hesperidin has been researched along with Acute Liver Injury, Drug-Induced in 29 studies
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 0 (0.00) | 18.7374 |
| 1990's | 1 (3.45) | 18.2507 |
| 2000's | 1 (3.45) | 29.6817 |
| 2010's | 16 (55.17) | 24.3611 |
| 2020's | 11 (37.93) | 2.80 |
| Authors | Studies |
|---|---|
| Barnes, JC; Bradley, P; Day, NC; Fourches, D; Reed, JZ; Tropsha, A | 1 |
| Bu, FT; Huang, C; Jia, P; Li, J; Li, JJ; Lu, XY; Wang, A; Zhang, YL; Zhu, L | 1 |
| Caglayan, C; Gur, C; Kandemir, FM; Satıcı, E | 1 |
| El-Beheiry, KM; El-Masry, TA; El-Sayed El-Sayad, M; Elsisi, AE | 1 |
| Dong, K; Gao, X; Guo, C; Sun, Y; Wang, J; Wu, X | 1 |
| Bu, FT; Chen, SY; Chen, X; Chen, Y; Huang, C; Li, HD; Li, J; Li, XF; Pan, XY; Wang, JN; Zhu, S | 1 |
| Abdelazem, AZ; Abdelaziz, RM; Attia, YA; Hashem, KS | 1 |
| Chen, Y; He, Z; Jiang, R; Kuang, G; Wan, J; Ye, D; Zhang, L | 1 |
| Hashemzaei, M; Hosseinzadeh, H; Karimi, G; Tabeshpour, J | 1 |
| Shi, A; Sun, X; Wei, Y; Wen, Y; Wu, X; Zhang, G; Zhang, J | 1 |
| Bai, YF; Fan, XY; Sheng, H; Wang, SW; Wang, W; Weng, YY; Xu, ZC; Zhang, F; Zheng, F; Zhu, XT | 1 |
| Abo-Youssef, AM; Hassan, MIA; Hemeida, RAM; Osman, AT; Sharkawi, SMZ | 1 |
| Abo Sree, HT; Ahmed, OM; Al-Muzafar, HM; Amin, KA; Hassan, RA; Hozayen, WG | 1 |
| Chen, X; Ding, HW; Huang, C; Huang, HM; Li, HD; Li, J; Li, XF; Meng, XM; Pan, XY; Yang, Y; Zhang, YL | 1 |
| Ding, HW; Huang, AL; Huang, C; Li, B; Li, J; Ma, TT; Meng, XM; Zhang, YL | 1 |
| Ding, HW; Huang, AL; Huang, C; Li, B; Li, J; Meng, XM; Zhang, YL | 1 |
| Abdel-Rafei, MK; Hassan, AA; Thabet, NM | 1 |
| Abudawood, M; Alaraj, ASA; Ansar, S; Hamed, SS | 1 |
| Du, H; Hu, L; Li, L; Pi, R; Song, E; Song, Y; Wang, W; Xia, X; Xu, D | 1 |
| Chen, MJ; Gong, Q; Huang, WJ; Li, G; Nie, H; Shu, KG; Sun, T; Tang, SQ; Wang, C; Wang, CF; Yuan, TD | 1 |
| Mahmoud, AM | 1 |
| Chen, H; Fu, J; Li, X; Lu, B; Shi, Q; Song, E; Song, X; Song, Y; Su, C; Sun, Z; Wu, S; Xia, X; Xiao, C; Yang, S; Ye, X | 1 |
| Fu, J; Shi, Q; Song, E; Song, X; Song, Y; Su, C; Xia, X | 1 |
| Abdel Gaffar, F; Abdel Latif, H; El-Elaimy, I; Hassouna, I; Ibrahim, H | 1 |
| Arab, HH; Arafa, el-SA; El Sherbiny, GA; Elgendy, AN; Mohamed, WR; Omar, HA; Shehata, BA | 1 |
| Han, M; Ma, Y; Qin, H; Rao, Z; Wei, Y; Wu, X; Xi, L; Zhang, G; Zhou, Y; Zhu, J | 1 |
| Pari, L; Shagirtha, K | 1 |
| Chopra, K; Kaur, G; Tirkey, N | 1 |
| Hillon, P; Sgro, C; Taque, R; Zoll, A | 1 |
1 review(s) available for hesperidin and Acute Liver Injury, Drug-Induced
| Article | Year |
|---|---|
A review of the hepatoprotective effects of hesperidin, a flavanon glycoside in citrus fruits, against natural and chemical toxicities.
Topics: Animals; Chemical and Drug Induced Liver Injury; Citrus; Fruit; Gamma Rays; Hesperidin; Humans; Liver; Protective Agents; Toxins, Biological; X-Rays | 2020 |
28 other study(ies) available for hesperidin and Acute Liver Injury, Drug-Induced
| Article | Year |
|---|---|
Cheminformatics analysis of assertions mined from literature that describe drug-induced liver injury in different species.
Topics: Animals; Chemical and Drug Induced Liver Injury; Cluster Analysis; Databases, Factual; Humans; MEDLINE; Mice; Models, Chemical; Molecular Conformation; Quantitative Structure-Activity Relationship | 2010 |
O-alkyl and o-benzyl hesperetin derivative-1L attenuates inflammation and protects against alcoholic liver injury via inhibition of BRD2-NF-κB signaling pathway.
Topics: Alanine Transaminase; Animals; Anti-Inflammatory Agents; Aspartate Aminotransferases; Chemical and Drug Induced Liver Injury; Cholesterol; Cytokines; Hesperidin; Inflammation; Liver; Male; Mice; Mice, Inbred C57BL; RAW 264.7 Cells; Signal Transduction; Transcription Factor RelA; Transcription Factors; Triglycerides | 2022 |
Chemopreventive effects of hesperidin against paclitaxel-induced hepatotoxicity and nephrotoxicity via amendment of Nrf2/HO-1 and caspase-3/Bax/Bcl-2 signaling pathways.
Topics: Animals; Antioxidants; Apoptosis; bcl-2-Associated X Protein; Caspase 3; Chemical and Drug Induced Liver Injury; Hesperidin; NF-E2-Related Factor 2; Oxidative Stress; Paclitaxel; Rats; Signal Transduction | 2022 |
Combination of metformin and hesperidin mitigates cyclophosphamide-induced hepatotoxicity. Emerging role of PPAR-γ/Nrf-2/NF-κB signaling pathway.
Topics: Animals; Anti-Inflammatory Agents; Antioxidants; Chemical and Drug Induced Liver Injury; Cyclophosphamide; Hesperidin; Liver; Metformin; NF-kappa B; Oxidative Stress; PPAR gamma; Proto-Oncogene Proteins c-bcl-2; Rats; Signal Transduction; Tumor Necrosis Factor-alpha | 2023 |
Mixed micelles loaded with hesperidin protect against acetaminophen induced acute liver injury by inhibiting the mtDNA-cGAS-STING pathway.
Topics: Acetaminophen; Chemical and Drug Induced Liver Injury; DNA, Mitochondrial; Hesperidin; Humans; Liver; Micelles; Nucleotidyltransferases | 2024 |
Hesperetin derivative attenuates CCl
Topics: Animals; Apoptosis; Carbon Tetrachloride; Cells, Cultured; Chemical and Drug Induced Liver Injury; Cytokines; Hepatic Stellate Cells; Hesperidin; Humans; Liver Cirrhosis; Macrophages; Male; Mice, Inbred C57BL; Protective Agents; Transforming Growth Factor beta1; Zinc Finger Protein GLI1 | 2019 |
Protective effects of hesperidin against MTX-induced hepatotoxicity in male albino rats.
Topics: Animals; Anti-Inflammatory Agents; Antioxidants; Apoptosis; Apoptosis Regulatory Proteins; Chemical and Drug Induced Liver Injury; Disease Models, Animal; Gene Expression Regulation; Heme Oxygenase (Decyclizing); Hesperidin; Inflammation Mediators; Liver; Male; Methotrexate; NF-E2-Related Factor 2; Oxidative Stress; Rats, Sprague-Dawley; Signal Transduction; Tumor Suppressor Protein p53 | 2020 |
Hesperetin attenuated acetaminophen-induced hepatotoxicity by inhibiting hepatocyte necrosis and apoptosis, oxidative stress and inflammatory response via upregulation of heme oxygenase-1 expression.
Topics: Acetaminophen; Animals; Apoptosis; Cell Death; Cell Line; Chemical and Drug Induced Liver Injury; Dose-Response Relationship, Drug; Heme Oxygenase-1; Hepatocytes; Hesperidin; Inflammation; Liver; Male; Mice; Mice, Inbred C57BL; Necrosis; Oxidative Stress; Transaminases; Up-Regulation | 2020 |
Hesperidin alleviates cholestasis via activation of the farnesoid X receptor in vitro and in vivo.
Topics: Animals; ATP Binding Cassette Transporter, Subfamily B; ATP-Binding Cassette Sub-Family B Member 4; Bile Acids and Salts; Chemical and Drug Induced Liver Injury; Cholestasis; Down-Regulation; Feces; Gene Silencing; Hep G2 Cells; Hesperidin; Humans; Male; Mice; Mice, Inbred C57BL; Models, Molecular; Molecular Docking Simulation; Organic Anion Transporters, Sodium-Dependent; Protective Agents; Receptors, Cytoplasmic and Nuclear; Symporters | 2020 |
Hesperetin, a SIRT1 activator, inhibits hepatic inflammation via AMPK/CREB pathway.
Topics: Acetylation; AMP-Activated Protein Kinases; Animals; Anti-Inflammatory Agents; Chemical and Drug Induced Liver Injury; Cyclic AMP Response Element-Binding Protein; Disease Models, Animal; Enzyme Activation; Galactosamine; HEK293 Cells; Hesperidin; Humans; Liver; Macrophages; Male; Mice; Mice, Inbred BALB C; Protein Processing, Post-Translational; RAW 264.7 Cells; Signal Transduction; Sirtuin 1; Transcription Factor RelA | 2020 |
RETRACTED: Empagliflozin and neohesperidin mitigate methotrexate hepatotoxicity via Nrf2/PPARγ/HO-1 signalling initiation and suppression of NF-κB/Keap1/HSP70/caspase-3 axis in rats.
Topics: Animals; Antimetabolites, Antineoplastic; Benzhydryl Compounds; Caspase 3; Chemical and Drug Induced Liver Injury; Glucosides; Heme Oxygenase (Decyclizing); Hesperidin; HSP72 Heat-Shock Proteins; Kelch-Like ECH-Associated Protein 1; Male; Methotrexate; NF-E2-Related Factor 2; NF-kappa B; Oxidative Stress; Protective Agents; Rats; Signal Transduction | 2021 |
Naringin and Hesperidin Counteract Diclofenac-Induced Hepatotoxicity in Male Wistar Rats
Topics: Animals; Anti-Inflammatory Agents; Anti-Inflammatory Agents, Non-Steroidal; Antioxidants; Apoptosis; Chemical and Drug Induced Liver Injury; Cytokines; Diclofenac; Flavanones; Hesperidin; Male; Oxidative Stress; Rats; Rats, Wistar | 2021 |
Hesperetin derivative-14 alleviates inflammation by activating PPAR-γ in mice with CCl
Topics: Animals; Carbon Tetrachloride Poisoning; Chemical and Drug Induced Liver Injury; Gene Expression Regulation; Hesperidin; Inflammation; Janus Kinase 1; Lipopolysaccharides; Liver; Male; Mice; Mice, Inbred C57BL; PPAR gamma; Random Allocation; RAW 264.7 Cells; Silymarin; STAT1 Transcription Factor | 2017 |
Design, synthesis and biological evaluation of hesperetin derivatives as potent anti-inflammatory agent.
Topics: Animals; Anti-Inflammatory Agents; Chemical and Drug Induced Liver Injury; Hesperidin; Interleukin-6; Liver; Macrophages; MAP Kinase Signaling System; Mice; Mice, Inbred C57BL; NF-kappa B; Nitric Oxide; RAW 264.7 Cells; Tumor Necrosis Factor-alpha | 2017 |
Design, synthesis and investigation of potential anti-inflammatory activity of O-alkyl and O-benzyl hesperetin derivatives.
Topics: Animals; Anti-Inflammatory Agents; Carbon Tetrachloride; Chemical and Drug Induced Liver Injury; Disease Models, Animal; Hesperidin; Humans; Inflammation; Interleukin-1beta; Interleukin-6; Lipopolysaccharides; Macrophages; Mice; Mice, Inbred Strains; NF-kappa B; Nitric Oxide; Nitric Oxide Synthase Type II; RAW 264.7 Cells; Signal Transduction; Structure-Activity Relationship | 2018 |
Hyaluronan as a mediator for the hepatoprotective effect of Diosmin/Hesperidin complex.
Topics: Animals; Carbon Tetrachloride; Chemical and Drug Induced Liver Injury; Diosmin; Drug Combinations; Gamma Rays; Hesperidin; Hyaluronic Acid; Liver; Liver Function Tests; Male; Radiation Injuries, Experimental; Rats; Whole-Body Irradiation | 2018 |
Hesperidin alleviates zinc oxide nanoparticle induced hepatotoxicity and oxidative stress.
Topics: Alanine Transaminase; Animals; Antioxidants; Aspartate Aminotransferases; Chemical and Drug Induced Liver Injury; Glutathione; Hesperidin; Liver; Male; Malondialdehyde; Nanoparticles; Oxidative Stress; Rats, Wistar; Superoxide Dismutase; Zinc Oxide | 2018 |
Protective effects of neohesperidin dihydrochalcone against carbon tetrachloride-induced oxidative damage in vivo and in vitro.
Topics: Animals; Carbon Tetrachloride; Cell Survival; Chalcones; Chemical and Drug Induced Liver Injury; Gene Expression Regulation; Hep G2 Cells; Hesperidin; Humans; Liver; Liver Function Tests; Mice; Oxidative Stress; Protective Agents | 2014 |
Protective effects of hesperidin on concanavalin A-induced hepatic injury in mice.
Topics: Animals; Anti-Inflammatory Agents; Chemical and Drug Induced Liver Injury; Concanavalin A; Hepatocytes; Hesperidin; HMGB1 Protein; Interferon-gamma; Liver; Lymphocyte Activation; Male; Mice; Mice, Inbred C57BL; Oxidative Stress; Protective Agents; T-Lymphocytes; Tumor Necrosis Factor-alpha | 2014 |
Hesperidin protects against cyclophosphamide-induced hepatotoxicity by upregulation of PPARγ and abrogation of oxidative stress and inflammation.
Topics: Animals; Antineoplastic Agents, Alkylating; Antioxidants; Chemical and Drug Induced Liver Injury; Cyclophosphamide; Cytokines; Glutathione; Hesperidin; Inflammation; Lipid Peroxidation; Liver; Male; Nitric Oxide; Oxidative Stress; PPAR gamma; Rats, Wistar; Transaminases; Up-Regulation | 2014 |
Neohesperidin Dihydrochalcone versus CCl₄-Induced Hepatic Injury through Different Mechanisms: The Implication of Free Radical Scavenging and Nrf2 Activation.
Topics: Animals; Carbon Tetrachloride; Chalcones; Chemical and Drug Induced Liver Injury; Free Radical Scavengers; Heme Oxygenase-1; Hesperidin; Humans; JNK Mitogen-Activated Protein Kinases; Liver; Mice; NF-E2-Related Factor 2; Oxidative Stress; Reactive Oxygen Species; Signal Transduction | 2015 |
Artificial sweetener neohesperidin dihydrochalcone showed antioxidative, anti-inflammatory and anti-apoptosis effects against paraquat-induced liver injury in mice.
Topics: Alanine Transaminase; Animals; Anti-Inflammatory Agents, Non-Steroidal; Antioxidants; Apoptosis; Aspartate Aminotransferases; Chalcones; Chemical and Drug Induced Liver Injury; Hesperidin; Liver; Male; Mice; Paraquat; Reactive Oxygen Species; Signal Transduction; Sweetening Agents; Thiobarbituric Acid Reactive Substances | 2015 |
Simultaneous administration of hesperidin or garlic oil modulates diazinon-induced hemato- and immunotoxicity in rats.
Topics: Allyl Compounds; Animals; CD4-Positive T-Lymphocytes; CD8-Positive T-Lymphocytes; Chemical and Drug Induced Liver Injury; Diazinon; Hesperidin; Male; Rats; Sulfides | 2015 |
Hesperidin alleviates cisplatin-induced hepatotoxicity in rats without inhibiting its antitumor activity.
Topics: Alanine Transaminase; Animals; Antineoplastic Agents; Antioxidants; Aspartate Aminotransferases; Chemical and Drug Induced Liver Injury; Cholesterol; Cisplatin; Drug Interactions; Glutathione; Hesperidin; Liver; Male; Malondialdehyde; NF-kappa B; Nitrates; Nitrites; Oxidative Stress; Proto-Oncogene Proteins c-akt; Rats; Rats, Wistar; Triglycerides | 2016 |
Hesperidin Alleviates Oxidative Stress and Upregulates the Multidrug Resistance Protein 2 in Isoniazid and Rifampicin-Induced Liver Injury in Rats.
Topics: Alanine Transaminase; Animals; Antitubercular Agents; Aspartate Aminotransferases; ATP Binding Cassette Transporter, Subfamily B; Bilirubin; Chemical and Drug Induced Liver Injury; Glutathione; Glutathione Peroxidase; Glutathione Reductase; Hesperidin; Isoniazid; Liver; Male; Oxidative Stress; Protective Agents; Rats; Rats, Wistar; Rifampin; Up-Regulation | 2016 |
Hesperetin protects against oxidative stress related hepatic dysfunction by cadmium in rats.
Topics: Animals; Antioxidants; Cadmium; Chemical and Drug Induced Liver Injury; Disease Models, Animal; Hesperidin; Lipid Peroxidation; Male; Oxidative Stress; Rats; Rats, Wistar | 2012 |
Beneficial effect of hesperidin on lipopolysaccharide-induced hepatotoxicity.
Topics: Animals; Chemical and Drug Induced Liver Injury; Glutathione; Hesperidin; Lipopolysaccharides; Liver; Liver Function Tests; Male; Mitochondria, Liver; Nitrites; Oxidative Stress; Rats; Rats, Wistar; Reactive Nitrogen Species; Superoxide Dismutase | 2006 |
Cytolytic hepatitis with a venotonic drug.
Topics: Adult; Ascorbic Acid; Chemical and Drug Induced Liver Injury; Chymotrypsin; Drug Combinations; Female; Flavonoids; Hesperidin; Humans; Leg; Peptide Hydrolases; Phytosterols; Trypsin; Vascular Diseases; Veins | 1995 |