heparitin-sulfate and Cystitis--Interstitial

heparitin-sulfate has been researched along with Cystitis--Interstitial* in 2 studies

Other Studies

2 other study(ies) available for heparitin-sulfate and Cystitis--Interstitial

Article	Year
Determination of urinary hexosamines for diagnosis of bladder pain syndrome. International urogynecology journal, 2012, Volume: 23, Issue:10 Bladder pain syndrome (BPS) is a chronic disease characterized by urgency, bladder pain, and frequency, and urinary glycosaminoglycans are thought to reflect bladder epithelial deficiency in BPS. Sensitive and specific evaluation of total urinary glycosaminoglycans may be useful for the clinical diagnosis of BPS and its treatment.. A procedure for the simultaneous determination of glucosamine and galactosamine produced from urinary glycosaminoglycans has been performed in BPS patients and healthy subjects.. The total content of urinary hexosamines in BPS patients significantly increased by ~130% with the increase in glucosamine greater than galactosamine.. A significant increase in total hexosamines content and in particular in glucosamine belonging to urinary heparan sulfate was determined in BPS patients compared with controls. We propose HS and in particular its low-molecular mass fragments and glucosamine assay as useful markers for a biochemical diagnosis of BPS and for monitoring this syndrome. Topics: Adult; Aged; Biomarkers; Case-Control Studies; Cystitis, Interstitial; Female; Galactosamine; Glucosamine; Heparitin Sulfate; Hexosamines; Humans; Middle Aged; Sensitivity and Specificity	2012
Fine structural characterization of chondroitin sulfate in urine of bladder pain syndrome subjects. International urogynecology journal, 2011, Volume: 22, Issue:12 Urothelial glycosaminoglycans (GAGs) are decreased in bladder pain syndrome (BPS), and urinary GAGs are thought to reflect this deficiency. In previous researches, urine GAG levels were found increased, decreased, or similar between BPS and controls. Additionally, no study is available on the structure characterization of urinary chondroitin sulfate (CS) in BPS patients.. CS in the urine of BPS-affected patients and controls has been determined by specific electrophoresis, along with total GAGs and heparan sulfate (HS) percentage, and CS disaccharides have been quantified by high-performance liquid chromatography.. No significant differences were obtained for total amount of GAGs, absolute content of CS and HS, and their relative percentages. Moreover, no differences were observed for CS structure confirming similar urine CS composition in BPS subjects and controls.. This study found no significant differences of BPS and control urine GAG levels and CS structure to allow use of these parameters as diagnostic markers for BPS diagnosis. Topics: Adult; Aged; Biomarkers; Case-Control Studies; Chondroitin Sulfates; Chromatography, High Pressure Liquid; Cystitis, Interstitial; Electrophoresis, Agar Gel; Female; Glycosaminoglycans; Heparitin Sulfate; Humans; Middle Aged	2011

Article

Year

Determination of urinary hexosamines for diagnosis of bladder pain syndrome.

International urogynecology journal, 2012, Volume: 23, Issue:10

Bladder pain syndrome (BPS) is a chronic disease characterized by urgency, bladder pain, and frequency, and urinary glycosaminoglycans are thought to reflect bladder epithelial deficiency in BPS. Sensitive and specific evaluation of total urinary glycosaminoglycans may be useful for the clinical diagnosis of BPS and its treatment.. A procedure for the simultaneous determination of glucosamine and galactosamine produced from urinary glycosaminoglycans has been performed in BPS patients and healthy subjects.. The total content of urinary hexosamines in BPS patients significantly increased by ~130% with the increase in glucosamine greater than galactosamine.. A significant increase in total hexosamines content and in particular in glucosamine belonging to urinary heparan sulfate was determined in BPS patients compared with controls. We propose HS and in particular its low-molecular mass fragments and glucosamine assay as useful markers for a biochemical diagnosis of BPS and for monitoring this syndrome.

Topics: Adult; Aged; Biomarkers; Case-Control Studies; Cystitis, Interstitial; Female; Galactosamine; Glucosamine; Heparitin Sulfate; Hexosamines; Humans; Middle Aged; Sensitivity and Specificity

2012

Fine structural characterization of chondroitin sulfate in urine of bladder pain syndrome subjects.

International urogynecology journal, 2011, Volume: 22, Issue:12

Urothelial glycosaminoglycans (GAGs) are decreased in bladder pain syndrome (BPS), and urinary GAGs are thought to reflect this deficiency. In previous researches, urine GAG levels were found increased, decreased, or similar between BPS and controls. Additionally, no study is available on the structure characterization of urinary chondroitin sulfate (CS) in BPS patients.. CS in the urine of BPS-affected patients and controls has been determined by specific electrophoresis, along with total GAGs and heparan sulfate (HS) percentage, and CS disaccharides have been quantified by high-performance liquid chromatography.. No significant differences were obtained for total amount of GAGs, absolute content of CS and HS, and their relative percentages. Moreover, no differences were observed for CS structure confirming similar urine CS composition in BPS subjects and controls.. This study found no significant differences of BPS and control urine GAG levels and CS structure to allow use of these parameters as diagnostic markers for BPS diagnosis.

Topics: Adult; Aged; Biomarkers; Case-Control Studies; Chondroitin Sulfates; Chromatography, High Pressure Liquid; Cystitis, Interstitial; Electrophoresis, Agar Gel; Female; Glycosaminoglycans; Heparitin Sulfate; Humans; Middle Aged

2011