heparitin-sulfate has been researched along with Situs-Inversus* in 1 studies
1 other study(ies) available for heparitin-sulfate and Situs-Inversus
| Article | Year |
|---|---|
Ectodermal syndecan-2 mediates left-right axis formation in migrating mesoderm as a cell-nonautonomous Vg1 cofactor.
Heparan sulfate proteoglycans expressed on the Xenopus animal cap ectoderm have been implicated in transmitting left-right information to heart and gut primordia. We report here that syndecan-2 functions in the ectoderm to mediate cardiac and visceral situs, upstream of known asymmetrically expressed genes but independently of its ability to mediate fibronectin fibrillogenesis. Left-right development is dependent on a distinct subset of glycosaminoglycan attachment sites on syndecan-2. A novel in vivo approach with enterokinase demonstrates that syndecan-2 functions in left-right patterning during early gastrulation. We describe a cell-nonautonomous role for ectodermal syndecan-2 in transmitting left-right information to migrating mesoderm. The results further suggest that this function may be related to the transduction of Vg1-related signals. Topics: Activin Receptors, Type I; Amino Acid Sequence; Animals; Cell Movement; Digestive System; Ectoderm; Gastrula; Gene Expression Regulation, Developmental; Glycoproteins; Heart; Heparitin Sulfate; Membrane Glycoproteins; Mesoderm; Molecular Sequence Data; Proteins; Proteoglycans; Signal Transduction; Situs Inversus; Syndecan-2; Transforming Growth Factor beta; Xenopus; Xenopus Proteins; Zebrafish Proteins | 2002 |