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hexamethonium and Active Hyperemia

hexamethonium has been researched along with Active Hyperemia in 9 studies

Hexamethonium: A nicotinic cholinergic antagonist often referred to as the prototypical ganglionic blocker. It is poorly absorbed from the gastrointestinal tract and does not cross the blood-brain barrier. It has been used for a variety of therapeutic purposes including hypertension but, like the other ganglionic blockers, it has been replaced by more specific drugs for most purposes, although it is widely used a research tool.

Research Excerpts

ExcerptRelevanceReference
"The purpose of the present study is to assess the role of capsaicin-sensitive afferent nerves of the gut in bile-oleate-induced intestinal hyperemia."7.67Capsaicin-sensitive nerves are involved in bile-oleate-induced intestinal hyperemia. ( Jacobson, ED; Rozsa, Z, 1989)
"The purpose of the present study is to assess the role of capsaicin-sensitive afferent nerves of the gut in bile-oleate-induced intestinal hyperemia."3.67Capsaicin-sensitive nerves are involved in bile-oleate-induced intestinal hyperemia. ( Jacobson, ED; Rozsa, Z, 1989)
"The role of local intestinal nerves in the nutrient-induced intestinal hyperemia was investigated in jejunal segments of anesthetized dogs by comparing the hyperemic effect of intraluminal glucose and oleic acid solutions before and after mucosal anesthesia and infusions of methysergide, hexamethonium, and tetrodotoxin."3.66Evidence against local neural mechanism for intestinal postprandial hyperemia. ( Chou, CC; Nyhof, RA, 1983)
"To examine the contribution that reactive hyperemia makes in these settings, studies on the hindlimb circulation of anesthetized rats (n = 8) were carried out by imposing graded duration vascular occlusion (1, 2, 4, 10, and 30 s) to test the hypothesis that there is a threshold duration of reduction in perfusion that must be exceeded for reactive hyperemia to be triggered."1.33Is there a threshold duration of vascular occlusion for hindlimb reactive hyperemia? ( Rogers, J; Sheriff, DD, 2005)

Research

Studies (9)

TimeframeStudies, this research(%)All Research%
pre-19902 (22.22)18.7374
1990's5 (55.56)18.2507
2000's2 (22.22)29.6817
2010's0 (0.00)24.3611
2020's0 (0.00)2.80

Authors

AuthorsStudies
Rogers, J2
Sheriff, DD2
Nyhof, RA1
Chou, CC1
Leung, FW1
Hottenstein, OD2
Pawlik, WW2
Remak, G1
Jacobson, ED3
Holzer, P1
Lippe, IT1
McMeeken, JM1
Bell, C1
Rozsa, Z1

Other Studies

9 other studies available for hexamethonium and Active Hyperemia

ArticleYear
Role of estrogen in nitric oxide- and prostaglandin-dependent modulation of vascular conductance during treadmill locomotion in rats.
    Journal of applied physiology (Bethesda, Md. : 1985), 2004, Volume: 97, Issue:2

    Topics: Animals; Antihypertensive Agents; Blood Pressure; Cyclooxygenase Inhibitors; Enzyme Inhibitors; Estr

2004
Is there a threshold duration of vascular occlusion for hindlimb reactive hyperemia?
    Journal of applied physiology (Bethesda, Md. : 1985), 2005, Volume: 99, Issue:4

    Topics: Animals; Aorta; Autonomic Nervous System; Blood Pressure; Blood Vessels; Constriction; Differential

2005
Evidence against local neural mechanism for intestinal postprandial hyperemia.
    The American journal of physiology, 1983, Volume: 245, Issue:3

    Topics: Animals; Antihypertensive Agents; Blood Pressure; Dibucaine; Dogs; Eating; Female; Hexamethonium; He

1983
Inhibition of spinal afferent nerve-mediated gastric hyperemia by nicotine: role of ganglionic blockade.
    The American journal of physiology, 1993, Volume: 264, Issue:4 Pt 2

    Topics: Animals; Capsaicin; Dose-Response Relationship, Drug; Electric Stimulation; Ganglia, Spinal; Hexamet

1993
Capsaicin-sensitive nerves modulate reactive hyperemia in rat gut.
    Proceedings of the Society for Experimental Biology and Medicine. Society for Experimental Biology and Medicine (New York, N.Y.), 1992, Volume: 199, Issue:3

    Topics: Animals; Arterial Occlusive Diseases; Blood Flow Velocity; Blood Vessels; Capsaicin; Hexamethonium;

1992
Gastric mucosal hyperemia due to acid backdiffusion depends on splanchnic nerve activity.
    The American journal of physiology, 1992, Volume: 262, Issue:3 Pt 1

    Topics: Animals; Blood Pressure; Diffusion; Ethanol; Female; Gastric Mucosa; Guanethidine; Hexamethonium; He

1992
Adrenergic modulation of reactive hyperemia in rat gut.
    The American journal of physiology, 1991, Volume: 261, Issue:3 Pt 1

    Topics: Adrenalectomy; Animals; Blood Pressure; Electric Stimulation; Hexamethonium; Hexamethonium Compounds

1991
Effects of selective blood and tissue heating on blood flow in the dog hindlimb.
    Experimental physiology, 1990, Volume: 75, Issue:3

    Topics: Animals; Blood Flow Velocity; Blood Pressure; Body Temperature; Dogs; Female; Femoral Artery; Heart

1990
Capsaicin-sensitive nerves are involved in bile-oleate-induced intestinal hyperemia.
    The American journal of physiology, 1989, Volume: 256, Issue:3 Pt 1

    Topics: Animals; Atropine; Bile; Blood Pressure; Capsaicin; Female; Heart Rate; Hexamethonium; Hexamethonium

1989