Page last updated: 2024-10-28

hexamethonium and Aging

hexamethonium has been researched along with Aging in 14 studies

Hexamethonium: A nicotinic cholinergic antagonist often referred to as the prototypical ganglionic blocker. It is poorly absorbed from the gastrointestinal tract and does not cross the blood-brain barrier. It has been used for a variety of therapeutic purposes including hypertension but, like the other ganglionic blockers, it has been replaced by more specific drugs for most purposes, although it is widely used a research tool.

Aging: The gradual irreversible changes in structure and function of an organism that occur as a result of the passage of time.

Research Excerpts

ExcerptRelevanceReference
"After saline pretreatment, response to 5-HT consisted of immediate and brief apnea, bradycardia, and hypotension, followed by sustained tachypnea, tachycardia, pulmonary hypertension, and hypocapnic hypoxemia."3.69Parasympathetic component of 5-hydroxytryptamine-induced pulmonary dysfunctions in healthy calves. ( Amory, H; Desmecht, DJ; Lekeux, PM; Linden, AS, 1996)
"Propofol was then given as an IV bolus of 4."1.33Autonomic mechanisms in the age-related hypotensive effect of propofol. ( Heerdt, PM; Memtsoudis, SG; The, AHS, 2005)

Research

Studies (14)

TimeframeStudies, this research(%)All Research%
pre-19907 (50.00)18.7374
1990's4 (28.57)18.2507
2000's2 (14.29)29.6817
2010's1 (7.14)24.3611
2020's0 (0.00)2.80

Authors

AuthorsStudies
Lhermite, A1
Munoz Sastre, MT1
Sorum, PC1
Mullet, E1
LAPITSKII, VD1
Memtsoudis, SG1
The, AHS1
Heerdt, PM1
Knehans, AW1
Romsos, DR1
Kawa, K1
Roper, S1
Maggi, CA2
Santicioli, P2
Meli, A1
Glick, MR1
Gehman, JD1
Gascho, JA1
Linden, AS1
Desmecht, DJ1
Amory, H1
Lekeux, PM1
Radaelli, A1
Mircoli, L1
Mori, I1
Mancia, G1
Ferrari, AU1
Zhou, ZJ1
Zhao, D1
Lecci, A1
Giuliani, S1
Blozovski, D1
Hess, C1
Wilczynski, EA2
Leenen, FH2

Other Studies

14 other studies available for hexamethonium and Aging

ArticleYear
Decision-Making Capacity Among Elderly People: A Mapping of Health Professionals' and Laypeople's Views.
    International journal of aging & human development, 2019, Volume: 89, Issue:3

    Topics: Adult; Aged; Aging; Attitude of Health Personnel; Attitude to Health; Decision Making; Dementia; Fem

2019
[Features of the action, in relation to age, of aminazine, hexonium and tetamon].
    Zdravookhranenie Belorussii, 1962, Volume: 8

    Topics: Aging; Chlorpromazine; Hexamethonium; Hexamethonium Compounds; Tetraethylammonium

1962
Autonomic mechanisms in the age-related hypotensive effect of propofol.
    Anesthesia and analgesia, 2005, Volume: 100, Issue:1

    Topics: Aging; Anesthetics, Intravenous; Animals; Autonomic Nervous System; Baroreflex; Blood Pressure; Dose

2005
Norepinephrine turnover in obese (ob/ob) mice: effects of age, fasting, and acute cold.
    The American journal of physiology, 1983, Volume: 244, Issue:6

    Topics: Adipose Tissue, Brown; Aging; Animals; Cold Temperature; Fasting; Female; Growth; Heart; Hexamethoni

1983
On the two subdivisions and intrinsic synaptic connexions in the submandibular ganglion of the rat.
    The Journal of physiology, 1984, Volume: 346

    Topics: Action Potentials; Aging; Animals; Denervation; Female; Ganglia, Parasympathetic; Hexamethonium; Hex

1984
Postnatal development of myogenic contractile activity and excitatory innervation of rat urinary bladder.
    The American journal of physiology, 1984, Volume: 247, Issue:6 Pt 2

    Topics: Aging; Animals; Animals, Newborn; Atropine; Drug Resistance; Electric Stimulation; Hemicholinium 3;

1984
Aging increases venous compliance in awake instrumented rats.
    The American journal of physiology, 1993, Volume: 264, Issue:6 Pt 2

    Topics: Aging; Animals; Blood Pressure; Blood Volume; Ganglionic Blockers; Hemodynamics; Hexamethonium; Hexa

1993
Parasympathetic component of 5-hydroxytryptamine-induced pulmonary dysfunctions in healthy calves.
    American journal of veterinary research, 1996, Volume: 57, Issue:6

    Topics: Aging; Animals; Apnea; Atropine; Bradycardia; Cattle; Cattle Diseases; Cholinergic Agents; Ganglioni

1996
Nitric oxide dependent vasodilation in young spontaneously hypertensive rats.
    Hypertension (Dallas, Tex. : 1979), 1998, Volume: 32, Issue:4

    Topics: Aging; Animals; Antihypertensive Agents; Blood Pressure; Drug Interactions; Enzyme Inhibitors; Hexam

1998
Coordinated transitions in neurotransmitter systems for the initiation and propagation of spontaneous retinal waves.
    The Journal of neuroscience : the official journal of the Society for Neuroscience, 2000, Sep-01, Volume: 20, Issue:17

    Topics: 6-Cyano-7-nitroquinoxaline-2,3-dione; Aging; Animals; Animals, Newborn; Atropine; Bungarotoxins; Cal

2000
Involvement of 5-hydroxytryptamine1A receptors in the modulation of micturition reflexes in the anesthetized rat.
    The Journal of pharmacology and experimental therapeutics, 1992, Volume: 262, Issue:1

    Topics: 8-Hydroxy-2-(di-n-propylamino)tetralin; Administration, Topical; Aging; Animals; Antihypertensive Ag

1992
Hippocampal nicotinic cholinergic mechanisms mediate spontaneous alternation and fear during ontogenesis but not later in the rat.
    Behavioural brain research, 1989, Dec-01, Volume: 35, Issue:3

    Topics: Aging; Animals; Behavior, Animal; Cholinergic Fibers; Fear; Female; Hexamethonium; Hexamethonium Com

1989
Prevention of hypertension and maintenance of normotension in spontaneously hypertensive rats is dependent on continuous severe dietary sodium restriction.
    Canadian journal of physiology and pharmacology, 1987, Volume: 65, Issue:4

    Topics: Aging; Animals; Blood Pressure; Body Weight; Diet, Sodium-Restricted; Eating; Hexamethonium; Hexamet

1987
Dietary sodium intake and age in spontaneously hypertensive rats: effects on blood pressure and sympathetic activity.
    Life sciences, 1987, Aug-10, Volume: 41, Issue:6

    Topics: Aging; Animals; Blood Pressure; Body Weight; Catecholamines; Diet, Sodium-Restricted; Growth Disorde

1987