herbimycin and Vitreoretinopathy--Proliferative

herbimycin has been researched along with Vitreoretinopathy--Proliferative* in 1 studies

Other Studies

1 other study(ies) available for herbimycin and Vitreoretinopathy--Proliferative

Article	Year
Herbimycin A in the treatment of experimental proliferative vitreoretinopathy: toxicity and efficacy study. Graefe's archive for clinical and experimental ophthalmology = Albrecht von Graefes Archiv fur klinische und experimentelle Ophthalmologie, 2000, Volume: 238, Issue:5 Proliferative vitreoretinopathy (PVR) is partially caused by peptide growth factors, stimulating the cell by binding to a transmembrane tyrosine kinase receptor. We studied the effects of herbimycin A (HA), a tyrosine kinase inhibitor, in PVR.. Toxicity studies: Electroretinography and histological studies were performed after intravitreal injection of HA. Efficacy studies: Homologous rabbit dermal fibroblasts were injected intravitreally, followed by injection of HA. The presence of tractional retinal detachment (TRD) and severity of inflammation were assessed.. Toxicity studies: Eyes injected with HA exhibited decrease in B-wave amplitude initially, with subsequent recovery. Histologically, damage to photoreceptors was evident after injection of high but not of low doses of HA. Efficacy studies: Inflammatory response and the development of TRD were significantly reduced with all doses of HA.. HA (20 microM) was found to be effective and safe in preventing the development of inflammation and TRD. Topics: Animals; Antibiotics, Antineoplastic; Benzoquinones; Biopsy; Cells, Cultured; Electroretinography; Enzyme Inhibitors; Fibroblasts; Injections; Lactams, Macrocyclic; Photoreceptor Cells, Vertebrate; Protein-Tyrosine Kinases; Quinones; Rabbits; Retinal Detachment; Rifabutin; Vitreoretinopathy, Proliferative; Vitreous Body	2000

Article

Year

Herbimycin A in the treatment of experimental proliferative vitreoretinopathy: toxicity and efficacy study.

Graefe's archive for clinical and experimental ophthalmology = Albrecht von Graefes Archiv fur klinische und experimentelle Ophthalmologie, 2000, Volume: 238, Issue:5

Proliferative vitreoretinopathy (PVR) is partially caused by peptide growth factors, stimulating the cell by binding to a transmembrane tyrosine kinase receptor. We studied the effects of herbimycin A (HA), a tyrosine kinase inhibitor, in PVR.. Toxicity studies: Electroretinography and histological studies were performed after intravitreal injection of HA. Efficacy studies: Homologous rabbit dermal fibroblasts were injected intravitreally, followed by injection of HA. The presence of tractional retinal detachment (TRD) and severity of inflammation were assessed.. Toxicity studies: Eyes injected with HA exhibited decrease in B-wave amplitude initially, with subsequent recovery. Histologically, damage to photoreceptors was evident after injection of high but not of low doses of HA. Efficacy studies: Inflammatory response and the development of TRD were significantly reduced with all doses of HA.. HA (20 microM) was found to be effective and safe in preventing the development of inflammation and TRD.

Topics: Animals; Antibiotics, Antineoplastic; Benzoquinones; Biopsy; Cells, Cultured; Electroretinography; Enzyme Inhibitors; Fibroblasts; Injections; Lactams, Macrocyclic; Photoreceptor Cells, Vertebrate; Protein-Tyrosine Kinases; Quinones; Rabbits; Retinal Detachment; Rifabutin; Vitreoretinopathy, Proliferative; Vitreous Body

2000