hexamethonium has been researched along with Ache in 9 studies
Hexamethonium: A nicotinic cholinergic antagonist often referred to as the prototypical ganglionic blocker. It is poorly absorbed from the gastrointestinal tract and does not cross the blood-brain barrier. It has been used for a variety of therapeutic purposes including hypertension but, like the other ganglionic blockers, it has been replaced by more specific drugs for most purposes, although it is widely used a research tool.
| Excerpt | Relevance | Reference |
|---|---|---|
| " In the abdominal constriction test, LXM-10 had a significant dose-response effect, and the maximal inhibition ratio was 79." | 1.34 | Antinociceptive effects of the novel spirocyclopiperazinium salt compound LXM-10 in mice. ( Li, CL; Li, RT; Sun, Q; Ye, J; Yue, CQ, 2007) |
| "morphine were significantly attenuated by either bilateral CVAG or pre-treatment with the mu 2 opioid receptor antagonist beta-FNA." | 1.29 | The use of specific opioid agonists and antagonists to delineate the vagally mediated antinociceptive and cardiovascular effects of intravenous morphine. ( Randich, A; Robertson, JD; Willingham, T, 1993) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 3 (33.33) | 18.7374 |
| 1990's | 3 (33.33) | 18.2507 |
| 2000's | 3 (33.33) | 29.6817 |
| 2010's | 0 (0.00) | 24.3611 |
| 2020's | 0 (0.00) | 2.80 |
| Authors | Studies |
|---|---|
| Rueter, LE | 1 |
| Kohlhaas, KL | 1 |
| Curzon, P | 1 |
| Surowy, CS | 1 |
| Meyer, MD | 1 |
| ROWLANDS, EN | 1 |
| FRIEDLANDER, PH | 1 |
| Shafton, AD | 1 |
| Furness, JB | 1 |
| Ferens, D | 1 |
| Bogeski, G | 1 |
| Koh, SL | 1 |
| Lean, NP | 1 |
| Kitchener, PD | 1 |
| Yue, CQ | 1 |
| Ye, J | 1 |
| Li, CL | 1 |
| Li, RT | 1 |
| Sun, Q | 1 |
| Maixner, W | 1 |
| Touw, KB | 1 |
| Brody, MJ | 1 |
| Gebhart, GF | 1 |
| Long, JP | 1 |
| Randich, A | 1 |
| Robertson, JD | 1 |
| Willingham, T | 1 |
| Koley, J | 1 |
| Basak, AK | 1 |
| Das, M | 1 |
| Sinha, S | 1 |
| Koley, B | 1 |
| Decker, MW | 1 |
| Bannon, AW | 1 |
| Buckley, MJ | 1 |
| Kim, DJ | 1 |
| Holladay, MW | 1 |
| Ryther, KB | 1 |
| Lin, NH | 1 |
| Wasicak, JT | 1 |
| Williams, M | 1 |
| Arneric, SP | 1 |
| Yamada, S | 1 |
| Kagawa, Y | 1 |
| Takayanagi, N | 1 |
| Hayashi, E | 1 |
| Tsuji, K | 1 |
| Kosuge, T | 1 |
9 other studies available for hexamethonium and Ache
| Article | Year |
|---|---|
Peripheral and central sites of action for A-85380 in the spinal nerve ligation model of neuropathic pain.
Topics: Animals; Antihypertensive Agents; Benzopyrans; Chlorisondamine; Disease Models, Animal; Dose-Respons | 2003 |
Study of relationship between motility and pain in peptic ulcer, using hexamethonium.
Topics: Cell Movement; Hexamethonium; Humans; Pain; Peptic Ulcer | 1952 |
The visceromotor responses to colorectal distension and skin pinch are inhibited by simultaneous jejunal distension.
Topics: Abdominal Muscles; Afferent Pathways; Analgesia; Animals; Calcium Channel Blockers; Calcium Channels | 2006 |
Antinociceptive effects of the novel spirocyclopiperazinium salt compound LXM-10 in mice.
Topics: Analgesics; Animals; Atropine; Atropine Derivatives; Body Temperature; Drug Evaluation, Preclinical; | 2007 |
Factors influencing the altered pain perception in the spontaneously hypertensive rat.
Topics: Animals; Blood Pressure; Heart Rate; Hexamethonium; Hexamethonium Compounds; Hypertension; Male; Mus | 1982 |
The use of specific opioid agonists and antagonists to delineate the vagally mediated antinociceptive and cardiovascular effects of intravenous morphine.
Topics: 3,4-Dichloro-N-methyl-N-(2-(1-pyrrolidinyl)-cyclohexyl)-benzeneacetamide, (trans)-Isomer; Analysis o | 1993 |
Rectal response of cardiac origin in the cat: involvement of nitric oxide and acetylcholine.
Topics: Acetylcholine; Afferent Pathways; Animals; Arginine; Atropine; Blood Pressure; Cats; Coronary Vessel | 1997 |
Antinociceptive effects of the novel neuronal nicotinic acetylcholine receptor agonist, ABT-594, in mice.
Topics: Analgesics, Non-Narcotic; Animals; Azetidines; Hexamethonium; Lethal Dose 50; Male; Maze Learning; M | 1998 |
Inhibition by neosurugatoxin of nicotine-induced antinociception.
Topics: Animals; Central Nervous System; Hexamethonium; Hexamethonium Compounds; Male; Mecamylamine; Mice; M | 1986 |