heparitin-sulfate has been researched along with Zika-Virus-Infection* in 3 studies
3 other study(ies) available for heparitin-sulfate and Zika-Virus-Infection
Article | Year |
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Extracellular acidosis enhances Zika virus infection both in human cells and ex-vivo tissue cultures from female reproductive tract.
Zika virus (ZIKV) is a flavivirus transmitted by mosquitoes of the genus Topics: Acidosis; Animals; Cell Line; Cervix Uteri; Chlorocebus aethiops; Female; Heparitin Sulfate; Humans; Hydrogen-Ion Concentration; Microscopy, Fluorescence; Vagina; Vero Cells; Zika Virus; Zika Virus Infection | 2021 |
Glycosaminoglycan Compositional Analysis of Relevant Tissues in Zika Virus Pathogenesis and in Vitro Evaluation of Heparin as an Antiviral against Zika Virus Infection.
Zika virus (ZIKV) is an enveloped RNA virus from the flavivirus family that can cause fetal neural abnormalities in pregnant women. Previously, we established that ZIKV-EP (envelope protein) binds to human placental chondroitin sulfate (CS), suggesting that CS may be a potential host cell surface receptor in ZIKV pathogenesis. In this study, we further characterized the GAG disaccharide composition of other biological tissues (i.e., mosquitoes, fetal brain cells, and eye tissues) in ZIKV pathogenesis to investigate the role of tissue specific GAGs. Heparan sulfate (HS) was the major GAG, and levels of HS-6-sulfo, HS 0S (unsulfated HS), and CS 4S disaccharides were the main differences in the GAG composition of Aedes aegypti and Aedes albopictus mosquitoes. In human fetal neural progenitor and differentiated cells, HS 0S and CS 4S were the main disaccharides. A change in disaccharide composition levels was observed between undifferentiated and differentiated cells. In different regions of the bovine eyes, CS was the major GAG, and the amounts of hyaluronic acid or keratan sulfate varied depending on the region of the eye. Next, we examined heparin (HP) of various structures to investigate their potential in vitro antiviral activity against ZIKV and Dengue virus (DENV) infection in Vero cells. All compounds effectively inhibited DENV replication; however, they surprisingly promoted ZIKV replication. HP of longer chain lengths more strongly promoted activity in ZIKV replication. This study further expands our understanding of role of GAGs in ZIKV pathogenesis and carbohydrate-based antivirals against flaviviral infection. Topics: Aedes; Animals; Antiviral Agents; Cattle; Chlorocebus aethiops; Dengue; Dengue Virus; Eye; Fetus; Glycosaminoglycans; Heparitin Sulfate; Humans; In Vitro Techniques; Mosquito Vectors; Neural Stem Cells; Vero Cells; Virus Internalization; Virus Replication; Zika Virus; Zika Virus Infection | 2019 |
Polysulfonate suramin inhibits Zika virus infection.
Topics: Animals; Antibodies, Viral; Chlorates; Chlorocebus aethiops; Dextran Sulfate; DNA Helicases; Flavivirus; Glycosaminoglycans; Heparin; Heparitin Sulfate; Inhibitory Concentration 50; Mice; Molecular Docking Simulation; Molecular Dynamics Simulation; RNA Helicases; Serine Endopeptidases; Suramin; Vero Cells; Viral Envelope Proteins; Viral Nonstructural Proteins; Virus Internalization; Virus Replication; Zika Virus; Zika Virus Infection | 2017 |