heteronemin and Neurodegenerative-Diseases

heteronemin has been researched along with Neurodegenerative-Diseases* in 1 studies

Other Studies

1 other study(ies) available for heteronemin and Neurodegenerative-Diseases

Article	Year
Heteronemin, a marine sponge terpenoid, targets TDP-43, a key factor in several neurodegenerative disorders. Chemical communications (Cambridge, England), 2014, Jan-14, Volume: 50, Issue:4 Trans-activation response DNA-binding protein of 43 kDa (TDP-43), a key factor in several neurodegenerative conditions, was discovered as a novel target of heteronemin by chemical proteomics. Combining bio-physical orthogonal approaches with biological analysis, heteronemin was found to influence the binding of TDP-43-cognate nucleic acids and to modulate the TDP-43 aggregation state and its cellular localization. Topics: Animals; DNA-Binding Proteins; DNA, Single-Stranded; HeLa Cells; Humans; Microscopy, Confocal; Neurodegenerative Diseases; NF-kappa B; Porifera; Protein Binding; Terpenes	2014

Article

Year

Heteronemin, a marine sponge terpenoid, targets TDP-43, a key factor in several neurodegenerative disorders.

Chemical communications (Cambridge, England), 2014, Jan-14, Volume: 50, Issue:4

Trans-activation response DNA-binding protein of 43 kDa (TDP-43), a key factor in several neurodegenerative conditions, was discovered as a novel target of heteronemin by chemical proteomics. Combining bio-physical orthogonal approaches with biological analysis, heteronemin was found to influence the binding of TDP-43-cognate nucleic acids and to modulate the TDP-43 aggregation state and its cellular localization.

Topics: Animals; DNA-Binding Proteins; DNA, Single-Stranded; HeLa Cells; Humans; Microscopy, Confocal; Neurodegenerative Diseases; NF-kappa B; Porifera; Protein Binding; Terpenes

2014