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heptachlor and Delayed Effects, Prenatal Exposure

heptachlor has been researched along with Delayed Effects, Prenatal Exposure in 6 studies

Heptachlor: A man-made compound previously used to control termites and other insects. Even though production of heptachlor was phased out of use in the United States during the late 1980's it remains in soil and hazardous waste sites. It is clearly toxic to animals and humans but, the International Agency for Research on Cancer (IARC) has determined that heptachlor is not classifiable as to its carcinogenicity to humans. (From ATSDR Public Heath Statement, April 1989)
heptachlor : A cyclodiene organochlorine insecticide that is 3a,4,7,7a-tetrahydro-1H-4,7-methanoindene substituted by chlorine atoms at positions 1, 4, 5, 6, 7, 8 and 8. Formerly used to kill termites, ants and other insects in agricultural and domestic situations.

Research Excerpts

ExcerptRelevanceReference
"Heptachlor has been targeted for global elimination because of its toxicity and environmental persistence, in accordance with the Stockholm Convention on Persistent Organic Pollutants (POPs)."1.46Effects on the reproductive parameters of two generations of Rattus norvegicus offspring from dams exposed to heptachlor during gestation and lactation. ( Cerbón, M; Martínez-Ibarra, A; Morimoto, S; Prado-Flores, G, 2017)
"Heptachlor is a cyclodiene pesticide that was widely used for many years, and for which inadvertent exposure to children and fetuses took place in the early 1980s; yet little is known regarding the developmental neurotoxicity of it and other cyclodienes."1.31Neurotoxicological outcomes of perinatal heptachlor exposure in the rat. ( Chapin, RE; Harris, MW; Meacham, CA; Moser, VC; Shafer, TJ; Ward, TR, 2001)
" Time-bred pregnant female Sprague-Dawley rats were dosed by gavage with H (0, 30, 300, or 3000 microg/kg/day) from gestation day (GD) 12 to postnatal day (PND) 7, followed by direct dosing of the pups with H through PND 42."1.31The effects of perinatal/juvenile heptachlor exposure on adult immune and reproductive system function in rats. ( Chapin, RE; Copeland, CB; Davis, BJ; Harris, MW; Overstreet, D; Smialowicz, RJ; Williams, WC, 2001)

Research

Studies (6)

TimeframeStudies, this research(%)All Research%
pre-19900 (0.00)18.7374
1990's1 (16.67)18.2507
2000's4 (66.67)29.6817
2010's1 (16.67)24.3611
2020's0 (0.00)2.80

Authors

AuthorsStudies
Martínez-Ibarra, A1
Morimoto, S1
Cerbón, M1
Prado-Flores, G1
Richardson, JR1
Caudle, WM1
Wang, MZ1
Dean, ED1
Pennell, KD1
Miller, GW1
Lawson, G1
Luderer, U1
Moser, VC1
Shafer, TJ1
Ward, TR1
Meacham, CA1
Harris, MW2
Chapin, RE2
Smialowicz, RJ1
Williams, WC1
Copeland, CB1
Overstreet, D1
Davis, BJ1

Reviews

1 review available for heptachlor and Delayed Effects, Prenatal Exposure

ArticleYear
Chlordane and heptachlor.
    IARC monographs on the evaluation of carcinogenic risks to humans, 1991, Volume: 53

    Topics: Air Pollutants, Occupational; Animals; Carcinogenicity Tests; Case-Control Studies; Chlordan; Cocarc

1991

Other Studies

5 other studies available for heptachlor and Delayed Effects, Prenatal Exposure

ArticleYear
Effects on the reproductive parameters of two generations of Rattus norvegicus offspring from dams exposed to heptachlor during gestation and lactation.
    Environmental toxicology, 2017, Volume: 32, Issue:3

    Topics: Animals; Cervix Uteri; Endocrine Disruptors; Estrogen Receptor alpha; Female; Heptachlor; Immunohist

2017
Developmental heptachlor exposure increases susceptibility of dopamine neurons to N-methyl-4-phenyl-1,2,3,6-tetrahydropyridine (MPTP)in a gender-specific manner.
    Neurotoxicology, 2008, Volume: 29, Issue:5

    Topics: Analysis of Variance; Animals; Animals, Newborn; Disease Models, Animal; Dopamine; Dopamine Plasma M

2008
Gestational and lactational exposure to heptachlor does not alter reproductive system development in rats.
    Veterinary and human toxicology, 2004, Volume: 46, Issue:3

    Topics: Animals; Dose-Response Relationship, Drug; Female; Heptachlor; Insecticides; Lactation; Male; Organ

2004
Neurotoxicological outcomes of perinatal heptachlor exposure in the rat.
    Toxicological sciences : an official journal of the Society of Toxicology, 2001, Volume: 60, Issue:2

    Topics: Animals; Animals, Newborn; Behavior, Animal; Body Weight; Brain; Brain Chemistry; Chlorides; Embryon

2001
The effects of perinatal/juvenile heptachlor exposure on adult immune and reproductive system function in rats.
    Toxicological sciences : an official journal of the Society of Toxicology, 2001, Volume: 61, Issue:1

    Topics: Animals; Animals, Newborn; Antibody Formation; Body Weight; Dose-Response Relationship, Drug; Enzyme

2001