hesperidin has been researched along with Alloxan Diabetes in 31 studies
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 0 (0.00) | 18.7374 |
| 1990's | 3 (9.68) | 18.2507 |
| 2000's | 1 (3.23) | 29.6817 |
| 2010's | 18 (58.06) | 24.3611 |
| 2020's | 9 (29.03) | 2.80 |
| Authors | Studies |
|---|---|
| Aksu, EH; Kandemir, FM; Küçükler, S | 1 |
| Abd Elkader, HAE; Abdou, HM | 1 |
| Deng, Z; Liu, H; Liu, Y; Yan, C; Yin, X; Zhu, X | 1 |
| Abdou, HM; Ali, EY; Ghoneum, MH; Hamaad, FA | 1 |
| Hanchang, W; Rojanaverawong, W; Wongmanee, N; Yoopum, S | 1 |
| Altındağ, F; Bayir, MH; Yıldızhan, K | 1 |
| Hanchang, W; Khamchan, A; Seedadee, C; Wongmanee, N | 1 |
| Bai, YF; Fan, XY; Fu, JQ; Sheng, H; Wang, SW; Weng, YY; Zhang, F; Zheng, F | 1 |
| Abdel-Moneim, A; Ebeid, ASM; El-Shahawy, AAG; Eldin, ZE; Zanaty, MI | 1 |
| Chen, YJ; Liu, YW; Zhang, MY; Zhang, YM; Zhu, X | 1 |
| Dokumacioglu, E; Ince, I; Iskender, H; Kanbay, Y; Saral, S; Sen, TM | 1 |
| Guo, F; Li, Z; Qin, G; Wang, B; Zhang, Y | 1 |
| Abd El Motteleb, DM; Elshazly, SM; Ibrahim, IAAE | 1 |
| Baluchnejadmojarad, T; Roghani, M; Samie, A; Sedaghat, R | 1 |
| Dokumacioglu, E; Iskender, H; Musmul, A | 1 |
| Chen, YJ; Kong, L; Liu, Y; Liu, YW; Tang, ZZ; Wang, TY; Zhang, YM | 1 |
| Haseena Banu, H; Nandhakumar, E; Sundaram, R | 1 |
| Agrawal, YO; Arya, DS; Goyal, SN; Sharma, PK; Shrivastava, B | 1 |
| Grigorova-Borsos, AM; Guillot, R; Jacolot, P; Kassab, I; Peyroux, J; Sternberg, M; Tessier, F; Urios, P | 1 |
| Ashafaq, M; Khan, MH; Naseem, M; Parvez, S; Salman, M; Varshney, L; Wajid, S | 1 |
| Abdallah, HM; El-Khatib, AS; El-Marasy, SA; El-Shabrawy, OA; El-Shenawy, SM; Kenawy, SA | 1 |
| Agrawal, YO; Arya, DS; Goyal, SN; Ojha, S; Sharma, PK; Shrivastava, B; Upadhya, HM | 1 |
| Gray, JP; Parmar, MS; Ray, SD; Syed, I | 1 |
| Abd El-Haleem, MR; Amer, MG; Karam, RA; Shehata, AS | 1 |
| Chen, T; Chen, Z; Jiang, X; Li, X; Wang, M; Wu, J; Zhang, B; Zheng, D | 1 |
| Guo, C; Li, F; Liao, S; Mi, H; Qi, D; Shi, X; Yang, Z; Zhang, C | 1 |
| Gupta, SK; Jha, KA; Kumar, B; Nag, TC; Saxena, R; Srinivasan, BP; Srivastava, S | 1 |
| Choi, MS; Jeong, KS; Jung, UJ; Lee, MK | 1 |
| Labrid, C | 1 |
| Bodinier, MC; Jean, T | 1 |
| Miyake, Y; Osawa, T; Tsujihara, N; Yamamoto, K | 1 |
31 other study(ies) available for hesperidin and Alloxan Diabetes
| Article | Year |
|---|---|
Ameliorative effect of hesperidin on streptozotocin-diabetes mellitus-induced testicular DNA damage and sperm quality degradation in Sprague-Dawley rats.
Topics: Animals; Diabetes Mellitus, Experimental; DNA Damage; Hesperidin; Humans; Male; Quality of Life; Rats; Rats, Sprague-Dawley; Sperm Motility; Spermatozoa; Streptozocin; Testis | 2021 |
The potential therapeutic effects of Trifolium alexandrinum extract, hesperetin and quercetin against diabetic nephropathy via attenuation of oxidative stress, inflammation, GSK-3β and apoptosis in male rats.
Topics: Animals; Antioxidants; Apoptosis; Diabetes Mellitus, Experimental; Diabetic Nephropathies; Glycogen Synthase Kinase 3 beta; Hesperidin; Hypoglycemic Agents; Inflammation; Kidney; Male; Oxidative Stress; Phytotherapy; Plant Extracts; Quercetin; Rats; Rats, Wistar; Trifolium | 2022 |
Hesperidin Exerts Anxiolytic-like Effects in Rats with Streptozotocin- Induced Diabetes via PKA/CREB Signaling.
Topics: Animals; Anti-Anxiety Agents; Brain-Derived Neurotrophic Factor; Diabetes Mellitus, Experimental; Hesperidin; Rats; Streptozocin | 2023 |
Antidiabetic efficacy of Trifolium alexandrinum extracts hesperetin and quercetin in ameliorating carbohydrate metabolism and activating IR and AMPK signaling in the pancreatic tissues of diabetic rats.
Topics: AMP-Activated Protein Kinases; Animals; Antioxidants; Carbohydrate Metabolism; Diabetes Mellitus, Experimental; Diabetes Mellitus, Type 2; Glucose Transport Proteins, Facilitative; Hesperidin; Hypoglycemic Agents; Insulin; Liver; Phosphatidylinositol 3-Kinases; Plant Extracts; Quercetin; Rats; Rats, Wistar; Receptor, Insulin; Streptozocin; Trifolium | 2022 |
Protective role of hesperidin against diabetes induced spleen damage: Mechanism associated with oxidative stress and inflammation.
Topics: Animals; Body Weight; Diabetes Mellitus, Experimental; Hesperidin; Hyperglycemia; Inflammation; Oxidative Stress; Rats; Spleen | 2022 |
Effect of Hesperidin on Sciatic Nerve Damage in STZ-Induced Diabetic Neuropathy: Modulation of TRPM2 Channel.
Topics: Animals; Diabetes Mellitus, Experimental; Diabetic Neuropathies; Hesperidin; Rats; Sciatic Nerve; Sciatic Neuropathy; Streptozocin; TRPM Cation Channels | 2023 |
Hesperidin ameliorates pancreatic β-cell dysfunction and apoptosis in streptozotocin-induced diabetic rat model.
Topics: Animals; Apoptosis; Apoptosis Regulatory Proteins; Blood Glucose; Diabetes Mellitus, Experimental; Eating; Endoplasmic Reticulum Stress; Glutathione Peroxidase; Heat-Shock Proteins; Hesperidin; Homeodomain Proteins; Inflammation; Insulin; Insulin-Secreting Cells; Male; Malondialdehyde; Oxidative Stress; Pancreas; Protective Agents; Rats; Superoxide Dismutase; Trans-Activators; Transcription Factor CHOP; Tumor Necrosis Factor-alpha; Tyrosine | 2019 |
Inhibition of histone acetyltransferase by naringenin and hesperetin suppresses Txnip expression and protects pancreatic β cells in diabetic mice.
Topics: Acetylation; Animals; Carrier Proteins; Citrus; Diabetes Mellitus, Experimental; Diabetes Mellitus, Type 2; Drugs, Chinese Herbal; Flavanones; Hesperidin; Histone Acetyltransferases; Histones; Hypoglycemic Agents; Insulin-Secreting Cells; Male; Mice; Mice, Inbred C57BL; Rats; Thioredoxins | 2021 |
A novel layered double hydroxide-hesperidin nanoparticles exert antidiabetic, antioxidant and anti-inflammatory effects in rats with diabetes.
Topics: Animals; Anti-Inflammatory Agents; Antioxidants; Blood Glucose; Diabetes Mellitus, Experimental; Diabetes Mellitus, Type 2; Glucose; Hesperidin; Hydroxides; Hypoglycemic Agents; Insulin; Male; Malondialdehyde; Nanoparticles; Oxidative Stress; PPAR gamma; Rats | 2021 |
Hesperetin ameliorates diabetes-associated anxiety and depression-like behaviors in rats via activating Nrf2/ARE pathway.
Topics: Animals; Anxiety; Depression; Diabetes Mellitus, Experimental; Glycogen Synthase Kinase 3 beta; Hesperidin; NF-E2-Related Factor 2; Oxidative Stress; Rats | 2021 |
The effect of hesperidin and quercetin on oxidative stress, NF-κB and SIRT1 levels in a STZ-induced experimental diabetes model.
Topics: Animals; Antioxidants; Biomarkers; Blood Glucose; Diabetes Mellitus, Experimental; Diabetic Nephropathies; Disease Models, Animal; Hesperidin; Kidney; Liver; Male; NF-kappa B; Oxidative Stress; Quercetin; Rats; Rats, Wistar; Sirtuin 1; Streptozocin | 2017 |
Involvement of the TGFβ1- ILK-Akt signaling pathway in the effects of hesperidin in type 2 diabetic nephropathy.
Topics: Animals; Anti-Inflammatory Agents; Cytokines; Diabetes Mellitus, Experimental; Diabetes Mellitus, Type 2; Diabetic Nephropathies; Diet, High-Fat; Hesperidin; Kidney; Male; Mice, Inbred ICR; Protein Serine-Threonine Kinases; Proto-Oncogene Proteins c-akt; Signal Transduction; Streptozocin; Transforming Growth Factor beta1 | 2018 |
Hesperidin protects against stress induced gastric ulcer through regulation of peroxisome proliferator activator receptor gamma in diabetic rats.
Topics: Animals; Antioxidants; Biomarkers; Blood Glucose; Body Weight; Cyclooxygenase 2; Diabetes Mellitus, Experimental; Disease Progression; Hesperidin; Hydrogen-Ion Concentration; Insulin; Leukocyte Common Antigens; Male; NF-kappa B; Nitric Oxide; Nitric Oxide Synthase Type II; Omeprazole; Oxidants; PPAR gamma; Protective Agents; Rats, Wistar; Stomach; Stomach Ulcer; Stress, Physiological; Tumor Necrosis Factor-alpha | 2018 |
Hesperetin, a citrus flavonoid, attenuates testicular damage in diabetic rats via inhibition of oxidative stress, inflammation, and apoptosis.
Topics: Animals; Antioxidants; Apoptosis; Cell Proliferation; Cells, Cultured; Citrus; Diabetes Mellitus, Experimental; Flavonoids; Hesperidin; Inflammation; Male; Oxidative Stress; Rats; Rats, Wistar; Testicular Diseases | 2018 |
Effect of hesperidin treatment on α-Klotho/FGF-23 pathway in rats with experimentally-induced diabetes.
Topics: Animals; Diabetes Mellitus, Experimental; Fibroblast Growth Factor-23; Fibroblast Growth Factors; Glucuronidase; Hesperidin; Kidney; Klotho Proteins; Liver; Male; Rats; Rats, Sprague-Dawley; Signal Transduction; Streptozocin | 2019 |
Hesperetin ameliorates diabetic nephropathy in rats by activating Nrf2/ARE/glyoxalase 1 pathway.
Topics: Animals; Carboxylic Ester Hydrolases; Diabetes Mellitus, Experimental; Diabetic Nephropathies; Glutamate-Cysteine Ligase; Glycation End Products, Advanced; Hesperidin; Inflammation; Kidney; Lactoylglutathione Lyase; Male; NF-E2-Related Factor 2; Protective Agents; Rats; Rats, Sprague-Dawley; Signal Transduction; Streptozocin; Up-Regulation | 2019 |
Hesperidin, a citrus flavonoid ameliorates hyperglycemia by regulating key enzymes of carbohydrate metabolism in streptozotocin-induced diabetic rats.
Topics: Animals; Blood Glucose; Body Weight; Carbohydrate Metabolism; Diabetes Mellitus, Experimental; Dose-Response Relationship, Drug; Eating; Fructose-Bisphosphatase; Glucose Tolerance Test; Glucose-6-Phosphatase; Glycated Hemoglobin; Hesperidin; Hexokinase; Hypoglycemic Agents; Insulin; Male; Rats, Wistar; Streptozocin | 2019 |
Hesperidin blunts streptozotocin-isoproternol induced myocardial toxicity in rats by altering of PPAR-γ receptor.
Topics: Anilides; Animals; Catalase; Creatine Kinase, MB Form; Diabetes Mellitus, Experimental; Female; Glutathione; Hesperidin; Isoproterenol; L-Lactate Dehydrogenase; Male; Microscopy, Electron, Transmission; Myocardial Infarction; PPAR gamma; Random Allocation; Rats, Wistar; Superoxide Dismutase; Thiobarbituric Acid Reactive Substances; Troponin I | 2014 |
A flavonoid fraction purified from Rutaceae aurantiae (Daflon(R)) inhibiting AGE formation, reduces urinary albumin clearance and corrects hypoalbuminemia in normotensive and hypertensive diabetic rats.
Topics: Albuminuria; Animals; Antioxidants; Blood Glucose; Blood Pressure; Diabetes Mellitus, Experimental; Diabetic Nephropathies; Diosmin; Flavonoids; Fructosamine; Glomerular Basement Membrane; Glycation End Products, Advanced; Hesperidin; Hyperglycemia; Hypoalbuminemia; Kidney Glomerulus; Male; Oxidative Stress; Phytotherapy; Plant Extracts; Rats, Inbred SHR; Rats, Wistar; Rutaceae | 2014 |
Neuromodulatory effects of hesperidin in mitigating oxidative stress in streptozotocin induced diabetes.
Topics: Animals; Antioxidants; Biomarkers; Brain; Diabetes Mellitus, Experimental; Glutathione; Hesperidin; Lipid Peroxidation; Male; Neuroprotective Agents; Neurotoxins; Oxidative Stress; Protein Carbonylation; Rats, Wistar; Streptozocin; Thiobarbituric Acid Reactive Substances | 2014 |
Anti-depressant effect of hesperidin in diabetic rats.
Topics: Animals; Antidepressive Agents; Behavior, Animal; Biogenic Monoamines; Brain-Derived Neurotrophic Factor; Depression; Diabetes Mellitus, Experimental; Fluoxetine; Glutathione; Hesperidin; Hyperglycemia; Inflammation; Interleukin-6; Male; Malondialdehyde; Oxidative Stress; Rats, Wistar; Streptozocin | 2014 |
Hesperidin produces cardioprotective activity via PPAR-γ pathway in ischemic heart disease model in diabetic rats.
Topics: Anilides; Animals; bcl-2-Associated X Protein; Cardiotonic Agents; Creatine Kinase, MB Form; Diabetes Mellitus, Experimental; Disease Models, Animal; Hemodynamics; Hesperidin; Lipid Peroxidation; Male; Microscopy, Electron, Transmission; Myocardial Ischemia; Myocardium; PPAR gamma; Proto-Oncogene Proteins c-bcl-2; Rats; Rats, Wistar; Tumor Necrosis Factor-alpha | 2014 |
Curcumin, Hesperidin, and Rutin Selectively Interfere with Apoptosis Signaling and Attenuate Streptozotocin-Induced Oxidative Stress-Mediated Hyperglycemia.
Topics: Analysis of Variance; Animals; Anti-Inflammatory Agents, Non-Steroidal; Apoptosis; Blood Glucose; Curcumin; Diabetes Mellitus, Experimental; Disease Models, Animal; Female; Flavonoids; Hesperidin; Liver; Mice, Inbred ICR; Nitrates; Oxidation-Reduction; Oxidative Stress; Rutin; Signal Transduction; Superoxide Dismutase | 2015 |
The ability of hesperidin compared to that of insulin for preventing osteoporosis induced by type I diabetes in young male albino rats: A histological and biochemical study.
Topics: Animals; Bone and Bones; Diabetes Mellitus, Experimental; Diabetes Mellitus, Type 1; Hesperidin; Hypoglycemic Agents; Insulin; Male; Osteoporosis; Random Allocation; Rats; Real-Time Polymerase Chain Reaction | 2017 |
Synthesis and anti-hyperglycemic activity of hesperidin derivatives.
Topics: Administration, Oral; alpha-Glucosidases; Animals; Blood Glucose; Diabetes Mellitus, Experimental; Flavanones; Glycoside Hydrolase Inhibitors; Hep G2 Cells; Hesperidin; Humans; Hypoglycemic Agents; Mice; Structure-Activity Relationship | 2012 |
Hesperidin prevents retinal and plasma abnormalities in streptozotocin-induced diabetic rats.
Topics: Aldehyde Reductase; Angiogenesis Inhibitors; Animals; Anti-Inflammatory Agents; Antioxidants; Blood Glucose; Blood-Retinal Barrier; Diabetes Mellitus, Experimental; Diabetic Retinopathy; Glycation End Products, Advanced; Hesperidin; Intercellular Adhesion Molecule-1; Interleukin-1beta; Male; Malondialdehyde; Oxidative Stress; Rats; Rats, Sprague-Dawley; Retina; Streptozocin; Superoxide Dismutase; Tumor Necrosis Factor-alpha; Vascular Endothelial Growth Factor A | 2012 |
Hesperetin rescues retinal oxidative stress, neuroinflammation and apoptosis in diabetic rats.
Topics: Animals; Anti-Inflammatory Agents; Antioxidants; Apoptosis; Aquaporin 4; Blood Glucose; Body Weight; Caspase 3; Catalase; Diabetes Mellitus, Experimental; Diabetic Retinopathy; Female; Glial Fibrillary Acidic Protein; Glutathione; Hesperidin; Immunohistochemistry; Inflammation; Inflammation Mediators; Interleukin-1beta; Male; Microscopy, Electron, Transmission; Oxidative Stress; Rats; Rats, Wistar; Retina; Streptozocin; Superoxide Dismutase; Time Factors; Tumor Necrosis Factor-alpha | 2013 |
The hypoglycemic effects of hesperidin and naringin are partly mediated by hepatic glucose-regulating enzymes in C57BL/KsJ-db/db mice.
Topics: Animals; Blood Glucose; Diabetes Mellitus, Experimental; Flavanones; Glucokinase; Gluconeogenesis; Glucose-6-Phosphatase; Hesperidin; Hypoglycemic Agents; Insulin; Liver; Male; Mice; Pancreas | 2004 |
Pharmacologic properties of Daflon 500 mg.
Topics: Animals; Capillary Permeability; Diabetes Mellitus, Experimental; Dinoprostone; Diosmin; Dogs; Drug Combinations; Edema; Flavonoids; Hesperidin; Inflammation; Kidney Glomerulus; Lymph; Muscles; Rats; Thoracic Duct; Thromboxane B2 | 1994 |
Mediators involved in inflammation: effects of Daflon 500 mg on their release.
Topics: Alloxan; Animals; Anti-Inflammatory Agents; Blood Glucose; Diabetes Mellitus, Experimental; Diosmin; Drug Combinations; Flavonoids; Free Radicals; Granuloma; Hesperidin; Humans; Inflammation; Kidney Glomerulus; Macrophages; Mice; Neutrophils; Permeability; Prostaglandins; Rats; Thromboxane B2 | 1994 |
Protective effects of lemon flavonoids on oxidative stress in diabetic rats.
Topics: 8-Hydroxy-2'-Deoxyguanosine; Animals; Deoxyguanosine; Diabetes Mellitus, Experimental; Flavanones; Hesperidin; Kidney; Lipid Peroxides; Liver; Male; Oxidative Stress; Rats; Rats, Wistar; Thiobarbituric Acid Reactive Substances | 1998 |