hexachlorophene has been researched along with Clinically Isolated CNS Demyelinating Syndrome in 9 studies
Hexachlorophene: A chlorinated bisphenol antiseptic with a bacteriostatic action against Gram-positive organisms, but much less effective against Gram-negative organisms. It is mainly used in soaps and creams and is an ingredient of various preparations used for skin disorders. (From Martindale, The Extra Pharmacopoeia, 30th ed, p797)
hexachlorophene : An organochlorine compound that is diphenylmethane in which each of the phenyl groups is substituted by chlorines at positions 2, 3, and 5, and by a hydroxy group at position 6. An antiseptic that is effective against Gram-positive organisms, it is used in soaps and creams for the treatment of various skin disorders. It is also used in agriculture as an acaricide and fungicide, but is not approved for such use within the European Union.
| Excerpt | Relevance | Reference |
|---|---|---|
| " When labeled rats were given demyelinating agents (triethyl tin chloride, hexachlorophene, sodium cyanide) and when experimental allergic encephalomyelitis was induced, a measurable increase in urinary 14C label above control levels was found." | 3.69 | Central nervous system demyelinating diseases and increased release of cholesterol into the urinary system of rats. ( Nicholas, HJ; Taylor, J, 1994) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 8 (88.89) | 18.7374 |
| 1990's | 1 (11.11) | 18.2507 |
| 2000's | 0 (0.00) | 29.6817 |
| 2010's | 0 (0.00) | 24.3611 |
| 2020's | 0 (0.00) | 2.80 |
| Authors | Studies |
|---|---|
| Nicholas, HJ | 1 |
| Taylor, J | 1 |
| Powell, HC | 1 |
| Myers, RR | 1 |
| Zweifach, BW | 1 |
| Lampert, PW | 1 |
| Maxwell, IC | 1 |
| Le Quesne, PM | 1 |
| Dési, I | 1 |
| Towfighi, J | 2 |
| Gonatas, NK | 1 |
| McCree, L | 1 |
| De Jesus, PV | 1 |
| Pleasure, DE | 1 |
| Pleasure, D | 1 |
| Silberberg, D | 1 |
| Parris, J | 1 |
| Webster, Hde F | 1 |
| Reier, PJ | 1 |
| Kies, MW | 1 |
| O'Connell, MF | 1 |
| Pratt, H | 1 |
9 other studies available for hexachlorophene and Clinically Isolated CNS Demyelinating Syndrome
| Article | Year |
|---|---|
Central nervous system demyelinating diseases and increased release of cholesterol into the urinary system of rats.
Topics: Animals; Carbon Radioisotopes; Central Nervous System Diseases; Cholesterol; Demyelinating Diseases; | 1994 |
Endoneurial pressure in hexachlorophene neuropathy.
Topics: Animals; Axons; Demyelinating Diseases; Edema; Hexachlorophene; Microcirculation; Nerve Degeneration | 1978 |
Conduction velocity in hexachlorophane neuropathy: correlation between electrophysiological and histological findings.
Topics: Action Potentials; Animals; Demyelinating Diseases; Edema; Hexachlorophene; Muscles; Myelin Sheath; | 1979 |
[Balance of the usefulness and hazard of the antiseptic hexachlorophene].
Topics: Animals; Brain; Demyelinating Diseases; Dogs; Haplorhini; Hexachlorophene; Humans; Lethal Dose 50; R | 1975 |
Hexachlorophene neuropathy in rats.
Topics: Administration, Oral; Animals; Demyelinating Diseases; Female; Hexachlorophene; Male; Microscopy, El | 1973 |
Hexachlorophene neuropathy.
Topics: Animals; Centrifugation, Density Gradient; Demyelinating Diseases; Disease Models, Animal; Dose-Resp | 1973 |
The pathogenesis of hexachlorophene neuropathy: in vivo and in vitro studies.
Topics: Adenosine Diphosphate; Adenosine Triphosphate; Animals; Animals, Newborn; Binding Sites; Carbon Radi | 1974 |
A simple method for quantitative morphological studies of CNS demyelination: whole mounts of tadpole optic nerves examined by differential-interference microscopy.
Topics: Animals; Blood Transfusion; Demyelinating Diseases; Disease Models, Animal; Encephalomyelitis, Autoi | 1974 |
Canavan's disease and spongiform encephalopathy.
Topics: Brain; Demyelinating Diseases; Hexachlorophene; Humans; Infant; Lipidoses; Vision Disorders | 1972 |