hexahydroubiquinone-4 and Coronary-Disease

hexahydroubiquinone-4 has been researched along with Coronary-Disease* in 2 studies

Other Studies

2 other study(ies) available for hexahydroubiquinone-4 and Coronary-Disease

Article	Year
[Intermediators of the Krebs cycle and electron acceptor systems as new cardiac agents]. Vestnik Akademii meditsinskikh nauk SSSR, 1982, Issue:5 Topics: Animals; Benzoquinones; Cardiovascular Agents; Citric Acid Cycle; Coronary Circulation; Coronary Disease; Electron Transport; Hypoxia; Malates; Mice; Myocardium; Quinones; Rats; Succinates; Ubiquinone	1982
[Effect of hexahydroubiquinone-4 (KoQ4) on the bioenergetics and functional activity of the myocardium in ischemia]. Kardiologiia, 1977, Volume: 17, Issue:12 The effect of KoQ4 on the energetics, contractility, and electrogram of the ischemized myocardium was studied in acute experiments on dogs with induced myocardial ischemia. Intracornoary administration of KoQ4, 1.3 mg/kg, directly into the focus of ischemia for 15 min promoted a decrease in the lactate level in blood draining from the ischemic zone as compared to the control data in the absence of a difference in the dynamics of the pyruvic acid content. In distinction to the control experimental series, there was no decrease in the concentration of glucose in samples of venous blood draining from the focus of ischemia. Under the effect of KoQ4 the amplitude of left ventricular pressure and the maximum rate of its growth (dp/dt) increased moderately and the ST segment and ST/R coefficient of the epicardial electrogram from the border zone of ischemia decreased. It was shown in the rat experiments that preliminary intravenous administration of KoQ4 (14 mg/kg) increased myocardial resistance to oxygen deficiency under conditions of diacetylcholine-induced apnoe. Topics: Acute Disease; Animals; Blood Glucose; Blood Pressure; Coronary Disease; Dogs; Drug Evaluation, Preclinical; Energy Metabolism; Heart; Heart Rate; Lactates; Myocardial Contraction; Myocardium; Pyruvates; Time Factors; Ubiquinone	1977

Article

Year

[Intermediators of the Krebs cycle and electron acceptor systems as new cardiac agents].

Vestnik Akademii meditsinskikh nauk SSSR, 1982, Issue:5

Topics: Animals; Benzoquinones; Cardiovascular Agents; Citric Acid Cycle; Coronary Circulation; Coronary Disease; Electron Transport; Hypoxia; Malates; Mice; Myocardium; Quinones; Rats; Succinates; Ubiquinone

1982

[Effect of hexahydroubiquinone-4 (KoQ4) on the bioenergetics and functional activity of the myocardium in ischemia].

Kardiologiia, 1977, Volume: 17, Issue:12

The effect of KoQ4 on the energetics, contractility, and electrogram of the ischemized myocardium was studied in acute experiments on dogs with induced myocardial ischemia. Intracornoary administration of KoQ4, 1.3 mg/kg, directly into the focus of ischemia for 15 min promoted a decrease in the lactate level in blood draining from the ischemic zone as compared to the control data in the absence of a difference in the dynamics of the pyruvic acid content. In distinction to the control experimental series, there was no decrease in the concentration of glucose in samples of venous blood draining from the focus of ischemia. Under the effect of KoQ4 the amplitude of left ventricular pressure and the maximum rate of its growth (dp/dt) increased moderately and the ST segment and ST/R coefficient of the epicardial electrogram from the border zone of ischemia decreased. It was shown in the rat experiments that preliminary intravenous administration of KoQ4 (14 mg/kg) increased myocardial resistance to oxygen deficiency under conditions of diacetylcholine-induced apnoe.

Topics: Acute Disease; Animals; Blood Glucose; Blood Pressure; Coronary Disease; Dogs; Drug Evaluation, Preclinical; Energy Metabolism; Heart; Heart Rate; Lactates; Myocardial Contraction; Myocardium; Pyruvates; Time Factors; Ubiquinone

1977