hexacyanoferrate-iii and Glioblastoma

hexacyanoferrate-iii has been researched along with Glioblastoma* in 1 studies

Other Studies

1 other study(ies) available for hexacyanoferrate-iii and Glioblastoma

Article	Year
Inhibition of membrane redox activity by rhein and adriamycin in human glioma cells. Anti-cancer drugs, 1992, Volume: 3, Issue:6 The effect of the combination of adriamycin (ADM) with the anti-inflammatory drug rhein (RH) on the membrane redox activity in human glioma cells was investigated. RH, although less effective than ADM, inhibits ferricyanide reduction by human glioma cells in a dose-dependent manner as well as ferricyanide-induced proton release. The inhibition of the plasma membrane redox system might represent a further mechanism by which RH, other than ATP depletion, affects cell survival. The analysis of the interaction between ADM and RH, performed with the isobolar method, demonstrates a strong synergic response, probably due to an effect on different sites of action. The synergism of the ADM-RH association allows us to achieve a pre-established extent of inhibition with ADM concentrations much lower than with ADM alone. RH might, therefore, represent a very useful tool to improve the therapeutic index of ADM and to lower its general toxicity. Topics: Anthraquinones; Cell Membrane; Cell Survival; Doxorubicin; Electron Transport; Ferricyanides; Glioblastoma; Humans; NADH, NADPH Oxidoreductases; Oxidation-Reduction; Tumor Cells, Cultured	1992

Article

Year

Inhibition of membrane redox activity by rhein and adriamycin in human glioma cells.

Anti-cancer drugs, 1992, Volume: 3, Issue:6

The effect of the combination of adriamycin (ADM) with the anti-inflammatory drug rhein (RH) on the membrane redox activity in human glioma cells was investigated. RH, although less effective than ADM, inhibits ferricyanide reduction by human glioma cells in a dose-dependent manner as well as ferricyanide-induced proton release. The inhibition of the plasma membrane redox system might represent a further mechanism by which RH, other than ATP depletion, affects cell survival. The analysis of the interaction between ADM and RH, performed with the isobolar method, demonstrates a strong synergic response, probably due to an effect on different sites of action. The synergism of the ADM-RH association allows us to achieve a pre-established extent of inhibition with ADM concentrations much lower than with ADM alone. RH might, therefore, represent a very useful tool to improve the therapeutic index of ADM and to lower its general toxicity.

Topics: Anthraquinones; Cell Membrane; Cell Survival; Doxorubicin; Electron Transport; Ferricyanides; Glioblastoma; Humans; NADH, NADPH Oxidoreductases; Oxidation-Reduction; Tumor Cells, Cultured

1992