Page last updated: 2024-10-28

hexamethonium and Ache

hexamethonium has been researched along with Ache in 9 studies

Hexamethonium: A nicotinic cholinergic antagonist often referred to as the prototypical ganglionic blocker. It is poorly absorbed from the gastrointestinal tract and does not cross the blood-brain barrier. It has been used for a variety of therapeutic purposes including hypertension but, like the other ganglionic blockers, it has been replaced by more specific drugs for most purposes, although it is widely used a research tool.

Research Excerpts

ExcerptRelevanceReference
" In the abdominal constriction test, LXM-10 had a significant dose-response effect, and the maximal inhibition ratio was 79."1.34Antinociceptive effects of the novel spirocyclopiperazinium salt compound LXM-10 in mice. ( Li, CL; Li, RT; Sun, Q; Ye, J; Yue, CQ, 2007)
"morphine were significantly attenuated by either bilateral CVAG or pre-treatment with the mu 2 opioid receptor antagonist beta-FNA."1.29The use of specific opioid agonists and antagonists to delineate the vagally mediated antinociceptive and cardiovascular effects of intravenous morphine. ( Randich, A; Robertson, JD; Willingham, T, 1993)

Research

Studies (9)

TimeframeStudies, this research(%)All Research%
pre-19903 (33.33)18.7374
1990's3 (33.33)18.2507
2000's3 (33.33)29.6817
2010's0 (0.00)24.3611
2020's0 (0.00)2.80

Authors

AuthorsStudies
Rueter, LE1
Kohlhaas, KL1
Curzon, P1
Surowy, CS1
Meyer, MD1
ROWLANDS, EN1
FRIEDLANDER, PH1
Shafton, AD1
Furness, JB1
Ferens, D1
Bogeski, G1
Koh, SL1
Lean, NP1
Kitchener, PD1
Yue, CQ1
Ye, J1
Li, CL1
Li, RT1
Sun, Q1
Maixner, W1
Touw, KB1
Brody, MJ1
Gebhart, GF1
Long, JP1
Randich, A1
Robertson, JD1
Willingham, T1
Koley, J1
Basak, AK1
Das, M1
Sinha, S1
Koley, B1
Decker, MW1
Bannon, AW1
Buckley, MJ1
Kim, DJ1
Holladay, MW1
Ryther, KB1
Lin, NH1
Wasicak, JT1
Williams, M1
Arneric, SP1
Yamada, S1
Kagawa, Y1
Takayanagi, N1
Hayashi, E1
Tsuji, K1
Kosuge, T1

Other Studies

9 other studies available for hexamethonium and Ache

ArticleYear
Peripheral and central sites of action for A-85380 in the spinal nerve ligation model of neuropathic pain.
    Pain, 2003, Volume: 103, Issue:3

    Topics: Animals; Antihypertensive Agents; Benzopyrans; Chlorisondamine; Disease Models, Animal; Dose-Respons

2003
Study of relationship between motility and pain in peptic ulcer, using hexamethonium.
    Clinical science, 1952, Volume: 11, Issue:3

    Topics: Cell Movement; Hexamethonium; Humans; Pain; Peptic Ulcer

1952
The visceromotor responses to colorectal distension and skin pinch are inhibited by simultaneous jejunal distension.
    Pain, 2006, Volume: 123, Issue:1-2

    Topics: Abdominal Muscles; Afferent Pathways; Analgesia; Animals; Calcium Channel Blockers; Calcium Channels

2006
Antinociceptive effects of the novel spirocyclopiperazinium salt compound LXM-10 in mice.
    Pharmacology, biochemistry, and behavior, 2007, Volume: 86, Issue:4

    Topics: Analgesics; Animals; Atropine; Atropine Derivatives; Body Temperature; Drug Evaluation, Preclinical;

2007
Factors influencing the altered pain perception in the spontaneously hypertensive rat.
    Brain research, 1982, Apr-08, Volume: 237, Issue:1

    Topics: Animals; Blood Pressure; Heart Rate; Hexamethonium; Hexamethonium Compounds; Hypertension; Male; Mus

1982
The use of specific opioid agonists and antagonists to delineate the vagally mediated antinociceptive and cardiovascular effects of intravenous morphine.
    Brain research, 1993, Feb-19, Volume: 603, Issue:2

    Topics: 3,4-Dichloro-N-methyl-N-(2-(1-pyrrolidinyl)-cyclohexyl)-benzeneacetamide, (trans)-Isomer; Analysis o

1993
Rectal response of cardiac origin in the cat: involvement of nitric oxide and acetylcholine.
    European journal of pharmacology, 1997, May-01, Volume: 325, Issue:2-3

    Topics: Acetylcholine; Afferent Pathways; Animals; Arginine; Atropine; Blood Pressure; Cats; Coronary Vessel

1997
Antinociceptive effects of the novel neuronal nicotinic acetylcholine receptor agonist, ABT-594, in mice.
    European journal of pharmacology, 1998, Apr-03, Volume: 346, Issue:1

    Topics: Analgesics, Non-Narcotic; Animals; Azetidines; Hexamethonium; Lethal Dose 50; Male; Maze Learning; M

1998
Inhibition by neosurugatoxin of nicotine-induced antinociception.
    Brain research, 1986, Jun-11, Volume: 375, Issue:2

    Topics: Animals; Central Nervous System; Hexamethonium; Hexamethonium Compounds; Male; Mecamylamine; Mice; M

1986