hevizos and Herpes-Labialis

Herpetic skin lesions have importance and growing frequency in the population. The authors report a double blind study involving 51 patients suffering from recurrent labial herpes to compare the effectiveness and adverse reactions of two topical antiviral preparations, the aciclovir (Zovirax) and epervudine (Hevizos). There was no significant difference between the two treatment groups in the healing tendency of herpetic lesions. The rate of relapses in a two months period was 44.4% in the group treated with aciclovir and 20.8% in the group treated with epervudine, the difference is not significant. Both preparation was well tolerated, only itching occurred as adverse reaction in the group treated with aciclovir. According to the results of the study the original Hungarian product (Hevizos), is at least as effective as the other topical preparation.

Topics: Acyclovir; Administration, Topical; Adult; Aged; Antiviral Agents; Deoxyuridine; Double-Blind Method; Female; Herpes Labialis; Herpes Simplex; Humans; Male; Middle Aged; Ointments; Simplexvirus

After a brief summary of the effects of Hevizos ointment, major clinical studies conducted in Hungary are described. In a double-blind comparative clinical study involving the dermatological departments of three medical universities, Hevizos has been found more effective than Virungent ointment in herpes simplex labials and herpes zoster. In herpes genitalis the two products were of identical efficacy. Both Hevizos and Virungent proved to be more effective than placebo in all three indications. By the evidence of an open clinical trial Hevizos is not superseded by Zovirax ointment: confirmation of these findings in a double-blind study is underway.

Topics: Antiviral Agents; Deoxyuridine; Double-Blind Method; Herpes Genitalis; Herpes Labialis; Herpes Zoster; Humans; Ointments