hesperidin has been researched along with Disease Models, Animal in 103 studies
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 1 (0.97) | 18.7374 |
| 1990's | 0 (0.00) | 18.2507 |
| 2000's | 12 (11.65) | 29.6817 |
| 2010's | 65 (63.11) | 24.3611 |
| 2020's | 25 (24.27) | 2.80 |
| Authors | Studies |
|---|---|
| Akhtar, F; Kumar, R; Rizvi, SI | 2 |
| Chae, S; Im, AR; Ji, KY; Kim, KM; Kim, T; Lee, JY; Park, DH | 1 |
| Akour, A; Al-Tammemi, AB; AlMuhaissen, SA; Alrawashdeh, MN; An, H; Anastasia, L; Apkon, S; Armstrong, WS; Ayala Izurieta, JE; Barnett, K; Bhowmick, S; Biniskos, N; Booka, E; Brown, JC; Buchanan, SW; Campbell, C; Camporeale, A; Cantos, VD; Cao, Z; Chakraborty, RD; Chaturvedi, V; Chen, C; Chen, G; Chen, Y; Chou, PT; Ciconte, G; Colasanti, JA; Collins, LF; Darras, BT; de Carvalho, RM; De Morais, DC; Delegido, J; Dodd, J; Doki, Y; Dunfield, K; Elfring, G; Feng, B; Ferry, VE; Galaviz, KI; García, VJ; Greven, M; Guo, J; Gutierrez, M; Hameed, S; Hippler, M; Huang, JW; Isaac, ME; Ishihara, R; Ishikawa, H; Ito, Y; Jacobson, A; Jalouqa, S; James, TD; Jara Santillán, CA; Jiang, K; Jordan, R; Kampf, JW; Kato, H; Kato, K; Katzmarzyk, PT; Kaviani, A; Kawachi, H; Kawakubo, H; Khansari Nejad, N; Kitagawa, Y; Kojima, T; Kono, K; Koplowitz, B; Kubo, Y; Kuribayashi, S; Lahiri, CD; Lei, H; Leighton, C; Li, J; Liu, G; Lombardi, M; Lu, Y; Luo, Y; Ma, P; Mafa-Attoye, T; Mahmoud, NN; Makhlina, M; Makino, T; Manguso, F; Mano, M; Manso, AP; Marconi, VC; Márquez, CO; Matsubara, H; Matsuda, S; McDonald, CM; Mecarocci, V; Metcalfe, GD; Micaglio, E; Miele, L; Mire, EF; Miyazaki, T; Moi, CT; Moore, CM; Moran, CA; Muto, M; Nemoto, K; Nguyen, ML; Nusair, MB; Ochoa, A; Owen, G; Oyama, T; Palma-Dibb, RG; Pappone, C; Parsons, JA; Pasqualotto, N; Peltz, SW; Pesco Koplowitz, L; Pica, S; Postiglione, WM; Qureshi, M; Rhodes, J; Saeki, H; Sakai, M; Santinelli, V; Santos, C; Shah, NS; Shanahan, JP; Shieh, PB; Sisti, JM; Smith, TW; Sohda, M; Song, Y; Spana, C; Sturla, F; Su, BK; Sumitani, J; Szabo, B; Szymczak, NK; Tabiś, W; Takeuchi, H; Tang, X; Thevathasan, NV; Toh, Y; Tondi, L; Trifillis, P; Tsushima, T; Van Wittenberghe, S; Vicedomini, G; Wang, H; Wang, K; Wang, S; Wang, W; Wang, X; Wang, Y; Wu, F; Wu, X; Yamaji, T; Yamamoto, K; Yamatsuji, T; Yang, L; Yang, S; Yang, WH; Yang, Y; Yoshida, M; Yu, B; Yuan, L; Zabaleta, J; Zhang, C; Zhang, H; Zhang, L; Zhang, X; Zhang, Z; Zheng, WQ; Zheng, YX; Zhou, H; Zhou, J; Zhou, N; Zhu, W | 1 |
| Fujita, K; Ge, S; Himori, N; Maekawa, S; Nakazawa, T; Nishiguchi, KM; Ohno-Oishi, M; Omodaka, K; Ozawa, M; Sato, K; Sato, T; Shiga, Y; Yabana, T; Yasuda, M | 1 |
| Araujo, SM; Bortolotto, VC; Janner, DE; La Rosa Novo, D; Meichtry, LB; Mesko, MF; Musachio, EAS; Poetini, MR; Prigol, M; Ramborger, BP; Roehrs, R; Silva, NC | 1 |
| Chen, H; Ma, J; Nie, T; Shan, A; Zhang, P | 1 |
| Abourehab, MAS; Gupta, P; Kesharwani, P; Sheikh, A | 1 |
| Cho, JS; Gee, MS; Jeon, SH; Ju, YJ; Jung, MJ; Kim, N; Lee, D; Lee, JK; Lee, S; Lee, Y | 1 |
| Chen, F; Deng, ZY; Hua, L; Li, X; Luo, T; Wang, Y; Wu, M; Yao, Y | 1 |
| Kang, SW; Park, HK; Park, MS | 1 |
| Feng, F; Zhang, Q | 1 |
| Akash, MSH; Arafa, EA; Buabeid, MA; Chohan, TA; Jabeen, K; Munawar, SM; Rehman, K; Tariq, M | 1 |
| Artero, NA; Badaro-Garcia, S; Casagrande, R; de Freitas, A; Fattori, V; Ferraz, CR; Manchope, MF; Rasquel-Oliveira, FS; Saraiva-Santos, T; Staurengo-Ferrari, L; Verri, WA; Zaninelli, TH | 1 |
| Abdelazem, AZ; Abdelaziz, RM; Attia, YA; Hashem, KS | 1 |
| Ding, J; He, N; Liu, L; Sun, Y; Wang, S; Xing, H | 1 |
| Choi, GM; Lee, B; Sur, B | 1 |
| Ding, Y; Fu, X; Liu, F; Lou, Y; Wen, H; Yang, L; Yang, Q; Zhang, J; Zhang, L | 1 |
| Baradaran, S; Ghasemi-Kasman, M; Moghaddam, AH | 1 |
| Bai, YF; Fan, XY; Sheng, H; Wang, SW; Wang, W; Weng, YY; Xu, ZC; Zhang, F; Zheng, F; Zhu, XT | 1 |
| Baracat, MM; Borghi, SM; Casagrande, R; Fattori, V; Ferraz, CR; Guazelli, CFS; Verri, WA | 1 |
| Altug, ME; Kucukgul, A; Secinti, IE; Unsaldi, E; Yurtal, Z | 1 |
| Kurokawa, M; Sugita, C; Tsuhako, R; Yoshida, H | 1 |
| Cui, SS; Li, M; Li, RM; Qiu, ZC; Tan, X; Yuan, YL; Zhang, FX | 1 |
| Alsemeh, AE; Bendary, MA; Mandour, DA | 1 |
| Alizadeh Makvandi, A; Amiri Moghaddam, S; Khalili, M; Roghani, M | 1 |
| Dokumacioglu, E; Ince, I; Iskender, H; Kanbay, Y; Saral, S; Sen, TM | 1 |
| Adefegha, SA; Doleski, PH; Ecker, A; Leal, DBR; Ledur, PC | 1 |
| Daigaku, R; Fujita, K; Maekawa, S; Maruyama, K; Moritoh, S; Murayama, N; Nakazawa, T; Nishiguchi, KM; Omodaka, K; Sato, K; Shiga, Y; Tawarayama, H; Yabana, T | 1 |
| Hajizadeh Moghaddam, A; Kheradmand, E; Zare, M | 1 |
| Blanc-Guillemaud, V; Bouskela, E; Cyrino, FZ; das Graças C de Souza, M; de Carvalho, JJ | 1 |
| Basak, N; Cetin, A; Ciftci, O; Eraslan, S; Melekoglu, R | 1 |
| Ding, HW; Huang, AL; Huang, C; Li, B; Li, J; Meng, XM; Zhang, YL | 1 |
| Kong, R; Lu, J; Luo, H; Wang, N | 1 |
| Baradaran, S; Ghasemi-Kasman, M; Hajizadeh Moghaddam, A | 1 |
| Alan, S; Basak, N; Cetinkaya, EA; Ciftci, O; Oztanır, MN | 1 |
| Chang, JH; Hong, J; Jeon, MT; Jung, UJ; Kim, DW; Kim, S; Kim, SR; Kwon, JY; Moon, GJ; Shin, M | 1 |
| Chiang, CY; Chiu, HC; Fu, E; Fu, MM; Fu, MW; Ku, CT; Kuo, PJ; Lin, CY; Tu, HP | 1 |
| Ding, YS; Guo, JY; He, S; Jiang, YN; Lin, MX; Luo, J; Ma, XJ; Shi, JL; Wang, SN; Zhao, CB | 1 |
| Abbasi, MM; Ghorbanihaghjo, A; Kosari-Nasab, M; Salari, AA; Shokouhi, G | 1 |
| Aydogmus, E; Bahadir, B; Gul, S | 1 |
| Dortbudak, MB; Gozeler, MS; Kandemir, FM; Kilic, K; Kucukler, S; Sakat, MS; Yildirim, S | 1 |
| Aguiar, AC; Krettli/, AU; Penna-Coutinho, J | 1 |
| Ding, H; Fan, W; Gao, G; Zhuang, C | 1 |
| Di, T; Li, N; Li, P; Li, X; Liu, Z; Meng, Y; Wang, M; Xie, X; Zhai, C; Zhang, L | 1 |
| Ali, T; Ikram, M; Jo, MG; Khan, A; Kim, MO; Muhammad, T; Rehman, SU | 1 |
| Kaufman, RJ; Li, H; Monks, TJ; O'Meara, M; Seyoum, B; Wang, JM; Yi, Z; Zhang, K; Zhang, X | 1 |
| Bai, Y; Dai, G; Jing, W; Ju, W; Song, L; Song, S; Sun, H; Xu, M; Zhang, W; Zhang, Y | 1 |
| An, H; Che, D; Ding, Y; Fu, J; Gao, Z; Hu, S; Li, C; Liu, R; Ma, P; Wang, J; Zhang, T; Zhang, Y; Zhao, T | 1 |
| Abtahi-Eivary, SH; Khaki, A; Khaki, AA; Moghimian, M; Shokoohi, M; Shoorei, H | 1 |
| Abuelsaad, AS; Allam, G | 1 |
| Chen, G; Gong, H; Tang, W; Wang, J; Xiang, J; Zhao, J | 1 |
| Kumar, A; Lalitha, S; Mishra, J | 1 |
| Chaudhary, T; Kumar, A; Mishra, J | 1 |
| Hattori, T; Iizuka, S; Miura, A; Mogami, S; Nakazato, M; Tsubouchi, H; Yamada, C; Yanagi, S | 1 |
| Aswar, M; Aswar, U; Kute, P; Mahajan, S; Mahajan, U; Nerurkar, G | 1 |
| Liu, L; Wang, D; Wang, Y; Wu, W; Zhu, X | 1 |
| Muriel, P; Pérez-Vargas, JE; Segovia, J; Shibayama, M; Tsutsumi, V; Zarco, N | 1 |
| Agrawal, YO; Arya, DS; Goyal, SN; Ojha, S; Sharma, PK; Shrivastava, B; Upadhya, HM | 1 |
| Iranshahi, M; Parhiz, H; Rezaee, R; Roohbakhsh, A; Soltani, F | 1 |
| Li, C; Qu, H; Schluesener, H; Zhang, Z; Zug, C | 1 |
| Borghi, SM; Casagrande, R; Guazelli, CF; Hohmann, MS; Manchope, MF; Pinho-Ribeiro, FA; Verri, WA; Zarpelon, AC | 1 |
| Ansarin, K; Kolahian, S; Pour Moghaddam, M; Sakhinia, E; Sakhinia, M; Seyedrezazadeh, E; Shahbazfar, AA; Vafa, M | 1 |
| Baracat, MM; Casagrande, R; Caviglione, CV; Georgetti, SR; Martinez, RM; Pinho-Ribeiro, FA; Steffen, VS; Verri, WA; Vignoli, JA | 1 |
| Gray, JP; Parmar, MS; Ray, SD; Syed, I | 1 |
| Bando, M; Nakazawa, Y; Oka, M; Takehana, M | 1 |
| Chang, CY; Chou, SS; Huang, SK; Lin, TY; Lu, CW; Wang, SJ; Wang, YC | 1 |
| An, Z; Hong, Y | 1 |
| Caldwell, RB; Kimura, S; Kobayashi, H; Matsumoto, C; Nagaoka, T; Narayanan, SP; Ono, S; Shimouchi, A; Takumi, H; Tamai, T; Yokota, H; Yoshida, A | 1 |
| Fu, J; Shi, Q; Song, E; Song, X; Song, Y; Su, C; Xia, X | 1 |
| Hasan, SK; Nafees, S; Rashid, S; Saidullah, B; Siddiqi, A; Sultana, S | 1 |
| Chen, SM; Chen, XM; Geng, D; Li, CF; Liu, Q; Mu, RH; Wang, SS; Yi, LT | 1 |
| Demirtaş, S; Dereköy, FS; Güçlü, O; Kara, M; Karaca, T; Türkön, H; Türkyılmaz, M; Uysal, S | 1 |
| Alwasel, SH; Ekinci Akdemir, FN; Gülçin, İ; Karagöz, B; Soslu, R | 1 |
| Haghmorad, D; Jalayer, Z; Kokhaei, P; Mahmoudi, M; Mahmoudi, MB; Momtazi Brojeni, AA; Rastin, M; Salehipour, Z | 1 |
| Alvarado-Vázquez, N; Carballo-Villalobos, AI; González-Trujano, ME; López-Muñoz, FJ | 1 |
| Aranganathan, S; Nalini, N; Selvam, JP | 1 |
| Li, P; Xu, L; Yang, ZL; Zhou, YQ | 1 |
| Balaraman, R; Gandhi, C; Upaganalawar, A | 1 |
| Aranganathan, S; Nalini, N | 1 |
| Abd-Ellah, MF; Aly, HA; Arafa, HM; El-Refaey, HM | 1 |
| Kumar, A; Kumar, P | 1 |
| Cho, YY; Choi, MS; Jeon, SM; Kim, HJ; Kwon, EY; Lee, JH; Lee, MK | 1 |
| Dube, V; Joseph, SK; Lakshmi, V; Mishra, SK; Murthy, PK; Sahoo, MK; Srivastava, S; Verma, SK | 1 |
| Pugalendi, KV; Selvaraj, P | 1 |
| Pari, L; Shagirtha, K | 1 |
| Chu, X; Ci, X; Deng, X; Hua, S; Wei, D; Wei, M | 1 |
| Jena, GB; Kushwaha, S; Tripathi, DN; Trivedi, PP | 1 |
| Jeong, HJ; Kim, HM; Oh, HA | 1 |
| Kim, BK; Kim, SH; Lee, YC | 1 |
| Ahmad, A; Ashafaq, M; Islam, F; Javed, H; Khan, MM; Khuwaja, G; Raza, SS; Safhi, MM; Siddiqui, MS; Tabassum, R | 1 |
| Chen, CM; Han, CY; Hsu, HT; Ko, WC; Wang, KH; Yang, YL | 1 |
| Cai, L; Hu, CM; Li, J; Li, R; Ren, DY; Xie, XF | 1 |
| Abdel-Tawab, AM; Khalifa, AE; Menze, ET; Tadros, MG | 1 |
| Bracke, ME; Heugebaert, TS; Roman, BI; Stevens, CV | 1 |
| de la Rocha, NE; Guardia, T; Juárez, AO; Pelzer, LE; Rotelli, AE | 1 |
| Kawaguchi, K; Kometani, T; Kumazawa, Y; Maruyama, H | 1 |
| Chee, WS; Coxam, V; Davicco, MJ; Gil-Izquierdo, A; Habauzit, V; Horcajada, MN; Lebecque, P; Mardon, J; Morand, C; Offord, E; Trzeciakiewicz, A | 1 |
| Cai, L; Hu, CM; Li, J; Li, R; Zhang, L | 1 |
| Fujita, T; Fumuro, M; Gato, T; Iwaki, M; Kawase, A; Masuda, M; Matsuda, H; Sasaki, K; Shiura, T; Tokunaga, M; Utsunomiya, N | 1 |
| Asaka, M; Hattori, T; Katsurada, T; Nagai, K; Ohkawara, T; Sadakane, C; Takeda, H | 1 |
| Dancel, J; Hontz, BA; Liang, X; Proch, J; Sandone, N; Vinson, JA | 1 |
| Czernicki, Z | 1 |
3 review(s) available for hesperidin and Disease Models, Animal
| Article | Year |
|---|---|
Topics: Adult; Alcohol Drinking; Ammonia; Animals; Anti-Inflammatory Agents; Area Under Curve; B-Lymphocytes; Black or African American; Bleaching Agents; Body Mass Index; Brugada Syndrome; Carbon; China; Climate Models; Codon, Nonsense; Cohort Studies; Colitis; Colon; COVID-19; Cytokines; Dental Enamel; Dextran Sulfate; Disease Models, Animal; Disease Outbreaks; Dogs; Electrocardiography; Escherichia coli; Esophageal Neoplasms; Female; Follow-Up Studies; Forests; Georgia; Glucosides; Healthy Volunteers; Heart Ventricles; Hesperidin; HIV Infections; Humans; Humidity; Hydrogen Peroxide; Incidence; Influenza, Human; Longitudinal Studies; Magnetic Resonance Imaging, Cine; Male; Melanocortins; Mice; Mice, Inbred C57BL; Microscopy, Electron, Scanning; Middle Aged; Muscular Dystrophy, Duchenne; Naphthol AS D Esterase; Naphthols; Neoplasms; Nitrates; Nitrites; Nitrous Oxide; Obesity; Pandemics; Patient Outcome Assessment; Patient Satisfaction; Plants; Prednisolone; Prednisone; Pregnenediones; Proportional Hazards Models; Prospective Studies; Pulmonary Disease, Chronic Obstructive; Rats; Receptor, Melanocortin, Type 1; Retrospective Studies; Risk Factors; SARS-CoV-2; Seasons; Soil; Stroke Volume; T-Lymphocytes; Telemedicine; Temperature; Tetralogy of Fallot; Tooth Bleaching; Tooth Bleaching Agents; Trees; Urea; White People | 2021 |
Antioxidant and anti-inflammatory properties of the citrus flavonoids hesperidin and hesperetin: an updated review of their molecular mechanisms and experimental models.
Topics: Animals; Anti-Inflammatory Agents; Antioxidants; Citrus; Disease Models, Animal; Hesperidin; Humans; Inflammation; NF-kappa B; Oxidative Stress; Signal Transduction | 2015 |
Assessment of the antineoplastic potential of chalcones in animal models.
Topics: Animals; Antineoplastic Agents; Chalcones; Disease Models, Animal; Hesperidin; Humans; Structure-Activity Relationship | 2013 |
100 other study(ies) available for hesperidin and Disease Models, Animal
| Article | Year |
|---|---|
Protective effect of hesperidin in Poloxamer-407 induced hyperlipidemic experimental rats.
Topics: Animals; Disease Models, Animal; Hesperidin; Hyperlipidemias; Oxidative Stress; Poloxamer; Protective Agents; Protective Factors; Rats | 2021 |
Hesperidin Inhibits UVB-Induced VEGF Production and Angiogenesis via the Inhibition of PI3K/Akt Pathway in HR-1 Hairless Mice.
Topics: Animals; Disease Models, Animal; Fibroblasts; Hesperidin; Humans; Keratinocytes; Male; Mice; Mice, Hairless; Neovascularization, Pathologic; Phosphatidylinositol 3-Kinases; Phosphorylation; Primary Cell Culture; Proto-Oncogene Proteins c-akt; Ribosomal Protein S6 Kinases, 70-kDa; Signal Transduction; Skin; Ultraviolet Rays; Vascular Endothelial Growth Factor A | 2021 |
CHOP deletion and anti-neuroinflammation treatment with hesperidin synergistically attenuate NMDA retinal injury in mice.
Topics: Animals; Blotting, Western; Calcium-Binding Proteins; Cytokines; Disease Models, Animal; Drug Synergism; Gene Deletion; Hesperidin; Immunohistochemistry; In Situ Nick-End Labeling; Male; Mice; Mice, Inbred C57BL; Mice, Knockout; Microfilament Proteins; Microglia; N-Methylaspartate; Neuroprotection; NF-kappa B; Oxidative Stress; Real-Time Polymerase Chain Reaction; Retinal Diseases; Retinal Ganglion Cells; Transcription Factor CHOP | 2021 |
Improvement of non-motor and motor behavioral alterations associated with Parkinson-like disease in Drosophila melanogaster: Comparative effects of treatments with hesperidin and L-dopa.
Topics: Animals; Disease Models, Animal; Dopamine; Drosophila melanogaster; Hesperidin; Levodopa; Parkinson Disease | 2022 |
Hesperidin attenuates hepatic lipid accumulation in mice fed high-fat diet and oleic acid induced HepG2 via AMPK activation.
Topics: AMP-Activated Protein Kinases; Animals; Diet, High-Fat; Dietary Supplements; Disease Models, Animal; Enzyme Activation; Hep G2 Cells; Hesperidin; Humans; Lipid Metabolism; Lipids; Male; Mice, Inbred C57BL; Non-alcoholic Fatty Liver Disease; Oleic Acid; Phosphorylation | 2022 |
Amelioration of Full-Thickness Wound Using Hesperidin Loaded Dendrimer-Based Hydrogel Bandages.
Topics: Animals; Bandages, Hydrocolloid; Dendrimers; Disease Models, Animal; Hesperidin; Hydrogels; Wound Healing | 2022 |
Hesperidin Improves Memory Function by Enhancing Neurogenesis in a Mouse Model of Alzheimer's Disease.
Topics: Alzheimer Disease; AMP-Activated Protein Kinases; Animals; Disease Models, Animal; Hesperidin; Hippocampus; Mice; Mice, Transgenic; Neurodegenerative Diseases; Neurogenesis | 2022 |
Effect of Hesperidin Supplementation on Liver Metabolomics and Gut Microbiota in a High-Fat Diet-Induced NAFLD Mice Model.
Topics: Animals; Diet, High-Fat; Dietary Supplements; Disease Models, Animal; Gastrointestinal Microbiome; Hesperidin; Lipid Metabolism; Liver; Male; Metabolomics; Mice; Mice, Inbred C57BL; Non-alcoholic Fatty Liver Disease | 2022 |
Hesperidin Ameliorates Hepatic Ischemia-Reperfusion Injury in Sprague-Dawley Rats.
Topics: Alanine Transaminase; Animals; Antioxidants; Aspartate Aminotransferases; Catalase; Disease Models, Animal; Glutathione Peroxidase; Hesperidin; Liver; Liver Diseases; Male; Nitric Oxide; Rats; Rats, Sprague-Dawley; Reperfusion Injury; Superoxide Dismutase | 2019 |
The Effects of Different Varieties of
Topics: Animals; Chromatography, High Pressure Liquid; Depression; Disaccharides; Disease Models, Animal; Drug Synergism; Drugs, Chinese Herbal; Flavanones; Hesperidin; Intestinal Absorption; Iridoids; Male; Rats; Rats, Sprague-Dawley | 2019 |
Hesperidin attenuates altered redox homeostasis in an experimental hyperlipidaemic model of rat.
Topics: Animals; Biomarkers; Disease Models, Animal; Hesperidin; Homeostasis; Hyperlipidemias; Male; Oxidation-Reduction; Rats; Rats, Wistar | 2020 |
Hesperidin improves insulin resistance via down-regulation of inflammatory responses: Biochemical analysis and in silico validation.
Topics: Animals; Anti-Inflammatory Agents, Non-Steroidal; Anti-Obesity Agents; Diet, High-Fat; Disease Models, Animal; Drug Therapy, Combination; Hesperidin; Hyperlipidemias; Inflammation; Insulin Resistance; Leptin; Molecular Docking Simulation; Molecular Dynamics Simulation; Obesity; Orlistat; Rats, Wistar | 2020 |
Hesperidin methyl chalcone interacts with NFκB Ser276 and inhibits zymosan-induced joint pain and inflammation, and RAW 264.7 macrophage activation.
Topics: Analgesics; Animals; Anti-Inflammatory Agents; Antioxidants; Arthralgia; Arthritis, Experimental; Cell Line; Chalcones; Cytokines; Disease Models, Animal; Edema; Hesperidin; Inflammation; Macrophage Activation; Macrophages; Mice; Molecular Docking Simulation; NF-kappa B; Oxidative Stress; RAW 264.7 Cells; Signal Transduction; Zymosan | 2020 |
Protective effects of hesperidin against MTX-induced hepatotoxicity in male albino rats.
Topics: Animals; Anti-Inflammatory Agents; Antioxidants; Apoptosis; Apoptosis Regulatory Proteins; Chemical and Drug Induced Liver Injury; Disease Models, Animal; Gene Expression Regulation; Heme Oxygenase (Decyclizing); Hesperidin; Inflammation Mediators; Liver; Male; Methotrexate; NF-E2-Related Factor 2; Oxidative Stress; Rats, Sprague-Dawley; Signal Transduction; Tumor Suppressor Protein p53 | 2020 |
Function of hesperidin alleviating inflammation and oxidative stress responses in COPD mice might be related to SIRT1/PGC-1α/NF-κB signaling axis.
Topics: Animals; Bronchoalveolar Lavage Fluid; Disease Models, Animal; Hesperidin; Humans; Inflammation; Interleukin-6; Interleukin-8; Lung; Mice; NF-kappa B; Oxidative Stress; Peroxidase; Peroxisome Proliferator-Activated Receptor Gamma Coactivator 1-alpha; Pulmonary Disease, Chronic Obstructive; Signal Transduction; Sirtuin 1; Smoke; Superoxide Dismutase; Transcription Factor RelA | 2020 |
Antidepressant-Like Effects of Hesperidin in Animal Model of Post-Traumatic Stress Disorder.
Topics: Animals; Antidepressive Agents; Behavior, Animal; Disease Models, Animal; Hesperidin; Hippocampus; Male; Rats; Rats, Sprague-Dawley; Stress Disorders, Post-Traumatic | 2021 |
Neohesperidin inhibits cardiac remodeling induced by Ang II in vivo and in vitro.
Topics: Angiotensin II; Animals; Cells, Cultured; Disease Models, Animal; Fibrosis; Gene Expression Regulation; Hesperidin; Hypertrophy, Left Ventricular; Inflammation Mediators; Male; Mice, Inbred C57BL; Myocytes, Cardiac; Oxidative Stress; Rats, Sprague-Dawley; Signal Transduction; Ventricular Function, Left; Ventricular Remodeling | 2020 |
Nano-hesperetin enhances the functional recovery and endogenous remyelination of the optic pathway in focal demyelination model.
Topics: Animals; Demyelinating Diseases; Disease Models, Animal; Evoked Potentials, Visual; Hesperidin; Male; Optic Chiasm; Rats; Rats, Wistar; Recovery of Function; Remyelination; Visual Cortex; Visual Pathways | 2020 |
Hesperetin, a SIRT1 activator, inhibits hepatic inflammation via AMPK/CREB pathway.
Topics: Acetylation; AMP-Activated Protein Kinases; Animals; Anti-Inflammatory Agents; Chemical and Drug Induced Liver Injury; Cyclic AMP Response Element-Binding Protein; Disease Models, Animal; Enzyme Activation; Galactosamine; HEK293 Cells; Hesperidin; Humans; Liver; Macrophages; Male; Mice; Mice, Inbred BALB C; Protein Processing, Post-Translational; RAW 264.7 Cells; Signal Transduction; Sirtuin 1; Transcription Factor RelA | 2020 |
Antioxidant and anti-inflammatory effects of hesperidin methyl chalcone in experimental ulcerative colitis.
Topics: Animals; Anti-Inflammatory Agents; Antioxidants; Chalcones; Colitis, Ulcerative; Colon; Cytokines; Disease Models, Animal; Edema; Hesperidin; Male; Mice; Neutrophil Infiltration; NF-kappa B; Oxidative Stress | 2021 |
Investigation of Neuroprotective and Therapeutic Effects of Hesperidin in Experimental Spinal Cord Injury.
Topics: Animals; Anti-Inflammatory Agents; Antioxidants; Disease Models, Animal; Hesperidin; Male; Neuroprotective Agents; Rats; Rats, Wistar; Spinal Cord; Spinal Cord Injuries | 2020 |
Glucosyl Hesperidin Has an Anti-diabetic Effect in High-Fat Diet-Induced Obese Mice.
Topics: 3T3-L1 Cells; Adipose Tissue; Animals; Chemokine CCL2; Coculture Techniques; Diet, High-Fat; Disease Models, Animal; Glucosides; Hesperidin; Hyperglycemia; Hypoglycemic Agents; Macrophages; Male; Mice; Mice, Inbred C57BL; Obesity; RAW 264.7 Cells | 2021 |
Dissection of the potential pharmacological function of neohesperidin dihydrochalcone - a food additive - by in vivo substances profiling and network pharmacology.
Topics: Animals; Chalcones; Disease Models, Animal; Dissection; Food Additives; Hesperidin; Liver; Male; Phosphatidylinositol 3-Kinases; Rats, Sprague-Dawley; Signal Transduction | 2021 |
Histological and imunohistochemical alterations of hippocampus and prefrontal cortex in a rat model of Alzheimer like-disease with a preferential role of the flavonoid "hesperidin".
Topics: Alzheimer Disease; Animals; Behavior, Animal; Body Weight; Disease Models, Animal; Glial Fibrillary Acidic Protein; Glutathione; Hesperidin; Hippocampus; Immunohistochemistry; Male; Malondialdehyde; Organ Size; Phosphorylation; Prefrontal Cortex; Pyramidal Cells; Rats, Sprague-Dawley; Synaptophysin; tau Proteins | 2021 |
Hesperetin ameliorates electroconvulsive therapy-induced memory impairment through regulation of hippocampal BDNF and oxidative stress in a rat model of depression.
Topics: Adrenergic Uptake Inhibitors; Animals; Brain-Derived Neurotrophic Factor; Depression; Disease Models, Animal; Electroconvulsive Therapy; Hesperidin; Hippocampus; Male; Maze Learning; Memory Disorders; Oxidative Stress; Rats; Rats, Wistar; Reserpine | 2021 |
The effect of hesperidin and quercetin on oxidative stress, NF-κB and SIRT1 levels in a STZ-induced experimental diabetes model.
Topics: Animals; Antioxidants; Biomarkers; Blood Glucose; Diabetes Mellitus, Experimental; Diabetic Nephropathies; Disease Models, Animal; Hesperidin; Kidney; Liver; Male; NF-kappa B; Oxidative Stress; Quercetin; Rats; Rats, Wistar; Sirtuin 1; Streptozocin | 2017 |
Peripheral blood mononuclear cells from rat model of pleurisy: The effects of hesperidin on ectoenzymes activity, apoptosis, cell cycle and reactive oxygen species production.
Topics: Animals; Apoptosis; Carrageenan; Cell Cycle; Cell Cycle Checkpoints; Cell Survival; Disease Models, Animal; Female; Hesperidin; Hydrolysis; Leukocytes, Mononuclear; Necrosis; Nucleotides; Pleurisy; Rats, Wistar; Reactive Oxygen Species; Staining and Labeling | 2017 |
The neuroprotective effect of hesperidin in NMDA-induced retinal injury acts by suppressing oxidative stress and excessive calpain activation.
Topics: Animals; Apoptosis; Calpain; Cells, Cultured; Disease Models, Animal; Evoked Potentials, Visual; Hesperidin; Male; Mice; N-Methylaspartate; Neuroprotective Agents; Oxidative Stress; Retina; Retinal Diseases; Retinal Ganglion Cells; Treatment Outcome; Tumor Necrosis Factor-alpha | 2017 |
Neuroprotective effect of hesperetin and nano-hesperetin on recognition memory impairment and the elevated oxygen stress in rat model of Alzheimer's disease.
Topics: Alzheimer Disease; Animals; Antioxidants; Disease Models, Animal; Dose-Response Relationship, Drug; Glutathione; Glutathione Peroxidase; Glutathione Reductase; Hesperidin; Hippocampus; Male; Malondialdehyde; Memory Disorders; Nanoparticles; Neuroprotective Agents; Oxidative Stress; Rats; Rats, Wistar; Superoxide Dismutase | 2018 |
Protective Effects of Micronized Purified Flavonoid Fraction (MPFF) on a Novel Experimental Model of Chronic Venous Hypertension.
Topics: Animals; Capillary Permeability; Cricetinae; Diosmin; Disease Models, Animal; Drug Evaluation, Preclinical; Flavonoids; Glycosides; Hesperidin; Hypertension; Iliac Vein; Male; Microcirculation; Reperfusion Injury | 2018 |
The beneficial effects of nerolidol and hesperidin on surgically induced endometriosis in a rat model
Topics: Animals; Disease Models, Animal; Endometriosis; Female; Glutathione; Hesperidin; Malondialdehyde; Rats; Rats, Wistar; Sesquiterpenes; Superoxide Dismutase; Treatment Outcome; Uterus | 2018 |
Design, synthesis and investigation of potential anti-inflammatory activity of O-alkyl and O-benzyl hesperetin derivatives.
Topics: Animals; Anti-Inflammatory Agents; Carbon Tetrachloride; Chemical and Drug Induced Liver Injury; Disease Models, Animal; Hesperidin; Humans; Inflammation; Interleukin-1beta; Interleukin-6; Lipopolysaccharides; Macrophages; Mice; Mice, Inbred Strains; NF-kappa B; Nitric Oxide; Nitric Oxide Synthase Type II; RAW 264.7 Cells; Signal Transduction; Structure-Activity Relationship | 2018 |
Hesperetin Mitigates Bile Duct Ligation-Induced Liver Fibrosis by Inhibiting Extracellular Matrix and Cell Apoptosis via the TGF-β1/Smad Pathway.
Topics: Animals; Apoptosis; Disease Models, Animal; Extracellular Matrix; Hesperidin; Interleukin-6; Liver Cirrhosis; Male; Mice; Signal Transduction; Smad Proteins; Transforming Growth Factor beta1; Tumor Necrosis Factor-alpha | 2018 |
Hesperetin reduces myelin damage and ameliorates glial activation in lysolecithin-induced focal demyelination model of rat optic chiasm.
Topics: Animals; Antioxidants; Citrus; Demyelinating Diseases; Disease Models, Animal; Evoked Potentials, Visual; Hesperidin; Lysophosphatidylcholines; Male; Multiple Sclerosis; Myelin Sheath; Neuroglia; Optic Chiasm; Rats; Rats, Wistar | 2018 |
The efficacy of hesperidin for treatment of acute otitis media.
Topics: Acute Disease; Animals; Anti-Bacterial Agents; Cytokines; Disease Models, Animal; Drug Therapy, Combination; Epithelium; Hesperidin; Inflammation; Interleukin-1beta; Interleukin-4; Interleukin-6; Organ Size; Otitis Media; Rats; Sclerosis; Tumor Necrosis Factor-alpha; Tympanic Membrane | 2019 |
Beneficial Effects of Hesperetin in a Mouse Model of Temporal Lobe Epilepsy.
Topics: Administration, Oral; Animals; Anticonvulsants; Citrus; Disease Models, Animal; Epilepsy, Temporal Lobe; Fruit; Hesperidin; Kainic Acid; Male; Mice; Phytotherapy | 2018 |
Ameliorative effect of hesperidin on ligation-induced periodontitis in rats.
Topics: Alveolar Bone Loss; Animals; Disease Models, Animal; Hesperidin; Ligation; Periodontitis; Rats; Rats, Sprague-Dawley; Rats, Wistar; X-Ray Microtomography | 2019 |
Identification of Bioactive Chemical Markers in
Topics: Adrenocorticotropic Hormone; Animals; Anxiety; Chlorogenic Acid; Chromatography, High Pressure Liquid; Disease Models, Animal; Drugs, Chinese Herbal; Hesperidin; Least-Squares Analysis; Male; Neuropeptides; Plant Roots; Rats; Receptors, Corticotropin-Releasing Hormone; Rhizome; Valerian | 2018 |
Hesperidin attenuates depression-related symptoms in mice with mild traumatic brain injury.
Topics: Animals; Antidepressive Agents; Brain Concussion; Cytokines; Depression; Depressive Disorder; Disease Models, Animal; Flavonoids; Hesperidin; Hippocampus; Inflammation; Interleukin-1beta; Male; Malondialdehyde; Mice; Nerve Growth Factors; Neuroprotective Agents; Oxidative Stress; Tumor Necrosis Factor-alpha | 2018 |
Neuroprotective Effects of Hesperidin on Cerebral Vasospasm After Experimental Subarachnoid Hemorrhage in Rats: Biochemical, Pathologic, and Histomorphometric Analysis.
Topics: Animals; Antioxidants; Basilar Artery; Disease Models, Animal; Drug Administration Schedule; Hesperidin; Lipid Peroxidation; Male; Malondialdehyde; Neuroprotective Agents; Random Allocation; Rats, Wistar; Subarachnoid Hemorrhage; Vasospasm, Intracranial | 2019 |
The amendatory effect of hesperidin and thymol in allergic rhinitis: an ovalbumin-induced rat model.
Topics: Animals; Anti-Infective Agents; Antioxidants; Disease Models, Animal; Hesperidin; Immunoglobulin E; Inflammation; Interleukin-13; Interleukin-5; Nasal Cavity; Ovalbumin; Oxidants; Rats, Sprague-Dawley; Rhinitis, Allergic; Thymol; Tumor Necrosis Factor-alpha | 2019 |
Commercial drugs containing flavonoids are active in mice with malaria and in vitro against chloroquine-resistant Plasmodium falciparum.
Topics: Animals; Antimalarials; Disease Models, Animal; Drug Resistance; Female; Genistein; Hesperidin; Lethal Dose 50; Malaria; Mice; Parasitemia; Parasitic Sensitivity Tests; Plasmodium falciparum; Quercetin | 2018 |
Effects of Hesperidin on H₂O₂-Treated Chondrocytes and Cartilage in a Rat Osteoarthritis Model.
Topics: Animals; Apoptosis; Cartilage; Cartilage, Articular; Chondrocytes; Collagen Type II; Disease Models, Animal; Gene Expression; Hesperidin; Hydrogen Peroxide; Interleukin-1beta; Knee Joint; Male; Nitric Oxide Synthase Type II; Osteoarthritis; Rats; Rats, Sprague-Dawley; Signal Transduction; Tumor Necrosis Factor-alpha | 2018 |
Hesperidin inhibits keratinocyte proliferation and imiquimod-induced psoriasis-like dermatitis via the IRS-1/ERK1/2 pathway.
Topics: Animals; Blotting, Western; Cell Proliferation; Dermatologic Agents; Disease Models, Animal; Dose-Response Relationship, Drug; Enzyme-Linked Immunosorbent Assay; Fluorescent Antibody Technique; Hesperidin; Humans; Imiquimod; Keratinocytes; Lipopolysaccharides; Male; MAP Kinase Signaling System; Methotrexate; Mice; Mice, Inbred BALB C; Psoriasis; Real-Time Polymerase Chain Reaction | 2019 |
Hesperetin Confers Neuroprotection by Regulating Nrf2/TLR4/NF-κB Signaling in an Aβ Mouse Model.
Topics: Alzheimer Disease; Amyloid beta-Peptides; Animals; Apoptosis; Astrocytes; Biomarkers; Cell Line; Cognitive Dysfunction; Disease Models, Animal; Hesperidin; Hippocampus; Male; Memory; Memory Disorders; Mice, Inbred C57BL; Microglia; Nerve Tissue Proteins; Neuroprotection; NF-E2-Related Factor 2; NF-kappa B; Oxidative Stress; Signal Transduction; Synapses; Toll-Like Receptor 4 | 2019 |
Ameliorating Methylglyoxal-Induced Progenitor Cell Dysfunction for Tissue Repair in Diabetes.
Topics: Animals; Bone Marrow Cells; Cell- and Tissue-Based Therapy; Diabetes Mellitus, Type 2; Disease Models, Animal; Endoribonucleases; Gene Knock-In Techniques; Gene Transfer Techniques; Hesperidin; Lactoylglutathione Lyase; Mice; Neovascularization, Physiologic; Protein Serine-Threonine Kinases; Pyruvaldehyde; Resveratrol; Skin; Stem Cells; Wound Healing; Wounds and Injuries | 2019 |
Comparative pharmacokinetic study of four major bioactive components after oral administration of Zhi-Zi-Hou-Po decoction in normal and corticosterone-induced depressive rats.
Topics: Administration, Oral; Animals; Biphenyl Compounds; Corticosterone; Depression; Disease Models, Animal; Drugs, Chinese Herbal; Hesperidin; Iridoids; Lignans; Limit of Detection; Linear Models; Male; Rats; Rats, Sprague-Dawley; Reproducibility of Results | 2019 |
Neohesperidin suppresses IgE-mediated anaphylactic reactions and mast cell activation via Lyn-PLC-Ca
Topics: Anaphylaxis; Animals; Disease Models, Animal; Hesperidin; Immunoglobulin E; Male; Mast Cells; Mice | 2019 |
Hesperidin attenuated apoptotic-related genes in testicle of a male rat model of varicocoele.
Topics: Animals; Apoptosis; bcl-2-Associated X Protein; Disease Models, Animal; Drug Evaluation, Preclinical; Gene Expression; Hesperidin; Male; Rats; Testis; Varicocele | 2020 |
In vitro and in vivo effects of hesperidin treatment on adult worms of Schistosoma mansoni.
Topics: Animals; Anthelmintics; Antibodies, Helminth; Disease Models, Animal; Female; Helminths; Hesperidin; Immunoglobulin A; Immunoglobulin E; Immunoglobulin G; Immunoglobulin M; Male; Mice; Parasite Load; Schistosoma mansoni; Schistosomiasis mansoni; Survival Analysis; Treatment Outcome | 2014 |
Pharmacokinetic and pharmacodynamic studies of four major phytochemical components of Da-Cheng-Qi decoction to treat acute pancreatitis.
Topics: Animals; Anthraquinones; Apoptosis; Biphenyl Compounds; Cells, Cultured; Disease Models, Animal; Drugs, Chinese Herbal; Flavanones; Hesperidin; Lignans; Male; Necrosis; Pancreas; Pancreatitis, Acute Necrotizing; Phytotherapy; Rats; Rats, Sprague-Dawley; Reactive Oxygen Species | 2013 |
Possible nitric oxide mechanism in the protective effect of hesperidin against pentylenetetrazole (PTZ)-induced kindling and associated cognitive dysfunction in mice.
Topics: Animals; Avoidance Learning; Brain; Cognition Disorders; Convulsants; Disease Models, Animal; Dose-Response Relationship, Drug; Drug Interactions; Enzyme Inhibitors; Epilepsy, Generalized; Hesperidin; Kindling, Neurologic; Lipid Peroxidation; Male; Maze Learning; Mice; Nitric Oxide; Pentylenetetrazole; Reinforcement, Psychology; Time Factors | 2013 |
Minocycline modulates neuroprotective effect of hesperidin against quinolinic acid induced Huntington's disease like symptoms in rats: behavioral, biochemical, cellular and histological evidences.
Topics: Animals; Behavior, Animal; Brain; Caspase 3; Disease Models, Animal; Drug Synergism; Electron Transport Complex IV; Glutathione; Hesperidin; Huntington Disease; Male; Maze Learning; Minocycline; Motor Activity; Neuroprotective Agents; Nitrites; Quinolinic Acid; Quinone Reductases; Rats; Rats, Wistar; Succinate Dehydrogenase; Superoxide Dismutase; Tumor Necrosis Factor-alpha | 2013 |
Rikkunshito ameliorates bleomycin-induced acute lung injury in a ghrelin-independent manner.
Topics: Acute Lung Injury; Animals; Anti-Inflammatory Agents; Apoptosis; Bleomycin; Disease Models, Animal; Drugs, Chinese Herbal; Eating; Epithelial Cells; Ghrelin; Glycyrrhizic Acid; Hesperidin; Male; Mice; Mice, Inbred C57BL; Neutrophil Infiltration; NF-kappa B; Pulmonary Alveoli; Pulmonary Fibrosis; Signal Transduction | 2014 |
Protective effect of hesperetin in rat model of partial sciatic nerve ligation induced painful neuropathic pain: an evidence of anti-inflammatory and anti-oxidative activity.
Topics: Animals; Anti-Inflammatory Agents; Antioxidants; Disease Models, Animal; Female; Hesperidin; Male; Neuralgia; Rats; Rats, Wistar; RNA, Messenger; Sciatic Nerve; Tumor Necrosis Factor-alpha | 2014 |
Hesperidin alleviates cognitive impairment, mitochondrial dysfunction and oxidative stress in a mouse model of Alzheimer's disease.
Topics: Alzheimer Disease; Amyloid beta-Protein Precursor; Animals; Antioxidants; Behavior, Animal; Brain; Cognition Disorders; Disease Models, Animal; Exploratory Behavior; Glutathione; Glycogen Synthase Kinase 3; Glycogen Synthase Kinase 3 beta; Hesperidin; Hydrogen Peroxide; Malondialdehyde; Memory; Mice, Inbred C57BL; Mice, Transgenic; Mitochondria; Oxidative Stress; Presenilin-1 | 2014 |
Hesperidin prevents liver fibrosis in rats by decreasing the expression of nuclear factor-κB, transforming growth factor-β and connective tissue growth factor.
Topics: Animals; Antioxidants; Blotting, Western; Carbon Tetrachloride; Connective Tissue Growth Factor; Disease Models, Animal; Gene Expression Regulation; Hesperidin; Lipid Peroxidation; Liver Cirrhosis; Male; Necrosis; NF-kappa B; Oxidative Stress; Rats; Rats, Wistar; Transforming Growth Factor beta | 2014 |
Hesperidin produces cardioprotective activity via PPAR-γ pathway in ischemic heart disease model in diabetic rats.
Topics: Anilides; Animals; bcl-2-Associated X Protein; Cardiotonic Agents; Creatine Kinase, MB Form; Diabetes Mellitus, Experimental; Disease Models, Animal; Hemodynamics; Hesperidin; Lipid Peroxidation; Male; Microscopy, Electron, Transmission; Myocardial Ischemia; Myocardium; PPAR gamma; Proto-Oncogene Proteins c-bcl-2; Rats; Rats, Wistar; Tumor Necrosis Factor-alpha | 2014 |
Hesperidin ameliorates behavioral impairments and neuropathology of transgenic APP/PS1 mice.
Topics: Alzheimer Disease; Amyloid beta-Protein Precursor; Animals; Brain; Disease Models, Animal; Hesperidin; Male; Mice; Mice, Transgenic; Microglia; Plaque, Amyloid; Presenilin-1; Psychomotor Performance; Social Behavior; Transforming Growth Factor beta; Treatment Outcome | 2015 |
Protective effects of the flavonoid hesperidin methyl chalcone in inflammation and pain in mice: role of TRPV1, oxidative stress, cytokines and NF-κB.
Topics: Analgesics; Animals; Anti-Inflammatory Agents, Non-Steroidal; Chalcones; Cytokines; Disease Models, Animal; Dose-Response Relationship, Drug; Hesperidin; Inflammation; Male; Mice; Molecular Structure; NF-kappa B; Oxidative Stress; Pain; Structure-Activity Relationship; TRPV Cation Channels | 2015 |
Effects of the flavanone combination hesperetin-naringenin, and orange and grapefruit juices, on airway inflammation and remodeling in a murine asthma model.
Topics: Airway Remodeling; Animals; Asthma; Beverages; Bronchoalveolar Lavage Fluid; Citrus paradisi; Citrus sinensis; Disease Models, Animal; Eosinophils; Flavanones; Fruit; Hesperidin; Inflammation; Lung; Macrophages; Male; Mice; Mice, Inbred BALB C | 2015 |
Hesperidin methyl chalcone inhibits oxidative stress and inflammation in a mouse model of ultraviolet B irradiation-induced skin damage.
Topics: Animals; Antioxidants; Chalcones; Cytokines; Disease Models, Animal; Edema; Glutathione; Hesperidin; Inflammation; Lipid Peroxidation; Matrix Metalloproteinase 9; Membrane Glycoproteins; Mice; Mice, Hairless; NADPH Oxidase 2; NADPH Oxidases; Oxidative Stress; RNA, Messenger; Skin; Superoxides; Ultraviolet Rays | 2015 |
Curcumin, Hesperidin, and Rutin Selectively Interfere with Apoptosis Signaling and Attenuate Streptozotocin-Induced Oxidative Stress-Mediated Hyperglycemia.
Topics: Analysis of Variance; Animals; Anti-Inflammatory Agents, Non-Steroidal; Apoptosis; Blood Glucose; Curcumin; Diabetes Mellitus, Experimental; Disease Models, Animal; Female; Flavonoids; Hesperidin; Liver; Mice, Inbred ICR; Nitrates; Oxidation-Reduction; Oxidative Stress; Rutin; Signal Transduction; Superoxide Dismutase | 2015 |
Hesperetin prevents selenite-induced cataract in rats.
Topics: Animals; Antioxidants; Ascorbic Acid; Cataract; Disease Models, Animal; Eye Proteins; Female; Free Radical Scavengers; Glutathione; Hesperidin; Intermediate Filament Proteins; Lens, Crystalline; Oxidative Stress; Proteolysis; Rats; Rats, Sprague-Dawley; Sodium Selenite | 2015 |
Hesperidin inhibits glutamate release and exerts neuroprotection against excitotoxicity induced by kainic acid in the hippocampus of rats.
Topics: 4-Aminopyridine; Animals; Calcium; Disease Models, Animal; Egtazic Acid; Enzyme Inhibitors; Excitatory Amino Acid Agonists; Excitatory Postsynaptic Potentials; Glutamic Acid; Hesperidin; Hippocampus; Kainic Acid; Male; Membrane Potentials; Neuroprotective Agents; Neurotoxicity Syndromes; Potassium Channel Blockers; Rats; Rats, Sprague-Dawley; Sodium Channel Blockers; Synaptosomes; Tetrodotoxin | 2015 |
Hesperidin attenuates learning and memory deficits in APP/PS1 mice through activation of Akt/Nrf2 signaling and inhibition of RAGE/NF-κB signaling.
Topics: Alzheimer Disease; Amyloid beta-Protein Precursor; Animals; Chimera; Disease Models, Animal; Hesperidin; Humans; Male; Maze Learning; Memory Disorders; Mice; Mice, Transgenic; Neuroprotective Agents; NF-E2-Related Factor 2; NF-kappa B; Oxidative Stress; Phosphorylation; Presenilin-1; Proto-Oncogene Proteins c-akt; Receptor for Advanced Glycation End Products; Signal Transduction | 2018 |
Neuroprotective effect of water-dispersible hesperetin in retinal ischemia reperfusion injury.
Topics: Animals; Biomarkers; Blotting, Western; Disease Models, Animal; Hesperidin; Immunohistochemistry; In Situ Nick-End Labeling; Injections, Intraperitoneal; Interleukin-1beta; Mice; Mice, Inbred C57BL; Microscopy, Confocal; Mitogen-Activated Protein Kinases; Neuroprotective Agents; Oxidative Stress; Reactive Oxygen Species; Real-Time Polymerase Chain Reaction; Reperfusion Injury; Retinal Diseases; Retinal Ganglion Cells; Retinal Vessels; Solubility; Water | 2016 |
Neohesperidin dihydrochalcone down-regulates MyD88-dependent and -independent signaling by inhibiting endotoxin-induced trafficking of TLR4 to lipid rafts.
Topics: Animals; Antioxidants; Blotting, Western; Chalcones; Disease Models, Animal; Down-Regulation; Electrophoretic Mobility Shift Assay; Endotoxins; Flow Cytometry; Fluorescent Antibody Technique; Hesperidin; Immunohistochemistry; Liver Failure, Acute; Membrane Microdomains; Mice; Myeloid Differentiation Factor 88; Protein Transport; RNA, Small Interfering; Signal Transduction; Sweetening Agents; Toll-Like Receptor 4; Transfection | 2015 |
Chemopreventive efficacy of hesperidin against chemically induced nephrotoxicity and renal carcinogenesis via amelioration of oxidative stress and modulation of multiple molecular pathways.
Topics: Animals; Apoptosis; Carcinogenesis; Carcinogens; Carcinoma, Renal Cell; Cell Proliferation; Disease Models, Animal; Ferric Compounds; Hesperidin; Immunohistochemistry; Kidney Neoplasms; Male; Nitrilotriacetic Acid; Oxidative Stress; Rats; Rats, Wistar; Signal Transduction | 2015 |
ERK-dependent brain-derived neurotrophic factor regulation by hesperidin in mice exposed to chronic mild stress.
Topics: Aminoacetonitrile; Animals; Antidepressive Agents; Brain-Derived Neurotrophic Factor; Corticosterone; Disease Models, Animal; Extracellular Signal-Regulated MAP Kinases; Food Deprivation; Food Preferences; Gene Expression Regulation; Hesperidin; Hippocampus; Male; Mice; Mice, Inbred ICR; Phosphorylation; Protease Inhibitors; Stress, Psychological; Sucrose | 2016 |
Evaluation of the protective effects of hesperetin against cisplatin-induced ototoxicity in a rat animal model.
Topics: Animals; Antineoplastic Agents; Antioxidants; Apoptosis; Cell Proliferation; Cisplatin; Cochlea; Disease Models, Animal; Ear, Inner; Hearing Loss; Hesperidin; Immunohistochemistry; In Situ Nick-End Labeling; Injections, Intraperitoneal; Male; Otoacoustic Emissions, Spontaneous; Oxidative Stress; Random Allocation; Rats; Rats, Wistar; Signal-To-Noise Ratio; Spiral Ganglion | 2016 |
A comparative study on the antioxidant effects of hesperidin and ellagic acid against skeletal muscle ischemia/reperfusion injury.
Topics: Administration, Oral; Animals; Antioxidants; Disease Models, Animal; Ellagic Acid; Hesperidin; Lipid Peroxidation; Muscle, Skeletal; Rats; Rats, Sprague-Dawley; Reperfusion Injury | 2016 |
Hesperidin ameliorates immunological outcome and reduces neuroinflammation in the mouse model of multiple sclerosis.
Topics: Animals; Cells, Cultured; Disease Models, Animal; Encephalomyelitis, Autoimmune, Experimental; Female; Hesperidin; Inflammation; Mice; Mice, Inbred C57BL; Multiple Sclerosis; Spleen; Treatment Outcome | 2017 |
Pro-inflammatory cytokines involvement in the hesperidin antihyperalgesic effects at peripheral and central levels in a neuropathic pain model.
Topics: Analgesics; Animals; Anti-Inflammatory Agents; Cytokines; Disease Models, Animal; Hesperidin; Hyperalgesia; Inflammation Mediators; Male; Neuralgia; Rats; Spinal Cord; Treatment Outcome | 2017 |
Effect of hesperetin, a citrus flavonoid, on bacterial enzymes and carcinogen-induced aberrant crypt foci in colon cancer rats: a dose-dependent study.
Topics: 1,2-Dimethylhydrazine; Animals; Bacteria; Body Weight; Carcinogens; Cell Transformation, Neoplastic; Citrus; Colon; Colonic Neoplasms; Disease Models, Animal; Dose-Response Relationship, Drug; Enzyme Activation; Feces; Flavanones; Hesperidin; Injections, Subcutaneous; Intestinal Mucosa; Male; Phytotherapy; Precancerous Conditions; Rats; Rats, Wistar | 2008 |
Modulating effect of Hesperidin on experimental murine colitis induced by dextran sulfate sodium.
Topics: Animals; Citrus; Colitis, Ulcerative; Colon; Cytokines; Dextran Sulfate; Disease Models, Animal; Hesperidin; Male; Malondialdehyde; Mice; Mice, Inbred BALB C; Organ Size; Peroxidase; Phytotherapy; Plant Extracts | 2009 |
Protection against in vivo focal myocardial ischemia/reperfusion injury-induced arrhythmias and apoptosis by hesperidin.
Topics: Animals; Anti-Arrhythmia Agents; Anti-Inflammatory Agents; Antioxidants; Apoptosis; Arrhythmias, Cardiac; Biomarkers; Blood Pressure; Catalase; Creatine Kinase, MB Form; Disease Models, Animal; Electrocardiography; Female; Glutathione; Heart Rate; Hesperidin; Male; Malondialdehyde; Myocardial Infarction; Myocardial Reperfusion Injury; Myocardium; Nitrites; Oxidative Stress; Peroxidase; Rats; Rats, Sprague-Dawley; Superoxide Dismutase; Tumor Necrosis Factor-alpha; Ventricular Pressure | 2009 |
Efficacy of the potential chemopreventive agent, hesperetin (citrus flavanone), on 1,2-dimethylhydrazine induced colon carcinogenesis.
Topics: 1,2-Dimethylhydrazine; Adenocarcinoma; Animals; Antineoplastic Agents, Phytogenic; Catalase; Colon; Colonic Neoplasms; Disease Models, Animal; Hesperidin; Lipid Peroxidation; Liver; Male; Rats; Rats, Wistar; Superoxide Dismutase | 2009 |
Hesperidin attenuates benzo[alpha] pyrene-induced testicular toxicity in rats via regulation of oxidant/antioxidant balance.
Topics: Animals; Antioxidants; Benzo(a)pyrene; Carcinogens; Disease Models, Animal; Glutathione; Glutathione Transferase; Hesperidin; L-Lactate Dehydrogenase; Male; Malondialdehyde; Necrosis; Organ Size; Rats; Seminiferous Tubules; Sperm Count; Spermatocytes; Superoxide Dismutase; Testicular Diseases; Testis | 2009 |
Protective effect of hesperidin and naringin against 3-nitropropionic acid induced Huntington's like symptoms in rats: possible role of nitric oxide.
Topics: Analysis of Variance; Animals; Antioxidants; Body Weight; Catalase; Corpus Striatum; Disease Models, Animal; Electron Transport Complex I; Electron Transport Complex II; Electron Transport Complex IV; Flavanones; Hand Strength; Hesperidin; Huntington Disease; Lipid Peroxidation; Male; Mitochondria; Motor Activity; Nitric Oxide; Nitrites; Nitro Compounds; Propionates; Rats; Rats, Wistar; Rotarod Performance Test; Superoxide Dismutase | 2010 |
Comparison of hesperetin and its metabolites for cholesterol-lowering and antioxidative efficacy in hypercholesterolemic hamsters.
Topics: Animals; Anticholesteremic Agents; Antioxidants; Caffeic Acids; Cholesterol; Cholesterol, HDL; Coumaric Acids; Cricetinae; Disease Models, Animal; Hesperidin; Humans; Hypercholesterolemia; Male; Mesocricetus | 2010 |
Antifilarial activity in vitro and in vivo of some flavonoids tested against Brugia malayi.
Topics: Animals; Brugia malayi; Coloring Agents; Disease Models, Animal; Elephantiasis, Filarial; Female; Filaricides; Flavanones; Flavonoids; Gerbillinae; Hesperidin; Humans; Male; Murinae; Rutin; Survival Analysis; Tetrazolium Salts; Thiazoles | 2010 |
Efficacy of hesperidin on plasma, heart and liver tissue lipids in rats subjected to isoproterenol-induced cardiotoxicity.
Topics: Animals; Cardiotonic Agents; Disease Models, Animal; Heart; Hesperidin; Isoproterenol; Lipid Metabolism; Lipids; Liver; Male; Myocardial Ischemia; Rats; Rats, Wistar | 2012 |
Hesperetin protects against oxidative stress related hepatic dysfunction by cadmium in rats.
Topics: Animals; Antioxidants; Cadmium; Chemical and Drug Induced Liver Injury; Disease Models, Animal; Hesperidin; Lipid Peroxidation; Male; Oxidative Stress; Rats; Rats, Wistar | 2012 |
Hesperidin suppresses ovalbumin-induced airway inflammation in a mouse allergic asthma model.
Topics: Animals; Anti-Asthmatic Agents; Anti-Inflammatory Agents, Non-Steroidal; Asthma; Bronchial Hyperreactivity; Bronchoalveolar Lavage Fluid; Cytokines; Disease Models, Animal; Female; Hesperidin; Immunoglobulin E; Inflammation; Interleukin-13; Interleukin-4; Interleukin-5; Leukocytes; Methacholine Chloride; Mice; Mice, Inbred BALB C; Ovalbumin; Respiratory System; Th2 Cells | 2012 |
Cardioprotective effects of hesperetin against doxorubicin-induced oxidative stress and DNA damage in rat.
Topics: Animals; Antibiotics, Antineoplastic; Antioxidants; Apoptosis; Caspase 3; Comet Assay; Cytoprotection; Disease Models, Animal; DNA Damage; Dose-Response Relationship, Drug; Doxorubicin; Glutathione; Heart Diseases; Hesperidin; In Situ Nick-End Labeling; Male; Malondialdehyde; Myocytes, Cardiac; NF-kappa B; Oxidative Stress; p38 Mitogen-Activated Protein Kinases; Rats; Rats, Sprague-Dawley; Time Factors | 2011 |
Alleviation of allergic rhinitis symptoms with Pyeongwee-San extract (KMP6).
Topics: Administration, Oral; Animals; Disease Models, Animal; Drug Evaluation, Preclinical; Drugs, Chinese Herbal; Female; Hesperidin; Mice; Mice, Inbred BALB C; Plant Extracts; Rhinitis, Allergic, Seasonal | 2012 |
Antiasthmatic effects of hesperidin, a potential Th2 cytokine antagonist, in a mouse model of allergic asthma.
Topics: Animals; Anti-Asthmatic Agents; Asthma; Bronchial Hyperreactivity; Bronchoalveolar Lavage Fluid; Bronchodilator Agents; Cytokines; Disease Models, Animal; Eosinophils; Ethanolamines; Female; Formoterol Fumarate; Hesperidin; Humans; Interleukins; Lung; Mice; Mice, Inbred BALB C; Ovalbumin; Th2 Cells | 2011 |
Hesperidin ameliorates functional and histological outcome and reduces neuroinflammation in experimental stroke.
Topics: Animals; Anti-Inflammatory Agents; Brain Infarction; Catalase; Cytokines; Disease Models, Animal; Dose-Response Relationship, Drug; Encephalitis; Glial Fibrillary Acidic Protein; Glutathione; Glutathione Peroxidase; Glutathione Reductase; Hesperidin; Infarction, Middle Cerebral Artery; Male; Mitochondria; Motor Activity; Muscle Strength; Nitric Oxide Synthase Type II; Psychomotor Performance; Rats; Reactive Oxygen Species; Superoxide Dismutase; Thiobarbituric Acid Reactive Substances | 2011 |
Hesperetin-7,3'-O-dimethylether selectively inhibits phosphodiesterase 4 and effectively suppresses ovalbumin-induced airway hyperresponsiveness with a high therapeutic ratio.
Topics: Animals; Asthma; Binding Sites; Blood Cell Count; Bronchial Hyperreactivity; Bronchoalveolar Lavage Fluid; Cyclic Nucleotide Phosphodiesterases, Type 1; Cyclic Nucleotide Phosphodiesterases, Type 3; Cyclic Nucleotide Phosphodiesterases, Type 4; Cytokines; Disease Models, Animal; Female; Guinea Pigs; Hesperidin; Immunoglobulins; Male; Mice; Mice, Inbred BALB C; Ovalbumin; Phosphodiesterase 4 Inhibitors; Pulmonary Disease, Chronic Obstructive; Rolipram | 2011 |
Therapeutic effect of 7, 3'-dimethoxy hesperetin on adjuvant arthritis in rats through inhibiting JAK2-STAT3 signal pathway.
Topics: Animals; Ankle Joint; Arthritis, Experimental; Arthritis, Rheumatoid; Disease Models, Animal; Down-Regulation; Freund's Adjuvant; Hesperidin; Humans; Interleukin-6; Janus Kinase 2; Male; Rats; Rats, Sprague-Dawley; Signal Transduction; STAT3 Transcription Factor; Synovial Membrane | 2012 |
Potential neuroprotective effects of hesperidin on 3-nitropropionic acid-induced neurotoxicity in rats.
Topics: Acoustic Stimulation; Analysis of Variance; Animals; Brain; Catalase; Convulsants; Disease Models, Animal; Dose-Response Relationship, Drug; Hesperidin; Inhibition, Psychological; Lipid Peroxidation; Male; Motor Activity; Neuroprotective Agents; Neurotoxicity Syndromes; Nitric Oxide Synthase Type II; Nitro Compounds; Propionates; Rats; Rats, Wistar; Reflex, Startle; Time Factors | 2012 |
Comparative study of flavonoids in experimental models of inflammation.
Topics: Animals; Arthritis, Experimental; Carrageenan; Disease Models, Animal; Ear; Edema; Flavonoids; Hesperidin; Hindlimb; Inflammation; Mice; Molecular Structure; Quercetin; Random Allocation; Rats; Rats, Wistar; Rutin; Xylenes | 2003 |
Suppression of collagen-induced arthritis by oral administration of the citrus flavonoid hesperidin.
Topics: Administration, Oral; Animals; Anti-Inflammatory Agents, Non-Steroidal; Arthritis, Rheumatoid; Citrus; Collagen; Disease Models, Animal; Down-Regulation; Hesperidin; Knee Joint; Macrophages; Mice; Phytotherapy; Plant Extracts; RNA, Messenger; Specific Pathogen-Free Organisms; Tumor Necrosis Factor-alpha | 2006 |
Hesperidin inhibits ovariectomized-induced osteopenia and shows differential effects on bone mass and strength in young and adult intact rats.
Topics: Age Factors; Amino Acids; Animals; Biomechanical Phenomena; Body Composition; Bone Density; Bone Density Conservation Agents; Bone Diseases, Metabolic; Bone Remodeling; Bone Resorption; Cholesterol; Disease Models, Animal; Female; Femur; Hesperidin; Hypolipidemic Agents; Osteocalcin; Osteoporosis; Ovariectomy; Rats; Rats, Wistar; Triglycerides; Uterus | 2008 |
Suppression of adjuvant arthritis by hesperidin in rats and its mechanisms.
Topics: Animals; Anti-Inflammatory Agents; Arthritis, Experimental; Arthritis, Rheumatoid; Disease Models, Animal; Dose-Response Relationship, Drug; Freund's Adjuvant; Gene Expression Regulation; Hesperidin; Interleukins; Macrophages; Male; Rats; Rats, Sprague-Dawley; T-Lymphocytes; Tumor Necrosis Factor-alpha | 2008 |
Anti-allergic effect of a combination of Citrus unshiu unripe fruits extract and prednisolone on picryl chloride-induced contact dermatitis in mice.
Topics: Administration, Oral; Animals; Anti-Allergic Agents; Citrus; Dermatitis, Contact; Disease Models, Animal; Dose-Response Relationship, Drug; Drug Synergism; Drug Therapy, Combination; Edema; Erythema; Female; Fruit; Glucocorticoids; Hesperidin; Injections, Subcutaneous; Mice; Mice, Inbred ICR; Phytotherapy; Picryl Chloride; Plant Extracts; Prednisolone | 2008 |
Rikkunshito, an herbal medicine, suppresses cisplatin-induced anorexia in rats via 5-HT2 receptor antagonism.
Topics: Acylation; Aminopyridines; Animals; Anorexia; Antineoplastic Agents; Body Weight; Chalcones; Cisplatin; Disease Models, Animal; Dopamine Antagonists; Dose-Response Relationship, Drug; Drugs, Chinese Herbal; Eating; Flavones; Gastric Mucosa; Gastrointestinal Agents; Ghrelin; Hesperidin; Indoles; Male; Oligopeptides; Piperazines; Protein Binding; Quinolines; Rats; Rats, Sprague-Dawley; Receptor, Serotonin, 5-HT2B; Receptor, Serotonin, 5-HT2C; Receptors, Ghrelin; Serotonin; Serotonin 5-HT2 Receptor Antagonists; Serotonin Receptor Agonists; Stomach; Thiophenes; Vagotomy | 2008 |
Polyphenol antioxidants in citrus juices: in vitro and in vivo studies relevant to heart disease.
Topics: Adult; Animals; Antioxidants; Arteriosclerosis; Ascorbic Acid; Beverages; Citrus; Cricetinae; Diet, Atherogenic; Disease Models, Animal; Drug Evaluation; Drug Evaluation, Preclinical; Female; Flavonoids; Heart Diseases; Hesperidin; Humans; Hypercholesterolemia; Hypertriglyceridemia; Lipids; Male; Mesocricetus; Middle Aged; Oxidation-Reduction; Phenols; Plant Extracts; Polymers; Species Specificity | 2002 |
Treatment of experimental brain oedema following sudden decompression, surgical wound, and cold lesion with vasoprotective drugs and the proteinase inhibitor "Trasylol".
Topics: Animals; Brain Edema; Cats; Cerebral Cortex; Cold Temperature; Decompression; Disease Models, Animal; Drug Combinations; Drug Therapy, Combination; Esculin; Flavonoids; Hesperidin; Protease Inhibitors; Rutin; Sparteine | 1979 |