hesperidin has been researched along with Alzheimer Disease in 17 studies
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 0 (0.00) | 18.7374 |
| 1990's | 0 (0.00) | 18.2507 |
| 2000's | 0 (0.00) | 29.6817 |
| 2010's | 9 (52.94) | 24.3611 |
| 2020's | 8 (47.06) | 2.80 |
| Authors | Studies |
|---|---|
| Bandyopadhyay, J; Basu, S; Chakraborty, S | 1 |
| Lai, MC; Liou, SS; Liu, IM; Liu, WY | 1 |
| Cho, JS; Gee, MS; Jeon, SH; Ju, YJ; Jung, MJ; Kim, N; Lee, D; Lee, JK; Lee, S; Lee, Y | 1 |
| Kumar, D; More, UA; Noolvi, MN; Tripathi, A | 1 |
| Han, J; Li, J; Li, Z; Liu, T; Wang, M; Wu, M; Zhang, Y; Zhu, X | 1 |
| Eckert, GP; Grewal, R; Keck, CM; Stahr, PL | 1 |
| Bandyopadhyay, J; Basu, S; Chakraborty, S; Rakshit, J | 1 |
| Chen, S; Chen, X; Fang, L; Li, Z; Liu, T; Wang, M; Zhang, Y; Zheng, Y | 1 |
| Alsemeh, AE; Bendary, MA; Mandour, DA | 1 |
| Hajizadeh Moghaddam, A; Kheradmand, E; Zare, M | 1 |
| Liu, X; Wang, J; Yuan, Y; Zhang, H; Zhang, P; Zhang, Y | 1 |
| Ali, T; Ikram, M; Jo, MG; Khan, A; Kim, MO; Muhammad, T; Rehman, SU | 1 |
| Liu, L; Wang, D; Wang, Y; Wu, W; Zhu, X | 1 |
| Li, C; Qu, H; Schluesener, H; Zhang, Z; Zug, C | 1 |
| Janakiraman, U; Justin Thenmozhi, A; Manivasagam, T; Raja, TR | 1 |
| An, Z; Hong, Y | 1 |
| Huang, SM; Lin, JA; Tsai, SY; Wu, CH; Yen, GC | 1 |
17 other study(ies) available for hesperidin and Alzheimer Disease
| Article | Year |
|---|---|
Multi-target screening mines hesperidin as a multi-potent inhibitor: Implication in Alzheimer's disease therapeutics.
Topics: Alzheimer Disease; Amino Acid Sequence; Amyloid Precursor Protein Secretases; Antioxidants; Benzothiazoles; Data Mining; DNA; Drug Evaluation, Preclinical; Enzyme Inhibitors; Hesperidin; Molecular Docking Simulation; Protein Conformation; Reproducibility of Results; Sulfonic Acids | 2016 |
The Citrus Flavonoid Hesperetin Encounters Diabetes-Mediated Alzheimer-Type Neuropathologic Changes through Relieving Advanced Glycation End-Products Inducing Endoplasmic Reticulum Stress.
Topics: Alzheimer Disease; Apoptosis; Citrus; Diabetes Mellitus; Endoplasmic Reticulum Stress; Flavonoids; Glycation End Products, Advanced; Hesperidin; Humans | 2022 |
Hesperidin Improves Memory Function by Enhancing Neurogenesis in a Mouse Model of Alzheimer's Disease.
Topics: Alzheimer Disease; AMP-Activated Protein Kinases; Animals; Disease Models, Animal; Hesperidin; Hippocampus; Mice; Mice, Transgenic; Neurodegenerative Diseases; Neurogenesis | 2022 |
Exploring the Molecular Structural Requirements of Flavonoids as Beta- Secretase-1 Inhibitors Using Molecular Modeling Studies.
Topics: Alzheimer Disease; Amyloid Precursor Protein Secretases; Aspartic Acid Endopeptidases; Flavonoids; Hesperidin; Humans; Molecular Docking Simulation; Molecular Dynamics Simulation | 2023 |
Biological evaluation of 7-O-amide hesperetin derivatives as multitarget-directed ligands for the treatment of Alzheimer's disease.
Topics: Acetylcholinesterase; Alzheimer Disease; Amides; Amyloid beta-Peptides; Animals; Anti-Inflammatory Agents; Antioxidants; Cell Line; Cholinesterase Inhibitors; Hesperidin; Inflammation; Ligands; Male; Mice; Mice, Inbred C57BL; Neuroprotective Agents; Peptide Fragments; Protein Aggregates; Rats | 2021 |
Investigating hesperetin nanocrystals with tailor-made sizes for the prevention and treatment of Alzheimer's disease.
Topics: Alzheimer Disease; Hesperidin; Humans; Nanoparticles; Solubility | 2021 |
Multi-target inhibition ability of neohesperidin dictates its neuroprotective activity: Implication in Alzheimer's disease therapeutics.
Topics: Alzheimer Disease; Amyloid beta-Peptides; Amyloid beta-Protein Precursor; Amyloid Precursor Protein Secretases; Aspartic Acid Endopeptidases; Cell Line, Tumor; Hesperidin; Humans; Neuroprotective Agents; Peptide Fragments | 2021 |
Discovery of 7-O-1, 2, 3-triazole hesperetin derivatives as multi-target-directed ligands against Alzheimer's disease.
Topics: Alzheimer Disease; Animals; Anti-Inflammatory Agents; Butyrylcholinesterase; Cell Line, Tumor; Cholinesterase Inhibitors; Drug Discovery; Hesperidin; Ligands; Male; Mice, Inbred C57BL; Molecular Docking Simulation; Neuroprotective Agents; Nitric Oxide; Protein Binding; Rats; Transcription Factor RelA; Triazoles | 2021 |
Histological and imunohistochemical alterations of hippocampus and prefrontal cortex in a rat model of Alzheimer like-disease with a preferential role of the flavonoid "hesperidin".
Topics: Alzheimer Disease; Animals; Behavior, Animal; Body Weight; Disease Models, Animal; Glial Fibrillary Acidic Protein; Glutathione; Hesperidin; Hippocampus; Immunohistochemistry; Male; Malondialdehyde; Organ Size; Phosphorylation; Prefrontal Cortex; Pyramidal Cells; Rats, Sprague-Dawley; Synaptophysin; tau Proteins | 2021 |
Neuroprotective effect of hesperetin and nano-hesperetin on recognition memory impairment and the elevated oxygen stress in rat model of Alzheimer's disease.
Topics: Alzheimer Disease; Animals; Antioxidants; Disease Models, Animal; Dose-Response Relationship, Drug; Glutathione; Glutathione Peroxidase; Glutathione Reductase; Hesperidin; Hippocampus; Male; Malondialdehyde; Memory Disorders; Nanoparticles; Neuroprotective Agents; Oxidative Stress; Rats; Rats, Wistar; Superoxide Dismutase | 2018 |
Neohesperidin Prevents Aβ
Topics: Alzheimer Disease; Amyloid beta-Peptides; Animals; Apoptosis; Brain Ischemia; Hesperidin; Hippocampus; Neurons; Neuroprotective Agents; Peptide Fragments; Protein Disulfide-Isomerases; Rats, Sprague-Dawley | 2018 |
Hesperetin Confers Neuroprotection by Regulating Nrf2/TLR4/NF-κB Signaling in an Aβ Mouse Model.
Topics: Alzheimer Disease; Amyloid beta-Peptides; Animals; Apoptosis; Astrocytes; Biomarkers; Cell Line; Cognitive Dysfunction; Disease Models, Animal; Hesperidin; Hippocampus; Male; Memory; Memory Disorders; Mice, Inbred C57BL; Microglia; Nerve Tissue Proteins; Neuroprotection; NF-E2-Related Factor 2; NF-kappa B; Oxidative Stress; Signal Transduction; Synapses; Toll-Like Receptor 4 | 2019 |
Hesperidin alleviates cognitive impairment, mitochondrial dysfunction and oxidative stress in a mouse model of Alzheimer's disease.
Topics: Alzheimer Disease; Amyloid beta-Protein Precursor; Animals; Antioxidants; Behavior, Animal; Brain; Cognition Disorders; Disease Models, Animal; Exploratory Behavior; Glutathione; Glycogen Synthase Kinase 3; Glycogen Synthase Kinase 3 beta; Hesperidin; Hydrogen Peroxide; Malondialdehyde; Memory; Mice, Inbred C57BL; Mice, Transgenic; Mitochondria; Oxidative Stress; Presenilin-1 | 2014 |
Hesperidin ameliorates behavioral impairments and neuropathology of transgenic APP/PS1 mice.
Topics: Alzheimer Disease; Amyloid beta-Protein Precursor; Animals; Brain; Disease Models, Animal; Hesperidin; Male; Mice; Mice, Transgenic; Microglia; Plaque, Amyloid; Presenilin-1; Psychomotor Performance; Social Behavior; Transforming Growth Factor beta; Treatment Outcome | 2015 |
Neuroprotective effect of hesperidin on aluminium chloride induced Alzheimer's disease in Wistar rats.
Topics: Aluminum Chloride; Aluminum Compounds; Alzheimer Disease; Animals; Behavior, Animal; Chlorides; Hesperidin; Male; Neuroprotective Agents; Rats; Rats, Wistar | 2015 |
Hesperidin attenuates learning and memory deficits in APP/PS1 mice through activation of Akt/Nrf2 signaling and inhibition of RAGE/NF-κB signaling.
Topics: Alzheimer Disease; Amyloid beta-Protein Precursor; Animals; Chimera; Disease Models, Animal; Hesperidin; Humans; Male; Maze Learning; Memory Disorders; Mice; Mice, Transgenic; Neuroprotective Agents; NF-E2-Related Factor 2; NF-kappa B; Oxidative Stress; Phosphorylation; Presenilin-1; Proto-Oncogene Proteins c-akt; Receptor for Advanced Glycation End Products; Signal Transduction | 2018 |
Cytoprotective effects of hesperetin and hesperidin against amyloid β-induced impairment of glucose transport through downregulation of neuronal autophagy.
Topics: Alzheimer Disease; Amyloid beta-Peptides; Animals; Autophagy; Biological Transport; Cell Line; Cytoprotection; Down-Regulation; Energy Metabolism; Glucose; Glucose Transporter Type 3; Glucose Transporter Type 4; Hesperidin; Mice; Neurons; Neuroprotective Agents; Peptide Fragments; Proto-Oncogene Proteins c-akt; RNA, Messenger | 2012 |