heparitin-sulfate and Osteoporosis

heparitin-sulfate has been researched along with Osteoporosis* in 1 studies

Other Studies

1 other study(ies) available for heparitin-sulfate and Osteoporosis

Article	Year
Antiresorptive activity of osteoprotegerin requires an intact heparan sulfate-binding site. Proceedings of the National Academy of Sciences of the United States of America, 2020, 07-21, Volume: 117, Issue:29 Osteoprotegerin (OPG), a secreted decoy receptor for receptor activator of nuclear factor B ligand (RANKL), plays an essential role in regulating bone resorption. While much is known about the function of the N-terminal domains of OPG, which is responsible for binding to RANKL, the exact biological functions of the three C-terminal domains of OPG remain uncertain. We have previously shown that one likely function of the C-terminal domains of OPG is to bind cell surface heparan sulfate (HS), but the in vivo evidence was lacking. To investigate the biological significance of OPG-HS interaction in bone remodeling, we created OPG knock-in mice ( Topics: Animals; Binding Sites; Bone and Bones; Bone Density Conservation Agents; Bone Resorption; Cell Line; Disease Models, Animal; Female; Heparitin Sulfate; Male; Mice; Mice, Inbred C57BL; Mice, Knockout; Osteoblasts; Osteoclasts; Osteogenesis; Osteoporosis; Osteoprotegerin; RANK Ligand; Transcriptome	2020

Article

Year

Antiresorptive activity of osteoprotegerin requires an intact heparan sulfate-binding site.

Proceedings of the National Academy of Sciences of the United States of America, 2020, 07-21, Volume: 117, Issue:29

Osteoprotegerin (OPG), a secreted decoy receptor for receptor activator of nuclear factor B ligand (RANKL), plays an essential role in regulating bone resorption. While much is known about the function of the N-terminal domains of OPG, which is responsible for binding to RANKL, the exact biological functions of the three C-terminal domains of OPG remain uncertain. We have previously shown that one likely function of the C-terminal domains of OPG is to bind cell surface heparan sulfate (HS), but the in vivo evidence was lacking. To investigate the biological significance of OPG-HS interaction in bone remodeling, we created OPG knock-in mice (

Topics: Animals; Binding Sites; Bone and Bones; Bone Density Conservation Agents; Bone Resorption; Cell Line; Disease Models, Animal; Female; Heparitin Sulfate; Male; Mice; Mice, Inbred C57BL; Mice, Knockout; Osteoblasts; Osteoclasts; Osteogenesis; Osteoporosis; Osteoprotegerin; RANK Ligand; Transcriptome

2020