hexachlorophene has been researched along with Chemical and Drug Induced Liver Injury in 9 studies
Hexachlorophene: A chlorinated bisphenol antiseptic with a bacteriostatic action against Gram-positive organisms, but much less effective against Gram-negative organisms. It is mainly used in soaps and creams and is an ingredient of various preparations used for skin disorders. (From Martindale, The Extra Pharmacopoeia, 30th ed, p797)
hexachlorophene : An organochlorine compound that is diphenylmethane in which each of the phenyl groups is substituted by chlorines at positions 2, 3, and 5, and by a hydroxy group at position 6. An antiseptic that is effective against Gram-positive organisms, it is used in soaps and creams for the treatment of various skin disorders. It is also used in agriculture as an acaricide and fungicide, but is not approved for such use within the European Union.
Chemical and Drug Induced Liver Injury: A spectrum of clinical liver diseases ranging from mild biochemical abnormalities to ACUTE LIVER FAILURE, caused by drugs, drug metabolites, herbal and dietary supplements and chemicals from the environment.
| Excerpt | Relevance | Reference |
|---|---|---|
| " An understanding of structure-activity relationships (SARs) of chemicals can make a significant contribution to the identification of potential toxic effects early in the drug development process and aid in avoiding such problems." | 1.36 | Developing structure-activity relationships for the prediction of hepatotoxicity. ( Fisk, L; Greene, N; Naven, RT; Note, RR; Patel, ML; Pelletier, DJ, 2010) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 3 (33.33) | 18.7374 |
| 1990's | 0 (0.00) | 18.2507 |
| 2000's | 0 (0.00) | 29.6817 |
| 2010's | 6 (66.67) | 24.3611 |
| 2020's | 0 (0.00) | 2.80 |
| Authors | Studies |
|---|---|
| Fourches, D | 1 |
| Barnes, JC | 1 |
| Day, NC | 1 |
| Bradley, P | 1 |
| Reed, JZ | 1 |
| Tropsha, A | 1 |
| Greene, N | 1 |
| Fisk, L | 1 |
| Naven, RT | 1 |
| Note, RR | 1 |
| Patel, ML | 1 |
| Pelletier, DJ | 1 |
| Ekins, S | 1 |
| Williams, AJ | 1 |
| Xu, JJ | 1 |
| Liu, Z | 1 |
| Shi, Q | 1 |
| Ding, D | 1 |
| Kelly, R | 1 |
| Fang, H | 1 |
| Tong, W | 1 |
| Itaba, N | 2 |
| Kono, Y | 2 |
| Watanabe, K | 1 |
| Yokobata, T | 1 |
| Oka, H | 1 |
| Osaki, M | 2 |
| Kakuta, H | 1 |
| Morimoto, M | 2 |
| Shiota, G | 2 |
| Matsumi, Y | 1 |
| Okinaka, K | 1 |
| Ashla, AA | 1 |
| Sugiyama, N | 1 |
| Ohashi, K | 1 |
| Okano, T | 1 |
| Meiss, R | 1 |
| Robenek, H | 1 |
| Rassat, J | 1 |
| Themann, H | 1 |
| Harvey, DG | 1 |
| Hoe, CM | 1 |
| Thorpe, E | 1 |
9 other studies available for hexachlorophene and Chemical and Drug Induced Liver Injury
| Article | Year |
|---|---|
Cheminformatics analysis of assertions mined from literature that describe drug-induced liver injury in different species.
Topics: Animals; Chemical and Drug Induced Liver Injury; Cluster Analysis; Databases, Factual; Humans; MEDLI | 2010 |
Developing structure-activity relationships for the prediction of hepatotoxicity.
Topics: Chemical and Drug Induced Liver Injury; Databases, Factual; Humans; Structure-Activity Relationship; | 2010 |
A predictive ligand-based Bayesian model for human drug-induced liver injury.
Topics: Bayes Theorem; Chemical and Drug Induced Liver Injury; Humans; Ligands | 2010 |
Translating clinical findings into knowledge in drug safety evaluation--drug induced liver injury prediction system (DILIps).
Topics: Animals; Anti-Infective Agents; Anti-Inflammatory Agents; Chemical and Drug Induced Liver Injury; Da | 2011 |
Reversal of established liver fibrosis by IC-2-engineered mesenchymal stem cell sheets.
Topics: Animals; Bone Marrow Cells; Bridged Bicyclo Compounds; Chemical and Drug Induced Liver Injury; Colla | 2019 |
Human mesenchymal stem cell-engineered hepatic cell sheets accelerate liver regeneration in mice.
Topics: Animals; Cell Differentiation; Cells, Cultured; Chemical and Drug Induced Liver Injury; Complement C | 2015 |
New aspects of the origin of hepatocellular vacuoles. An ultrastructural study on rat and mice liver after different intoxications.
Topics: Aging; Amanitins; Animals; Biphenyl Compounds; Chemical and Drug Induced Liver Injury; Female; Hexac | 1981 |
The application of some liver function tests to sheep dosed with carbon tetrachloride and hexachlorphene.
Topics: Alkaline Phosphatase; Animals; Arginase; Aspartate Aminotransferases; Bilirubin; Blood Proteins; Car | 1971 |
Histochemical study of the effects of some anthelmintics in experimental fascioliasis in the rat.
Topics: Adenosine Triphosphatases; Alkaline Phosphatase; Anilides; Animals; Anthelmintics; Carbon Tetrachlor | 1968 |