Page last updated: 2024-08-23

heme and Infections, Plasmodium

heme has been researched along with Infections, Plasmodium in 107 studies

Research

Studies (107)

Timeframe	Studies, this research(%)	All Research%
pre-1990	16 (14.95)	18.7374
1990's	14 (13.08)	18.2507
2000's	25 (23.36)	29.6817
2010's	35 (32.71)	24.3611
2020's	17 (15.89)	2.80

Authors

Authors	Studies
Mali, SN; Pandey, A	1
Adjei, A; Botchway, F; Cespedes, JC; Chambliss, C; Harbuzariu, A; Jolly, P; Liu, M; Nti, AM; Onyekaba, J; Salifu, H; Stiles, JK	1
Baptista, V; Calçada, C; Catarino, SO; Costa, MS; Gil, JP; Silva, M; Veiga, MI	1
Matz, JM	1
Adhikari, N; Bhattacharjee, M; Gupta, D; Pamnani, S; Panda, A; Rizvi, Z; Shehzad, S; Sijwali, PS; Sudhakar, R	1
Araujo-Neto, JH; Chibale, K; Dziwornu, GA; Moreira, DRM; Quadros, HC; Sousa, CC	1
Dzikowski, R; Elbaum, M; Leiserowitz, L; Mullick, D; Rechav, K; Regev-Rudzki, N	1
Bailly, C; Hénichart, JP	1
Bashi, A; Botchway, F; Driss, A; Harp, KO; Hood, JL; Stiles, JK; Thomas, JJ; Thompson, WE; Wilson, MD	1
Makde, RD; Singh, R; Srihari, V	1
Adeniyi, AA; Awolade, P; Kumar, S; Kumar, V; Legac, J; Rani, A; Rosenthal, PJ; Singh, P	1
Kerchberger, VE; Ware, LB	1
Abrahams, JP; Blackman, MJ; Blum, TB; Burrell, A; Collinson, LM; Drepper, B; Martin, P; Matuschewski, K; Matz, JM; Stach, T; van Genderen, E	1
Pádua, TA; Souza, MC	1
Arwati, H; Basuki, DR; Ekasari, W; Wahyuni, TS	1
Aratikatla, EK; Asad, M; Bhattacharya, AK; Datta, G; Kalamuddin, M; Malhotra, P; Mohmmed, A; Rana, KC; Sundararaman, S	1
de Villiers, KA; Egan, TJ	1
Kumar, P; Manhas, A; Mishra, S; Pal, A; Sashidhara, KV; Shanker, K; Singh, SP; Singh, SV; Srivastava, K; Tiwari, N	1
Goodman, CD; McFadden, GI; Rathnapala, UL	1
Sullivan, DJ	1
Alano, P; Avery, VM; Combrinck, JM; Corey, VC; Delves, MJ; Duffy, S; Egan, TJ; Ferreira, PE; Fidock, DA; Gulati, S; Henrich, PP; Hoffman, SL; Kumar, TRS; Lee Sim, K; Li, T; Lieberman, OJ; Lucantoni, L; Murithi, JM; Ng, CL; Rubiano, K; Ruecker, A; Siciliano, G; Sinden, RE; Vanaerschot, M; Veiga, MI; Winzeler, EA	1
Goldberg, DE; Sigala, PA	2
Brewer, J; Faulds, K; Frame, L; Graham, D; Lee, R	1
Anderson, DA; Andrew, D; Chernenko, T; Diem, M; Doerig, C; Evans, C; Garcia-Bustos, J; Heraud, P; Hudson, A; Marzec, KM; Matthäus, C; McNaughton, D; Miljkovic, M; Perez-Guaita, D; Richards, JS; Wood, BR	1
Abiri, A	1
Ademolue, TW; Agarwal, A; Bank, C; Blankenhaus, B; Bolisetty, S; Braza, F; Cardoso, S; Carlos, AR; Del Barrio, L; Faísca, P; Gjini, E; Gouveia, Z; Gozzelino, R; Jeney, V; Martins, R; Ramos, S; Rebelo, S; Ribeiro, A; Soares, MP; Sundaram, B; Trujillo, D; Zarjou, A	1
Benoit-Vical, F; Liu, Y; Meunier, B; Robert, A	1
Coban, C; Hobro, AJ; Konishi, A; Smith, NI	1
Benoit-Vical, F; Claparols, C; Robert, A; Witkowski, B	1
Fong, KY; Wright, DW	1
Cheu, KW; Coghi, P; Haynes, RK; Monti, D; N'Da, D	1
Braam, J; Campbell, KM; Constantinou, PE; Lapotko, DO; Lukianova-Hleb, EY; Olson, JS; Sullivan, DJ; Ware, RE	1
Choudhury, TP; Gupta, K; Gupta, L; Kajla, M; Kakani, P; Kumar, S	1
Conroy, AL; Elphinstone, RE; Hawkes, M; Hermann, L; John, CC; Kain, KC; Liles, WC; Namasopo, S; Warren, HS	1
Hassana, S; Liu, M; Stiles, JK	1
Agarwal, P; Ahmad, H; Dola, VR; Dwivedi, AK; Haq, W; Katti, SB; Puri, SK; Raju, KS; Rashid, M; Soni, A; Srivastava, K; Wahajuddin, M	1
Ademolue, TW; Amodu, OK; Awandare, GA	1
Benoit-Vical, F; Bousejra-El Garah, F; Claparols, C; Meunier, B; Robert, A	1
Balla, G; Balla, J; Ferreira, A; Jeney, V; Soares, MP	1
Harada, S; Hirayama, K; Huy, NT; Kamei, K; Nhien, NT; Oida, T; Trang, DT; Uyen, DT	1
Beattie, MJ; Clardy, J; Cortese, JF; Martyn, DC; Patel, V; Ramirez, AP; Rush, MA; Woerpel, KA	1
Bambal, RB; Bates, M; Berry, N; Biagini, GA; Bonar-Law, R; Bray, PG; Brigandi, RA; Davis, CB; Gargallo, DV; Gibbons, P; Gomez-delas-Heras, FM; Gresham, SL; Hart, TK; Hindley, S; Lawrence, RM; Maggs, JL; Mukhtar, A; O'Neill, PM; Park, BK; Roberts, P; Shone, AE; Stocks, PA; Ward, SA; Winstanley, PA	1
Chora, A; Coutinho, A; Ferreira, A; Gozzelino, R; Larsen, R; Penido, C; Rebelo, S; Seixas, E; Silva, G; Smith, NR; Soares, MP	1
Medzhitov, R	1
Chies, JA; Garcia-Santos, D	1
Brun, R; Burgess, SJ; Kelly, JX; Liebmann, K; Peyton, DH; Shomloo, S; Wittlin, S	1
Gozzelino, R; Soares, MP	1
Cunnington, AJ; de Souza, JB; Riley, EM; Walther, M	1
MacLennan, CA	1
Andrade, BB; Barral-Netto, M; Borges, VM; Gonçalves, MS; Luz, NF; Mendonça, VR; Santos, NJ	1
Bouquet, J; Chevalley, S; Deharo, E; Jullian, V; Rivaud, M; Valentin, A	1
Haq, W; Katti, SB; Puri, SK; Solomon, VR; Srivastava, K	1
Amodu, AS; Battle, M; Hibbert, JM; Liu, M; Ofori-Acquah, SF; Patrickson, J; Pitts, S; Stiles, JK	1
Alam, A; Bandyopadhyay, U; Bindu, S; Das, SK; Dey, S; Goyal, M; Iqbal, MS; Pal, C; Panda, G; Singh, P	1
Alam, A; Bandyopadhyay, U; Bindu, S; Dey, S; Goyal, M; Iqbal, MS; Kumar, R; Pal, C; Sarkar, S	1
Als-Nielsen, J; Berthing, T; Dierolf, M; Hviid, L; Kapishnikov, S; Leiserowitz, L; Menzel, A; Pfeiffer, F	1
Bhattacharyya, KD; Goldschmidt, BS; Samson, EB; Sudduth, AS; Viator, JA; Whiteside, PJ	1
Barboza, R; Barreto, CR; Braga, TT; Câmara, NO; Castoldi, A; Cenedeze, MA; Correa-Costa, M; D'Império-Lima, MR; Elias, RM; Figueiredo-Neto, AM; Gonçalves, GM; Hayashida, CY; Hyane, MI; Keller, AC; Marinho, CR; Pacheco-Silva, A; Reis, MA; Rios, FJ; Silva, RC	1
Mann, M	1
Kitamuro, T; Shibahara, S; Takahashi, K	1
Wellems, TE	1
Chauhan, VS; Kannan, R; Sahal, D	1
Padmanaban, G	1
RUDZINSKA, MA; TRAGER, W	1
CANTRELL, WF; SCHUELER, FW	1
Basilico, N; Mondani, M; Monti, D; Olliaro, P; Parapini, S; Taramelli, D	1
Demirev, PA	1
Lieber, MJ; Luckhart, S; Vodovotz, Y; Zamora, R	1
Carney, CK; Miller, CM; Schrimpe, AC; Wright, DW	1
Domínguez, JN; Gamboa de Domínguez, N; Gut, J; León, C; Rodrigues, J; Rosenthal, PJ	1
Alizadeh-Shekalgourabi, S; Auparakkitanon, S; Carr, P; Dascombe, MJ; Drew, MG; Dyas, AM; Evans, PG; Ismail, FM; Lloyd, M; Morris, H; Moule, WA; Wilairat, P	1
Benoit-Vical, F; Claparols, C; Meunier, B; Robert, A	1
Nagaraj, VA; Padmanaban, G; Rangarajan, PN	1
Berry, N; Biagini, GA; Bonar-Law, R; Bray, PG; Fisher, N; Meunier, B; O'Neill, PM; Owen, A; Stocks, PA; Ward, SA; Williams, DP	1
Pollack, S	1
Fitch, CD	3
Chevli, R; Dutta, P; Fitch, CD; Kanjananggulpan, P	1
Eaton, JW; Rock, LM; Wood, PA	1
Banyal, HS; Fitch, CD	1
Demel, RA; Ginsburg, H	1
Chou, AC; Fitch, CD	1
Bendrat, K; Berger, BJ; Cerami, A	1
Pandey, VC; Puri, SK; Srivastava, P	1
Eaton, JW; Wood, PA	1
Dutta, GP; Pandey, VC; Puri, SK; Srivastava, P	1
Bhaduri, AP; Pandey, VC; Srivastava, R	1
Basilico, N; Ghione, M; Grande, R; Monti, D; Olliaro, P; Pagani, E; Taramelli, D	1
Atamna, H; Deharo, E; Ginsburg, H; Krugliak, M; Pescarmona, G; Shalmiev, G	1
Adams, PA; Berman, PA; Egan, TJ; Marsh, PJ; Silver, J	1
Kamboj, KK; Sharma, GD	1
Pandey, AV; Tekwani, BL	1
Raynes, K	1
Padmanaban, G; Rangarajan, PN	1
Chauhan, VS; Pandey, AV; Puri, SK; Singh, N; Tekwani, BL	1
Bonday, ZQ; Dhanasekaran, S; Padmanaban, G; Rangarajan, PN	1
Linck, R; Wright, DW; Ziegler, J	1
Garg, SK; Tekwani, BL; Tripathi, AK	1
Berger, E; Eaton, JW; Eckman, JR; Engel, RR; Modler, S	1
Pizzolato, P	1
Dutta, GP; Pandey, VC; Sahni, SK; Saxena, N; Tekwani, BL	1
Fitch, CD; Kanjananggulpan, P	1
Fitch, CD; Janney, SK; Joist, JJ	1
Pimstone, NR	1
Aviado, DM; Kishimoto, T; Oskoui, M	1

Reviews

24 review(s) available for heme and Infections, Plasmodium

Article	Year
Hemozoin (beta-hematin) Formation Inhibitors: Promising Target for the Development of New Antimalarials: Current Update and Future Prospect. Combinatorial chemistry & high throughput screening, 2022, Volume: 25, Issue:11 Topics: Antimalarials; Heme; Hemeproteins; Hemoglobins; Humans; Malaria; Plant Extracts; Plasmodium falciparum	2022
The Future in Sensing Technologies for Malaria Surveillance: A Review of Hemozoin-Based Diagnosis. ACS sensors, 2021, 11-26, Volume: 6, Issue:11 Topics: Heme; Hemeproteins; Humans; Malaria; Microscopy	2021
Plasmodium's bottomless pit: properties and functions of the malaria parasite's digestive vacuole. Trends in parasitology, 2022, Volume: 38, Issue:7 Topics: Animals; Antimalarials; Heme; Hemoglobins; Humans; Malaria; Parasites; Plasmodium falciparum; Vacuoles	2022
Advocacy for the Medicinal Plant Molecules (Basel, Switzerland), 2022, Sep-21, Volume: 27, Issue:19 Topics: Annonaceae; Antimalarials; Antioxidants; Aporphines; Benzylisoquinolines; Dioxanes; Ferrous Compounds; Flavonoids; Folic Acid Antagonists; Heme; Humans; Iron; Ketones; Malaria; Peroxides; Plant Extracts; Plants, Medicinal; Plasmodium falciparum; Sesquiterpenes	2022
The Role of Circulating Cell-Free Hemoglobin in Sepsis-Associated Acute Kidney Injury. Seminars in nephrology, 2020, Volume: 40, Issue:2 Topics: Acetaminophen; Acute Kidney Injury; Anemia, Sickle Cell; Animals; Coronary Artery Bypass; Disseminated Intravascular Coagulation; Eryptosis; Erythrocyte Deformability; Haptoglobins; Heme; Hemoglobins; Hemolysis; Hemopexin; Humans; Kidney Tubules; Malaria; Nitric Oxide; Oxidative Stress; Reactive Oxygen Species; Sepsis; Transfusion Reaction	2020
Heme on Pulmonary Malaria: Friend or Foe? Frontiers in immunology, 2020, Volume: 11 Topics: Acute Lung Injury; Animals; Heme; Hemolysis; Malaria	2020
Heme Detoxification in the Malaria Parasite: A Target for Antimalarial Drug Development. Accounts of chemical research, 2021, 06-01, Volume: 54, Issue:11 Topics: Animals; Antimalarials; Drug Development; Heme; Humans; Malaria; Parasitic Sensitivity Tests; Plasmodium falciparum	2021
Plasmodium heme biosynthesis: To be or not to be essential? PLoS pathogens, 2017, Volume: 13, Issue:9 Topics: Animals; Heme; Host-Parasite Interactions; Humans; Malaria; Plasmodium falciparum	2017
Parasites under the Spotlight: Applications of Vibrational Spectroscopy to Malaria Research. Chemical reviews, 2018, 06-13, Volume: 118, Issue:11 Topics: Animals; Erythrocytes; Heme; Hemeproteins; Humans; Malaria; Plasmodium; Spectroscopy, Fourier Transform Infrared; Spectrum Analysis, Raman; Vibration	2018
Small Molecules: The Past or the Future in Drug Innovation? Metal ions in life sciences, 2019, Jan-14, Volume: 19 Topics: Alzheimer Disease; Antimalarials; Artemisinins; Copper; Drug Design; Heme; Humans; Iron; Malaria; Schistosomiasis	2019
Hemozoin and antimalarial drug discovery. Future medicinal chemistry, 2013, Volume: 5, Issue:12 Topics: Animals; Antimalarials; Drug Evaluation, Preclinical; Heme; Hemeproteins; High-Throughput Screening Assays; Humans; Malaria; Plasmodium falciparum	2013
Considerations on the mechanism of action of artemisinin antimalarials: part 1--the 'carbon radical' and 'heme' hypotheses. Infectious disorders drug targets, 2013, Volume: 13, Issue:4 Topics: Animals; Antimalarials; Artemisinins; Carbon; Heme; Humans; Malaria	2013
The peculiarities and paradoxes of Plasmodium heme metabolism. Annual review of microbiology, 2014, Volume: 68 Topics: Animals; Heme; Humans; Malaria; Plasmodium	2014
A central role for free heme in the pathogenesis of severe malaria: the missing link? Journal of molecular medicine (Berlin, Germany), 2008, Volume: 86, Issue:10 Topics: Animals; Carbon Monoxide; Disease Models, Animal; Heme; Heme Oxygenase-1; Hemoglobins; Humans; Malaria; Malaria, Cerebral; Models, Biological	2008
Heme degradation and human disease: diversity is the soul of life. Antioxidants & redox signaling, 2002, Volume: 4, Issue:4 Topics: Animals; Antioxidants; Bilirubin; Carbon Monoxide; Cardiovascular Diseases; Crigler-Najjar Syndrome; Gene Expression Regulation, Enzymologic; Gilbert Disease; Glucuronosyltransferase; Heme; Heme Oxygenase (Decyclizing); Heme Oxygenase-1; Hepatocytes; Humans; Infant, Newborn; Isoenzymes; Jaundice, Neonatal; Malaria; Membrane Proteins; Nervous System Diseases; Oxygen	2002
Drug targets in malaria parasites. Advances in biochemical engineering/biotechnology, 2003, Volume: 84 Topics: Animals; Antimalarials; Drug Delivery Systems; Drug Design; Drug Resistance; Heme; Humans; India; Malaria; Metabolism; Plasmodium; Plasmodium falciparum; Plasmodium vivax	2003
Mass spectrometry for malaria diagnosis. Expert review of molecular diagnostics, 2004, Volume: 4, Issue:6 Topics: Animals; Biomarkers; Heme; Humans; Malaria; Mass Spectrometry; Molecular Structure	2004
Cross-talk between nitric oxide and transforming growth factor-beta1 in malaria. Current molecular medicine, 2004, Volume: 4, Issue:7 Topics: Animals; Anopheles; Cytokines; Heme; Humans; Insect Proteins; Malaria; Nitric Oxide; Nitric Oxide Synthase; Nitric Oxide Synthase Type II; Nitrogen Oxides; Plasmodium; Signal Transduction; Transforming Growth Factor beta; Transforming Growth Factor beta1	2004
Involvement of heme in the antimalarial action of chloroquine. Transactions of the American Clinical and Climatological Association, 1998, Volume: 109 Topics: Animals; Antimalarials; Chloroquine; Digestion; Drug Resistance; Erythrocytes; Heme; Hemeproteins; Hemoglobins; Humans; Hydrogen-Ion Concentration; In Vitro Techniques; Malaria; Mice; Plasmodium; Vacuoles	1998
Bisquinoline antimalarials: their role in malaria chemotherapy. International journal for parasitology, 1999, Volume: 29, Issue:3 Topics: Animals; Antimalarials; Drug Design; Drug Resistance; Heme; Hemeproteins; Humans; Malaria; Plasmodium; Quinolines	1999
Heme metabolism of Plasmodium is a major antimalarial target. Biochemical and biophysical research communications, 2000, Feb-24, Volume: 268, Issue:3 Topics: 5-Aminolevulinate Synthetase; Animals; Antimalarials; Chloroquine; Erythrocytes; Heme; Humans; Malaria; Models, Biological; Plasmodium; Porphobilinogen Synthase	2000
Heme Aggregation inhibitors: antimalarial drugs targeting an essential biomineralization process. Current medicinal chemistry, 2001, Volume: 8, Issue:2 Topics: Animals; Antimalarials; Heme; Humans; Malaria; Minerals	2001
Ferriprotoporphyrin IX: role in chloroquine susceptibility and resistance in malaria. Progress in clinical and biological research, 1989, Volume: 313 Topics: Animals; Chloroquine; Drug Resistance; Erythrocytes; Heme; Hemin; Hemoglobins; Malaria; Plasmodium; Verapamil	1989
Renal degradation of hemoglobin. Seminars in hematology, 1972, Volume: 9, Issue:1 Topics: Amino Acids; Anemia, Hemolytic; Anemia, Sickle Cell; Animals; Bilirubin; Carbon Isotopes; Carbon Monoxide; Glomerular Filtration Rate; Haptoglobins; Heart Valve Prosthesis; Heme; Hemoglobins; Hemoglobinuria, Paroxysmal; Humans; Iron; Iron Isotopes; Kidney; Malaria; Microsomes; Oxygenases; Protein Binding; Rats; Thalassemia	1972

Other Studies

83 other study(ies) available for heme and Infections, Plasmodium

Article	Year
Effects of Iron Supplements on Heme Scavengers in Pregnancy. The American journal of tropical medicine and hygiene, 2021, 09-27, Volume: 105, Issue:5 Topics: Adolescent; Adult; Anemia, Iron-Deficiency; Cross-Sectional Studies; Dietary Supplements; Female; Free Radical Scavengers; Ghana; Heme; Humans; Iron; Malaria; Pregnancy; Pregnancy Complications; Young Adult	2021
Bazedoxifene, a Postmenopausal Drug, Acts as an Antimalarial and Inhibits Hemozoin Formation. Microbiology spectrum, 2022, 06-29, Volume: 10, Issue:3 Topics: Animals; Antimalarials; Female; Heme; Hemeproteins; Hemoglobins; Humans; Indoles; Malaria; Malaria, Falciparum; Male; Mice; Neoplasms; Osteoporosis, Postmenopausal; Plasmodium falciparum; Postmenopause; Raloxifene Hydrochloride; Selective Estrogen Receptor Modulators; Tamoxifen	2022
Antimalarial Pyrido[1,2- ACS infectious diseases, 2022, 08-12, Volume: 8, Issue:8 Topics: Aminoquinolines; Animals; Antimalarials; Antiparasitic Agents; Benzimidazoles; Chloroquine; Folic Acid Antagonists; Heme; Malaria; Mice; Plasmodium falciparum	2022
Diffraction contrast in cryo-scanning transmission electron tomography reveals the boundary of hemozoin crystals Faraday discussions, 2022, 11-08, Volume: 240, Issue:0 Topics: Electron Microscope Tomography; Heme; Humans; Lipids; Malaria	2022
MiR-451a and let-7i-5p loaded extracellular vesicles attenuate heme-induced inflammation in hiPSC-derived endothelial cells. Frontiers in immunology, 2022, Volume: 13 Topics: Cytokines; Endothelial Cells; Extracellular Vesicles; Heme; Hemolysis; Humans; Induced Pluripotent Stem Cells; Inflammation; Malaria; MicroRNAs; Plasmodium	2022
ACS infectious diseases, 2023, 08-11, Volume: 9, Issue:8 Topics: Antimalarials; Chloroquine; Heme; Humans; Malaria	2023
Design, synthesis, heme binding and density functional theory studies of isoindoline-dione-4-aminoquinolines as potential antiplasmodials. Future medicinal chemistry, 2020, Volume: 12, Issue:3 Topics: Aminoquinolines; Antimalarials; Binding Sites; Density Functional Theory; Drug Design; Heme; Humans; Isoindoles; Malaria; Microwaves; Molecular Structure; Parasitic Sensitivity Tests; Plasmodium falciparum	2020
A lipocalin mediates unidirectional heme biomineralization in malaria parasites. Proceedings of the National Academy of Sciences of the United States of America, 2020, 07-14, Volume: 117, Issue:28 Topics: Amino Acid Sequence; Animals; Heme; Hemeproteins; Humans; Lipocalins; Malaria; Mice; Plasmodium berghei; Plasmodium falciparum; Protozoan Proteins	2020
Antiplasmodial activity of Ethanolic extract of Cassia spectabilis DC leaf and its inhibition effect in Heme detoxification. BMC complementary medicine and therapies, 2021, Feb-19, Volume: 21, Issue:1 Topics: Animals; Antimalarials; Artesunate; Cassia; Chloroquine; Heme; Ketones; Malaria; Male; Mice, Inbred BALB C; Phytotherapy; Piperidines; Plant Extracts; Plant Leaves; Plasmodium berghei; Plasmodium falciparum	2021
Combating multi-drug resistant malaria parasite by inhibiting falcipain-2 and heme-polymerization: Artemisinin-peptidyl vinyl phosphonate hybrid molecules as new antimalarials. European journal of medicinal chemistry, 2021, Aug-05, Volume: 220 Topics: Antimalarials; Artemisinins; Cysteine Endopeptidases; Dose-Response Relationship, Drug; Drug Resistance, Multiple; Heme; Malaria; Molecular Structure; Organophosphonates; Parasitic Sensitivity Tests; Peptides; Plasmodium falciparum; Polymerization; Structure-Activity Relationship; Vinyl Compounds	2021
A phenolic glycoside from Flacourtia indica induces heme mediated oxidative stress in Plasmodium falciparum and attenuates malaria pathogenesis in mice. Phytomedicine : international journal of phytotherapy and phytopharmacology, 2017, Jul-01, Volume: 30 Topics: Animals; Antimalarials; Chloroquine; Glycosides; Heme; Malaria; Male; Mice; Oxidative Stress; Phenols; Plants, Medicinal; Plasmodium berghei; Plasmodium falciparum; Salicaceae	2017
A novel genetic technique in Plasmodium berghei allows liver stage analysis of genes required for mosquito stage development and demonstrates that de novo heme synthesis is essential for liver stage development in the malaria parasite. PLoS pathogens, 2017, Volume: 13, Issue:6 Topics: Animals; Anopheles; Erythrocytes; Female; Genetic Complementation Test; Heme; Humans; Life Cycle Stages; Liver; Malaria; Male; Mice; Plasmodium berghei; Protozoan Proteins	2017
Quinolines block every step of malaria heme crystal growth. Proceedings of the National Academy of Sciences of the United States of America, 2017, 07-18, Volume: 114, Issue:29 Topics: Antimalarials; Crystallization; Heme; Humans; Malaria; Quinolines	2017
Hexahydroquinolines are antimalarial candidates with potent blood-stage and transmission-blocking activity. Nature microbiology, 2017, Volume: 2, Issue:10 Topics: Amino Acid Sequence; Animals; Anopheles; Antimalarials; CRISPR-Cas Systems; DNA, Protozoan; Drug Combinations; Drug Resistance; Endocytosis; Ethanolamines; Fluorenes; Gene Editing; HEK293 Cells; Heme; Hemoglobins; High-Throughput Screening Assays; Humans; Lumefantrine; Malaria; Malaria, Falciparum; Male; Membrane Transport Proteins; Multidrug Resistance-Associated Proteins; Mutation; Oocysts; Plasmodium berghei; Plasmodium falciparum; Quinolines	2017
Development of a label-free Raman imaging technique for differentiation of malaria parasite infected from non-infected tissue. The Analyst, 2017, Dec-18, Volume: 143, Issue:1 Topics: Animals; Female; Heme; Hemoglobins; Malaria; Mice; Mice, Inbred BALB C; Plasmodium; Spectrum Analysis, Raman; Spleen	2017
Plerixafor and related macrocyclic amines are potential drug candidates in treatment of malaria by "filling the flap" region of plasmepsin enzymes. Medical hypotheses, 2018, Volume: 118 Topics: Amines; Antimalarials; Aspartic Acid Endopeptidases; Benzylamines; Cyclams; Drug Discovery; Hematopoietic Stem Cells; Heme; Hemoglobins; Heterocyclic Compounds; Humans; Malaria; Models, Theoretical; Plasmodium falciparum; Protease Inhibitors; Protein Domains; Protozoan Proteins; Software	2018
Renal control of disease tolerance to malaria. Proceedings of the National Academy of Sciences of the United States of America, 2019, 03-19, Volume: 116, Issue:12 Topics: Animals; Apoferritins; Cell Line; Disease Progression; Epithelial Cells; Ferritins; Heme; Heme Oxygenase-1; Humans; Immune Tolerance; Kidney; Malaria; Mice; Mice, Inbred C57BL; NF-E2-Related Factor 2; Oxidoreductases; Plasmodium berghei; Up-Regulation	2019
Raman spectroscopic analysis of malaria disease progression via blood and plasma samples. The Analyst, 2013, Jul-21, Volume: 138, Issue:14 Topics: Animals; Cell Membrane; Disease Progression; Erythrocytes; Heme; Hemeproteins; Least-Squares Analysis; Malaria; Mice; Mice, Inbred BALB C; Plasmodium falciparum; Principal Component Analysis; Spectrum Analysis, Raman	2013
Correlation between Plasmodium yoelii nigeriensis susceptibility to artemisinin and alkylation of heme by the drug. Antimicrobial agents and chemotherapy, 2013, Volume: 57, Issue:8 Topics: Alkylation; Animals; Antimalarials; Artemisinins; Disease Models, Animal; Drug Evaluation, Preclinical; Drug Resistance; Erythrocytes; Female; Heme; Malaria; Mice; Plasmodium yoelii; Protein Binding; Spleen	2013
Hemozoin-generated vapor nanobubbles for transdermal reagent- and needle-free detection of malaria. Proceedings of the National Academy of Sciences of the United States of America, 2014, Jan-21, Volume: 111, Issue:3 Topics: Administration, Cutaneous; Animals; Erythrocytes; Female; Gases; Heme; Hemeproteins; Humans; Lasers; Malaria; Mice; Mice, Inbred BALB C; Nanoparticles; Needles; Plasmodium falciparum	2014
Characterization and expression analysis of gene encoding heme peroxidase HPX15 in major Indian malaria vector Anopheles stephensi (Diptera: Culicidae). Acta tropica, 2016, Volume: 158 Topics: Animals; Anopheles; Disease Vectors; Gene Expression Regulation; Genetic Code; Heme; India; Malaria; Peroxidases; Plasmodium falciparum	2016
Alterations in Systemic Extracellular Heme and Hemopexin Are Associated With Adverse Clinical Outcomes in Ugandan Children With Severe Malaria. The Journal of infectious diseases, 2016, 10-15, Volume: 214, Issue:8 Topics: Acute Kidney Injury; Child, Preschool; Double-Blind Method; Female; Heme; Hemopexin; Humans; Malaria; Male; Plasma; Severity of Illness Index; Uganda	2016
Heme-mediated apoptosis and fusion damage in BeWo trophoblast cells. Scientific reports, 2016, 10-31, Volume: 6 Topics: Apoptosis; Blood Proteins; Caspase 3; Cell Differentiation; Cell Fusion; Cell Line; Colforsin; Female; Galectin 3; Galectins; Gene Expression; Heme; Hemeproteins; Humans; Malaria; Placenta; Poly(ADP-ribose) Polymerases; Pregnancy; Pregnancy Proteins; Signal Transduction; STAT3 Transcription Factor; Trophoblasts	2016
Synthesis and Evaluation of Chirally Defined Side Chain Variants of 7-Chloro-4-Aminoquinoline To Overcome Drug Resistance in Malaria Chemotherapy. Antimicrobial agents and chemotherapy, 2017, Volume: 61, Issue:3 Topics: Administration, Oral; Aminoquinolines; Animals; Antimalarials; Chlorocebus aethiops; Chloroquine; Drug Resistance; Erythrocytes; Heme; Hemin; Inhibitory Concentration 50; Macaca mulatta; Malaria; Malaria, Falciparum; Parasitic Sensitivity Tests; Plasmodium cynomolgi; Plasmodium falciparum; Plasmodium yoelii; Structure-Activity Relationship; Vero Cells	2017
Sickle cell trait is associated with controlled levels of haem and mild proinflammatory response during acute malaria infection. Clinical and experimental immunology, 2017, Volume: 188, Issue:2 Topics: Child, Preschool; Convalescence; Cytokines; Female; Genotype; Heme; Heme Oxygenase-1; Hemoglobins; Humans; Infant; Inflammation; Malaria; Malaria, Falciparum; Male; Plasmodium falciparum; Sickle Cell Trait	2017
The antimalarial trioxaquine DU1301 alkylates heme in malaria-infected mice. Antimicrobial agents and chemotherapy, 2008, Volume: 52, Issue:8 Topics: Animals; Antimalarials; Chromatography, Liquid; Heme; Malaria; Mass Spectrometry; Mice; Molecular Structure; Sesquiterpenes	2008
Effects of amino acids on malarial heme crystallization. Biological & pharmaceutical bulletin, 2008, Volume: 31, Issue:8 Topics: Amino Acids; Chemical Phenomena; Chemistry, Physical; Crystallization; Cysteine; Heme; Hemeproteins; Hemin; Humans; Hydrogen-Ion Concentration; Kinetics; Malaria; Polysorbates; Solutions; Surface Tension; Surface-Active Agents	2008
Synthesis of spiro-1,2-dioxolanes and their activity against Plasmodium falciparum. Bioorganic & medicinal chemistry letters, 2008, Dec-15, Volume: 18, Issue:24 Topics: Amines; Amino Acid Motifs; Animals; Antigens, Protozoan; Antimalarials; Antiprotozoal Agents; Chemistry, Pharmaceutical; Dioxolanes; Drug Design; Heme; Humans; Malaria; Models, Chemical; Peroxides; Plasmodium falciparum	2008
Candidate selection and preclinical evaluation of N-tert-butyl isoquine (GSK369796), an affordable and effective 4-aminoquinoline antimalarial for the 21st century. Journal of medicinal chemistry, 2009, Mar-12, Volume: 52, Issue:5 Topics: Aminoquinolines; Amodiaquine; Animals; Antimalarials; Benzylamines; Cytochrome P-450 Enzyme Inhibitors; Dogs; Drug Evaluation, Preclinical; Drug Resistance; Female; Haplorhini; Heme; Humans; Malaria; Mice; Models, Molecular; Plasmodium berghei; Plasmodium falciparum; Plasmodium yoelii; Rats; Structure-Activity Relationship	2009
Heme oxygenase-1 affords protection against noncerebral forms of severe malaria. Proceedings of the National Academy of Sciences of the United States of America, 2009, Sep-15, Volume: 106, Issue:37 Topics: Acetylcysteine; Animals; Antioxidants; Apoptosis; Gene Expression; Heme; Heme Oxygenase-1; Hepatocytes; Liver Failure; Malaria; Mice; Mice, Inbred BALB C; Mice, Inbred DBA; Mice, Knockout; Mice, SCID; Oxidative Stress; Plasmodium chabaudi; Transplantation Chimera; Tumor Necrosis Factor-alpha	2009
Damage control in host-pathogen interactions. Proceedings of the National Academy of Sciences of the United States of America, 2009, Sep-15, Volume: 106, Issue:37 Topics: Animals; Apoptosis; Erythrocytes; Heme; Heme Oxygenase-1; Hepatocytes; Host-Pathogen Interactions; Humans; Malaria; Plasmodium; Reactive Oxygen Species	2009
HO-1 polymorphism as a genetic determinant behind the malaria resistance afforded by haemolytic disorders. Medical hypotheses, 2010, Volume: 74, Issue:5 Topics: Anemia, Hemolytic, Congenital; Heme; Heme Oxygenase-1; Humans; Immunity, Innate; Malaria; Molecular Structure; Polymorphism, Genetic; Selection, Genetic	2010
Synthesis, structure-activity relationship, and mode-of-action studies of antimalarial reversed chloroquine compounds. Journal of medicinal chemistry, 2010, Sep-09, Volume: 53, Issue:17 Topics: Animals; Antimalarials; Chloroquine; Drug Resistance; Heme; Hemeproteins; Lymphocytes; Malaria; Mice; Plasmodium berghei; Plasmodium falciparum; Protein Binding; Pyridines; Spleen; Structure-Activity Relationship	2010
Heme sensitization to TNF-mediated programmed cell death. Advances in experimental medicine and biology, 2011, Volume: 691 Topics: Animals; Apoptosis; Heme; Humans; Malaria; Mice; Models, Immunological; Tumor Necrosis Factors	2011
Malaria impairs resistance to Salmonella through heme- and heme oxygenase-dependent dysfunctional granulocyte mobilization. Nature medicine, 2011, Dec-18, Volume: 18, Issue:1 Topics: Animals; Bacteremia; Cell Movement; Coinfection; Disease Models, Animal; Disease Resistance; Gene Expression; Granulocytes; Heme; Heme Oxygenase-1; Hemin; Hemolysis; Humans; Malaria; Membrane Proteins; Mice; Mice, Inbred C57BL; Phenylhydrazines; Plasmodium yoelii; Respiratory Burst; Salmonella Infections; Salmonella typhimurium	2011
Host defense against malaria favors Salmonella. Nature medicine, 2012, Jan-06, Volume: 18, Issue:1 Topics: Animals; Bacteremia; Coinfection; Granulocytes; Heme; Heme Oxygenase-1; Humans; Malaria; Membrane Proteins; Plasmodium yoelii; Salmonella Infections; Salmonella typhimurium	2012
Association between the haptoglobin and heme oxygenase 1 genetic profiles and soluble CD163 in susceptibility to and severity of human malaria. Infection and immunity, 2012, Volume: 80, Issue:4 Topics: Adult; Alleles; Antigens, CD; Antigens, Differentiation, Myelomonocytic; Brazil; Disease Susceptibility; Female; Haptoglobins; Heme; Heme Oxygenase-1; Hemoglobins; Humans; Malaria; Male; Microsatellite Repeats; Middle Aged; Polymorphism, Genetic; Receptors, Cell Surface	2012
Biological activities of nitidine, a potential anti-malarial lead compound. Malaria journal, 2012, Mar-09, Volume: 11 Topics: Animals; Antimalarials; Benzophenanthridines; Cell Survival; Cells, Cultured; Chlorocebus aethiops; Cytoplasm; Drug Resistance; Erythrocytes; HeLa Cells; Heme; Hemeproteins; Humans; Inhibitory Concentration 50; Malaria; Mice; Microscopy, Confocal; Plasmodium; Plasmodium falciparum; Vero Cells; Zanthoxylum	2012
Design, synthesis of 4-aminoquinoline-derived thiazolidines and their antimalarial activity and heme polymerization inhibition studies. Journal of enzyme inhibition and medicinal chemistry, 2013, Volume: 28, Issue:3 Topics: Aminoquinolines; Animals; Antimalarials; Chemistry Techniques, Synthetic; Drug Design; Drug Evaluation, Preclinical; Heme; Hemeproteins; Malaria; Mice; Plasmodium falciparum; Polymerization; Thiazolidines	2013
Heme mediated STAT3 activation in severe malaria. PloS one, 2012, Volume: 7, Issue:3 Topics: Animals; Brain; Chemokine CXCL10; Chemokines; Female; Gene Expression Regulation; Heme; Heme Oxygenase-1; Humans; Kidney; Lung; Malaria; Membrane Proteins; Mice; Mice, Inbred C57BL; Mice, Transgenic; Models, Biological; Plasmodium berghei; Receptors, CXCR3; Signal Transduction; STAT3 Transcription Factor	2012
Aryl aryl methyl thio arenes prevent multidrug-resistant malaria in mouse by promoting oxidative stress in parasites. Free radical biology & medicine, 2012, Jul-01, Volume: 53, Issue:1 Topics: Animals; Antimalarials; Drug Resistance, Multiple; Glutathione; Heme; Hydrocarbons, Aromatic; Malaria; Male; Mice; Mice, Inbred BALB C; Oxidative Stress; Plasmodium falciparum	2012
Impact of intravascular hemolysis in malaria on liver dysfunction: involvement of hepatic free heme overload, NF-κB activation, and neutrophil infiltration. The Journal of biological chemistry, 2012, Aug-03, Volume: 287, Issue:32 Topics: Animals; Base Sequence; Blotting, Western; Disease Models, Animal; DNA Primers; Electrophoretic Mobility Shift Assay; Heme; Heme Oxygenase (Decyclizing); Hemolysis; In Situ Nick-End Labeling; Liver; Malaria; Male; Mice; Mice, Inbred BALB C; Neutrophil Infiltration; NF-kappa B; Oxidative Stress; Plasmodium yoelii; Tumor Necrosis Factor-alpha	2012
Aligned hemozoin crystals in curved clusters in malarial red blood cells revealed by nanoprobe X-ray Fe fluorescence and diffraction. Proceedings of the National Academy of Sciences of the United States of America, 2012, Jul-10, Volume: 109, Issue:28 Topics: Animals; Crystallography, X-Ray; Erythrocytes; Heme; Hemeproteins; Humans; Lipids; Malaria; Molecular Probes; Nanotechnology; Optics and Photonics; Plasmodium; Synchrotrons; Water; X-Ray Diffraction	2012
Total internal reflection photoacoustic spectroscopy for the detection of β-hematin. Journal of biomedical optics, 2012, Volume: 17, Issue:6 Topics: Absorption; Biosensing Techniques; Coloring Agents; Electric Impedance; Electronics; Equipment Design; Heme; Hemeproteins; Humans; Hydrogen Bonding; Lasers; Malaria; Optical Fibers; Optics and Photonics; Photoacoustic Techniques; Sensitivity and Specificity; Spectrophotometry; Transducers	2012
Oxidative stress and modification of renal vascular permeability are associated with acute kidney injury during P. berghei ANKA infection. PloS one, 2012, Volume: 7, Issue:8 Topics: Acute Kidney Injury; Animals; Apoptosis; Capillary Permeability; Cell Adhesion; Cell Hypoxia; Endothelial Cells; Erythrocytes; Heme; Inflammation; Kidney; Malaria; Mice; Mice, Inbred BALB C; Oxidative Stress; Plasmodium berghei; Reactive Oxygen Species	2012
Mass tool for diagnosis. Nature, 2002, Aug-15, Volume: 418, Issue:6899 Topics: Cholesterol; Erythrocytes; Heme; Humans; Malaria; Sensitivity and Specificity; Spectrometry, Mass, Matrix-Assisted Laser Desorption-Ionization	2002
Plasmodium chloroquine resistance and the search for a replacement antimalarial drug. Science (New York, N.Y.), 2002, Oct-04, Volume: 298, Issue:5591 Topics: Alleles; Animals; Antimalarials; ATP-Binding Cassette Transporters; Biological Evolution; Chloroquine; Databases, Nucleic Acid; Drug Resistance; Genes, Protozoan; Genetic Variation; Genome, Protozoan; Heme; Humans; Malaria; Malaria, Falciparum; Membrane Proteins; Membrane Transport Proteins; Plasmodium; Plasmodium falciparum; Point Mutation; Polymorphism, Single Nucleotide; Protozoan Proteins; Selection, Genetic; Sequence Analysis, DNA	2002
Applying malaria parasite's heme detoxification system for screening potential antimalarial drugs. Analytical biochemistry, 2003, Jan-15, Volume: 312, Issue:2 Topics: Animals; Antimalarials; Drug Evaluation, Preclinical; Heme; Inactivation, Metabolic; Inhibitory Concentration 50; Malaria; Plasmodium falciparum	2003
Phagotrophy and two new structures in the malaria parasite Plasmodium berghei. The Journal of biophysical and biochemical cytology, 1959, Volume: 6, Issue:1 Topics: Animals; Cell Membrane; Cell Nucleus; Cytoplasm; Endoplasmic Reticulum; Ferritins; Heme; Hemoglobins; Malaria; Microscopy, Electron; Mitochondria; Parasites; Plasmodium; Plasmodium berghei; Rats; Reticulocytes; Vacuoles	1959
ANTAGONISM OF THE ANTIMALARIAL ACTION OF CHLOROQUINE BY FERRIHEMATE AND AN HYPOTHESIS FOR THE MECHANISM OF CHLOROQUINE RESISTANCE. The Journal of pharmacology and experimental therapeutics, 1964, Volume: 143 Topics: Antimalarials; Chloroquine; Drug Tolerance; Heme; Malaria; Pharmacology; Rats; Research	1964
Evidence that haem iron in the malaria parasite is not needed for the antimalarial effects of artemisinin. FEBS letters, 2004, Sep-24, Volume: 575, Issue:1-3 Topics: Animals; Antimalarials; Artemisinins; Carbon Monoxide; Chloroquine; Erythrocytes; Heme; Hemoglobins; Humans; Iron; Malaria; Oxidation-Reduction; Oxidative Stress; Oxygen; Plasmodium falciparum; Sesquiterpenes	2004
beta-Hematin (hemozoin) mediated decompostion of polyunsaturated fatty acids to 4-hydroxy-2-nonenal. Inorganic chemistry, 2005, Apr-04, Volume: 44, Issue:7 Topics: Aldehydes; Animals; Fatty Acids, Unsaturated; Heme; Hemeproteins; Malaria; Myoglobin; Plasmodium falciparum	2005
Synthesis and evaluation of new antimalarial phenylurenyl chalcone derivatives. Journal of medicinal chemistry, 2005, May-19, Volume: 48, Issue:10 Topics: Animals; Antimalarials; Chalcones; Cysteine Endopeptidases; Globins; Heme; Hemeproteins; Hydrolysis; Malaria; Mice; Phenylurea Compounds; Plasmodium berghei; Plasmodium falciparum; Polymers; Protease Inhibitors; Structure-Activity Relationship	2005
Mapping antimalarial pharmacophores as a useful tool for the rapid discovery of drugs effective in vivo: design, construction, characterization, and pharmacology of metaquine. Journal of medicinal chemistry, 2005, Aug-25, Volume: 48, Issue:17 Topics: Aminoquinolines; Animals; Antimalarials; Databases, Factual; Drug Design; Heme; Hemin; Malaria; Mass Spectrometry; Mice; Models, Molecular; Molecular Structure; Phenylenediamines; Plasmodium berghei; Protein Binding; Quantitative Structure-Activity Relationship; Quinolines; Solubility; Spectrophotometry, Ultraviolet; Temperature	2005
The antimalarial drug artemisinin alkylates heme in infected mice. Proceedings of the National Academy of Sciences of the United States of America, 2005, Sep-20, Volume: 102, Issue:38 Topics: Alkylation; Animals; Antimalarials; Artemisinins; Female; Heme; Malaria; Mice; Plasmodium; Sesquiterpenes; Spleen; Urine	2005
An alternative model for heme biosynthesis in the malarial parasite. Trends in biochemical sciences, 2007, Volume: 32, Issue:10 Topics: Animals; Genome, Viral; Heme; Humans; Malaria; Models, Biological; Organelles; Subcellular Fractions	2007
Acridinediones: selective and potent inhibitors of the malaria parasite mitochondrial bc1 complex. Molecular pharmacology, 2008, Volume: 73, Issue:5 Topics: Acridines; Animals; Antimalarials; Atovaquone; Cattle; Drug Synergism; Electron Transport Complex III; Heme; Hemeproteins; Humans; Malaria; Male; Membrane Potential, Mitochondrial; Mitochondria; Oxidation-Reduction; Parasitic Sensitivity Tests; Plasmodium falciparum; Rats; Rats, Wistar; Saccharomyces cerevisiae	2008
Malaria and iron. British journal of haematology, 1983, Volume: 53, Issue:2 Topics: Deferoxamine; Female; Heme; Humans; Iron Deficiencies; Malaria; Plasmodium; Plasmodium falciparum; Pregnancy; Transferrin	1983
Mode of action of antimalarial drugs. Ciba Foundation symposium, 1983, Volume: 94 Topics: Anemia, Hemolytic; Animals; Antimalarials; Chloroquine; Drug Resistance; Heme; Hemin; Hemoglobins; Humans; Malaria; Plasmodium; Plasmodium berghei; Plasmodium falciparum; Receptors, Drug	1983
Ferriprotoporphyrin IX: a mediator of the antimalarial action of oxidants and 4-aminoquinoline drugs. Progress in clinical and biological research, 1984, Volume: 155 Topics: Aminoquinolines; Animals; Antimalarials; Cell Membrane; Chloroquine; Erythrocytes; Heme; Hemin; Hemolysis; Malaria; Oxidation-Reduction; Plasmodium berghei; Rabbits; Vitamin K	1984
Chloroquine resistance and host cell hemoglobin catabolism in Plasmodium berghei. Progress in clinical and biological research, 1984, Volume: 155 Topics: Animals; Chloroquine; Drug Resistance, Microbial; Erythrocytes; Heme; Hemoglobins; Iron; Kinetics; Malaria; Male; Mice; Plasmodium berghei	1984
Ferriprotoporphyrin IX binding substances and the mode of action of chloroquine against malaria. Life sciences, 1982, Sep-13, Volume: 31, Issue:11 Topics: Animals; Chloroquine; Heme; Hemin; Malaria; Plasmodium berghei; Serum Albumin, Bovine	1982
The effect of ferriprotoporphyrin IX and chloroquine on phospholipid monolayers and the possible implications to antimalarial activity. Biochimica et biophysica acta, 1983, Jul-13, Volume: 732, Issue:1 Topics: Chloroquine; Heme; Hemin; Humans; Liposomes; Malaria; Phosphatidylcholines; Structure-Activity Relationship	1983
Hemolysis of mouse erythrocytes by ferriprotoporphyrin IX and chloroquine. Chemotherapeutic implications. The Journal of clinical investigation, 1980, Volume: 66, Issue:4 Topics: Animals; Chloroquine; Drug Interactions; Erythrocytes; Heme; Hemin; Hemolysis; In Vitro Techniques; Malaria; Mice	1980
Haem polymerization in malaria. Nature, 1995, Nov-09, Volume: 378, Issue:6553 Topics: Animals; Biopolymers; Chromatography, High Pressure Liquid; Erythrocytes; Heme; Hemeproteins; Hemin; Humans; Malaria; Plasmodium falciparum; Transferases	1995
Effect of Plasmodium berghei infection and antimalarial treatment on heme synthesis in mice. International journal for parasitology, 1994, Volume: 24, Issue:5 Topics: 5-Aminolevulinate Synthetase; Animals; Chloroquine; Ferrochelatase; Heme; Liver; Malaria; Mice; Plasmodium berghei; Porphobilinogen Synthase; Tryptophan Oxygenase	1994
Hemoglobin catabolism and host-parasite heme balance in chloroquine-sensitive and chloroquine-resistant Plasmodium berghei infections. The American journal of tropical medicine and hygiene, 1993, Volume: 48, Issue:4 Topics: Analysis of Variance; Animals; Chloroquine; Drug Resistance; Erythrocytes; Heme; Hemoglobins; Host-Parasite Interactions; Malaria; Male; Mice; Plasmodium berghei; Rats; Rats, Sprague-Dawley; Reticulocytes	1993
Effect of chloroquine on hepatic heme-oxygenase during Plasmodium berghei infection in mice. International journal for parasitology, 1993, Volume: 23, Issue:2 Topics: Animals; Chloroquine; Heme; Heme Oxygenase (Decyclizing); Liver; Malaria; Mice; Microsomes, Liver; Plasmodium berghei	1993
Evaluation of resistant-reversal, CDRI compound 87/209 and its possible mode of action in rodent experimental malaria. Tropical medicine and parasitology : official organ of Deutsche Tropenmedizinische Gesellschaft and of Deutsche Gesellschaft fur Technische Zusammenarbeit (GTZ), 1995, Volume: 46, Issue:2 Topics: Animals; Antimalarials; Chloroquine; Drug Resistance, Multiple; Heme; Heme Oxygenase (Decyclizing); Hemeproteins; Malaria; Mice; Muridae; Pigments, Biological; Plasmodium; Plasmodium berghei; Plasmodium yoelii; Pyrrolidines; Species Specificity; Transferases	1995
The heme moiety of malaria pigment (beta-hematin) mediates the inhibition of nitric oxide and tumor necrosis factor-alpha production by lipopolysaccharide-stimulated macrophages. Experimental parasitology, 1995, Volume: 81, Issue:4 Topics: Animals; Dose-Response Relationship, Drug; Female; Heme; Hemeproteins; Lipopolysaccharides; Macrophages, Peritoneal; Malaria; Mice; Microglia; Nitric Oxide; Sulfhydryl Compounds; Tumor Necrosis Factor-alpha	1995
Mode of antimalarial effect of methylene blue and some of its analogues on Plasmodium falciparum in culture and their inhibition of P. vinckei petteri and P. yoelii nigeriensis in vivo. Biochemical pharmacology, 1996, Mar-08, Volume: 51, Issue:5 Topics: Animals; Antimalarials; Heme; Humans; Malaria; Male; Methylene Blue; Mice; Oxidation-Reduction; Pentose Phosphate Pathway; Plasmodium falciparum; Plasmodium yoelii; Tumor Cells, Cultured	1996
The iron environment in heme and heme-antimalarial complexes of pharmacological interest. Journal of inorganic biochemistry, 1996, Volume: 63, Issue:1 Topics: Animals; Antimalarials; Artemisinins; Artesunate; Chloroquine; Heme; Hemeproteins; Hemin; Humans; Iron; Malaria; Quinine; Sesquiterpenes; Spectroscopy, Mossbauer	1996
Studies on heme and heme oxygenase during Plasmodium berghei infection in golden hamsters. Indian journal of experimental biology, 1995, Volume: 33, Issue:11 Topics: Animals; Cricetinae; Heme; Heme Oxygenase (Decyclizing); Liver; Malaria; Mesocricetus; Parasitemia; Plasmodium berghei; Spleen	1995
Depolymerization of malarial hemozoin: a novel reaction initiated by blood schizontocidal antimalarials. FEBS letters, 1997, Feb-03, Volume: 402, Issue:2-3 Topics: Animals; Antimalarials; Chloroquine; Heme; Hemeproteins; Hemoglobins; Kinetics; Malaria; Mice; Models, Biological; Pigments, Biological; Plasmodium yoelii	1997
Assay of beta-hematin formation by malaria parasite. Journal of pharmaceutical and biomedical analysis, 1999, Volume: 20, Issue:1-2 Topics: Animals; Antimalarials; Biological Assay; Drug Evaluation, Preclinical; Heme; Hemin; Malaria; Male; Mice; Plasmodium yoelii; Reproducibility of Results	1999
Import of host delta-aminolevulinate dehydratase into the malarial parasite: identification of a new drug target. Nature medicine, 2000, Volume: 6, Issue:8 Topics: Animals; Antimalarials; Biological Transport, Active; Cell Membrane; Erythrocytes; Heme; Malaria; Mice; Mice, Inbred BALB C; Plasmodium berghei; Porphobilinogen Synthase	2000
A physiochemical mechanism of hemozoin (beta-hematin) synthesis by malaria parasite. Biochemical and biophysical research communications, 2002, Jan-11, Volume: 290, Issue:1 Topics: alpha-Linolenic Acid; Aminophenols; Animals; Antioxidants; Dithionite; Dithiothreitol; Free Radicals; Glutathione; Heme; Hemeproteins; Hemin; Linoleic Acid; Lipid Metabolism; Malaria; Mercaptoethanol; Mice; Models, Chemical; Oxygen; Plasmodium yoelii; Reducing Agents; Superoxide Dismutase; Temperature	2002
Host heme catabolism in drug-sensitive and drug-resistant malaria. The Journal of laboratory and clinical medicine, 1977, Volume: 90, Issue:4 Topics: Animals; Carbon Monoxide; Chloroquine; Drug Resistance; Heme; Malaria; Male; Mice; Plasmodium berghei	1977
Formalin pigment (acid hematin) and related pigments. The American journal of medical technology, 1976, Volume: 42, Issue:11 Topics: Animals; Formaldehyde; Heme; Hemin; Histological Techniques; Humans; Lung Diseases, Parasitic; Malaria; Mite Infestations; Peptic Ulcer; Pigments, Biological; Schistosomiasis	1976
Status of hepatic heme and heme oxygenase during Plasmodium yoelii nigeriensis infection in mice. Experimental and molecular pathology, 1991, Volume: 55, Issue:1 Topics: Administration, Oral; Animals; Cell Fractionation; Chloroquine; Cobalt; Heme; Heme Oxygenase (Decyclizing); Injections, Subcutaneous; Liver; Malaria; Mice; Plasmodium yoelii	1991
The state of ferriprotoporphyrin IX in malaria pigment. The Journal of biological chemistry, 1987, Nov-15, Volume: 262, Issue:32 Topics: Animals; Chloroquine; Drug Resistance; Heme; Hemin; Malaria; Mice; Osmotic Fragility; Peptide Hydrolases; Plasmodium berghei; Solubility; Streptomyces griseus	1987
Excess release of ferriheme in G6PD-deficient erythrocytes: possible cause of hemolysis and resistance to malaria. Blood, 1986, Volume: 67, Issue:2 Topics: Chloroquine; Erythrocyte Membrane; Ferric Compounds; Glucosephosphate Dehydrogenase Deficiency; Heme; Hemolysis; Humans; Malaria; Male; Vitamin K	1986
Pathologic physiology and chemotherapy of Plasmodium berghei. 3. Renal function in rats infected with Plasmodium berghei. Experimental parasitology, 1968, Volume: 22, Issue:2 Topics: Adrenalectomy; Aminohippuric Acids; Animals; Blood; Chlorides; Glomerular Filtration Rate; Hematocrit; Heme; Inulin; Kidney; Kidney Function Tests; Malaria; Potassium; Rats; Sodium	1968