hexachlorophene has been researched along with Brain Edema in 18 studies
Hexachlorophene: A chlorinated bisphenol antiseptic with a bacteriostatic action against Gram-positive organisms, but much less effective against Gram-negative organisms. It is mainly used in soaps and creams and is an ingredient of various preparations used for skin disorders. (From Martindale, The Extra Pharmacopoeia, 30th ed, p797)
hexachlorophene : An organochlorine compound that is diphenylmethane in which each of the phenyl groups is substituted by chlorines at positions 2, 3, and 5, and by a hydroxy group at position 6. An antiseptic that is effective against Gram-positive organisms, it is used in soaps and creams for the treatment of various skin disorders. It is also used in agriculture as an acaricide and fungicide, but is not approved for such use within the European Union.
Brain Edema: Increased intracellular or extracellular fluid in brain tissue. Cytotoxic brain edema (swelling due to increased intracellular fluid) is indicative of a disturbance in cell metabolism, and is commonly associated with hypoxic or ischemic injuries (see HYPOXIA, BRAIN). An increase in extracellular fluid may be caused by increased brain capillary permeability (vasogenic edema), an osmotic gradient, local blockages in interstitial fluid pathways, or by obstruction of CSF flow (e.g., obstructive HYDROCEPHALUS). (From Childs Nerv Syst 1992 Sep; 8(6):301-6)
| Excerpt | Relevance | Reference |
|---|---|---|
| "To assess neurotoxic effects of hexachlorophene in the human population previously shown to be most at risk, a blind clinicopathological analysis was made of all premature infants under 1,400 gm birth weight who survived at least four days and were examined by autopsy over a 7." | 3.65 | Neurotoxicity of hexachlorophene in humans. II. A clinicopathological study of 46 premature infants. ( Alvord, EC; Leech, RW; Shuman, RM, 1975) |
| " The dose was determined in a prior dose-response investigation." | 1.28 | A preliminary investigation of promotion of brain tumours by hexachlorophane in Sprague-Dawley rats transplacentally exposed to N-ethylnitrosourea. ( Dayan, A; Purves, D, 1992) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 10 (55.56) | 18.7374 |
| 1990's | 6 (33.33) | 18.2507 |
| 2000's | 2 (11.11) | 29.6817 |
| 2010's | 0 (0.00) | 24.3611 |
| 2020's | 0 (0.00) | 2.80 |
| Authors | Studies |
|---|---|
| Rakhit, G | 1 |
| Hanig, JP | 2 |
| Yoder, PD | 1 |
| Krop, S | 1 |
| Andreas, K | 5 |
| Häntzschel, A | 2 |
| Kinoshita, Y | 1 |
| Matsumura, H | 1 |
| Igisu, H | 1 |
| Yokota, A | 1 |
| Reulen, HJ | 1 |
| Graham, R | 1 |
| Spatz, M | 1 |
| Klatzo, I | 1 |
| Shuman, RM | 1 |
| Leech, RW | 1 |
| Alvord, EC | 1 |
| Purves, D | 1 |
| Dayan, A | 1 |
| Purves, DC | 1 |
| Garrod, IJ | 1 |
| Dayan, AD | 1 |
| Blaschke, M | 1 |
| Bergsträsser, E | 1 |
| Fischer, HD | 1 |
| Schmidt, J | 1 |
| Lampert, P | 1 |
| O'Brien, J | 1 |
| Garrett, R | 1 |
| Powell, HC | 1 |
| Lampert, PW | 1 |
| Edds, GT | 1 |
| Simpson, CF | 1 |
| Martinez, AJ | 1 |
| Boehm, R | 1 |
| Hadfield, MG | 1 |
| Kimbrough, RD | 2 |
| Gaines, TB | 1 |
1 review available for hexachlorophene and Brain Edema
| Article | Year |
|---|---|
Review of the toxicity of hexachlorophene.
Topics: Adult; Animals; Brain Diseases; Brain Edema; Burns; Child; Hexachlorophene; Humans; Infant, Newborn; | 1971 |
17 other studies available for hexachlorophene and Brain Edema
| Article | Year |
|---|---|
Interaction of hexachlorophene and other compounds with spin-labeled brain membranes.
Topics: Animals; Brain; Brain Edema; Cell Membrane; Cerebellum; Cyclic N-Oxides; Electron Spin Resonance Spe | 1984 |
Protection with butylated hydroxytoluene and other compounds against intoxication and mortality caused by hexachlorophene.
Topics: Animals; Antidotes; Antioxidants; Brain Edema; Butylated Hydroxytoluene; Edema; Hexachlorophene; Int | 1984 |
Efficacy of cerebroprotective substances in the management of functional disorders induced by the cytotoxic brain oedema-producing substance hexachlorophene.
Topics: Animals; Behavior, Animal; Brain Edema; Calcium Channel Blockers; Disease Models, Animal; Hexachloro | 1993 |
Efficacy of glutamate receptor antagonists in the management of functional disorders in cytotoxic brain oedema induced by hexachlorophene.
Topics: 2-Amino-5-phosphonovalerate; 6-Cyano-7-nitroquinoxaline-2,3-dione; Animals; Brain; Brain Edema; Dizo | 1998 |
Non-N-methyl-D-aspartate (NMDA) receptor antagonist 1,2,3, 4-tetrahydro-6-nitro-2,3-dioxo-benzo(f)quinoxaline-7-sulphonamide (NBQX) decreases functional disorders in cytotoxic brain oedema.
Topics: Animals; Behavior, Animal; Brain; Brain Edema; Excitatory Amino Acid Antagonists; Hexachlorophene; M | 2000 |
Hexachlorophene-induced brain edema in rat observed by proton magnetic resonance.
Topics: Animals; Brain; Brain Edema; Corpus Callosum; Diffusion; Hexachlorophene; Magnetic Resonance Imaging | 2000 |
Role of pressure gradients and bulk flow in dynamics of vasogenic brain edema.
Topics: Animals; Bis(4-Methyl-1-Homopiperazinylthiocarbonyl)disulfide; Body Fluids; Body Water; Brain Edema; | 1977 |
Neurotoxicity of hexachlorophene in humans. II. A clinicopathological study of 46 premature infants.
Topics: Administration, Topical; Birth Weight; Brain Diseases; Brain Edema; Brain Stem; Gastrointestinal Mot | 1975 |
A preliminary investigation of promotion of brain tumours by hexachlorophane in Sprague-Dawley rats transplacentally exposed to N-ethylnitrosourea.
Topics: Animals; Body Weight; Brain; Brain Edema; Brain Neoplasms; Carcinogens; Cocarcinogenesis; Eating; Et | 1992 |
A comparison of spongiosis induced in the brain by hexachlorophene, cuprizone and triethyl tin in the Sprague-Dawley rat.
Topics: Animals; Body Weight; Brain; Brain Edema; Cuprizone; Dose-Response Relationship, Drug; Drinking; Eat | 1991 |
Cytotoxic brain oedema as a model in the examination of cerebroprotective substances.
Topics: Animals; Body Water; Brain Chemistry; Brain Edema; Cell Survival; Dexamethasone; Hexachlorophene; Ma | 1991 |
Neurochemical characterization of hexachlorophene induced brain oedema.
Topics: Animals; Brain Chemistry; Brain Edema; Calcium; Calcium-Transporting ATPases; Corpus Striatum; Dopam | 1991 |
Hexachlorophene encephalopathy.
Topics: Animals; Axons; Brain; Brain Edema; Chromatography, Thin Layer; Copper; Extracellular Space; Hexachl | 1973 |
Bithionol: a possible substitute for hexachlorophene.
Topics: Administration, Oral; Animals; Body Weight; Brain; Brain Edema; Chelating Agents; Chlorobenzenes; Co | 1973 |
Hexachlorophene-pHisohex toxicity in pups.
Topics: Administration, Intranasal; Animals; Brain; Brain Edema; Coma; Dog Diseases; Dogs; Hexachlorophene; | 1974 |
Acute hexachlorophene encephalopathy: clinico-neuropathological correlation.
Topics: Acute Disease; Arrhythmias, Cardiac; Autopsy; Blindness; Brain Diseases; Brain Edema; Child; Diarrhe | 1974 |
Hexachlorophene effects on the rat brain: study of high doses by light and electron microscopy.
Topics: Administration, Oral; Animals; Brain; Brain Edema; Cerebellum; Female; Hexachlorophene; Hindlimb; Mi | 1971 |