Page last updated: 2024-08-23

heme and Iron Overload

heme has been researched along with Iron Overload in 34 studies

Research

Studies (34)

Timeframe	Studies, this research(%)	All Research%
pre-1990	0 (0.00)	18.7374
1990's	3 (8.82)	18.2507
2000's	13 (38.24)	29.6817
2010's	14 (41.18)	24.3611
2020's	4 (11.76)	2.80

Authors

Authors	Studies
Armitage, AE; Drakesmith, H; Frost, JN; Teh, MR	1
Alves, FM; Ayton, S; Bush, AI; Caldow, MK; Chung, JD; Crouch, PJ; Hardee, JP; Hare, DJ; Koopman, R; Kysenius, K; Lynch, GS; Trieu, J	1
Abdullah, Y; Adlung, L; Altamura, S; Andrieux, G; Boehm, ME; Boerries, M; Busch, H; Chakraborty, S; Gröne, HJ; Helm, B; Kastl, P; Klingmüller, U; Lehmann, WD; Muckenthaler, MU; Schilling, M; Schwarzmüller, LE; Wagner, MC	1
Abe, K; Furusawa, S; Ide, T; Ikeda, M; Imai, H; Ishimaru, K; Koumura, T; Matsushima, S; Miyake, R; Miyamoto, HD; Tadokoro, T; Tsutsui, H; Tsutsui, Y; Watanabe, M; Yamada, KI	1
Hasuike, Y; Kuragano, T; Nagasawa, Y; Nakanishi, T; Nanami, M	1
Holmes-Hampton, G; Kim, KS; Maio, N; Rouault, TA; Singh, A	1
Ebata, Y; Hama, S; Ikeda, Y; Kawahara, A; Kogure, K; Kojima, C; Shiota, G; Shudo, K; Tsuchiya, H; Yoshikawa, O	1
Chang, Z; Hu, H; Hu, R; Huang, Y; Hui, L; Kong, X; Li, D; Li, L; Ruan, K; Shang, Y; Shen, J; Sheng, X; Wang, F; Wang, S; Wu, Q; Wu, Y; Xie, D; Xuan, Z; Yu, L	1
Kato, GJ; Leitman, S; Mendelsohn, L; Noguchi, CT; Perkins, A; Raghavachari, N; Rogers, H; Tallack, M; Taylor, JG; Wang, X; Yang, Y; Yau, YY	1
Aslan, M; Fanis, P; Kleanthous, M; Phylactides, M; Voskou, S	1
Bao, W; Bowers, K; Chavarro, JE; Hu, FB; Li, S; Tobias, DK; Zhang, C	1
Arosio, P; Gozzelino, R	1
Palmer, LD; Skaar, EP	1
Beaumont, C; de Franceschi, L; De Verneuil, H; Delaby, C; Deybach, JC; Ducrot, N; Ged, C; Gouya, L; Karim, Z; Lefebvre, T; Lettéron, P; Lyoumi, S; Millot, S; Moulouel, B; Pilard, N; Puy, H	1
Fader, KA; Kirby, MP; Markous, G; Matthews, J; Nault, R; Zacharewski, TR	1
Williams, DS	1
Levi, S; Rovida, E	1
Becker, EM; Huang, ML; Ponka, P; Richardson, DR; Suryo Rahmanto, Y; Whitnall, M	1
Ciudin, A; Hernández, C; Simó, R	1
Ganapathy, V; Gnana-Prakasam, JP; Martin, PM; Reddy, SK; Smith, SB; Veeranan-Karmegam, R	1
Fox, C; Olynyk, JK; Trinder, D; Vautier, G	1
Hankinson, SE; Liu, JM; Ma, J; Rifai, N; Stampfer, MJ; Willett, WC	1
Ascherio, A; Hu, FB; Jiang, R; Ma, J; Stampfer, MJ; Willett, WC	1
Aljama, P; Espinosa, M; López Rubio, F; Ortega, R; Sánchez, J; Santamaría, R; Torres, A	1
Anderson, GJ; Frazer, DM; McKie, AT; Smith, A; Vulpe, CD	1
Beaumont, C; Boileau, C; Camadro, JM; Da Silva, V; Deybach, JC; Flamme, M; Gouya, L; Grandchamp, B; Lamoril, J; Lyoumi, S; Malonova, E; Puy, H; Rose, C; Schmitt, C	1
Ackermann, GE; Balzan, R; Barut, BA; Brownlie, A; Cope, JJ; Corson, K; Donovan, A; Gwynn, B; Hersey, C; Kaplan, J; Lambert, AJ; Li, L; Minet, E; Paw, BH; Peters, LL; Shaw, GC; Traver, D; Trede, NS; Weiss, MJ; Wingert, RA; Zhou, Y; Zon, LI	1
Duricová, D; Krijt, J; Necas, E; Sefc, L; Vokurka, M	1
Arosio, P; Biasiotto, G; Cavadini, P; Corrado, M; Derosas, M; Ingrassia, R; Levi, S; Poli, M; Verardi, R; Zanella, I	1
Chernova, T; Clothier, B; Davies, R; Edwards, RE; Gant, TW; Greaves, P; Luo, J; Robinson, SW; Smith, AG	1
Worwood, M	1
Moos, T; Morgan, EH; Oates, PS	1
Konijn, AM; McKie, AT; Peters, TJ; Pountney, DJ; Raja, KB; Salisbury, JR; Simpson, RJ	1
Bacon, BR; Britton, RS; Fleming, RE; Jazwinska, EC; Roopenian, DC; Sly, WS; Sproule, TJ	1

Reviews

10 review(s) available for heme and Iron Overload

Article	Year
Misdistribution of iron and oxidative stress in chronic kidney disease. Free radical biology & medicine, 2019, Volume: 133 Topics: Aminolevulinic Acid; Anemia; Hematinics; Heme; Hepcidins; Humans; Inflammation; Iron; Iron Overload; Leptin; Mitochondria; Oxidative Stress; Renal Insufficiency, Chronic	2019
Oxidative stress in β-thalassaemia and sickle cell disease. Redox biology, 2015, Volume: 6 Topics: Anemia, Sickle Cell; Anion Exchange Protein 1, Erythrocyte; beta-Globins; beta-Thalassemia; Erythrocytes; Heme; Hemeproteins; Humans; Iron; Iron Overload; Oxidative Stress; Phosphatidylserines; Protein Stability; Reactive Oxygen Species; Reperfusion Injury; Thrombophilia	2015
Iron Homeostasis in Health and Disease. International journal of molecular sciences, 2016, Jan-20, Volume: 17, Issue:1 Topics: Aging; Anemia, Iron-Deficiency; Animals; Cation Transport Proteins; Gene Expression Regulation; Heme; Hemochromatosis; Hepcidins; Homeostasis; Humans; Iron; Iron Overload; Iron Regulatory Protein 1; Iron Regulatory Protein 2; Response Elements; Signal Transduction	2016
Transition Metals and Virulence in Bacteria. Annual review of genetics, 2016, Nov-23, Volume: 50 Topics: Animals; Bacteria; Bacterial Infections; Deficiency Diseases; Diet; Heme; Host-Pathogen Interactions; Humans; Iron; Iron Overload; Metals; Siderophores	2016
The role of iron in mitochondrial function. Biochimica et biophysica acta, 2009, Volume: 1790, Issue:7 Topics: Anemia, Sideroblastic; Animals; Friedreich Ataxia; Heme; Humans; Iron; Iron Overload; Iron-Sulfur Proteins; Mitochondria; Mitochondrial Proteins; Muscular Diseases	2009
The ins and outs of mitochondrial iron-loading: the metabolic defect in Friedreich's ataxia. Journal of molecular medicine (Berlin, Germany), 2010, Volume: 88, Issue:4 Topics: Animals; Cation Transport Proteins; Cytosol; Frataxin; Friedreich Ataxia; Heme; Humans; Iron; Iron Overload; Iron-Binding Proteins; Iron-Sulfur Proteins; Mice; Mitochondria; Models, Biological; Mutation; Receptors, Transferrin	2010
Iron overload in diabetic retinopathy: a cause or a consequence of impaired mechanisms? Experimental diabetes research, 2010, Volume: 2010 Topics: Cytokines; Diabetic Retinopathy; Heme; Homeostasis; Humans; Iron; Iron Overload; Oxidative Stress; Retina; Retinal Hemorrhage; Retinal Neurons	2010
Molecular pathogenesis of iron overload. Gut, 2002, Volume: 51, Issue:2 Topics: Enterocytes; Gene Expression; Heme; Hemochromatosis; Humans; Intestinal Absorption; Iron; Iron Overload; Liver; Liver Diseases; Models, Biological; Receptors, Transferrin	2002
Mechanisms of haem and non-haem iron absorption: lessons from inherited disorders of iron metabolism. Biometals : an international journal on the role of metal ions in biology, biochemistry, and medicine, 2005, Volume: 18, Issue:4 Topics: Absorption; Animals; Biological Transport; Cation Transport Proteins; Disease Models, Animal; Erythropoiesis; Heme; Hepatocytes; Humans; Intestinal Mucosa; Iron; Iron Metabolism Disorders; Iron Overload; Iron-Binding Proteins; Macrophages; Mice; Models, Biological; Mutation	2005
Influence of disease on iron status. The Proceedings of the Nutrition Society, 1997, Volume: 56, Issue:1B Topics: Anemia; Female; Heme; Humans; Iron; Iron Deficiencies; Iron Overload; Liver Diseases; Male; Nutritional Status	1997

Trials

1 trial(s) available for heme and Iron Overload

Article	Year
Heme-bound iron activates placenta growth factor in erythroid cells via erythroid Krüppel-like factor. Blood, 2014, Aug-07, Volume: 124, Issue:6 Topics: Adult; Anemia, Sickle Cell; Animals; Cell Differentiation; Erythroid Cells; Heme; Hemin; Humans; Hypertension, Pulmonary; Iron; Iron Overload; K562 Cells; Kruppel-Like Transcription Factors; Mice; Mice, Knockout; Placenta Growth Factor; Pregnancy Proteins; Promoter Regions, Genetic; RNA, Messenger	2014

Article

Year

Heme-bound iron activates placenta growth factor in erythroid cells via erythroid Krüppel-like factor.

Blood, 2014, Aug-07, Volume: 124, Issue:6

Topics: Adult; Anemia, Sickle Cell; Animals; Cell Differentiation; Erythroid Cells; Heme; Hemin; Humans; Hypertension, Pulmonary; Iron; Iron Overload; K562 Cells; Kruppel-Like Transcription Factors; Mice; Mice, Knockout; Placenta Growth Factor; Pregnancy Proteins; Promoter Regions, Genetic; RNA, Messenger

2014

Other Studies

23 other study(ies) available for heme and Iron Overload

Article	Year
Analysis of Iron and Iron-Interacting Protein Dynamics During T-Cell Activation. Frontiers in immunology, 2021, Volume: 12 Topics: Animals; Cells, Cultured; Datasets as Topic; Epigenesis, Genetic; Gene Ontology; Heme; Hepcidins; Humans; Iron; Iron Deficiencies; Iron Overload; Iron-Binding Proteins; Lymphocyte Activation; Lymphopoiesis; Mice; Mice, Knockout; Models, Biological; Proteome; T-Lymphocyte Subsets; Th17 Cells	2021
Iron overload and impaired iron handling contribute to the dystrophic pathology in models of Duchenne muscular dystrophy. Journal of cachexia, sarcopenia and muscle, 2022, Volume: 13, Issue:3 Topics: Animals; Deferiprone; Dystrophin; Ferritins; Fibrosis; Heme; Iron; Iron Chelating Agents; Iron Overload; Mice; Mice, Inbred mdx; Muscular Dystrophy, Duchenne; Reactive Oxygen Species	2022
Erythropoietin-driven dynamic proteome adaptations during erythropoiesis prevent iron overload in the developing embryo. Cell reports, 2022, 09-20, Volume: 40, Issue:12 Topics: Erythropoiesis; Erythropoietin; Female; Heme; Hemoglobins; Humans; Iron; Iron Overload; Pregnancy; Proteome; Sulfur	2022
Doxorubicin causes ferroptosis and cardiotoxicity by intercalating into mitochondrial DNA and disrupting Alas1-dependent heme synthesis. Science signaling, 2022, Volume: 15, Issue:758 Topics: Aminolevulinic Acid; Animals; Cardiotoxicity; DNA, Mitochondrial; Doxorubicin; Ferroptosis; Heme; Iron; Iron Overload; Mice; Mitochondria; Myocytes, Cardiac	2022
Dimeric ferrochelatase bridges ABCB7 and ABCB10 homodimers in an architecturally defined molecular complex required for heme biosynthesis. Haematologica, 2019, Volume: 104, Issue:9 Topics: Anemia, Sideroblastic; ATP-Binding Cassette Transporters; Cation Transport Proteins; Cell Line; Cytosol; DNA Mutational Analysis; Ferrochelatase; Genetic Diseases, X-Linked; HEK293 Cells; HeLa Cells; Heme; Humans; Iron; Iron Overload; Iron Regulatory Protein 2; Mitochondria; Mitochondrial Proteins; Phenotype; Protein Multimerization	2019
A retinoic acid receptor agonist tamibarotene suppresses iron accumulation in the liver. Obesity (Silver Spring, Md.), 2013, Volume: 21, Issue:1 Topics: Animals; Benzoates; Biological Transport; Blood Glucose; Cation Transport Proteins; Gene Expression; Heme; Hemochromatosis; Insulin Resistance; Iron; Iron Overload; Lipids; Liver; Male; Mice; Mice, Inbred Strains; Oxidative Stress; Receptors, Retinoic Acid; Retinoic Acid Receptor alpha; Tetrahydronaphthalenes	2013
Iron metabolism regulates p53 signaling through direct heme-p53 interaction and modulation of p53 localization, stability, and function. Cell reports, 2014, Apr-10, Volume: 7, Issue:1 Topics: Active Transport, Cell Nucleus; Amino Acid Sequence; Animals; Carcinogenesis; Cell Line, Tumor; Cytosol; Down-Regulation; Heme; Humans; Hypoxia-Inducible Factor 1, alpha Subunit; Iron; Iron Overload; Male; Mice; Mice, Inbred C57BL; Mice, Knockout; Models, Molecular; Molecular Sequence Data; Sequence Homology, Amino Acid; Signal Transduction; Transcription, Genetic; Transcriptional Activation; Tumor Cells, Cultured; Tumor Suppressor Protein p53	2014
Long-term risk of type 2 diabetes in relation to habitual iron intake in women with a history of gestational diabetes: a prospective cohort study. The American journal of clinical nutrition, 2016, Volume: 103, Issue:2 Topics: Adult; Cohort Studies; Diabetes Mellitus, Type 2; Diabetes, Gestational; Dietary Supplements; Disease Progression; Female; Follow-Up Studies; Heme; Humans; Incidence; Iron Overload; Iron, Dietary; Meat; Nurses; Nutrition Surveys; Pregnancy; Proportional Hazards Models; Prospective Studies; Risk; United States; Young Adult	2016
Hemolytic anemia repressed hepcidin level without hepatocyte iron overload: lesson from Günther disease model. Haematologica, 2017, Volume: 102, Issue:2 Topics: Anemia, Hemolytic; Animals; Apoptosis; Biological Transport; Biomarkers; Disease Models, Animal; Erythrocytes; Erythropoiesis; Gene Expression; Heme; Hepatocytes; Hepcidins; Humans; Iron; Iron Overload; Macrophages; Mice; Mice, Knockout; Mice, Transgenic; Spleen; Stress, Physiological	2017
Convergence of hepcidin deficiency, systemic iron overloading, heme accumulation, and REV-ERBα/β activation in aryl hydrocarbon receptor-elicited hepatotoxicity. Toxicology and applied pharmacology, 2017, 04-15, Volume: 321 Topics: Animals; Dose-Response Relationship, Drug; Environmental Pollutants; Female; Heme; Hepcidins; Iron Overload; Liver; Male; Mice; Mice, Inbred C57BL; Nuclear Receptor Subfamily 1, Group D, Member 1; Polychlorinated Dibenzodioxins; Receptors, Aryl Hydrocarbon; Receptors, Cytoplasmic and Nuclear; Repressor Proteins	2017
Porphyria cutanea tarda. Journal of insurance medicine (New York, N.Y.), 2007, Volume: 39, Issue:4 Topics: Heme; Humans; Iron Overload; Porphyria Cutanea Tarda; Uroporphyrinogen Decarboxylase	2007
Polarized distribution of heme transporters in retinal pigment epithelium and their regulation in the iron-overload disease hemochromatosis. Investigative ophthalmology & visual science, 2011, Nov-29, Volume: 52, Issue:12 Topics: Animals; ATP Binding Cassette Transporter, Subfamily G, Member 2; ATP-Binding Cassette Transporters; Blotting, Western; Cells, Cultured; Disease Models, Animal; Female; Fluorescent Antibody Technique, Indirect; Gene Expression Regulation; Heme; Hemochromatosis; Herpesviridae Infections; Iron; Iron Overload; Male; Membrane Transport Proteins; Metalloporphyrins; Mice; Mice, Inbred BALB C; Mice, Inbred C57BL; Mice, Knockout; Muromegalovirus; Proton-Coupled Folate Transporter; Real-Time Polymerase Chain Reaction; Receptors, Virus; Retina; Retinal Pigment Epithelium; RNA, Messenger	2011
Body iron stores and their determinants in healthy postmenopausal US women. The American journal of clinical nutrition, 2003, Volume: 78, Issue:6 Topics: Adult; Aged; Alcohol Drinking; Cohort Studies; Diet; Female; Ferritins; Health Surveys; Heme; Humans; Iron; Iron Overload; Iron, Dietary; Linear Models; Logistic Models; Middle Aged; Nutritional Status; Postmenopause; Prospective Studies; Surveys and Questionnaires; United States	2003
Dietary iron intake and blood donations in relation to risk of type 2 diabetes in men: a prospective cohort study. The American journal of clinical nutrition, 2004, Volume: 79, Issue:1 Topics: Adult; Aged; Blood Donors; Diabetes Mellitus, Type 2; Heme; Humans; Iron Overload; Iron, Dietary; Male; Meat; Middle Aged; Prospective Studies	2004
[Acute renal failure in a patient with myelodysplastic syndrome and paroxysmal nocturnal hemoglobinuria phenotype]. Nefrologia : publicacion oficial de la Sociedad Espanola Nefrologia, 2004, Volume: 24 Suppl 3 Topics: Acute Kidney Injury; Aged; Biopsy; Diabetes Mellitus, Type 2; Heme; Hemoglobinuria, Paroxysmal; Hemolysis; Humans; Iron; Iron Overload; Kidney Tubular Necrosis, Acute; Kidney Tubules; Male; Myocardial Ischemia; Myoglobin; Oliguria; Phenotype; Rhabdomyolysis	2004
Mutations in human CPO gene predict clinical expression of either hepatic hereditary coproporphyria or erythropoietic harderoporphyria. Human molecular genetics, 2005, Oct-15, Volume: 14, Issue:20 Topics: Amino Acid Sequence; Coproporphyria, Hereditary; Coproporphyrinogen Oxidase; Exons; Gene Expression; Heme; Humans; Iron Overload; Molecular Sequence Data; Mutation; Mutation, Missense; Pedigree; Porphyrias, Hepatic; Protein Structure, Secondary; Sequence Homology	2005
Mitoferrin is essential for erythroid iron assimilation. Nature, 2006, Mar-02, Volume: 440, Issue:7080 Topics: Anemia; Animals; Cation Transport Proteins; Cell Differentiation; Conserved Sequence; Erythroblasts; Gene Expression Regulation; Genetic Complementation Test; Heme; Homeostasis; Humans; Iron; Iron Overload; Iron-Sulfur Proteins; Membrane Transport Proteins; Mice; Mitochondria; Mitochondrial Proteins; Molecular Sequence Data; Mutation; Phylogeny; Saccharomyces cerevisiae; Saccharomyces cerevisiae Proteins; Stem Cells; Zebrafish; Zebrafish Proteins	2006
Effect of lipopolysaccharide and bleeding on the expression of intestinal proteins involved in iron and haem transport. Folia biologica, 2006, Volume: 52, Issue:1-2 Topics: Animals; Antimicrobial Cationic Peptides; GPI-Linked Proteins; Heme; Hemochromatosis Protein; Hepcidins; Iron; Iron Deficiencies; Iron Overload; Lipopolysaccharides; Liver; Male; Membrane Proteins; Membrane Transport Proteins; Mice; Mice, Inbred C57BL; Proton-Coupled Folate Transporter; RNA, Messenger	2006
RNA silencing of the mitochondrial ABCB7 transporter in HeLa cells causes an iron-deficient phenotype with mitochondrial iron overload. Blood, 2007, Apr-15, Volume: 109, Issue:8 Topics: Anemia, Iron-Deficiency; Anemia, Sideroblastic; Ataxia; ATP-Binding Cassette Transporters; Biological Transport; Cytoplasm; Genetic Diseases, X-Linked; HeLa Cells; Heme; Humans; Iron; Iron Overload; Mitochondria; Mitochondrial Proteins; Phenotype; RNA Interference; RNA, Small Interfering	2007
Essential role of the AH receptor in the dysfunction of heme metabolism induced by 2,3,7,8-tetrachlorodibenzo-p-dioxin. Chemical research in toxicology, 2008, Volume: 21, Issue:2 Topics: Aminolevulinic Acid; Animals; Cytochrome P-450 CYP1A2; Disease Models, Animal; Environmental Pollutants; Female; Gene Expression; Gene Expression Profiling; Gene Silencing; Heme; Iron Overload; Liver; Male; Mice; Mice, Inbred C57BL; Mice, Inbred DBA; Mice, Knockout; Oxidative Stress; Polychlorinated Dibenzodioxins; Porphyria Cutanea Tarda; Receptors, Aryl Hydrocarbon; Up-Regulation; Uroporphyrins	2008
Iron-independent neuronal expression of transferrin receptor mRNA in the rat. Brain research. Molecular brain research, 1999, Oct-01, Volume: 72, Issue:2 Topics: Animals; Fetal Diseases; Gene Expression Regulation; Habenula; Heme; Iron; Iron Deficiencies; Iron Overload; Nerve Tissue Proteins; Neurons; Nitric Oxide; Rats; Receptors, Transferrin; RNA Processing, Post-Transcriptional; RNA, Messenger; Transferrin	1999
Iron proteins of duodenal enterocytes isolated from mice with genetically and experimentally altered iron metabolism. British journal of haematology, 1999, Volume: 105, Issue:4 Topics: Animals; Duodenum; Heme; Hemoglobins; Intestinal Absorption; Iron; Iron Metabolism Disorders; Iron Overload; Mice; Mice, Inbred BALB C; Transferrin	1999
Naturally variant autosomal and sex-linked loci determine the severity of iron overload in beta 2-microglobulin-deficient mice. Proceedings of the National Academy of Sciences of the United States of America, 2001, Apr-24, Volume: 98, Issue:9 Topics: Aging; Animals; beta 2-Microglobulin; Crosses, Genetic; Female; Genetic Linkage; Genetic Predisposition to Disease; Genetic Variation; Heme; Hemochromatosis; Hemochromatosis Protein; Histocompatibility Antigens Class I; HLA Antigens; Iron; Iron Overload; Liver; Male; Membrane Proteins; Mice; Mice, Inbred Strains; Phenotype; Sex Characteristics; Sex Chromosomes	2001