hexamethonium has been researched along with Alzheimer Disease in 2 studies
Hexamethonium: A nicotinic cholinergic antagonist often referred to as the prototypical ganglionic blocker. It is poorly absorbed from the gastrointestinal tract and does not cross the blood-brain barrier. It has been used for a variety of therapeutic purposes including hypertension but, like the other ganglionic blockers, it has been replaced by more specific drugs for most purposes, although it is widely used a research tool.
Alzheimer Disease: A degenerative disease of the BRAIN characterized by the insidious onset of DEMENTIA. Impairment of MEMORY, judgment, attention span, and problem solving skills are followed by severe APRAXIAS and a global loss of cognitive abilities. The condition primarily occurs after age 60, and is marked pathologically by severe cortical atrophy and the triad of SENILE PLAQUES; NEUROFIBRILLARY TANGLES; and NEUROPIL THREADS. (From Adams et al., Principles of Neurology, 6th ed, pp1049-57)
| Excerpt | Relevance | Reference |
|---|---|---|
| " Nefiracetam potentiated alpha4beta2-like ACh- and NMDA-induced currents at nanomolar concentrations forming bell-shaped dose-response curves with the maximum potentiation occurring at 1 and 10 nM, respectively." | 1.32 | Unique mechanism of action of Alzheimer's drugs on brain nicotinic acetylcholine receptors and NMDA receptors. ( Marszalec, W; Moriguchi, S; Narahashi, T; Yeh, JZ; Zhao, X, 2003) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 0 (0.00) | 18.7374 |
| 1990's | 0 (0.00) | 18.2507 |
| 2000's | 2 (100.00) | 29.6817 |
| 2010's | 0 (0.00) | 24.3611 |
| 2020's | 0 (0.00) | 2.80 |
| Authors | Studies |
|---|---|
| Narahashi, T | 1 |
| Marszalec, W | 1 |
| Moriguchi, S | 1 |
| Yeh, JZ | 1 |
| Zhao, X | 1 |
| Yang, YR | 1 |
| Chang, KC | 1 |
| Chen, CL | 1 |
| Chiu, TH | 1 |
2 other studies available for hexamethonium and Alzheimer Disease
| Article | Year |
|---|---|
Unique mechanism of action of Alzheimer's drugs on brain nicotinic acetylcholine receptors and NMDA receptors.
Topics: Acetylcholine; Aconitine; Alzheimer Disease; Animals; Brain Chemistry; Bungarotoxins; Dihydro-beta-E | 2003 |
Arecoline excites rat locus coeruleus neurons by activating the M2-muscarinic receptor.
Topics: Alzheimer Disease; Animals; Arecoline; Atropine; Cholinergic Agonists; Diamines; Hexamethonium; Locu | 2000 |