heparitin-sulfate and Epilepsy--Temporal-Lobe

heparitin-sulfate has been researched along with Epilepsy--Temporal-Lobe* in 2 studies

Other Studies

2 other study(ies) available for heparitin-sulfate and Epilepsy--Temporal-Lobe

Article	Year
Extracellular matrix components are altered in the hippocampus, cortex, and cerebrospinal fluid of patients with mesial temporal lobe epilepsy. Epilepsia, 2002, Volume: 43 Suppl 5 This work studied the profile of glycosaminoglycans (GAGs) in the hippocampus, cortex, and cerebrospinal fluid of patients with temporal lobe epilepsy (TLE).. The GAGs were analyzed by agarose gel electrophoresis, enzymatic degradation, and enzyme-linked immunosorbent assay (ELISA).. The hippocampus of TLE patients showed increased levels of chondroitin sulfate and hyaluronic acid against normal levels of these GAGs in the neocortex and cerebrospinal fluid (CSF).. These results suggest that these matrix components could be involved in the pathophysiology of TLE. Topics: Cerebral Cortex; Cerebrospinal Fluid; Chondroitin Sulfates; Epilepsy, Temporal Lobe; Extracellular Matrix; Glycosaminoglycans; Heparitin Sulfate; Hippocampus; Humans; Hyaluronic Acid	2002
Glycosaminoglycan levels and proteoglycan expression are altered in the hippocampus of patients with mesial temporal lobe epilepsy. Brain research bulletin, 2002, Sep-15, Volume: 58, Issue:5 Extracellular matrix proteoglycans (PGs) and glycosaminoglycans (GAGs) play a crucial role in cell differentiation and synaptogenesis by modulating neurite outgrowth. The chondroitin sulfate (CS)-rich PG, the receptor protein tyrosine phosphatase zeta/beta (RPTP zeta/beta), has been related to neural morphogenesis and axon guidance. Hippocampal sclerosis is the most frequent pathologic finding in patients with intractable mesial temporal lobe epilepsy (MTLE), which is associated with neuron loss, reactive gliosis, and mossy fiber sprouting. In the present study, we investigated the concentration of CS, heparan sulfate (HS) and hyaluronic acid (HA) in the hippocampus and temporal neocortex as well as RPTP zeta/beta expression in the hippocampus of patients with MTLE. Compared to autopsy control tissue, epileptic hippocampi showed a significantly increased concentration of CS (224%; p=0.0109) and HA (146%; p=0.039). HS was instead similar to control values. No differences were found in the concentration of CS, HS, or HA in the temporal neocortex of epileptic patients when compared to control values. In contrast, RPTP zeta/beta immunoreactivity was induced in astrocytes of the inner molecular layer of the dentate gyrus of the sclerotic hippocampus. Because matrix compounds have been associated with tissue injury and repair, the present findings suggest that changes in PGs and GAGs might be related to damage-induced gliosis and neuronal reorganization in the hippocampus of MTLE patients. Topics: Adult; Cerebral Cortex; Chondroitin Sulfates; Epilepsy, Temporal Lobe; Glycosaminoglycans; Heparitin Sulfate; Hippocampus; Humans; Hyaluronic Acid; Nerve Tissue Proteins; Protein Tyrosine Phosphatases; Proteoglycans; Receptor-Like Protein Tyrosine Phosphatases, Class 5; Sclerosis	2002

Article

Year

Extracellular matrix components are altered in the hippocampus, cortex, and cerebrospinal fluid of patients with mesial temporal lobe epilepsy.

Epilepsia, 2002, Volume: 43 Suppl 5

This work studied the profile of glycosaminoglycans (GAGs) in the hippocampus, cortex, and cerebrospinal fluid of patients with temporal lobe epilepsy (TLE).. The GAGs were analyzed by agarose gel electrophoresis, enzymatic degradation, and enzyme-linked immunosorbent assay (ELISA).. The hippocampus of TLE patients showed increased levels of chondroitin sulfate and hyaluronic acid against normal levels of these GAGs in the neocortex and cerebrospinal fluid (CSF).. These results suggest that these matrix components could be involved in the pathophysiology of TLE.

Topics: Cerebral Cortex; Cerebrospinal Fluid; Chondroitin Sulfates; Epilepsy, Temporal Lobe; Extracellular Matrix; Glycosaminoglycans; Heparitin Sulfate; Hippocampus; Humans; Hyaluronic Acid

2002

Glycosaminoglycan levels and proteoglycan expression are altered in the hippocampus of patients with mesial temporal lobe epilepsy.

Brain research bulletin, 2002, Sep-15, Volume: 58, Issue:5

Extracellular matrix proteoglycans (PGs) and glycosaminoglycans (GAGs) play a crucial role in cell differentiation and synaptogenesis by modulating neurite outgrowth. The chondroitin sulfate (CS)-rich PG, the receptor protein tyrosine phosphatase zeta/beta (RPTP zeta/beta), has been related to neural morphogenesis and axon guidance. Hippocampal sclerosis is the most frequent pathologic finding in patients with intractable mesial temporal lobe epilepsy (MTLE), which is associated with neuron loss, reactive gliosis, and mossy fiber sprouting. In the present study, we investigated the concentration of CS, heparan sulfate (HS) and hyaluronic acid (HA) in the hippocampus and temporal neocortex as well as RPTP zeta/beta expression in the hippocampus of patients with MTLE. Compared to autopsy control tissue, epileptic hippocampi showed a significantly increased concentration of CS (224%; p=0.0109) and HA (146%; p=0.039). HS was instead similar to control values. No differences were found in the concentration of CS, HS, or HA in the temporal neocortex of epileptic patients when compared to control values. In contrast, RPTP zeta/beta immunoreactivity was induced in astrocytes of the inner molecular layer of the dentate gyrus of the sclerotic hippocampus. Because matrix compounds have been associated with tissue injury and repair, the present findings suggest that changes in PGs and GAGs might be related to damage-induced gliosis and neuronal reorganization in the hippocampus of MTLE patients.

Topics: Adult; Cerebral Cortex; Chondroitin Sulfates; Epilepsy, Temporal Lobe; Glycosaminoglycans; Heparitin Sulfate; Hippocampus; Humans; Hyaluronic Acid; Nerve Tissue Proteins; Protein Tyrosine Phosphatases; Proteoglycans; Receptor-Like Protein Tyrosine Phosphatases, Class 5; Sclerosis

2002