heroin has been researched along with Paraplegia* in 10 studies
10 other study(ies) available for heroin and Paraplegia
Article | Year |
---|---|
Acute extensive myelopathy after single heroin and cocaine exposure in a patient with toxicological evidence of long-term drug abstinence.
Heroin-related myelopathy is an uncommon but often devastating complication of heroin intake. It is usually reported in individuals exposed to intravenous heroin after a variable drug-free period, leading to acute and complete spinal cord injury with poor long-term outcome. We describe an original case of acute longitudinally extensive transverse myelopathy following single heroin and cocaine intravenous exposure after a long period of abstinence confirmed by toxicological hair and retrospective urine drug analysis. This case could provide new insights in the understanding of this rare neurological complication. Topics: Anti-Inflammatory Agents; Cocaine; Extinction, Psychological; Fecal Incontinence; Female; Hair; Heroin; Humans; Methylprednisolone; Middle Aged; Myelitis, Transverse; Paraplegia; Severity of Illness Index; Spinal Puncture; Substance Abuse Detection; Substance Abuse, Intravenous; Treatment Outcome | 2019 |
Acute progressive paraplegia in heroin-associated myelopathy.
As the opioid epidemic continues, understanding manifestations of abuse, including heroin-associated myelopathy remains essential. Here we describe a young man with a past medical history significant for polysubstance abuse who developed acute-onset, rapidly progressive myelopathy after resumption of intravenous heroin use. He had significant spinal cord involvement with findings suggestive of heroin-associated myelopathy. The salient features of this case include diffusion imaging of the spine and spinal angiography supporting a possible vasculopathy as the pathophysiologic mechanism underlying heroin-associated myelopathy. Additionally, CSF studies showed the transition from a neutrophilic pleocytosis to a lymphocytic pleocytosis suggesting an inflammatory component. Topics: Acute Disease; Adult; Disease Progression; Heroin; Heroin Dependence; Humans; Injections, Intravenous; Male; Paraplegia; Spinal Cord Diseases | 2018 |
Heroin-induced acute myelopathy with extreme high levels of CSF glial fibrillar acidic protein indicating a toxic effect on astrocytes.
A man aged 33 years with previous heroin substance abuse was found unconscious lying in a bush. The patient had been without heroin for some time but had just started to use intravenous heroin again, 0.5-2 g daily. The patient had almost complete paraplegia and a sensory loss for all modalities below the mamillary level and a urine retention of 1.5 L. Acute MRI of the spine revealed an expanded spinal cord with increased intramedullary signal intensity, extending from C7-T9. The cerebrospinal fluid showed extremely high levels of nerve injury markers particularly glial fibrillar acidic protein (GFAP): 2 610 000/ng/L (ref. <750). The patient was empirically treated with intravenous 1 g methylprednisolone daily for 5 days and improved markedly. Very few diseases are known to produce such high levels of GFAP, indicating a toxic effect on astrocytes. Measuring GFAP could possibly aid in the diagnosis of heroin-induced myelopathy. Topics: Acute Disease; Adult; Astrocytes; Biomarkers; Drug Users; Glial Fibrillary Acidic Protein; Heroin; Humans; Magnetic Resonance Imaging; Male; Methylprednisolone; Paraplegia; Sensation Disorders; Spinal Cord; Spinal Cord Diseases; Substance Abuse, Intravenous | 2017 |
Acute myelopathy selectively involving lumbar anterior horns following intranasal insufflation of ecstasy and heroin.
Topics: Acute Disease; Administration, Inhalation; Adolescent; Drug Overdose; Female; Hallucinogens; Heroin; Humans; Lumbosacral Region; Magnetic Resonance Imaging; N-Methyl-3,4-methylenedioxyamphetamine; Narcotics; Paraplegia; Spinal Cord Diseases | 2007 |
Acute myelopathy following intranasal insufflation of heroin: a case report.
Topics: Administration, Inhalation; Heroin; Heroin Dependence; Humans; Magnetic Resonance Imaging; Male; Middle Aged; Paraplegia; Spinal Cord; Spinal Cord Diseases | 2000 |
Acute myelopathy following intravenous heroin: a case report.
A 43-year-old woman developed acute paraplegia and a Korsakoff syndrome following intravenous administration of heroin. Thirteen previously reported cases are similar to the one presented here. Based on those similarities, we conclude that these myelopathies are probably due to spinal cord infarction resulting from systemic hypoxemia and hypotension. Topics: Adult; Female; Heroin; Humans; Memory Disorders; Paraplegia; Substance Abuse, Intravenous | 1991 |
Acute heroin myelopathy--case report.
Description of a case of benign acute transverse myelopathy in a young woman who had taken heroin I.V. after a two-year free interval. Spinal angiography was negative but CT scanning of the cord showed a swelling at C3. Topics: Acute Disease; Adult; Drug Hypersensitivity; Female; Heroin; Humans; Hypesthesia; Injections, Intravenous; Paraplegia; Spinal Cord Diseases; Substance Withdrawal Syndrome | 1984 |
Anterior spinal artery syndrome after cervical injection of heroin.
Topics: Adult; Heroin; Humans; Male; Paraplegia; Spinal Cord; Syndrome | 1982 |
Encephalopathy and paraplegia occurring with use of heroin.
Topics: Adolescent; Adult; Brain Diseases; Heroin; Humans; Male; Paraplegia | 1971 |
Transverse myelitis associated with heroin addiction.
Topics: Adult; Heroin; Humans; Injections, Intravenous; Male; Myelitis; Paraplegia; Spinal Cord; Substance-Related Disorders | 1968 |