Page last updated: 2024-08-23

heme and HbS Disease

heme has been researched along with HbS Disease in 120 studies

Research

Studies (120)

Timeframe	Studies, this research(%)	All Research%
pre-1990	37 (30.83)	18.7374
1990's	4 (3.33)	18.2507
2000's	9 (7.50)	29.6817
2010's	40 (33.33)	24.3611
2020's	30 (25.00)	2.80

Authors

Authors	Studies
Bain, J; Black, J; Buehler, PW; Buzzi, RM; Edler, M; Ferguson, SK; Gentinetta, T; Hassell, K; Irwin, DC; Karoor, V; Majka, SM; Moldovan, R; Nuss, R; Pak, DI; Schaer, DJ; Schu, D; Sintas, C; Swindle, D; Vallelian, F; Wassmer, A	1
Buzzi, RM; Dubach, IL; Gentinetta, T; Hansen, K; Humar, R; Pfefferlé, M; Schaer, CA; Schaer, DJ; Schulthess, N; Vallelian, F; Wassmer, A; Yalamanoglu, A	1
Costa, FF; De Paula, EV; Hounkpe, BW; Lanaro, C; Moraes, CRP; Santos, MNN	1
Abdulla, F; Belcher, JD; Chen, C; Conglin, R; Cummings, J; Dudler, T; Ivy, ZK; Nguyen, J; Vercellotti, GM	1
Chonat, S; Dimitrov, JD; Ekdahl, KN; Gerogianni, A; McAdam, KE; Mohlin, C; Mollnes, TE; Nilsson, PH; Poillerat, V; Roumenina, LT; Sandholm, K; Zarantonello, A	1
Allali, S; Bouceba, T; de Montalembert, M; Hermine, O; Maciel, TT; Rignault-Bricard, R; Taylor, M	1
Anum, SJ; Bolívar, BE; Bouchier-Hayes, L; Flanagan, JM; Salgar, S	1
Chambliss, C; Gee, BE; Stiles, JK	1
Kuypers, FA; Larkin, SK; Soupene, E; Vichinsky, EP; Vissa, M	1
An, X; Antypiuk, A; Cox, JE; Manwani, D; Pearce, Q; Sharma, R; Vance, SZ; Vinchi, F; Yazdanbakhsh, K	1
Tolosano, E	1
Chen, R; Deng, J; Li, Y; Luo, S; Wang, C	1
Fuke, N; Keleku-Lukwete, N; Kuga, A; Panda, H; Suganuma, H; Suzuki, M; Yamamoto, M	1
Barratt-Due, A; Espevik, T; Fløisand, Y; Gerogianni, A; Lau, C; McAdam, MB; Mollnes, TE; Nilsson, PH; Thomas, AM	1
Bastarache, JA; DeBaun, MR; Kerchberger, VE; McNeil, JB; Rodeghier, M; Shaver, CM; Steinberg, MH; Ware, LB; Willen, SM	1
Ackah, EB; Crosby, D; Flage, B; Ghosh, S; Hazra, R; Lenhart, D; Ofori-Acquah, SF; Orikogbo, OO; Owusu-Dabo, E; Paintsil, V; Tan, RJ; Vitturi, DA	1
Saraf, SL	1
Kerchberger, VE; Ware, LB	1
Beyer, EC; Gemel, J; Harrington, M; Lapping-Carr, G; Mao, Y; Peddinti, R; Sparks, G	1
Belcher, JD; Hu, J; Kiser, ZM; Nath, KA; Nguyen, J; Trent, JO; Vercellotti, GM; Zhang, P	1
An, X; Bao, W; Liu, Y; Lobo, CA; Manwani, D; Minniti, C; Mitchell, WB; Pal, M; Shi, PA; Wang, R; Yazdanbakhsh, K; Zhong, H	1
Araújo, ADS; Bezerra, MAC; Borba-Junior, IT; Chenou, F; Costa, FF; da Costa, LNG; de Lima, F; De Paula, EV; Domingos, IF; Dos Santos, MNN; Fiusa, MML; Garcia-Weber, D; Hounkpe, BW; Lucena-Araújo, AR; Millán, J; Santaterra, VAG; Tonasse, WV	1
Pirenne, F	1
Gbotosho, OT; Kapetanaki, MG; Kato, GJ	1
Agarvas, AR; Belcher, JD; Fibach, E; Ghoti, H; Juaidi, H; Manwani, D; Muckenthaler, MU; Nandi, V; Passos, ST; Sharma, R; Silva, AMN; Sparla, R; Vance, SZ; Vercellotti, GM; Vinchi, F; Yazdanbakhsh, K; Zreid, HS	1
Belcher, JD; Bolívar, BE; Bouchier-Hayes, L; Brown-Suedel, AN; Charendoff, CI; Flanagan, JM; Rohrman, BA; Vercellotti, GM; Yazdani, V	1
Abdulla, F; Beckman, JD; Belcher, JD; Nelson, AT; Nguyen, J; Vercellotti, GM; Zhang, P	1
Baird, JH; Kato, GJ; Mendelsohn, L; Minniti, CP; van Beers, EJ; van Vuren, AJ	1
Brito, PL; Conran, N; Costa, FF; Fabris, FCZ; Ferreira, WA; Garcia, F; Gotardo, ÉMF; Leonardo, FC; Mendonça, R; Miguel, LI; Torres, LS	1
Asnani, A; Kim, J; Liu, J; Menon, AV; Tsai, HP; Yang, S; Zeng, L	1
Albuquerque, CCMX; Cardoso, EC; Cesar, P; Chenou, F; de Lima, F; De Paula, EV; Fraiji, NA; Garcia, NP; Hounkpe, BW; Malheiro, A; Silva-Junior, AL; Silva-Neto, PV	1
Alagbe, AE; Araújo, ADS; Arcanjo, GDS; Batista, THC; Bezerra, MAC; Chenou, F; Costa, FF; De Paula, EV; Domingos, IF; Dos Santos, MNN; Hounkpe, BW; Lucena-Araújo, AR; Santana, RM; Sonati, MF; Tonassé, WV	1
Eshbach, ML; Kaur, A; Rbaibi, Y; Tejero, J; Weisz, OA	1
Aleluia, MM; Ferreira, JRD; Figueiredo, CVB; Fiuza, LM; Gonçalves, MS; Guarda, CCD; Lyra, IM; Oliveira, RM; Santiago, RP; Yahouedehou, SCMA	1
Alayash, AI	1
Aires-da-Silva, F; Carlos, AR; Gomes, CM; Gonçalves, J; Gouveia, Z; Hamza, I; Iranzo, O; Leal, SS; Maghzal, GJ; Ramos, S; Santos, AC; Soares, MP; Stocker, R; Todorovic, S; Yuan, X	1
Brittain, J; Gupta, D; Hobbs, WE; Krishnamoorthy, S; Li, B; Li, H; Light, DR; Makala, L; Moore, N; Pace, B; Stone, I; Sturtevant, S; Thullen, T; Vieira, BF	1
Blanc-Brude, OP; Bouzekri, S; Brinkman, N; Charue, D; Chauvet, S; Dimitrov, JD; Edler, M; Figueres, ML; Fremeaux-Bacchi, V; Frimat, M; Gentinetta, T; Gnemmi, V; Grunenwald, A; Houillier, P; Knockaert, S; Le Jeune, S; Le-Hoang, M; Merle, NS; Miescher, S; Noe, R; Petrillo, S; Rabant, M; Rajaratnam, H; Robe-Rybkine, T; Roumenina, LT; Tolosano, E	1
Galamba, N; Pipolo, S	1
Baek, JH; Buehler, PW; Deuel, JW; Hassell, K; Hunt, RC; Irwin, DC; Redinius, K; Schaer, DJ; Yalamanoglu, A	1
Flage, B; Ghosh, S; Ofori-Acquah, SF; Weidert, F	1
Daugan, M; Dimitrov, JD; Frémeaux-Bacchi, V; Leon, J; Merle, NS; Paule, R; Poillerat, V; Robe-Rybkine, T; Roumenina, LT; Torset, C	1
Boudhabhay, I; Fremeaux-Bacchi, V; Leon, J; Merle, NS; Roumenina, LT	1
Bullock, GC; Gbotosho, OT; Ghosh, S; Kapetanaki, MG; Kato, GJ; Lin, Y; Ofori-Acquah, SF; Weidert, F	1
Altruda, F; Cimino, J; De Franceschi, L; Ghigo, A; Hirsch, E; Silengo, L; Tolosano, E; Townes, T; Vinchi, F	1
Adisa, OA; Aryee, D; Ghosh, S; Hu, Y; Ofori-Acquah, SF; Osunkwo, I	1
Barodka, VM; Berkowitz, DE; Mohanty, JG; Nagababu, E; Nyhan, D; Rifkind, JM; Strouse, JJ	1
Abdulla, F; Alayash, AI; Belcher, JD; Chen, C; Hebbel, RP; Milbauer, L; Nath, KA; Nguyen, J; Smith, A; Vercellotti, GM	1
Chen, G; Frenette, PS; Fuchs, TA; Manwani, D; Wagner, DD; Zhang, D	1
Kato, GJ; Leitman, S; Mendelsohn, L; Noguchi, CT; Perkins, A; Raghavachari, N; Rogers, H; Tallack, M; Taylor, JG; Wang, X; Yang, Y; Yau, YY	1
Gladwin, MT; Ofori-Acquah, SF	1
Feola, M; Moeller, JF; Simoni, G; Simoni, J; Wesson, DE	1
Brittain, JE	1
Chantrathammachart, P; Gailani, D; Gruber, A; Jonas, W; Kasthuri, R; Key, NS; Kirchhofer, D; Mackman, N; Pawlinski, R; Sparkenbaugh, EM; Wang, S	1
Abdulla, F; Belcher, JD; Benjamin, DR; Chen, C; Nguyen, J; Nguyen, M; Nguyen, P; Okeley, NM; Senter, PD; Vercellotti, GM	1
Abbyad, P; Alexandrou, A; Barja-Fidalgo, C; Blanc-Brude, OP; Bonnin, P; Boulanger, CM; Bruneval, P; Camus, SM; Charue, D; De Moraes, JA; Grimaud, L; Kiger, L; Lambry, JC; Larroque, C; Le Clésiau, H; Le Jeune, S; Lionnet, F; Loufrani, L; Renard, JM; Tedgui, A; Tharaux, PL	1
Yazdanbakhsh, K	1
Vercellotti, GM	1
Aslan, M; Fanis, P; Kleanthous, M; Phylactides, M; Voskou, S	1
Alayash, AI; Jana, S; Jia, Y; Kassa, T; Meng, F; Strader, MB; Wilson, MT	1
Canet-Soulas, E; Chirico, EN; Connes, P; Faës, C; Martin, C; Pialoux, V	1
Brinkman, N; Cerwenka, A; Costa da Silva, M; Ingoglia, G; Muckenthaler, MU; Petrillo, S; Tolosano, E; Vinchi, F; Zuercher, A	1
Ghosh, S; Manci, E; Mosunjac, M; Ofori-Acquah, SF; Tan, F	1
Borges, VM; da Guarda, CC; Goncalves, MS; Pitanga, TN; Santana, SS; Santiago, RP; Zanette, DL	1
Chou, ST; Cohen, D; Godefroy, E; Liu, Y; Manwani, D; Mitchell, WB; Shi, P; Yazdanbakhsh, K	1
Gaggar, A; Genschmer, K; Hamm, J; Kerby, JD; Lebensburger, J; Marques, MB; Oh, JY; Patel, RP; Pittet, JF; Xu, X; Zhong, M	1
Kurnikova, MG; Rafikov, R; Rafikova, O; Sakipov, S	1
Ashokan, K; Chottray, GP; Colah, RB; Ghosh, K; Italia, Y; Jain, D; Kaul, R; Mohanty, D; Mukherjee, MB; Muthuswamy, V; Shukla, DK; Wadia, M	1
LONDON, IM; RITTENBERG, D; SHEMIN, D	1
Betal, SG; Setty, BN; Stuart, MJ; Zhang, J	1
Balla, G; Balla, J; Beckman, JD; Belcher, JD; Vercellotti, G	1
Adisa, O; Ghosh, S; Li, Y; Mosunjac, M; Ofori-Acquah, SF; Tan, F; Yu, T	1
Diers, AR; Gladwin, MT; Hanson, MS; Hillery, CA; Hogg, N; Keszler, A; Piknova, B; Wang, X	1
Bonaventura, C; Ferruzzi, G; Godette, G; Henkens, R; Stevens, RD; Tesh, S	1
Cannon, RO; Gladwin, MT; Hogg, N; Reiter, CD; Schechter, AN; Tanus-Santos, JE; Wang, X	1
CLEVE, H; MULLER-EBERHARD, U	1
DIGGS, LW; IUCHI, I; LYLE, D; UPSHAW, JD	1
YAMAMOTO, T	1
FELDMAN, F; LICHTMAN, HC	1
SHINOWARA, GY; STUTMAN, LJ	1
LONDON, IM; SHEMIN, D	1
Eaton, WA; Hofrichter, J	1
Barré, J; Dailly, E; Reinert, P; Tillement, JP; Urien, S	1
Belcher, JD; Geiger, P; Girotti, AW; Hebbel, RP; Marker, PH; Steinberg, MH; Vercellotti, GM	1
Acharya, AS; Ho, C; Ho, NT; Kumar, R; Malavalli, A; Manjula, BN; Nagel, RL; Prabhakaran, M; Rao, MJ; Sun, DP	1
Alayash, AI; Cashon, RE; Hrinczenko, BW; Pannell, LK; Schechter, AN; Wojtkowski, TL	1
Abraham, NG; de Witte, T; Figdor, CG; van Kooyk, Y; Wagener, FA	1
Croatt, AJ; Grande, JP; Haggard, JJ; Hebbel, RP; Katusic, ZS; Nath, KA; Solovey, A	1
Bonaventura, C; Crumbliss, AL; Lafon, C; Low, PS; Stevens, RD; Taboy, CH	1
El-Hazmi, MA	1
Adachi, K; Asakura, T; Minakata, K; Russell, MO; Schwartz, E	1
Anderson, KE; Kappas, A; Peterson, CM; Sassa, S	1
Kolski, GB; Miller, DR	1
Cohen, HS; Forte, FJ; Freedman, ML; Rosman, J	1
Hartley, A; Rice-Evans, C	1
Hebbel, RP; Repka, T	1
Adams, JG; DeSimone, J; Newman, MV; Steinberg, MH	1
Hebbel, RP; Kuross, SA; Rank, BH	2
Hebbel, RP; Kuross, SA	1
Cox, TM; Gardner, LC	1
Liu, SC; Palek, J; Zhai, S	1
Eaton, JW; Hebbel, RP; Hedlund, BE; Morgan, WT	1
Alter, BP; Kaye, FJ; Schofield, JM; Weinberg, RS	1
Chevli, R; Fitch, CD; Orjih, AU	1
Kirschner-Zilber, I; Rabizadeh, E; Shaklai, N; Shviro, Y	1
Cajozzo, A; Citarrella, P; Malleo, C	1
Lehmann, H	1
Pimstone, NR	1
Bensinger, TA; Gillette, PN	1
Iio, A; Liem, HH; Muller-Eberhard, U; Spilberg, I; Wochner, RD	1
Carrell, RW; Lehmann, H	1
Eliot, RS; Guy, CR; Salhany, JM	1
Bookchin, RM; Grayzel, AI; Nagel, RL; Roth, EF	1
Scott, RB	1
Bensinger, TA; Conrad, ME; Mahmood, L; Maisels, MJ; McCurdy, PR	1
Perkins, RP	1
Mainzer, K	1
Hanna, M; Hanstein, A; Javid, J; Liem, HH; Muller-Eberhard, U	1
Heilmeyer, L	1

Reviews

18 review(s) available for heme and HbS Disease

Article	Year
The NLRP3 inflammasome fires up heme-induced inflammation in hemolytic conditions. Translational research : the journal of laboratory and clinical medicine, 2023, Volume: 252 Topics: Anemia, Sickle Cell; Heme; Hemolysis; Humans; Inflammasomes; Inflammation; Interleukin-1beta; NLR Family, Pyrin Domain-Containing 3 Protein	2023
Double-edged functions of hemopexin in hematological related diseases: from basic mechanisms to clinical application. Frontiers in immunology, 2023, Volume: 14 Topics: Anemia, Sickle Cell; Heme; Hemolysis; Hemopexin; Humans	2023
The Role of Circulating Cell-Free Hemoglobin in Sepsis-Associated Acute Kidney Injury. Seminars in nephrology, 2020, Volume: 40, Issue:2 Topics: Acetaminophen; Acute Kidney Injury; Anemia, Sickle Cell; Animals; Coronary Artery Bypass; Disseminated Intravascular Coagulation; Eryptosis; Erythrocyte Deformability; Haptoglobins; Heme; Hemoglobins; Hemolysis; Hemopexin; Humans; Kidney Tubules; Malaria; Nitric Oxide; Oxidative Stress; Reactive Oxygen Species; Sepsis; Transfusion Reaction	2020
The Worst Things in Life are Free: The Role of Free Heme in Sickle Cell Disease. Frontiers in immunology, 2020, Volume: 11 Topics: Anemia, Sickle Cell; Animals; Cardiovascular Diseases; Disease Progression; Heme; Heme Oxygenase-1; Hemolysis; Hemopexin; Humans; Hypertension, Pulmonary; Inflammation; Interleukin-6; Oxidative Stress; Placenta Growth Factor; Respiratory Hypersensitivity	2020
Heme-mediated cell activation: the inflammatory puzzle of sickle cell anemia. Expert review of hematology, 2017, Volume: 10, Issue:6 Topics: Anemia, Sickle Cell; Cell Movement; Endothelial Cells; Heme; Hemoglobins; Hemolysis; Humans; Inflammation; Iron; Leukocytes; Vascular Diseases	2017
Oxidative pathways in the sickle cell and beyond. Blood cells, molecules & diseases, 2018, Volume: 70 Topics: Anemia, Sickle Cell; Antioxidants; Blood Substitutes; Cell-Derived Microparticles; Erythrocytes; Erythrocytes, Abnormal; Heme; Hemoglobin, Sickle; Humans; Metabolic Networks and Pathways; Oxidation-Reduction; Oxidative Stress; Peroxidase	2018
Complement activation during intravascular hemolysis: Implication for sickle cell disease and hemolytic transfusion reactions. Transfusion clinique et biologique : journal de la Societe francaise de transfusion sanguine, 2019, Volume: 26, Issue:2 Topics: Anemia, Sickle Cell; Antibodies, Monoclonal, Humanized; Antibody-Dependent Cell Cytotoxicity; Biomarkers; Cell-Derived Microparticles; Complement Activation; Heme; Hemolysis; Humans; Time Factors; Transfusion Reaction	2019
Mechanisms of sickle cell alloimmunization. Transfusion clinique et biologique : journal de la Societe francaise de transfusion sanguine, 2015, Volume: 22, Issue:3 Topics: Anemia, Sickle Cell; B-Lymphocytes; Biomarkers; Blood Group Incompatibility; Erythrocyte Transfusion; Erythrocytes; Heme; Heme Oxygenase-1; Hemin; Humans; Interleukin-10; Interleukin-12; Isoantibodies; Lymphocyte Cooperation; Membrane Proteins; Models, Immunological; Monocytes; T-Lymphocyte Subsets; T-Lymphocytes, Regulatory; Transfusion Reaction	2015
Oxidative stress in β-thalassaemia and sickle cell disease. Redox biology, 2015, Volume: 6 Topics: Anemia, Sickle Cell; Anion Exchange Protein 1, Erythrocyte; beta-Globins; beta-Thalassemia; Erythrocytes; Heme; Hemeproteins; Humans; Iron; Iron Overload; Oxidative Stress; Phosphatidylserines; Protein Stability; Reactive Oxygen Species; Reperfusion Injury; Thrombophilia	2015
Role of Exercise-Induced Oxidative Stress in Sickle Cell Trait and Disease. Sports medicine (Auckland, N.Z.), 2016, Volume: 46, Issue:5 Topics: Anemia, Sickle Cell; Animals; Disease Models, Animal; Exercise; Heme; Hemoglobin, Sickle; Hemolysis; Humans; Hypoxia; Iron; Mice; NADPH Oxidases; Nitric Oxide; Oxidative Stress; Reperfusion Injury; Sickle Cell Trait; Xanthine Oxidase	2016
Heme degradation and vascular injury. Antioxidants & redox signaling, 2010, Volume: 12, Issue:2 Topics: Anemia, Sickle Cell; Animals; Blood Vessels; Enzyme Activation; Heme; Heme Oxygenase-1; Hemin; Hemoglobins; Humans; Hydrogen Peroxide; Mice; Models, Biological; Oxidants; Oxidation-Reduction; Oxidative Stress	2010
[ON THE SHUNT HYPERBILIRUBINEMIA]. Naika hokan. Japanese archives of internal medicine, 1964, Volume: 11 Topics: Anemia; Anemia, Hypochromic; Anemia, Pernicious; Anemia, Sickle Cell; Bilirubin; Blood Chemical Analysis; Carbon Isotopes; Erythropoiesis; Glycine; Heme; Hyperbilirubinemia; Hyperbilirubinemia, Hereditary; Jaundice; Leukemia; Leukemia, Myeloid; Metabolism; Physiology; Thalassemia	1964
Polarized absorption and linear dichroism spectroscopy of hemoglobin. Methods in enzymology, 1981, Volume: 76 Topics: Anemia, Sickle Cell; Heme; Hemoglobin, Sickle; Hemoglobins; Humans; Mathematics; Models, Molecular; Molecular Conformation; Porphyrins; Protein Conformation; Spectrophotometry; X-Ray Diffraction	1981
Heme-induced cell adhesion in the pathogenesis of sickle-cell disease and inflammation. Trends in pharmacological sciences, 2001, Volume: 22, Issue:2 Topics: Anemia, Sickle Cell; Cell Adhesion; Heme; Humans; Inflammation	2001
Renal degradation of hemoglobin. Seminars in hematology, 1972, Volume: 9, Issue:1 Topics: Amino Acids; Anemia, Hemolytic; Anemia, Sickle Cell; Animals; Bilirubin; Carbon Isotopes; Carbon Monoxide; Glomerular Filtration Rate; Haptoglobins; Heart Valve Prosthesis; Heme; Hemoglobins; Hemoglobinuria, Paroxysmal; Humans; Iron; Iron Isotopes; Kidney; Malaria; Microsomes; Oxygenases; Protein Binding; Rats; Thalassemia	1972
Hemolysis in sickle cell disease. Archives of internal medicine, 1974, Volume: 133, Issue:4 Topics: Adolescent; Adult; Anemia, Sickle Cell; Carbon Monoxide; Carbon Radioisotopes; Child; Chromium Radioisotopes; Drug Interactions; Erythrocyte Aging; Erythrocytes, Abnormal; Female; Fetal Hemoglobin; Glucosephosphate Dehydrogenase Deficiency; Half-Life; Heme; Hemoglobin, Sickle; Hemoglobins; Hemolysis; Humans; Male; Middle Aged; Mononuclear Phagocyte System; Nitrogen Isotopes; Oxygen; Splenectomy; Technetium; Terminology as Topic	1974
The unstable haemoglobin haemolytic anaemias. Seminars in hematology, 1969, Volume: 6, Issue:2 Topics: Anemia, Hemolytic; Anemia, Sickle Cell; Binding Sites; Electrophoresis; Erythrocytes; Globins; Glutathione; Heinz Bodies; Heme; Hemoglobins, Abnormal; Humans; Methemoglobin; Osmotic Fragility; Splenectomy; Sulfonamides	1969
Disorders of hemoglobin-oxygen release in ischemic heart disease. American heart journal, 1971, Volume: 82, Issue:6 Topics: Adenosine Triphosphate; Anemia, Sickle Cell; Carbon Monoxide Poisoning; Coronary Disease; Glycerophosphates; Heme; Hemoglobins; Hemoglobins, Abnormal; Humans; Hydrogen-Ion Concentration; Kinetics; Myocardial Infarction; Myocardium; Oxygen; Oxygen Consumption	1971

Trials

3 trial(s) available for heme and HbS Disease

Article	Year
Lactate dehydrogenase to carboxyhemoglobin ratio as a biomarker of heme release to heme processing is associated with higher tricuspid regurgitant jet velocity and early death in sickle cell disease. American journal of hematology, 2021, 09-01, Volume: 96, Issue:9 Topics: Adult; Anemia, Sickle Cell; Biomarkers; Carbon Monoxide; Carboxyhemoglobin; Heme; Hemolysis; Humans; L-Lactate Dehydrogenase; Tricuspid Valve Insufficiency	2021
Heme-bound iron activates placenta growth factor in erythroid cells via erythroid Krüppel-like factor. Blood, 2014, Aug-07, Volume: 124, Issue:6 Topics: Adult; Anemia, Sickle Cell; Animals; Cell Differentiation; Erythroid Cells; Heme; Hemin; Humans; Hypertension, Pulmonary; Iron; Iron Overload; K562 Cells; Kruppel-Like Transcription Factors; Mice; Mice, Knockout; Placenta Growth Factor; Pregnancy Proteins; Promoter Regions, Genetic; RNA, Messenger	2014
Iron deficiency anaemia in sickle cell disorders in India. The Indian journal of medical research, 2008, Volume: 127, Issue:4 Topics: Adolescent; Adult; Anemia, Iron-Deficiency; Anemia, Sickle Cell; Child; Female; Heme; Humans; India; Iron; Iron Deficiencies; Male; Prevalence; Protoporphyrins	2008

Other Studies

99 other study(ies) available for heme and HbS Disease

Article	Year
Hemopexin dosing improves cardiopulmonary dysfunction in murine sickle cell disease. Free radical biology & medicine, 2021, 11-01, Volume: 175 Topics: Anemia, Sickle Cell; Animals; Heme; Hemoglobins; Hemolysis; Hemopexin; Humans; Mice	2021
Heme-stress activated NRF2 skews fate trajectories of bone marrow cells from dendritic cells towards red pulp-like macrophages in hemolytic anemia. Cell death and differentiation, 2022, Volume: 29, Issue:8 Topics: Anemia, Sickle Cell; Animals; Bone Marrow Cells; Cell Differentiation; Dendritic Cells; Erythropoiesis; Granulocyte-Macrophage Colony-Stimulating Factor; Heme; Hemolysis; Iron; Macrophages; Mice; Mice, Inbred C57BL; NF-E2-Related Factor 2; RNA; Spleen	2022
Evaluation of the mechanisms of heme-induced tissue factor activation: Contribution of innate immune pathways. Experimental biology and medicine (Maywood, N.J.), 2022, Volume: 247, Issue:17 Topics: Anemia, Sickle Cell; Animals; Endothelial Cells; Factor Xa; Heme; Hemolysis; Humans; Immunity, Innate; RNA, Messenger; Thromboplastin; Toll-Like Receptor 4; Tumor Necrosis Factor-alpha	2022
MASP-2 and MASP-3 inhibitors block complement activation, inflammation, and microvascular stasis in a murine model of vaso-occlusion in sickle cell disease. Translational research : the journal of laboratory and clinical medicine, 2022, Volume: 249 Topics: Anemia, Sickle Cell; Animals; Antibodies, Monoclonal; Complement Activation; Disease Models, Animal; E-Selectin; Heme; Hemoglobins; Hemolysis; Hypoxia; Inflammation; Intercellular Adhesion Molecule-1; Mannose-Binding Lectins; Mannose-Binding Protein-Associated Serine Proteases; Mice; NF-kappa B; Vascular Cell Adhesion Molecule-1; Volatile Organic Compounds	2022
Heme Interferes With Complement Factor I-Dependent Regulation by Enhancing Alternative Pathway Activation. Frontiers in immunology, 2022, Volume: 13 Topics: Anemia, Sickle Cell; Complement Factor I; Fibrinogen; Heme; Hemopexin; Humans	2022
HbS promotes TLR4-mediated monocyte activation and proinflammatory cytokine production in sickle cell disease. Blood, 2022, 11-03, Volume: 140, Issue:18 Topics: Anemia, Sickle Cell; Animals; Cytokines; Heme; Humans; Inflammation; Mice; Monocytes; NF-kappa B; Signal Transduction; Toll-Like Receptor 4	2022
Neuregulin-1 attenuates hemolysis- and ischemia induced-cerebrovascular inflammation associated with sickle cell disease. Journal of stroke and cerebrovascular diseases : the official journal of National Stroke Association, 2023, Volume: 32, Issue:2 Topics: Anemia, Sickle Cell; Animals; Heme; Hemolysis; Humans; Inflammation; Ischemia; Mice; Mice, Transgenic; Neuregulin-1	2023
Assessment of total and unbound cell-free heme in plasma of patients with sickle cell disease. Experimental biology and medicine (Maywood, N.J.), 2023, Volume: 248, Issue:10 Topics: Anemia, Sickle Cell; Endothelial Cells; Heme; Hemoglobins; Hemolysis; Hemopexin; Humans	2023
Macrophage metabolic rewiring improves heme-suppressed efferocytosis and tissue damage in sickle cell disease. Blood, 2023, Jun-22, Volume: 141, Issue:25 Topics: Anemia, Sickle Cell; Heme; Humans; Inflammation; Interleukin-4; Macrophages; Peroxisome Proliferator-Activated Receptor Gamma Coactivator 1-alpha; PPAR gamma; Toll-Like Receptor 4	2023
Heme and macrophages: a complicated liaison. Blood, 2023, Jun-22, Volume: 141, Issue:25 Topics: Anemia, Sickle Cell; Heme; Humans; Macrophages; Phagocytosis	2023
Dietary supplementation with sulforaphane attenuates liver damage and heme overload in a sickle cell disease murine model. Experimental hematology, 2019, Volume: 77 Topics: Anemia, Sickle Cell; Animals; Dietary Supplements; Disease Models, Animal; Female; Heme; Humans; Isothiocyanates; Kelch-Like ECH-Associated Protein 1; Liver; Liver Diseases; Male; Mice; Mice, Transgenic; NF-E2-Related Factor 2; Sulfoxides	2019
Complement Component C5 and TLR Molecule CD14 Mediate Heme-Induced Thromboinflammation in Human Blood. Journal of immunology (Baltimore, Md. : 1950), 2019, 09-15, Volume: 203, Issue:6 Topics: Adult; Anemia, Sickle Cell; Animals; Blood Coagulation; Complement Activation; Complement C5; Cytokines; Granulocytes; Heme; Hemolysis; Humans; Inflammation; Lipopolysaccharide Receptors; Male; Monocytes; Swine; Thromboplastin	2019
Haptoglobin genotype predicts severe acute vaso-occlusive pain episodes in children with sickle cell anemia. American journal of hematology, 2020, Volume: 95, Issue:4 Topics: Acute Chest Syndrome; Acute Pain; Adolescent; Alleles; Anemia, Sickle Cell; Arterial Occlusive Diseases; Child; Child, Preschool; Gene Frequency; Genetic Association Studies; Genetic Predisposition to Disease; Haptoglobins; Heme; Humans; Incidence; Prospective Studies; Risk; Young Adult	2020
Hemopexin deficiency promotes acute kidney injury in sickle cell disease. Blood, 2020, 03-26, Volume: 135, Issue:13 Topics: Acute Kidney Injury; Anemia, Sickle Cell; Animals; Biopsy; Disease Models, Animal; Disease Progression; Disease Susceptibility; Erythrocytes; Glomerular Filtration Rate; Heme; Hemopexin; Humans; Kidney Function Tests; Mice; Models, Biological	2020
Heme A1M'ed at the kidney in sickle cell disease. Blood, 2020, 03-26, Volume: 135, Issue:13 Topics: Acute Kidney Injury; Anemia, Sickle Cell; Heme; Hemopexin; Humans; Kidney	2020
Circulating extracellular vesicles from patients with acute chest syndrome disrupt adherens junctions between endothelial cells. Pediatric research, 2021, Volume: 89, Issue:4 Topics: Actins; Acute Chest Syndrome; Adherens Junctions; Adolescent; Anemia, Sickle Cell; Antigens, CD; Cadherins; Cells, Cultured; Child; Child, Preschool; Endothelial Cells; Endothelium, Vascular; Extracellular Vesicles; Female; Heme; Humans; Male; Microcirculation; Nanoparticles	2021
Identification of a Heme Activation Site on the MD-2/TLR4 Complex. Frontiers in immunology, 2020, Volume: 11 Topics: Anemia, Sickle Cell; HEK293 Cells; Heme; Humans; Lymphocyte Antigen 96; Toll-Like Receptor 4	2020
Hemolysis inhibits humoral B-cell responses and modulates alloimmunization risk in patients with sickle cell disease. Blood, 2021, 01-14, Volume: 137, Issue:2 Topics: Anemia, Hemolytic, Autoimmune; Anemia, Sickle Cell; B-Lymphocytes; Blood Transfusion; Cells, Cultured; Guanine Nucleotide Exchange Factors; Heme; Hemolysis; Humans; Isoantibodies; Lymphocyte Activation; Transfusion Reaction	2021
Endothelial Barrier Integrity Is Disrupted Frontiers in immunology, 2020, Volume: 11 Topics: Anemia, Sickle Cell; Antigens, CD; Cadherins; Heme; Hemopexin; Human Umbilical Vein Endothelial Cells; Humans	2020
Heme control to major B (cell): are you listening? Blood, 2021, 01-14, Volume: 137, Issue:2 Topics: Anemia, Sickle Cell; B-Lymphocytes; Heme; Hemolysis; Humans	2021
Vasculo-toxic and pro-inflammatory action of unbound haemoglobin, haem and iron in transfusion-dependent patients with haemolytic anaemias. British journal of haematology, 2021, Volume: 193, Issue:3 Topics: Adolescent; Adult; Anemia, Sickle Cell; beta-Thalassemia; Blood Transfusion; Child; Child, Preschool; Endothelium, Vascular; Female; Heme; Hemoglobins; Humans; Inflammation; Intercellular Adhesion Molecule-1; Interleukin-6; Iron; Male; Spherocytosis, Hereditary; Tumor Necrosis Factor-alpha; Vascular Cell Adhesion Molecule-1; Vascular Endothelial Growth Factor A	2021
Noncanonical Roles of Caspase-4 and Caspase-5 in Heme-Driven IL-1β Release and Cell Death. Journal of immunology (Baltimore, Md. : 1950), 2021, 04-15, Volume: 206, Issue:8 Topics: Alarmins; Anemia, Sickle Cell; Caspases; Caspases, Initiator; Cell Death; Cells, Cultured; Erythrocytes; Heme; Hemolysis; Humans; Inflammasomes; Inflammation; Interleukin-1beta; Macrophages; Up-Regulation	2021
Soluble MD-2 and Heme in Sickle Cell Disease Plasma Promote Pro-Inflammatory Signaling in Endothelial Cells. Frontiers in immunology, 2021, Volume: 12 Topics: Anemia, Sickle Cell; Animals; Endothelial Cells; Heme; Hemopexin; Human Umbilical Vein Endothelial Cells; Humans; Inflammation; Interleukin-8; Lymphocyte Antigen 96; Mice; Signal Transduction; Toll-Like Receptor 4	2021
Heme induces significant neutrophil adhesion in vitro via an NFκB and reactive oxygen species-dependent pathway. Molecular and cellular biochemistry, 2021, Volume: 476, Issue:11 Topics: Anemia, Sickle Cell; CD18 Antigens; Cell Adhesion; Cells, Cultured; Endothelium, Vascular; Heme; Hemolysis; Humans; Intercellular Adhesion Molecule-1; Leukocytes, Mononuclear; Neutrophils; NF-kappa B; Reactive Oxygen Species; Signal Transduction	2021
Excess heme upregulates heme oxygenase 1 and promotes cardiac ferroptosis in mice with sickle cell disease. Blood, 2022, 02-10, Volume: 139, Issue:6 Topics: Anemia, Sickle Cell; Animals; Cardiomyopathies; Female; Ferroptosis; Heme; Heme Oxygenase-1; Male; Membrane Proteins; Mice; Mice, Transgenic; Myocardium	2022
Changes in Heme Levels During Acute Vaso-occlusive Crisis in Sickle Cell Anemia. Hematology/oncology and stem cell therapy, 2023, Jan-17, Volume: 16, Issue:2 Topics: Anemia, Sickle Cell; Biomarkers; Convalescence; Cross-Sectional Studies; Heme; Humans; Volatile Organic Compounds	2023
Effect of hydroxyurea therapy on intravascular hemolysis and endothelial dysfunction markers in sickle cell anemia patients. Annals of hematology, 2021, Volume: 100, Issue:11 Topics: ADAMTS13 Protein; Adolescent; Adult; Anemia, Sickle Cell; Antigens, CD; Antigens, Differentiation, Myelomonocytic; Biomarkers; Cross-Sectional Studies; Endothelium, Vascular; Female; Heme; Hemoglobins; Hemolysis; Humans; Hydroxyurea; L-Lactate Dehydrogenase; Male; Middle Aged; Prohibitins; Receptors, Cell Surface; Thrombospondin 1; von Willebrand Factor; Young Adult	2021
Hemoglobin inhibits albumin uptake by proximal tubule cells: implications for sickle cell disease. American journal of physiology. Cell physiology, 2017, Jun-01, Volume: 312, Issue:6 Topics: Amino Acid Sequence; Anemia, Sickle Cell; Animals; Binding Sites; Binding, Competitive; Cell Line; Cell Line, Transformed; Female; Haptoglobins; Heme; Hemoglobins; Hemolysis; Humans; Kidney Tubules, Proximal; Ligands; Low Density Lipoprotein Receptor-Related Protein-2; Male; Opossums; Oxidation-Reduction; Protein Binding; Protein Conformation, alpha-Helical; Sequence Alignment; Sequence Homology, Amino Acid; Serum Albumin	2017
Characterization of plasma labile heme in hemolytic conditions. The FEBS journal, 2017, Volume: 284, Issue:19 Topics: Amino Acid Sequence; Anemia, Sickle Cell; Animals; Antibodies, Monoclonal; Antibody Affinity; Antibody Specificity; Biotin; Cloning, Molecular; Enzyme-Linked Immunosorbent Assay; Erythrocytes; Escherichia coli; Gene Expression; Heme; Hemoglobins; Hemolysis; Humans; Kinetics; Mice; Mice, Inbred C57BL; Oxidation-Reduction; Peptide Library; Plasmodium falciparum; Protein Binding; Recombinant Proteins; Single-Domain Antibodies; Tetrapyrroles	2017
Dimethyl fumarate increases fetal hemoglobin, provides heme detoxification, and corrects anemia in sickle cell disease. JCI insight, 2017, 10-19, Volume: 2, Issue:20 Topics: Anemia; Anemia, Sickle Cell; Animals; Antioxidants; Dimethyl Fumarate; Disease Models, Animal; Fetal Hemoglobin; gamma-Globins; Gene Expression Regulation; Hematopoietic Stem Cells; Heme; Humans; Inflammation; Leukemia, Erythroblastic, Acute; Mice; NF-E2-Related Factor 2; RNA, Messenger; Spleen	2017
Intravascular hemolysis activates complement via cell-free heme and heme-loaded microvesicles. JCI insight, 2018, 06-21, Volume: 3, Issue:12 Topics: Acute Kidney Injury; Anemia, Sickle Cell; Animals; Cell-Free System; Complement C3; Complement Membrane Attack Complex; Disease Models, Animal; Endothelial Cells; Erythrocytes; Female; Heme; Hemolysis; Hemopexin; Hepatitis A Virus Cellular Receptor 1; Kidney; Mice; Mice, Inbred C57BL; P-Selectin; Receptor, Anaphylatoxin C5a; Receptors, G-Protein-Coupled	2018
On the Binding Free Energy and Molecular Origin of Sickle Cell Hemoglobin Aggregation. The journal of physical chemistry. B, 2018, 08-02, Volume: 122, Issue:30 Topics: Anemia, Sickle Cell; Heme; Hemoglobin, Sickle; Humans; Molecular Dynamics Simulation; Protein Aggregates; Protein Interaction Domains and Motifs; Static Electricity; Thermodynamics	2018
Depletion of haptoglobin and hemopexin promote hemoglobin-mediated lipoprotein oxidation in sickle cell disease. American journal of physiology. Lung cellular and molecular physiology, 2018, 11-01, Volume: 315, Issue:5 Topics: Adult; Anemia, Sickle Cell; Animals; Case-Control Studies; Cohort Studies; Female; Guinea Pigs; Haptoglobins; Heme; Hemoglobins; Hemopexin; Humans; Lipid Peroxidation; Lipids; Lipoproteins; Male; Mice; Mice, Inbred C57BL; Middle Aged; Oxidation-Reduction; Young Adult	2018
P-selectin plays a role in haem-induced acute lung injury in sickle mice. British journal of haematology, 2019, Volume: 186, Issue:2 Topics: Acute Lung Injury; Anemia, Sickle Cell; Animals; Disease Models, Animal; Heme; Mice; Mice, Mutant Strains; P-Selectin	2019
P-selectin drives complement attack on endothelium during intravascular hemolysis in TLR-4/heme-dependent manner. Proceedings of the National Academy of Sciences of the United States of America, 2019, 03-26, Volume: 116, Issue:13 Topics: Alanine Transaminase; Anemia, Sickle Cell; Animals; Complement Activation; Complement C3; Disease Models, Animal; Endothelium, Vascular; Gene Silencing; Heme; Hemolysis; Humans; Lipocalin-2; Liver; Mice; Mice, Inbred C57BL; Mice, Knockout; P-Selectin; Phenylhydrazines; Signal Transduction; Toll-Like Receptor 4	2019
Cardiac expression of HMOX1 and PGF in sickle cell mice and haem-treated wild type mice dominates organ expression profiles via Nrf2 (Nfe2l2). British journal of haematology, 2019, Volume: 187, Issue:5 Topics: Anemia, Sickle Cell; Animals; Female; Gene Expression Regulation; Heme; Heme Oxygenase-1; Male; Membrane Proteins; Mice; Mice, Knockout; NF-E2-Related Factor 2; Placenta Growth Factor	2019
Hemopexin therapy improves cardiovascular function by preventing heme-induced endothelial toxicity in mouse models of hemolytic diseases. Circulation, 2013, Mar-26, Volume: 127, Issue:12 Topics: Anemia, Sickle Cell; Animals; beta-Thalassemia; Cardiovascular System; Disease Models, Animal; Endothelium, Vascular; Heme; Hemopexin; Mice; Mice, Knockout; Mice, SCID; Nitric Oxide; Reactive Oxygen Species; Treatment Outcome	2013
Association between plasma free haem and incidence of vaso-occlusive episodes and acute chest syndrome in children with sickle cell disease. British journal of haematology, 2013, Volume: 162, Issue:5 Topics: Acute Chest Syndrome; Adolescent; Anemia, Sickle Cell; Arterial Occlusive Diseases; Biomarkers; Child; Child, Preschool; Female; Heme; Humans; Male	2013
New insights provided by a comparison of impaired deformability with erythrocyte oxidative stress for sickle cell disease. Blood cells, molecules & diseases, 2014, Volume: 52, Issue:4 Topics: Adolescent; Adult; Anemia, Sickle Cell; Child; Erythrocyte Deformability; Erythrocytes; Erythrocytes, Abnormal; Female; Fetal Hemoglobin; Heme; Hemoglobin, Sickle; Hemoglobins; Humans; Male; Oxidative Stress; Proteolysis; Sickle Cell Trait; Young Adult	2014
Heme triggers TLR4 signaling leading to endothelial cell activation and vaso-occlusion in murine sickle cell disease. Blood, 2014, Jan-16, Volume: 123, Issue:3 Topics: Anemia, Sickle Cell; Animals; Bone Marrow Cells; Cell Adhesion; Endothelial Cells; Haptoglobins; Heme; Hemoglobins; Hemolysis; Hemopexin; Human Umbilical Vein Endothelial Cells; Humans; Inflammation; Lipopolysaccharides; Mice; Mice, Inbred C57BL; Mice, Transgenic; NF-kappa B p50 Subunit; Oxidative Stress; Phenotype; Signal Transduction; Toll-Like Receptor 4; Vasoconstriction; von Willebrand Factor	2014
Heme-induced neutrophil extracellular traps contribute to the pathogenesis of sickle cell disease. Blood, 2014, Jun-12, Volume: 123, Issue:24 Topics: Adult; Anemia, Sickle Cell; Animals; Disease Models, Animal; Extracellular Space; Heme; Humans; Lung; Mice; Mice, Inbred C57BL; Mice, Transgenic; Microcirculation; Neutrophil Activation; Neutrophils	2014
Erythroid DAMPs drive inflammation in SCD. Blood, 2014, Jun-12, Volume: 123, Issue:24 Topics: Anemia, Sickle Cell; Animals; Heme; Humans; Neutrophil Activation; Neutrophils	2014
Artificial oxygen carrier with pharmacologic actions of adenosine-5'-triphosphate, adenosine, and reduced glutathione formulated to treat an array of medical conditions. Artificial organs, 2014, Volume: 38, Issue:8 Topics: Adenosine; Anemia, Sickle Cell; Animals; Blood Substitutes; Glutathione; Heme; Hemoglobins; Humans; Oxygen; Rats	2014
Ironing out placenta growth factor. Blood, 2014, Aug-07, Volume: 124, Issue:6 Topics: Anemia, Sickle Cell; Animals; Erythroid Cells; Heme; Humans; Iron; Kruppel-Like Transcription Factors; Placenta Growth Factor; Pregnancy Proteins	2014
Excess of heme induces tissue factor-dependent activation of coagulation in mice. Haematologica, 2015, Volume: 100, Issue:3 Topics: Anemia, Hemolytic; Anemia, Sickle Cell; Animals; Antibodies; Blood Coagulation; Capillary Permeability; Cells, Cultured; Factor XI; Factor XIIa; Female; Gene Deletion; Gene Expression; Heme; Hemopexin; Humans; Injections, Intravenous; Leukocytes, Mononuclear; Macrophages; Male; Mice; Mice, Inbred C57BL; Mice, Transgenic; RNA, Small Interfering; Swine; Thromboplastin	2015
The fucosylation inhibitor, 2-fluorofucose, inhibits vaso-occlusion, leukocyte-endothelium interactions and NF-ĸB activation in transgenic sickle mice. PloS one, 2015, Volume: 10, Issue:2 Topics: Anemia, Sickle Cell; Animals; Cell Adhesion; Cells, Cultured; Disease Models, Animal; Endothelial Cells; Endothelium; Erythrocytes; Female; Fucose; Heme; Hemoglobins; Humans; Inflammation; Leukocyte Rolling; Leukocytes; Male; Mice; Mice, Inbred C57BL; Mice, Transgenic; Microcirculation; Neutrophils; NF-kappa B; Vascular Cell Adhesion Molecule-1; Venules	2015
Circulating cell membrane microparticles transfer heme to endothelial cells and trigger vasoocclusions in sickle cell disease. Blood, 2015, Jun-11, Volume: 125, Issue:24 Topics: Anemia, Sickle Cell; Animals; Cell-Derived Microparticles; Cohort Studies; Endothelial Cells; Erythrocytes; Heme; Hemolysis; Humans; Male; Mice; Mice, Inbred C57BL; Oxidative Stress; Vascular Diseases	2015
Special delivery: microparticles convey heme. Blood, 2015, Jun-11, Volume: 125, Issue:24 Topics: Anemia, Sickle Cell; Animals; Cell-Derived Microparticles; Endothelial Cells; Heme; Humans; Male; Vascular Diseases	2015
Sickle Cell Hemoglobin in the Ferryl State Promotes βCys-93 Oxidation and Mitochondrial Dysfunction in Epithelial Lung Cells (E10). The Journal of biological chemistry, 2015, Nov-13, Volume: 290, Issue:46 Topics: Anemia, Hemolytic; Anemia, Sickle Cell; Catalysis; Cyclic N-Oxides; Cysteine; Energy Metabolism; Heme; Heme Oxygenase (Decyclizing); Hemoglobin, Sickle; Humans; Hydrogen Peroxide; Iron; Lung; Methemoglobin; Mitochondria; Oxidation-Reduction; Oxygen Consumption; Respiratory Mucosa	2015
Hemopexin therapy reverts heme-induced proinflammatory phenotypic switching of macrophages in a mouse model of sickle cell disease. Blood, 2016, Jan-28, Volume: 127, Issue:4 Topics: Anemia, Sickle Cell; Animals; Anti-Inflammatory Agents; Cell Line; Cells, Cultured; Cytokines; Disease Models, Animal; Gene Deletion; Heme; Hemopexin; Humans; Macrophages; Mice; Mice, Knockout; Reactive Oxygen Species; Toll-Like Receptor 4	2016
Original Research: Diametric effects of hypoxia on pathophysiology of sickle cell disease in a murine model. Experimental biology and medicine (Maywood, N.J.), 2016, Volume: 241, Issue:7 Topics: Anemia, Sickle Cell; Animals; Bilirubin; Disease Models, Animal; Haptoglobins; Heme; Hemoglobins; Hemolysis; Hemopexin; Hypoxia; Lung; Mice; Mice, Transgenic; Real-Time Polymerase Chain Reaction	2016
Heme changes HIF-α, eNOS and nitrite production in HUVECs after simvastatin, HU, and ascorbic acid therapies. Microvascular research, 2016, Volume: 106 Topics: Anemia, Sickle Cell; Ascorbic Acid; Cells, Cultured; Dose-Response Relationship, Drug; Heme; Human Umbilical Vein Endothelial Cells; Humans; Hydroxyurea; Hypoxia-Inducible Factor 1, alpha Subunit; Nitric Oxide Synthase Type III; Nitrites; Simvastatin	2016
Altered heme-mediated modulation of dendritic cell function in sickle cell alloimmunization. Haematologica, 2016, Volume: 101, Issue:9 Topics: Adolescent; Adult; Anemia, Sickle Cell; Antigens, CD; Biomarkers; CD83 Antigen; Cytokines; Dendritic Cells; Female; Heme; Heme Oxygenase-1; Humans; Immunoglobulins; Isoantibodies; Male; Membrane Glycoproteins; Models, Biological; Monocytes; NF-kappa B; T-Lymphocytes; Toll-Like Receptor 4; Transfusion Reaction; Young Adult	2016
Absorbance and redox based approaches for measuring free heme and free hemoglobin in biological matrices. Redox biology, 2016, Volume: 9 Topics: Anemia, Sickle Cell; Biomarkers; Cell-Derived Microparticles; Erythrocytes; Exosomes; Heme; Hemoglobins; Humans; Oxidation-Reduction; Oxidative Stress; Oxyhemoglobins; Wounds and Injuries	2016
Molecular mechanisms of bio-catalysis of heme extraction from hemoglobin. Redox biology, 2017, Volume: 11 Topics: Amino Acid Sequence; Anemia, Sickle Cell; Biocatalysis; Erythrocytes; Heme; Hemoglobins; Hemolysis; Humans; Iron; Iron-Regulatory Proteins; Molecular Dynamics Simulation; Nitric Oxide; Oxidative Stress; Staphylococcus aureus	2017
The in vitro synthesis of heme in the human red blood cell of sickle cell anemia. The Journal of biological chemistry, 1948, Volume: 173, Issue:2 Topics: Anemia, Sickle Cell; Erythrocytes; Heme; Humans; In Vitro Techniques	1948
Heme induces endothelial tissue factor expression: potential role in hemostatic activation in patients with hemolytic anemia. Journal of thrombosis and haemostasis : JTH, 2008, Volume: 6, Issue:12 Topics: Anemia, Hemolytic; Anemia, Sickle Cell; Cells, Cultured; Endothelium, Vascular; Heme; Hemostasis; Humans; NF-kappa B; RNA, Messenger; Thromboplastin; Transcriptional Activation; Tumor Necrosis Factor-alpha; Up-Regulation	2008
Global gene expression profiling of endothelium exposed to heme reveals an organ-specific induction of cytoprotective enzymes in sickle cell disease. PloS one, 2011, Mar-31, Volume: 6, Issue:3 Topics: Anemia, Sickle Cell; Animals; Cells, Cultured; Endothelial Cells; Endothelium; Gene Expression Profiling; Heme; Heme Oxygenase-1; Humans; Immunoblotting; Immunohistochemistry; Lung; Mice; Myocardium; NAD(P)H Dehydrogenase (Quinone); Oligonucleotide Array Sequence Analysis; Polymerase Chain Reaction	2011
Methaemalbumin formation in sickle cell disease: effect on oxidative protein modification and HO-1 induction. British journal of haematology, 2011, Volume: 154, Issue:4 Topics: Anemia, Sickle Cell; Animals; Cattle; Cells, Cultured; Endothelium, Vascular; Haptoglobins; Heme; Heme Oxygenase-1; Humans; Lipid Peroxidation; Methemalbumin; Oxidation-Reduction; Protein Binding; Serum Albumin	2011
Responses of normal and sickle cell hemoglobin to S-nitroscysteine: implications for therapeutic applications of NO in treatment of sickle cell disease. Biophysical chemistry, 2002, Jul-10, Volume: 98, Issue:1-2 Topics: Anemia, Sickle Cell; Animals; Chelating Agents; Cysteine; Dolphins; Heme; Hemoglobin, Sickle; Hemoglobins; Humans; Nitric Oxide; Oxidation-Reduction; Oxygen; Protein Binding; S-Nitrosothiols; Spectrometry, Mass, Electrospray Ionization; Vasodilator Agents	2002
Cell-free hemoglobin limits nitric oxide bioavailability in sickle-cell disease. Nature medicine, 2002, Volume: 8, Issue:12 Topics: Adult; Anemia, Sickle Cell; Biological Availability; Heme; Hemocyanins; Hemoglobins; Hemolysis; Humans; Middle Aged; Nitric Oxide; Oxidation-Reduction	2002
Immunoelectrophoretic studies of the beta1-haem-binding globulin (haemopexin) in hereditary haemolytic disorders. Nature, 1963, Feb-09, Volume: 197 Topics: Anemia; Anemia, Sickle Cell; beta-Thalassemia; Erythroblasts; Heme; Hemopexin; Humans; Serum Globulins; Spherocytosis, Hereditary	1963
SERUM BENZIDINE-POSITIVE PIGMENTS IN SICKLE CELL ANEMIA. The Journal of laboratory and clinical medicine, 1963, Volume: 62 Topics: Anemia; Anemia, Sickle Cell; Benzidines; Blood Chemical Analysis; Blood Protein Electrophoresis; Erythrocytes, Abnormal; Haptoglobins; Heme; Hemoglobins; Humans; Serum Albumin	1963
IN VITRO PORPHOBILINOGEN AND PORPHYRIN SYNTHESIS IN THALASSEMIA MAJOR AND SICKLE CELL ANEMIA. Annals of the New York Academy of Sciences, 1964, Oct-07, Volume: 119 Topics: Amino Acid Oxidoreductases; Anemia; Anemia, Sickle Cell; beta-Thalassemia; Heme; In Vitro Techniques; Levulinic Acids; Metabolism; Porphobilinogen; Porphyrins; Thalassemia	1964
PLASMA TETRAPYRROLE PIGMENTS IN SICKLE CELL ANEMIA; LONG TERM STUDIES AND THE EFFECTS OF LOW TEMPERATURES. American journal of clinical pathology, 1965, Volume: 43 Topics: Anemia; Anemia, Sickle Cell; Bilirubin; Black People; Blood; Cold Temperature; Erythrocytes, Abnormal; Heme; Hemoglobins; Pigments, Biological; Pyrroles; Temperature	1965
Heme synthesis and red blood cell dynamics in normal humans and in subjects with polycythemia vera, sickle-cell anemia, and pernicious anemia. The Journal of biological chemistry, 1949, Volume: 179, Issue:1 Topics: Anemia, Pernicious; Anemia, Sickle Cell; Erythrocytes; Heme; Polycythemia Vera	1949
Role of bilirubin in the regulation of the total peroxyl radical trapping antioxidant activity of plasma in sickle cell disease. Biochemical and biophysical research communications, 1998, Jul-20, Volume: 248, Issue:2 Topics: Anemia, Sickle Cell; Antioxidants; Bilirubin; Heme; Humans; Peroxides; Plasma; Vitamin E	1998
Low-density lipoprotein susceptibility to oxidation and cytotoxicity to endothelium in sickle cell anemia. The Journal of laboratory and clinical medicine, 1999, Volume: 133, Issue:6 Topics: Adolescent; Adult; Anemia, Sickle Cell; Animals; Aorta; Child; Child, Preschool; Endothelium, Vascular; Heme; Humans; In Vitro Techniques; Iron; Lipid Peroxidation; Lipoproteins, LDL; Middle Aged; Oxidation-Reduction; Swine; Time Factors	1999
Interspecies hybrid HbS: complete neutralization of Val6(beta)-dependent polymerization of human beta-chain by pig alpha-chains. Journal of molecular biology, 2000, Jul-28, Volume: 300, Issue:5 Topics: Allosteric Regulation; Amino Acid Sequence; Amino Acid Substitution; Anemia, Sickle Cell; Animals; Binding Sites; Dimerization; Genetic Therapy; Globins; Heme; Hemoglobin, Sickle; Humans; Hydrogen-Ion Concentration; Kinetics; Magnetic Resonance Spectroscopy; Models, Molecular; Oxygen; Protein Engineering; Protein Structure, Quaternary; Recombinant Fusion Proteins; Static Electricity; Swine; Valine	2000
Nitric oxide-mediated heme oxidation and selective beta-globin nitrosation of hemoglobin from normal and sickle erythrocytes. Biochemical and biophysical research communications, 2000, Sep-07, Volume: 275, Issue:3 Topics: Anemia, Sickle Cell; Cysteine; Diethylamines; Erythrocytes; Globins; Heme; Hemoglobin A; Hemoglobin, Sickle; Humans; Kinetics; Mass Spectrometry; Methemoglobin; Nitric Oxide; Nitrogen Oxides; Nitroso Compounds; Oxidation-Reduction; Oxygen; S-Nitrosothiols; Spectrophotometry; Thermodynamics	2000
Oxidative stress and induction of heme oxygenase-1 in the kidney in sickle cell disease. The American journal of pathology, 2001, Volume: 158, Issue:3 Topics: Anemia, Sickle Cell; Animals; Buthionine Sulfoximine; Creatinine; Endothelium, Vascular; Enzyme Inhibitors; Erythrocytes; Glutathione; Heme; Heme Oxygenase (Decyclizing); Heme Oxygenase-1; Humans; Kidney; Lipid Peroxidation; Membrane Proteins; Mice; Mice, Transgenic; Oxidative Stress; Transcriptional Activation	2001
Heme redox properties of S-nitrosated hemoglobin A0 and hemoglobin S: implications for interactions of nitric oxide with normal and sickle red blood cells. The Journal of biological chemistry, 2002, Apr-26, Volume: 277, Issue:17 Topics: Anemia, Sickle Cell; Erythrocytes, Abnormal; Heme; Hemoglobin, Sickle; Humans; Nitric Oxide; Oxidation-Reduction; Spectrometry, Mass, Electrospray Ionization	2002
On the nature of sickle-cell disease in the Arabian Peninsula. Human genetics, 1979, Volume: 52, Issue:3 Topics: Anemia, Sickle Cell; Gene Frequency; Heme; Heterozygote; Homozygote; Humans; Jordan; Saudi Arabia	1979
Denatured hemoglobin in sickle erythrocytes. The Journal of clinical investigation, 1977, Volume: 59, Issue:4 Topics: Adolescent; Adult; Anemia, Hemolytic, Autoimmune; Anemia, Sickle Cell; Child; Child, Preschool; Erythrocyte Membrane; Erythrocytes; Heme; Hemoglobin A; Hemoglobin, Sickle; Humans; Oxyhemoglobins; Protein Denaturation; Spectrophotometry; Spherocytosis, Hereditary	1977
Increased erythrocyte uroporphyrinogen-l-synthetase, delta-aminolevulinic acid dehydratase and protoporphyrin in hemolytic anemias. The American journal of medicine, 1977, Volume: 63, Issue:3 Topics: Ammonia-Lyases; Anemia, Hemolytic; Anemia, Sickle Cell; Erythrocyte Count; Erythrocytes; Heme; Hemoglobinopathies; Hemolysis; Humans; Hydro-Lyases; Hydroxymethylbilane Synthase; Porphobilinogen Synthase; Porphyrins; Protoporphyrins; Reticulocytes; Thalassemia	1977
Heme synthesis in hereditary hemolytic anemias: decreased delta-aminolevulinic acid synthetase in hemoglobin Köln disease. Pediatric research, 1976, Volume: 10, Issue:7 Topics: 5-Aminolevulinate Synthetase; Adult; Anemia, Hemolytic, Congenital; Anemia, Sickle Cell; Erythrocytes; Heme; Hemoglobinopathies; Hemoglobins, Abnormal; Humans; Infant; Infant, Newborn; Porphobilinogen Synthase; Pyruvate Kinase; Thalassemia	1976
Hemin reversal of benzene-induced inhibition of reticulocyte protein synthesis. Blood, 1976, Volume: 47, Issue:1 Topics: Adenosine Triphosphate; Anemia, Sickle Cell; Animals; Benzene; Blood Proteins; Glutathione; Heme; Hemin; Humans; Rabbits; Reticulocytes; Ribosomes	1976
The chelation of nonheme iron within sickle erythrocytes by the hydroxypyridinone chelator CP094. Archives of biochemistry and biophysics, 1992, Volume: 297, Issue:2 Topics: Anemia, Sickle Cell; Erythrocyte Membrane; Erythrocytes; Heme; Humans; In Vitro Techniques; Iron; Iron Chelating Agents; Kinetics; Lipid Peroxidation; Pyridones; Reference Values	1992
Hydroxyl radical formation by sickle erythrocyte membranes: role of pathologic iron deposits and cytoplasmic reducing agents. Blood, 1991, Nov-15, Volume: 78, Issue:10 Topics: Anemia, Sickle Cell; Ascorbic Acid; Deferoxamine; Erythrocyte Membrane; Free Radicals; Glutathione; Heme; Humans; Hydrogen Peroxide; Hydroxides; Hydroxyl Radical; Iron; Kinetics; Lipid Peroxidation; NAD; NADP; Oxidation-Reduction; Reference Values	1991
Effect of lead and ethanol upon gamma-globin synthesis in sickle reticulocytes. The American journal of the medical sciences, 1986, Volume: 292, Issue:5 Topics: Anemia, Sickle Cell; Animals; Dogs; Ethanol; Fetal Hemoglobin; Globins; Heme; Humans; Lead; Protein Multimerization; Reticulocytes	1986
Iron compartments associated with sickle RBC membranes: a mechanism for the targeting of oxidative damage. Progress in clinical and biological research, 1989, Volume: 319 Topics: Anemia, Sickle Cell; Cell Compartmentation; Erythrocyte Membrane; Heme; Humans; Iron; Oxidation-Reduction; Peroxides; tert-Butylhydroperoxide	1989
Nonheme iron in sickle erythrocyte membranes: association with phospholipids and potential role in lipid peroxidation. Blood, 1988, Volume: 72, Issue:4 Topics: Adsorption; Anemia, Sickle Cell; Butylated Hydroxytoluene; Erythrocyte Membrane; Erythrocytes, Abnormal; Ferrozine; Heme; Humans; Iron; Kinetics; Lipid Peroxides; Liposomes; Membrane Lipids; Peroxides; Phospholipids; Quinones	1988
Excess heme in sickle erythrocyte inside-out membranes: possible role in thiol oxidation. Blood, 1988, Volume: 71, Issue:4 Topics: Anemia, Sickle Cell; Erythrocyte Membrane; Erythrocytes, Abnormal; Heme; Hemeproteins; Humans; Membrane Proteins; Oxidation-Reduction; Sulfhydryl Compounds	1988
Biosynthesis of heme in immature erythroid cells. The regulatory step for heme formation in the human erythron. The Journal of biological chemistry, 1988, May-15, Volume: 263, Issue:14 Topics: Adolescent; Adult; Aminolevulinic Acid; Anemia, Sickle Cell; Animals; Bone Marrow; Child; Cycloheximide; Feedback; Female; Globins; Glycine; Heme; Humans; Iron Radioisotopes; Kinetics; Male; Methionine; Middle Aged; Protein Biosynthesis; Rabbits; Reticulocytes; Transferrin	1988
Detection of hemin release during hemoglobin S denaturation. Blood, 1988, Volume: 71, Issue:6 Topics: Anemia, Sickle Cell; Cytosol; Erythrocytes; Heme; Hemin; Hemoglobin A; Hemoglobin, Sickle; Humans; In Vitro Techniques; Oxyhemoglobins; Protein Denaturation	1988
Accelerated autoxidation and heme loss due to instability of sickle hemoglobin. Proceedings of the National Academy of Sciences of the United States of America, 1988, Volume: 85, Issue:1 Topics: Anemia, Sickle Cell; Drug Stability; Heme; Hemoglobin A; Hemoglobin, Sickle; Humans; Kinetics; Oxidation-Reduction; Reference Values; Spectrophotometry	1988
The effect of hemin in vitro and in vivo on human erythroid progenitor cells. International journal of cell cloning, 1987, Volume: 5, Issue:1 Topics: Adult; Anemia, Sickle Cell; Colony-Forming Units Assay; Erythropoiesis; Female; Globins; Hematopoietic Stem Cells; Heme; Hemin; Humans; Male; Porphyrias	1987
Toxic heme in sickle cells: an explanation for death of malaria parasites. The American journal of tropical medicine and hygiene, 1985, Volume: 34, Issue:2 Topics: Adolescent; Adult; Anemia, Sickle Cell; Animals; Chloroquine; Erythrocytes; Female; Heme; Hemin; Humans; Male; Plasmodium falciparum; Sickle Cell Trait	1985
Accumulation and drainage of hemin in the red cell membrane. Biochimica et biophysica acta, 1985, Dec-05, Volume: 821, Issue:2 Topics: Albumins; Anemia, Sickle Cell; Dioxanes; Erythrocyte Aging; Erythrocyte Membrane; Heme; Hemin; Hemolysis; Humans; Thalassemia; Water	1985
[Use of the determination of haptoglobin and hemopexin in evaluation of the course of hemolytic syndromes of various types]. Haematologica, 1971, Volume: 56, Issue:11 Topics: Anemia, Hemolytic; Anemia, Hemolytic, Autoimmune; Anemia, Sickle Cell; Beta-Globulins; Favism; Haptoglobins; Heme; Hemopexin; Humans; Spherocytosis, Hereditary; Thalassemia	1971
Some aspects of the haemoglobinopathies. Transactions of the Royal Society of Tropical Medicine and Hygiene, 1974, Volume: 68, Issue:2 Topics: Amino Acid Sequence; Anemia, Sickle Cell; Fetal Hemoglobin; Genetic Variation; Heme; Hemoglobinometry; Hemoglobinopathies; Hemoglobins, Abnormal; Heterozygote; Humans; Imino Acids; Molecular Conformation; Mutation; Structure-Activity Relationship; Thalassemia	1974
Hemopexin metabolism in sickle-cell disease, porphyrias and control subjects--effects of heme injection. The New England journal of medicine, 1974, Apr-11, Volume: 290, Issue:15 Topics: Anemia, Sickle Cell; Erythropoiesis; Half-Life; Heme; Hemopexin; Humans; Injections, Intravenous; Iodine Radioisotopes; Middle Aged; Porphyrias; Skin Manifestations; Time Factors	1974
Nitrogen mustard: an "in vitro" inhibitor of erythrocyte sickling. Biochemical and biophysical research communications, 1972, Aug-07, Volume: 48, Issue:3 Topics: Anemia, Sickle Cell; Electrophoresis, Starch Gel; Erythrocytes; Gels; Heme; Hemoglobins; Hemoglobins, Abnormal; Hemolysis; Humans; In Vitro Techniques; Mechlorethamine; Osmotic Fragility; Oxygen; Protein Binding	1972
Urea therapy in sickle-cell anemia. The New England journal of medicine, 1971, Oct-28, Volume: 285, Issue:18 Topics: Anemia, Sickle Cell; Cyanates; Heme; Hemolysis; Humans; Pain; Urea	1971
Effect of intravenous urea in invert sugar on heme catabolism in sickle-cell anemia. The New England journal of medicine, 1971, Oct-28, Volume: 285, Issue:18 Topics: Anemia, Sickle Cell; Bilirubin; Blood Urea Nitrogen; Carbon Monoxide; Erythrocyte Count; Female; Fructose; Glucose; Hematocrit; Heme; Hemoglobins; Humans; Injections, Intravenous; Male; Reticulocytes; Solutions; Urea	1971
Inherited disorders of hemoglobin synthesis and pregnancy. American journal of obstetrics and gynecology, 1971, Volume: 111, Issue:1 Topics: Abortion, Induced; Abortion, Therapeutic; Adult; Anemia, Sickle Cell; Cesarean Section; Female; Fetal Death; Fetal Hemoglobin; Hematopoiesis; Hematuria; Heme; Hemoglobin C Disease; Hemoglobinopathies; Hemoglobins; Humans; Infant, Newborn; Infertility, Female; Kidney Diseases; Lung Diseases; Maternal-Fetal Exchange; Obstetric Labor, Premature; Pre-Eclampsia; Pregnancy; Pregnancy Complications, Cardiovascular; Pregnancy Complications, Hematologic; Splenomegaly; Thalassemia; Uterine Hemorrhage	1971
[Significance of disorders of hemoglobin synthesis for the clinical practice]. Die Medizinische Welt, 1967, Dec-16, Volume: 50 Topics: Anemia, Macrocytic; Anemia, Sickle Cell; Deferoxamine; Erythrocyte Aging; Erythropoiesis; Hematologic Diseases; Heme; Hemoglobinopathies; Hemoglobins; Hemoglobins, Abnormal; Humans; Methemoglobinemia; Mitochondria; Peptide Biosynthesis	1967
Plasma concentrations of hemopexin, haptoglobin and heme in patients with various hemolytic diseases. Blood, 1968, Volume: 32, Issue:5 Topics: Adolescent; Adult; Aged; Anemia, Hemolytic, Autoimmune; Anemia, Sickle Cell; Blood Proteins; Child; Haptoglobins; Heme; Hemoglobinuria, Paroxysmal; Humans; Middle Aged; Myoglobinuria; Porphyrias; Spherocytosis, Hereditary; Thalassemia	1968
[The clinical picture of erythropathies]. Folia haematologica; internationales Magazin fur Blutforschung, 1964, Volume: 9, Issue:3 Topics: Anemia, Hemolytic, Congenital; Anemia, Macrocytic; Anemia, Sickle Cell; Erythrocytes; Glucosephosphate Dehydrogenase Deficiency; Hematologic Diseases; Heme; Humans; Methemoglobinemia; Porphyrias; Spherocytosis, Hereditary; Thalassemia	1964