hemiasterlin and Skin-Neoplasms

hemiasterlin has been researched along with Skin-Neoplasms* in 1 studies

Other Studies

1 other study(ies) available for hemiasterlin and Skin-Neoplasms

Article	Year
Targeting Human Cancer by a Glycosaminoglycan Binding Malaria Protein. Cancer cell, 2015, 10-12, Volume: 28, Issue:4 Plasmodium falciparum engineer infected erythrocytes to present the malarial protein, VAR2CSA, which binds a distinct type chondroitin sulfate (CS) exclusively expressed in the placenta. Here, we show that the same CS modification is present on a high proportion of malignant cells and that it can be specifically targeted by recombinant VAR2CSA (rVAR2). In tumors, placental-like CS chains are linked to a limited repertoire of cancer-associated proteoglycans including CD44 and CSPG4. The rVAR2 protein localizes to tumors in vivo and rVAR2 fused to diphtheria toxin or conjugated to hemiasterlin compounds strongly inhibits in vivo tumor cell growth and metastasis. Our data demonstrate how an evolutionarily refined parasite-derived protein can be exploited to target a common, but complex, malignancy-associated glycosaminoglycan modification. Topics: Animals; Antigens, Protozoan; Cell Line, Tumor; Chondroitin Sulfate Proteoglycans; Chondroitin Sulfates; Female; HEK293 Cells; Human Umbilical Vein Endothelial Cells; Humans; Hyaluronan Receptors; Melanoma, Experimental; Membrane Proteins; Mice; Molecular Targeted Therapy; Oligopeptides; Organ Specificity; Placenta; Pregnancy; Recombinant Proteins; Skin Neoplasms	2015

Article

Year

Targeting Human Cancer by a Glycosaminoglycan Binding Malaria Protein.

Cancer cell, 2015, 10-12, Volume: 28, Issue:4

Plasmodium falciparum engineer infected erythrocytes to present the malarial protein, VAR2CSA, which binds a distinct type chondroitin sulfate (CS) exclusively expressed in the placenta. Here, we show that the same CS modification is present on a high proportion of malignant cells and that it can be specifically targeted by recombinant VAR2CSA (rVAR2). In tumors, placental-like CS chains are linked to a limited repertoire of cancer-associated proteoglycans including CD44 and CSPG4. The rVAR2 protein localizes to tumors in vivo and rVAR2 fused to diphtheria toxin or conjugated to hemiasterlin compounds strongly inhibits in vivo tumor cell growth and metastasis. Our data demonstrate how an evolutionarily refined parasite-derived protein can be exploited to target a common, but complex, malignancy-associated glycosaminoglycan modification.

Topics: Animals; Antigens, Protozoan; Cell Line, Tumor; Chondroitin Sulfate Proteoglycans; Chondroitin Sulfates; Female; HEK293 Cells; Human Umbilical Vein Endothelial Cells; Humans; Hyaluronan Receptors; Melanoma, Experimental; Membrane Proteins; Mice; Molecular Targeted Therapy; Oligopeptides; Organ Specificity; Placenta; Pregnancy; Recombinant Proteins; Skin Neoplasms

2015