herbacetin has been researched along with Disease-Models--Animal* in 1 studies
1 other study(ies) available for herbacetin and Disease-Models--Animal
| Article | Year |
|---|---|
Discovery of Herbacetin as a Novel SGK1 Inhibitor to Alleviate Myocardial Hypertrophy.
Cardiac hypertrophy is a pivotal pathophysiological step of various cardiovascular diseases, which eventually leads to heart failure and death. Extracts of Rhodiola species (Ext.R), a class of commonly used medicinal herbs in Europe and East Asia, can attenuate cardiac hypertrophy both in vitro and in vivo. Serum/glucocorticoid regulated kinase 1 (SGK1) is identified as a potential target of Ext. R. By mass spectrometry-based kinase inhibitory assay, herbacetin (HBT) from Ext.R is identified as a novel SGK1 inhibitor with IC Topics: Animals; Cardiomegaly; Cells, Cultured; Disease Models, Animal; Flavonoids; Immediate-Early Proteins; Male; Mice; Mice, Inbred C57BL; Myocytes, Cardiac; Protein Serine-Threonine Kinases; Signal Transduction | 2022 |