heparitin-sulfate and Multiple-Sclerosis

heparitin-sulfate has been researched along with Multiple-Sclerosis* in 2 studies

Other Studies

2 other study(ies) available for heparitin-sulfate and Multiple-Sclerosis

Article	Year
Mature oligodendrocytes bordering lesions limit demyelination and favor myelin repair via heparan sulfate production. eLife, 2020, 06-09, Volume: 9 Myelin destruction is followed by resident glia activation and mobilization of endogenous progenitors (OPC) which participate in myelin repair. Here we show that in response to demyelination, mature oligodendrocytes (OLG) bordering the lesion express Ndst1, a key enzyme for heparan sulfates (HS) synthesis. Ndst1+ OLG form a belt that demarcates lesioned from intact white matter. Mice with selective inactivation of Ndst1 in the OLG lineage display increased lesion size, sustained microglia and OPC reactivity. HS production around the lesion allows Sonic hedgehog (Shh) binding and favors the local enrichment of this morphogen involved in myelin regeneration. In MS patients, Ndst1 is also found overexpressed in oligodendroglia and the number of Ndst1-expressing oligodendroglia is inversely correlated with lesion size and positively correlated with remyelination potential. Our study suggests that mature OLG surrounding demyelinated lesions are not passive witnesses but contribute to protection and regeneration by producing HS. Topics: Animals; Corpus Callosum; Demyelinating Diseases; Disease Models, Animal; Gene Deletion; Hedgehog Proteins; HEK293 Cells; Heparitin Sulfate; Humans; Lysophosphatidylcholines; Macrophage Activation; Mice, Transgenic; Microglia; Multiple Sclerosis; Oligodendroglia; Remyelination; Sulfotransferases; Up-Regulation	2020
Abdominal wall ulceration and mucinosis secondary to recombinant human interferon-beta-1b. The Australasian journal of dermatology, 2005, Volume: 46, Issue:3 46-year-old woman developed painful ulcers over her lower abdomen in the form of reticulate erythema after injecting interferon beta-1b subcutaneously for multiple sclerosis. Skin biopsy revealed multiple superficial thrombosed vessels with focal epidermal necrosis as well as prominent interstitial mucinosis. Treatment with low-molecular-weight heparin followed by a heparinoid resulted in slow healing of the ulcers but also allowed the subcutaneous interferon injections to be continued. Topics: Abdominal Wall; Adjuvants, Immunologic; Chondroitin Sulfates; Dermatan Sulfate; Enoxaparin; Female; Fibrinolytic Agents; Heparitin Sulfate; Humans; Injections, Subcutaneous; Interferon beta-1b; Interferon-beta; Middle Aged; Mucinoses; Multiple Sclerosis; Thrombosis; Treatment Outcome; Ulcer	2005

Article

Year

Mature oligodendrocytes bordering lesions limit demyelination and favor myelin repair via heparan sulfate production.

eLife, 2020, 06-09, Volume: 9

Myelin destruction is followed by resident glia activation and mobilization of endogenous progenitors (OPC) which participate in myelin repair. Here we show that in response to demyelination, mature oligodendrocytes (OLG) bordering the lesion express Ndst1, a key enzyme for heparan sulfates (HS) synthesis. Ndst1+ OLG form a belt that demarcates lesioned from intact white matter. Mice with selective inactivation of Ndst1 in the OLG lineage display increased lesion size, sustained microglia and OPC reactivity. HS production around the lesion allows Sonic hedgehog (Shh) binding and favors the local enrichment of this morphogen involved in myelin regeneration. In MS patients, Ndst1 is also found overexpressed in oligodendroglia and the number of Ndst1-expressing oligodendroglia is inversely correlated with lesion size and positively correlated with remyelination potential. Our study suggests that mature OLG surrounding demyelinated lesions are not passive witnesses but contribute to protection and regeneration by producing HS.

Topics: Animals; Corpus Callosum; Demyelinating Diseases; Disease Models, Animal; Gene Deletion; Hedgehog Proteins; HEK293 Cells; Heparitin Sulfate; Humans; Lysophosphatidylcholines; Macrophage Activation; Mice, Transgenic; Microglia; Multiple Sclerosis; Oligodendroglia; Remyelination; Sulfotransferases; Up-Regulation

2020

Abdominal wall ulceration and mucinosis secondary to recombinant human interferon-beta-1b.

The Australasian journal of dermatology, 2005, Volume: 46, Issue:3

46-year-old woman developed painful ulcers over her lower abdomen in the form of reticulate erythema after injecting interferon beta-1b subcutaneously for multiple sclerosis. Skin biopsy revealed multiple superficial thrombosed vessels with focal epidermal necrosis as well as prominent interstitial mucinosis. Treatment with low-molecular-weight heparin followed by a heparinoid resulted in slow healing of the ulcers but also allowed the subcutaneous interferon injections to be continued.

Topics: Abdominal Wall; Adjuvants, Immunologic; Chondroitin Sulfates; Dermatan Sulfate; Enoxaparin; Female; Fibrinolytic Agents; Heparitin Sulfate; Humans; Injections, Subcutaneous; Interferon beta-1b; Interferon-beta; Middle Aged; Mucinoses; Multiple Sclerosis; Thrombosis; Treatment Outcome; Ulcer

2005