heparitin-sulfate and Alopecia-Areata

Tenascin, a recently discovered extracellular matrix protein, was demonstrated in perifollicular connective tissue of normal human scalp using immunohistochemistry. Its localization was different from other well-known extracellular matrix components, like fibronectin, laminin and heparan sulphate proteoglycan. A comparison between alopecia areata and normal scalps did not reveal major qualitative differences, except for an increased expression near heavily infiltrated follicles.

Topics: Alopecia Areata; Cell Adhesion Molecules, Neuronal; Connective Tissue; Extracellular Matrix Proteins; Fibronectins; Hair; Heparitin Sulfate; Humans; Immunohistochemistry; Laminin; Scalp; Tenascin