Anesthesia; Animals; Diestrus; Estrus; Female; Ganglionic Blockers; Hexamethonium; Hormone Antagonis | 2004 |
Cholecystokinin and prostaglandins inhibit responses of vagal afferent activity to systemic administration of nicotine in anesthetized rats.
Topics: Anesthesia; Animals; Cholecystokinin; Cyclooxygenase Inhibitors; Devazepide; Dose-Response Relations | 2004 |
Presynaptic alpha receptors in relation to the cardiovascular effect of yohimbine in the anesthetized cat.
Topics: Adrenergic alpha-Antagonists; Anesthesia; Animals; Blood Pressure; Cats; Female; Heart Rate; Hemodyn | 1981 |
Effects of peripherally administered GABA and other amino acids on cardiopulmonary responses in anesthetized rats and dogs.
Topics: Amino Acids; Anesthesia; Animals; Atropine; Diphenhydramine; Dogs; Female; gamma-Aminobutyric Acid; | 1982 |
Action of nicotine on the respiratory activity of the diaphragm and genioglossus muscles and the nerves that innervate them.
Topics: Anesthesia; Animals; Carotid Sinus; Cats; Consciousness; Diaphragm; Female; Hexamethonium; Hexametho | 1984 |
Mechanisms of the putative cardioprotective effect of hexamethonium in anesthetized dogs given a large dose of bupivacaine.
Topics: Anesthesia; Animals; Antihypertensive Agents; Atrial Function; Atropine; Bupivacaine; Cardiac Pacing | 1994 |
Roles of endothelin receptors in the regional and systemic vascular responses to ET-1 in the anaesthetized ganglion-blocked rat: use of selective antagonists.
Topics: Anesthesia; Animals; Blood Pressure; Cardiac Output; Endothelin Receptor Antagonists; Endothelins; G | 1995 |
Analysis of miosis produced by McN-A-343 in anesthetized cats.
Topics: (4-(m-Chlorophenylcarbamoyloxy)-2-butynyl)trimethylammonium Chloride; Anesthesia; Animals; Atropine; | 1995 |
[Relationship between distal colonic motility and nitric oxide in anesthetized rats].
Topics: Anesthesia; Animals; Atropine; Colon; Gastrointestinal Motility; Hexamethonium; Male; Muscarinic Ant | 1995 |
Effects of PACAP-38 on the SA nodal pacemaker activity in autonomically decentralized hearts of anesthetized dogs.
Topics: Acetylcholine; Anesthesia; Animals; Atrial Fibrillation; Atropine; Dogs; Female; Heart Rate; Hexamet | 1997 |
Different effect of anticholinergic agents and potassium channel openers on urinary bladder response to pelvic nerve stimulation in anaesthetized dogs.
Topics: Anesthesia; Animals; Cholinergic Antagonists; Dogs; Dose-Response Relationship, Drug; Electric Stimu | 1997 |
Pituitary adenylate cyclase-activating polypeptide-27 causes a biphasic chronotropic effect and atrial fibrillation in autonomically decentralized, anesthetized dogs.
Topics: Anesthesia; Animals; Atrial Fibrillation; Atropine; Dogs; Female; Heart Rate; Hexamethonium; Male; N | 1997 |
Nervous control of alkaline secretion in the duodenum as studied by the use of cholera toxin in the anaesthetized rat.
Topics: Alkalies; Anesthesia; Anesthetics, Local; Animals; Atropine; Calcium Channel Blockers; Cholera Toxin | 1998 |
The role of tachykinin NK1 and NK2 receptors in atropine-resistant colonic propulsion in anaesthetized guinea-pigs.
Topics: Anesthesia; Animals; Apamin; Atropine; Benzamides; Colon; Guinea Pigs; Hexamethonium; Male; Models, | 1998 |
Afferent signals from leptin sensors in the white adipose tissue of the epididymis, and their reflex effect in the rat.
Topics: Adipose Tissue; Anesthesia; Anesthetics, Local; Animals; Carrier Proteins; Dose-Response Relationshi | 1998 |
Cardiovascular activity of 14-deoxy-11,12-didehydroandrographolide in the anaesthetised rat and isolated right atria.
Topics: Anesthesia; Animals; Antihypertensive Agents; Blood Pressure; Captopril; DDT; Dose-Response Relation | 1998 |
Mechanisms of acute cardiovascular response to periodic apneas in sedated pigs.
Topics: Anesthesia; Animals; Apnea; Blood Pressure; Cardiac Output; Epinephrine; Female; Heart Rate; Hemodyn | 1999 |
The effects on net fluid transport of noxious stimulation of jejunal mucosa in anaesthetized rats.
Topics: Anesthesia; Animals; Atropine; Axons; Calcium Channel Blockers; Calcium Channels; Capsaicin; Enteric | 1999 |
Role of AT(1) receptors and autonomic nervous system in mediating acute pressor responses to ANG II in anesthetized mice.
Topics: Adrenergic beta-Antagonists; Anesthesia; Angiotensin II; Angiotensin Receptor Antagonists; Animals; | 1999 |
Influence of neurohumoral blockade on heart rate and blood pressure responses to haemorrhage in isoflurane anaesthetized rats.
Topics: Anesthesia; Anesthetics, Inhalation; Angiotensin Receptor Antagonists; Angiotensin-Converting Enzyme | 2000 |
Receptor subtypes mediating depressor responses to microinjections of nicotine into medial NTS of the rat.
Topics: alpha7 Nicotinic Acetylcholine Receptor; Anesthesia; Animals; Blood Pressure; Bungarotoxins; Calcium | 2000 |
Compensatory vasoconstrictor effects of sodium pentobarbital on the hindquarters of conscious normotensive control and lumbar-sympathectomized Wistar rats.
Topics: Anesthesia; Animals; Aorta, Abdominal; Blood Pressure; Consciousness; Ganglionic Blockers; Hexametho | 2000 |
Caseinomacropeptide specifically stimulates exocrine pancreatic secretion in the anesthetized rat.
Topics: Anesthesia; Animals; Atropine; Capsaicin; Caseins; Devazepide; Dose-Response Relationship, Drug; Enz | 2000 |
Effect of acupuncture-like stimulation on cortical cerebral blood flow in anesthetized rats.
Topics: Acetylcholine; Acupuncture Therapy; Adrenergic alpha-Antagonists; Adrenergic beta-Antagonists; Affer | 2000 |
Nitric oxide facilitates vagal control of heart rate via actions in the cardiac parasympathetic ganglia of the anaesthetised dog.
Topics: Anesthesia; Animals; Bradycardia; Dogs; Electrocardiography; Enzyme Inhibitors; Ganglia, Parasympath | 2002 |
Fluid restitution and shift of blood volume in anesthetized rabbits subject to cyclic hemorrhage.
Topics: Anesthesia; Animals; Antihypertensive Agents; Blood Pressure; Blood Volume; Body Fluids; Hemorrhage; | 1992 |
Effects of selective tachykinin receptor antagonists on capsaicin- and tachykinin-induced bronchospasm in anaesthetized guinea-pigs.
Topics: Anesthesia; Animals; Atropine; Biphenyl Compounds; Bronchial Spasm; Capsaicin; Guinea Pigs; Hexameth | 1992 |
Sympathetic vasoconstrictor tone induced by pentobarbital anesthesia in hindquarters of rats.
Topics: Anesthesia; Animals; Denervation; Ganglia; Hexamethonium; Hexamethonium Compounds; Male; Pentobarbit | 1992 |
Evidence for the existence of a urethro-urethral excitatory reflex in urethane anesthetized rats: involvement of peripheral ganglionic structures.
Topics: Anesthesia; Animals; Atropine; Decerebrate State; Dimethylphenylpiperazinium Iodide; Ganglia; Gangli | 1991 |
Effects of dihydroergotamine and etilefrine on experimentally-induced postural hypotension in dogs.
Topics: Anesthesia; Animals; Antihypertensive Agents; Blood Pressure; Cardiac Output; Dihydroergotamine; Dog | 1990 |
The effect of supranodose vagotomy on the hexamethonium-resistant bradycardia in the anaesthetized rabbit.
Topics: Action Potentials; Anesthesia; Animals; Bradycardia; Cardiovascular Physiological Phenomena; Cardiov | 1990 |
Basal and spontaneous exocrine pancreatic secretion in conscious and anaesthetized chickens, Gallus domesticus.
Topics: Amylases; Anesthesia; Animals; Atropine; Chickens; Hexamethonium; Hexamethonium Compounds; Pancreas; | 1985 |
Mechanisms involved in the respiratory depressant actions of nicotine in anesthetized rats.
Topics: Anesthesia; Animals; Female; Hexamethonium; Hexamethonium Compounds; Mecamylamine; Naltrexone; Nicot | 1989 |
The effect of peripherally administered GABA on noradrenaline-induced reflex vagal bradycardia in urethane anaesthetized rats.
Topics: Anesthesia; Animals; Drug Interactions; Electric Stimulation; gamma-Aminobutyric Acid; Heart Rate; H | 1985 |
Mechanism of the pressor action of LY171555, a specific dopamine D2 receptor agonist, in the conscious rat.
Topics: Adrenal Medulla; Anesthesia; Animals; Arginine Vasopressin; Blood Pressure; Ergolines; Hexamethonium | 1986 |
Electrical control activity of the lower esophageal sphincter in unanesthetized opossums.
Topics: Anesthesia; Animals; Atropine; Duodenum; Eating; Electrophysiology; Esophagogastric Junction; Esopha | 1987 |
Stimulatory effect of pentobarbital and some anesthetics on gastric secretion in the continuously perfused stomach in rats under urethane anesthesia.
Topics: Anesthesia; Anesthetics; Animals; Chloralose; Decerebrate State; Gastric Acid; Gastric Mucosa; Hexam | 1987 |
Mechanisms mediating the positive inotropic and chronotropic changes induced by dopexamine in the anesthetized dog.
Topics: Adrenergic Agonists; Albuterol; Anesthesia; Animals; Atropine; Blood Pressure; Dogs; Dopamine; Heart | 1987 |