hesperidin-methylchalcone and Arthralgia

hesperidin-methylchalcone has been researched along with Arthralgia* in 1 studies

Other Studies

1 other study(ies) available for hesperidin-methylchalcone and Arthralgia

Article	Year
Hesperidin methyl chalcone interacts with NFκB Ser276 and inhibits zymosan-induced joint pain and inflammation, and RAW 264.7 macrophage activation. Inflammopharmacology, 2020, Volume: 28, Issue:4 Arthritis can be defined as a painful musculoskeletal disorder that affects the joints. Hesperidin methyl chalcone (HMC) is a flavonoid with analgesic, anti-inflammatory, and antioxidant effects. However, its effects on a specific cell type and in the zymosan-induced inflammation are unknown. We aimed at evaluating the effects of HMC in a zymosan-induced arthritis model. A dose-response curve of HMC (10, 30, or 100 mg/kg) was performed to determine the most effective analgesic dose after intra-articular zymosan stimuli. Knee joint oedema was determined using a calliper. Leukocyte recruitment was performed by cell counting on knee joint wash as well as histopathological analysis. Oxidative stress was measured by colorimetric assays (GSH, FRAP, ABTS and NBT) and RT-qPCR (gp91 Topics: Analgesics; Animals; Anti-Inflammatory Agents; Antioxidants; Arthralgia; Arthritis, Experimental; Cell Line; Chalcones; Cytokines; Disease Models, Animal; Edema; Hesperidin; Inflammation; Macrophage Activation; Macrophages; Mice; Molecular Docking Simulation; NF-kappa B; Oxidative Stress; RAW 264.7 Cells; Signal Transduction; Zymosan	2020

Article

Year

Hesperidin methyl chalcone interacts with NFκB Ser276 and inhibits zymosan-induced joint pain and inflammation, and RAW 264.7 macrophage activation.

Inflammopharmacology, 2020, Volume: 28, Issue:4

Arthritis can be defined as a painful musculoskeletal disorder that affects the joints. Hesperidin methyl chalcone (HMC) is a flavonoid with analgesic, anti-inflammatory, and antioxidant effects. However, its effects on a specific cell type and in the zymosan-induced inflammation are unknown. We aimed at evaluating the effects of HMC in a zymosan-induced arthritis model. A dose-response curve of HMC (10, 30, or 100 mg/kg) was performed to determine the most effective analgesic dose after intra-articular zymosan stimuli. Knee joint oedema was determined using a calliper. Leukocyte recruitment was performed by cell counting on knee joint wash as well as histopathological analysis. Oxidative stress was measured by colorimetric assays (GSH, FRAP, ABTS and NBT) and RT-qPCR (gp91

Topics: Analgesics; Animals; Anti-Inflammatory Agents; Antioxidants; Arthralgia; Arthritis, Experimental; Cell Line; Chalcones; Cytokines; Disease Models, Animal; Edema; Hesperidin; Inflammation; Macrophage Activation; Macrophages; Mice; Molecular Docking Simulation; NF-kappa B; Oxidative Stress; RAW 264.7 Cells; Signal Transduction; Zymosan

2020