hexahydrocurcumin and Leukemia

hexahydrocurcumin has been researched along with Leukemia* in 1 studies

Other Studies

1 other study(ies) available for hexahydrocurcumin and Leukemia

Article	Year
Curcumin is a potent DNA hypomethylation agent. Bioorganic & medicinal chemistry letters, 2009, Feb-01, Volume: 19, Issue:3 Molecular docking of the interaction of curcumin and DNMT1 suggested that curcumin covalently blocks the catalytic thiolate of C1226 of DNMT1 to exert its inhibitory effect. This was validated by showing that curcumin inhibits the activity of M. SssI with an IC(50) of 30 nM, but no inhibitory activity of hexahydrocurcumin up to 100 microM. In addition, curcumin can induce global DNA hypomethylation in a leukemia cell line. Topics: Catalysis; Catalytic Domain; Cell Line, Tumor; Curcumin; Cytosine; DNA (Cytosine-5-)-Methyltransferase 1; DNA (Cytosine-5-)-Methyltransferases; DNA Methylation; Dose-Response Relationship, Drug; Drug Design; Humans; Inhibitory Concentration 50; Leukemia; Models, Chemical; Molecular Conformation	2009

Article

Year

Curcumin is a potent DNA hypomethylation agent.

Bioorganic & medicinal chemistry letters, 2009, Feb-01, Volume: 19, Issue:3

Molecular docking of the interaction of curcumin and DNMT1 suggested that curcumin covalently blocks the catalytic thiolate of C1226 of DNMT1 to exert its inhibitory effect. This was validated by showing that curcumin inhibits the activity of M. SssI with an IC(50) of 30 nM, but no inhibitory activity of hexahydrocurcumin up to 100 microM. In addition, curcumin can induce global DNA hypomethylation in a leukemia cell line.

Topics: Catalysis; Catalytic Domain; Cell Line, Tumor; Curcumin; Cytosine; DNA (Cytosine-5-)-Methyltransferase 1; DNA (Cytosine-5-)-Methyltransferases; DNA Methylation; Dose-Response Relationship, Drug; Drug Design; Humans; Inhibitory Concentration 50; Leukemia; Models, Chemical; Molecular Conformation

2009