heptaphylline and Neoplasms

heptaphylline has been researched along with Neoplasms* in 1 studies

Other Studies

1 other study(ies) available for heptaphylline and Neoplasms

Article	Year
Semi-Synthesis of Small Molecules of Aminocarbazoles: Tumor Growth Inhibition and Potential Impact on p53. Molecules (Basel, Switzerland), 2021, Mar-15, Volume: 26, Issue:6 The tumor suppressor p53 is inactivated by mutation in approximately 50% of human cancers. Small molecules that bind and stabilize those mutants may represent effective anticancer drugs. Herein, we report the tumor cell growth inhibitory activity of carbazole alkaloids and amino derivatives, as well as their potential activation of p53. Twelve aminocarbazole alkaloids were semi-synthesized from heptaphylline ( Topics: Alkaloids; Antineoplastic Agents; Carbazoles; Cell Line; Cell Line, Tumor; Clausena; HCT116 Cells; HT29 Cells; Humans; Mutation; Neoplasms; Small Molecule Libraries; Tumor Suppressor Protein p53	2021

Article

Year

Semi-Synthesis of Small Molecules of Aminocarbazoles: Tumor Growth Inhibition and Potential Impact on p53.

Molecules (Basel, Switzerland), 2021, Mar-15, Volume: 26, Issue:6

The tumor suppressor p53 is inactivated by mutation in approximately 50% of human cancers. Small molecules that bind and stabilize those mutants may represent effective anticancer drugs. Herein, we report the tumor cell growth inhibitory activity of carbazole alkaloids and amino derivatives, as well as their potential activation of p53. Twelve aminocarbazole alkaloids were semi-synthesized from heptaphylline (

Topics: Alkaloids; Antineoplastic Agents; Carbazoles; Cell Line; Cell Line, Tumor; Clausena; HCT116 Cells; HT29 Cells; Humans; Mutation; Neoplasms; Small Molecule Libraries; Tumor Suppressor Protein p53

2021