heparitin-sulfate and Infarction--Middle-Cerebral-Artery

Although VEGF. Both rat brain endothelial cell line 4 and primary rat neural progenitor cells were used to evaluate the potential angiogenic and neurogenic effects of HS7 in vitro. For in vivo experiments, male Sprague-Dawley rats were subjected to 100 minutes of transient focal cerebral ischemia, then treated after 4 days with either PBS or HS7. One week later, infarct volume, behavioral sequelae, immunohistochemical markers of angiogenesis and neural stem cell proliferation were assessed.. A VEGF-activating glycosaminoglycan sugar, by itself, is able to enhance endogenous VEGF

Topics: Animals; Blood-Brain Barrier; Brain Ischemia; Cell Proliferation; Heparitin Sulfate; Infarction, Middle Cerebral Artery; Injections, Intraventricular; Ischemic Attack, Transient; Male; Neovascularization, Physiologic; Neural Stem Cells; Rats; Rats, Sprague-Dawley; Recovery of Function; Stroke; Vascular Endothelial Growth Factor A; Vascular Endothelial Growth Factor Receptor-2