herbacetin and Pneumonia--Viral

Coronavirus disease 2019 (COVID-19) has been a pandemic disease of which the termination is not yet predictable. Currently, researches to develop vaccines and treatments is going on globally to cope with this disastrous disease. Main protease (3CLpro) from severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) is one of the good targets to find antiviral agents before vaccines are available. Some flavonoids are known to inhibit 3CLpro from SARS-CoV which causes SARS. Since their sequence identity is 96%, a similar approach was performed with a flavonoid library. Baicalin, herbacetin, and pectolinarin have been discovered to block the proteolytic activity of SARS-CoV-2 3CLpro. An

Topics: Antiviral Agents; Betacoronavirus; Coronavirus Infections; COVID-19; COVID-19 Drug Treatment; Drug Design; Flavonoids; Fluorescence Resonance Energy Transfer; Humans; Molecular Docking Simulation; Pandemics; Pneumonia, Viral; Polyproteins; Protease Inhibitors; Protein Binding; Protein Conformation; SARS-CoV-2; Spectrophotometry; Tryptophan; Viral Proteins