heme has been researched along with Di Guglielmo Disease in 126 studies
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 82 (65.08) | 18.7374 |
| 1990's | 29 (23.02) | 18.2507 |
| 2000's | 9 (7.14) | 29.6817 |
| 2010's | 4 (3.17) | 24.3611 |
| 2020's | 2 (1.59) | 2.80 |
| Authors | Studies |
|---|---|
| Chen, CY; Chien, HF; Fu, YH; Lai, ZS; Lin, LI; Ou, DL; Shen, CJ; Su, KW; Tien, HF; Yang, YR | 1 |
| Bergonia, H; Danoff, A; Gillis, S; Jackson, L; Nicolas, G; O'Neill, L; Perfetto, M; Phillips, JD; Puy, H; Rondelli, CM; West, R; Yien, YY | 1 |
| Brittain, J; Gupta, D; Hobbs, WE; Krishnamoorthy, S; Li, B; Li, H; Light, DR; Makala, L; Moore, N; Pace, B; Stone, I; Sturtevant, S; Thullen, T; Vieira, BF | 1 |
| Blank, V; Garcia-Santos, D; Gasiorek, JJ; Hui, ST; Mikhael, M; Ponka, P | 1 |
| Crooks, DR; Ghosh, MC; Haller, RG; Rouault, TA; Tong, WH | 1 |
| Berkovitch-Luria, G; Malik, Z; Nudelman, A; Rephaeli, A; Rozic, G; Weitman, M; Yakobovitch, S | 1 |
| Augery-Bourget, Y; Hafid-Medheb, K; Hanania, N; Minatchy, MN; Robert-Lézénès, J | 1 |
| Furukawa, T; Kakimoto, K; Masaki, R; Taketani, S; Ueta, H | 1 |
| Comelli, M; Di Pancrazio, F; Mavelli, I | 1 |
| Fujita, H; Igarashi, K; Mori, H; Nakanishi, K; Saito, T; Sun, J; Tahara, T; Taketani, S; Yamamoto, M | 1 |
| Hertogs, CF; Malik, Z; Pluznik, DH; Rothmann, J | 1 |
| Forsbeck, K; Nilsson, K | 1 |
| Ebert, PS; Frykholm, BC; Hess, RA; Tschudy, DP | 3 |
| Gambari, R | 1 |
| Borová, J; Fuchs, O; Hradilek, A; Neuwirt, J | 2 |
| Beaumont, C; da Silva, V; de Verneuil, H; Deybach, JC; Grandchamp, B; Nordmann, Y | 1 |
| Borova, J; Fuchs, O; Hradilek, A; Neuwirt, J; Trávnícek, M | 2 |
| Azzam, EI; Borsa, J; Einspenner, M; Raaphorst, GP; Vadasz, J | 1 |
| Ebert, PS; Frykholm, BC; Hess, RA; Tschudy, DP; Weinbach, EC | 1 |
| Gusella, JF; Housman, DE; Keys, C; Neumann, JR; Tsiftsoglou, AS; Volloch, V; Weil, SC | 1 |
| Aft, R; Lo, SC; Mueller, GC | 1 |
| Bernstein, A; Mager, D | 1 |
| Hugues, B; Osborne, HB | 1 |
| Farley, BA; Kosciolek, B; LaBella, S; Ohlsson-Wilhelm, BM; Rowley, PT; Rudolph, NS | 1 |
| Gusella, JF; Housman, DE; Neumann, J; Tsiftsoglou, AS; Volloch, V; Weil, SC | 1 |
| Fowler, DA; Sommadossi, JP; Weidner, DA | 1 |
| Dailey, HA; Prasad, AR | 1 |
| Furukawa, T; Inokuchi, H; Kohno, H; Nishimura, K; Taketani, S; Tokunaga, R; Yoshinaga, T | 1 |
| Fujita, H; Fukuda, Y; Sassa, S; Taketani, S | 1 |
| Fujita, H; Fukuda, Y; Garbaczewski, L; Sassa, S | 1 |
| Furukawa, T; Kohno, H; Okuda, M; Taketani, S; Tokunaga, R | 1 |
| Fuchs, O | 1 |
| Pilz, RB | 1 |
| Beri, R; Chandra, R | 1 |
| Irino, S; Kawanishi, K; Kubota, Y; Ohnishi, H; Takahara, J; Tanaka, T; Yamaguchi, M; Yamaoka, G | 1 |
| Cogley, M; McCormick, S; Nauseef, WM | 1 |
| Beaumont, C; Grandchamp, B; Hentze, MW; Picard, V; Porcher, C; Renaudie, F | 1 |
| Domachowske, JB; Malech, HL; Rafferty, SP | 1 |
| Elsayed, NM; Gaddam, A; Gorbunov, NV; Kagan, VE; Kisin, ER; Ritov, VB; Thampatty, P; Yalowich, JC | 1 |
| Akasaka, J; Fujita, H; Furuyama, K; Hayashi, N; Igarashi, K; Nagai, T; Sassa, S; Yamamoto, M | 1 |
| Hayakawa, T; Kawasaki, N; Morimoto, K | 1 |
| Akasaka, JE; Hayashi, N; Kobayashi, A; Nagai, T; Takahashi, S; Taketani, S; Yamamoto, M | 1 |
| Adachi, Y; Ikehara, S; Ishii, T; Kohno, H; Taketani, S; Tokunaga, R | 1 |
| Gregory, T; Orkin, SH; Shirihai, OS; Weiss, MJ; Yu, C | 1 |
| Chefalo, PJ; Chen, JJ; Crosby, JS; Leboulch, P; London, IM; Yeh, I; Ying, S | 1 |
| Dailey, HA; Woodard, SI | 1 |
| Di Risio, C; Garbossa, G; Nesse, A; Pérez, G; Vittori, D | 1 |
| Canonne-Hergaux, F; Gros, P; Ponka, P; Zhang, AS | 1 |
| Giladi, M; Preisler, HD | 2 |
| Bonkowsky, HL; Deisseroth, A; Ebert, PS | 1 |
| Beaudet, AL; Dabney, BJ | 2 |
| Belardelli, F; Benedetto, A; Cioé, L; Dolei, A; Matarese, GP; Rossi, GB | 1 |
| Abramczuk, J; Rovera, G; Surrey, S | 1 |
| Aden, D; Rovera, G; Surrey, S | 1 |
| Fischer, S; Glass, J; Nunez, MT; Robinson, SH | 1 |
| Granick, JL; Sassa, S | 1 |
| Friend, C; Gabelman, N; Price, P; Sassa, S; Scher, W; Tsuei, D | 1 |
| Benoff, S; Bruce, SA; Skoultchi, AI | 1 |
| Moore, MR; Rutherford, T; Thompson, GG | 1 |
| Eisen, H | 1 |
| Fibach, E; Gambari, R; Maniatis, G; Marks, PA; Reuben, RC; Rifkind, RA; Sassa, S; Shaw, PA | 1 |
| Rutherford, TR; Weatherall, DJ | 1 |
| Djaldetti, M; Halbrecht, I; Malik, Z | 1 |
| Lingrel, JB; Lowenhaupt, K | 1 |
| Harrison, PR; Rutherford, TR | 1 |
| Bigley, R; Evans, LH; Kabat, D; Koler, RD; Sherton, CC | 1 |
| Lyman, G; Preisler, HD | 1 |
| Christoff, G; Preisler, HD; Taylor, E | 1 |
| Forget, BG; Glass, J; Housman, D | 1 |
| Stout, DL | 1 |
| Chin, J; Haile, DJ; Harford, JB; Klausner, RD; Rouault, TA; Tang, CK | 1 |
| Clarke, MF; Danish, R; el-Awar, O; Langmore, J; Ryan, JJ; Turka, LA; Weber, BL | 1 |
| Dailey, HA; Eldridge, MG | 1 |
| Fuchs, O; Hradilek, A; Neuwirt, J | 1 |
| Harris, ED; Percival, SS | 1 |
| Affabris, E; Battistini, A; Bulgarini, D; Coccia, EM; Fiorucci, G; Marziali, G; Romeo, G; Rossi, GB; Scalzo, S; Testa, U | 1 |
| Bishop, TR; De Verneuil, H; Fujita, H; Hayashi, N; Morimoto, R; Sassa, S; Shibahara, S; Yamagami, T; Yamamoto, M; Yoshinaga, T | 1 |
| Cox, R; Kuykendall, JR | 1 |
| Ku, WW; Piper, WN | 1 |
| Hradilek, A; Neuwirt, J | 2 |
| Barbieri, R; Biagini, R; Gambari, R; Viola, L | 1 |
| Chinchar, VG; Kumar, G; Turner, LA | 1 |
| Haines, KM; Nicolaides, NC; Stoeckert, CJ | 1 |
| Kirschner-Zilber, I; Laufer, H; Shaklai, N | 1 |
| Prochownik, EV | 1 |
| Bevilacqua, C; Boiocchi, M; Maestro, R; Toffoli, G; Tumiotto, L; Viel, A | 1 |
| Bader, M; Hermann, M; Sarre, TF | 1 |
| Kupfer, B; Moroz, C; Shterman, N | 1 |
| Hensold, J; Robinson, SH; Tsiftsoglou, AS; Wong, W | 1 |
| Walker, MM; Wanda, PE | 1 |
| Kotzbauer, PT; Morimoto, RI; Theodorakis, NG; Williams, GT; Zand, DJ | 1 |
| Bottomley, SS; Bridges, KR; Wolfe, LC | 1 |
| Fagan, JM; Goldberg, AL; Tanaka, K; Waxman, L | 1 |
| Galbraith, RA; Kappas, A; Sassa, S | 1 |
| Kufe, DW; Shafman, TD; Sherman, ML | 1 |
| Kohno, H; Taketani, S; Tokunaga, R | 1 |
| Gräsbeck, R; Majuri, R | 1 |
| Maines, MD; Rowley, PT; Trakshel, GM | 1 |
| Boiocchi, M; Lorico, A; Toffoli, G | 1 |
| Barbieri, R; Feriotto, G; Gambari, R; Nastruzzi, C | 1 |
| Kurachi, S; Messner, H; Nakamoto, B; Papayannopoulou, T; Tweeddale, M | 1 |
| Scher, BM; Scher, W; Waxman, S | 1 |
| Galbraith, RA; Kappas, A; Sassa, S; Wissel, PS | 1 |
| Laskey, JD; Ponka, P; Schulman, HM | 1 |
| Decal, DL; Umlas, ME; Whittington, KB; Zucker, RM | 1 |
| Bauminger, RE; Fibach, E; Konijn, AM; Ofer, S; Rachmilewitz, EA | 1 |
| Dailey, HA; Fadigan, A | 1 |
| DiMambro, E; Galanti, M; Levy, SB | 1 |
| Barbieri, R; Feriotto, G; Gambari, R; Nastruzzi, C; Traniello, F | 1 |
| Baldini, A; de Capoa, A; Fantoni, A; Gambari, R; Marlekaj, P; Raschellà, G | 1 |
| Griffin, J; Kufe, D; Mitchell, T; Sabbath, K; Sariban, E; Watanabe, T | 1 |
| Beaumont, C; de Verneuil, H; Grandchamp, B; Nordmann, Y | 1 |
| Kufe, DW; Shafman, T; Watanabe, T | 1 |
| Bottomley, RH; Bottomley, SS; Hussein, KK; Shaw, MT | 1 |
| Eastman, PM; Schrier, SL; Schwartz, R | 1 |
| Hotta, T; Tanaka, M; Yamada, H | 1 |
| Dameshek, W; Necheles, TF | 1 |
| Goodman, JR; Hall, SG | 1 |
| Dameshek, W | 1 |
1 review(s) available for heme and Di Guglielmo Disease
| Article | Year |
|---|---|
Chemistry and biology of heme. Effect of metal salts, organometals, and metalloporphyrins on heme synthesis and catabolism, with special reference to clinical implications and interactions with cytochrome P-450.
Topics: Amino Acid Metabolism, Inborn Errors; Animals; Catalysis; Cytochrome P-450 Enzyme System; Drug Interactions; Heme; Humans; Hyperbilirubinemia; Infant, Newborn; Lead Poisoning; Leukemia, Erythroblastic, Acute; Metalloporphyrins; Metals; Organometallic Compounds; Tyrosine | 1993 |
125 other study(ies) available for heme and Di Guglielmo Disease
| Article | Year |
|---|---|
Cabozantinib promotes erythroid differentiation in K562 erythroleukemia cells through global changes in gene expression and JNK activation.
Topics: Anilides; Cell Differentiation; Enzyme Activation; Gene Expression; Heme; Humans; K562 Cells; Leukemia, Erythroblastic, Acute; MAP Kinase Kinase 4; Phosphatidylinositol 3-Kinases; Proto-Oncogene Proteins c-akt; Pyridines | 2022 |
The ubiquitous mitochondrial protein unfoldase CLPX regulates erythroid heme synthesis by control of iron utilization and heme synthesis enzyme activation and turnover.
Topics: 5-Aminolevulinate Synthetase; Animals; Cell Line, Tumor; Endopeptidase Clp; Enzyme Activation; Ferrochelatase; Gene Knockout Techniques; Heme; Iron; Leukemia, Erythroblastic, Acute; Mice; Mitochondria; Models, Animal; Proteolysis; Zebrafish | 2021 |
Dimethyl fumarate increases fetal hemoglobin, provides heme detoxification, and corrects anemia in sickle cell disease.
Topics: Anemia; Anemia, Sickle Cell; Animals; Antioxidants; Dimethyl Fumarate; Disease Models, Animal; Fetal Hemoglobin; gamma-Globins; Gene Expression Regulation; Hematopoietic Stem Cells; Heme; Humans; Inflammation; Leukemia, Erythroblastic, Acute; Mice; NF-E2-Related Factor 2; RNA, Messenger; Spleen | 2017 |
Thioredoxin-interacting protein regulates the differentiation of murine erythroid precursors.
Topics: Animals; Anthracenes; Butadienes; Carrier Proteins; Cell Differentiation; Cell Line; Cell Line, Tumor; Erythroblasts; Erythropoiesis; Extracellular Signal-Regulated MAP Kinases; Gene Expression; Heme; Imidazoles; Immunoblotting; Iron; JNK Mitogen-Activated Protein Kinases; Leukemia, Erythroblastic, Acute; Mice, Inbred C57BL; Mice, Knockout; Nitriles; p38 Mitogen-Activated Protein Kinases; Pyridines; Reverse Transcriptase Polymerase Chain Reaction; Thioredoxins | 2015 |
Posttranslational stability of the heme biosynthetic enzyme ferrochelatase is dependent on iron availability and intact iron-sulfur cluster assembly machinery.
Topics: Anemia, Iron-Deficiency; Animals; Biopsy; Cell Line, Tumor; Erythrocytes; Ferrochelatase; Gene Expression Regulation, Enzymologic; Heme; Humans; Iron; Iron Regulatory Protein 2; Leukemia, Erythroblastic, Acute; Mice; Mice, Mutant Strains; Mitochondrial Myopathies; Muscle, Skeletal; Oxidative Stress; Protein Processing, Post-Translational; RNA Processing, Post-Transcriptional; RNA, Messenger; Sulfur | 2010 |
A multifunctional 5-aminolevulinic acid derivative induces erythroid differentiation of K562 human erythroleukemic cells.
Topics: alpha-Globins; Aminolevulinic Acid; Butyric Acid; Cell Differentiation; Cell Proliferation; Erythroid Cells; Erythropoiesis; Erythropoietin; Ferrochelatase; Glycophorins; Heme; Hemoglobins; Humans; Hydrolysis; Hydroxymethylbilane Synthase; K562 Cells; Leukemia, Erythroblastic, Acute; Levulinic Acids; Prodrugs; RNA, Messenger | 2012 |
Bcl-XL is required for heme synthesis during the chemical induction of erythroid differentiation of murine erythroleukemia cells independently of its antiapoptotic function.
Topics: Animals; Apoptosis; bcl-X Protein; Cell Differentiation; Dimethyl Sulfoxide; Erythrocytes; Heme; Hemoglobins; Leukemia, Erythroblastic, Acute; Mice; Oligoribonucleotides, Antisense; Proto-Oncogene Proteins c-bcl-2; Transfection; Tumor Cells, Cultured | 2003 |
Involvement of ABC7 in the biosynthesis of heme in erythroid cells: interaction of ABC7 with ferrochelatase.
Topics: Animals; ATP-Binding Cassette Transporters; Cell Differentiation; Chlorocebus aethiops; COS Cells; Dimethyl Sulfoxide; Erythroid Precursor Cells; Erythropoiesis; Ferrochelatase; Gene Expression Regulation, Leukemic; Heme; Leukemia, Erythroblastic, Acute; Liver; Mice; Mitochondria; Oligodeoxyribonucleotides, Antisense; Recombinant Fusion Proteins; RNA, Messenger; Thionucleotides; Thioredoxins; Transfection; Tumor Cells, Cultured | 2003 |
Apoptosis is induced by decline of mitochondrial ATP synthesis in erythroleukemia cells.
Topics: Adenosine Diphosphate; Adenosine Monophosphate; Adenosine Triphosphate; Animals; Apoptosis; Catalysis; Cell Line, Tumor; Cell Respiration; Energy Metabolism; Heme; Hydrogen Peroxide; Iron; Lactic Acid; Leukemia, Erythroblastic, Acute; Mice; Mitochondria; Mitochondrial Proton-Translocating ATPases; Oligomycins; Oxidative Stress; Oxygen Consumption; Time Factors | 2003 |
Heme positively regulates the expression of beta-globin at the locus control region via the transcriptional factor Bach1 in erythroid cells.
Topics: Animals; Basic-Leucine Zipper Transcription Factors; Binding Sites; Blotting, Northern; Cell Line; Chelating Agents; Chromatin; Deferoxamine; Dimerization; Erythroid Cells; Fanconi Anemia Complementation Group Proteins; Gene Deletion; Gene Expression Regulation; Genes, Reporter; Globins; Heme; Heptanoates; Humans; Iron; K562 Cells; Leukemia, Erythroblastic, Acute; Mice; Mice, Inbred BALB C; Plasmids; Precipitin Tests; Promoter Regions, Genetic; Protein Binding; RNA; RNA, Messenger; Transcription Factors | 2004 |
Hemin stimulating effect on colony formation of leukemic and bone marrow cells.
Topics: Animals; Bone Marrow Cells; Cattle; Cell Transformation, Neoplastic; Colony-Forming Units Assay; Hematopoiesis; Heme; Hemin; Leukemia L1210; Leukemia, Erythroblastic, Acute; Leukemia, Myeloid; Male; Mast-Cell Sarcoma; Mice; Mice, Inbred ICR; Serum Albumin, Bovine; Stimulation, Chemical | 1983 |
Iron metabolism of established human hematopoietic cell lines in vitro.
Topics: Ammonium Chloride; Cell Line; Chloroquine; Endocytosis; Erythrocytes; Ferritins; Heme; Humans; Iron; Kinetics; Leukemia, Erythroblastic, Acute; Lymphocytes; Lymphoma; Macrophages; Transferrin | 1983 |
Characteristics of hematin uptake in malignant, embryonic and normal cells.
Topics: Absorption; Animals; Carcinoma 256, Walker; Cell Line; Cells, Cultured; Chick Embryo; Cyanides; Fibroblasts; Heme; Hemin; Hydrogen-Ion Concentration; Leukemia L1210; Leukemia, Erythroblastic, Acute; Liver; Mice; Rats | 1983 |
Desferrioxamine-mediated inhibition of heme and hemoglobin synthesis in murine erythroleukemia cells: expression of globin genes and commitment to erythroid differentiation.
Topics: Acetamides; Animals; Cell Differentiation; Cell Division; Cells, Cultured; Deferoxamine; Erythropoiesis; Gene Expression Regulation; Globins; Heme; Hemoglobins; Leukemia, Erythroblastic, Acute; Mice | 1983 |
Effect of hemin and heme synthesis inhibitors on cellular protein synthesis.
Topics: 2,2'-Dipyridyl; Anemia; Animals; Cell Line; Heme; Hemin; Hemoglobins; In Vitro Techniques; Isoniazid; Leukemia, Erythroblastic, Acute; Mice; Mice, Inbred ICR; Penicillamine; Protein Biosynthesis; Spleen | 1984 |
Effects of succinylacetone on dimethylsulfoxide-mediated induction of heme pathway enzymes in mouse friend virus-transformed erythroleukemia cells.
Topics: 5-Aminolevulinate Synthetase; Animals; Cell Transformation, Viral; Cells, Cultured; Dimethyl Sulfoxide; Enzyme Induction; Friend murine leukemia virus; Heme; Hemin; Hemoglobins; Heptanoates; Heptanoic Acids; Hydroxymethylbilane Synthase; Leukemia, Erythroblastic, Acute; Mice; Porphobilinogen Synthase | 1984 |
Effect of hemin on poly (A)-containing RNA synthesis and transport from nucleus into cytoplasm in Friend cells of the Fw line.
Topics: Animals; Biological Transport; Cell Line; Cell Nucleus; Cytoplasm; Heme; Hemin; Leukemia, Erythroblastic, Acute; Leukemia, Experimental; Mice; Poly A; RNA, Neoplasm | 1984 |
Hyperthermia in a differentiating murine erythroleukaemia cell line: II. Effect of heat on haem induction by radiation.
Topics: Animals; Cell Line; Cell Transformation, Neoplastic; Cells, Cultured; Dose-Response Relationship, Radiation; Heme; Hot Temperature; Hyperthermia, Induced; Leukemia, Erythroblastic, Acute; Mice; Temperature | 1983 |
Effect of heme depletion on growth, protein synthesis and respiration of murine erythroleukemia cells.
Topics: Animals; Cells, Cultured; Heme; Humans; Kinetics; Leukemia, Erythroblastic, Acute; Leukemia, Experimental; Neoplasm Proteins; Oxygen Consumption; Time Factors | 1980 |
Hemin does not cause commitment of murine erythroleukemia (MEL) cells to terminal differentiation.
Topics: Animals; Cell Differentiation; Cell Line; Dimethyl Sulfoxide; Globins; Heme; Hemin; Hemoglobins; Leukemia, Erythroblastic, Acute; Leukemia, Experimental; Mice; RNA, Messenger; Thioguanine | 1980 |
Role of nonhemoglobin heme accumulation in the terminal differentiation of Friend erythroleukemia cells.
Topics: Animals; Cell Differentiation; Cell Nucleus; Cells, Cultured; Dimethyl Sulfoxide; Erythropoiesis; Friend murine leukemia virus; Globins; Heme; Hemin; Leukemia, Erythroblastic, Acute; Mice | 1981 |
Uptake of hematin and growth of malignant murine erythroleukemia cells depleted of endogenous heme by succinylacetone.
Topics: 5-Aminolevulinate Synthetase; Animals; Biological Transport; Cell Division; Heme; Hemin; Heptanoates; Heptanoic Acids; Keto Acids; Leukemia, Erythroblastic, Acute; Leukemia, Experimental; Mice; Temperature | 1981 |
Phorbol ester tumor promoters block the transition from the early to the heme-dependent late program of Friend cell differentiation.
Topics: Animals; Cell Differentiation; Friend murine leukemia virus; Heme; Hemin; Kinetics; Leukemia, Erythroblastic, Acute; Mice; Phorbol Esters; Phorbols; Tetradecanoylphorbol Acetate | 1980 |
Dexamethasone inhibits a heme-independent event necessary for terminal differentiation of murine erythroleukemia cells.
Topics: Acetamides; Animals; Cell Differentiation; Cells, Cultured; Dexamethasone; Diamines; Gene Expression Regulation; Globins; Heme; Hemin; Hemoglobins; Leukemia, Erythroblastic, Acute; Mice; Nucleoproteins | 1981 |
The effect of heme on intracellular iron pools during differentiation of Friend erythroleukemia cells.
Topics: Animals; Cell Differentiation; Cell Line; Dimethyl Sulfoxide; Ferrochelatase; Friend murine leukemia virus; Heme; Hemin; Iron; Isoniazid; Leukemia, Erythroblastic, Acute; Leukemia, Experimental; Mice; Mitochondria | 1981 |
Effect of heme on globin messenger RNA synthesis.
Topics: Animals; Cell Line; Cells, Cultured; Globins; Heme; Hemin; Isoniazid; Leukemia, Erythroblastic, Acute; Mice; Mice, Inbred ICR; Nucleic Acid Hybridization; Penicillamine; RNA, Messenger; Spleen | 1981 |
Hemin preferentially stimulates synthesis of alpha-globin in K562 human erythroleukemia cells.
Topics: Cell Line; Clone Cells; Dose-Response Relationship, Drug; Electrophoresis, Polyacrylamide Gel; Gene Expression Regulation; Globins; Heme; Hemin; Humans; Leukemia, Erythroblastic, Acute | 1982 |
Dissociation of hemoglobin accumulation and commitment during murine erythroleukemia cell differentiation by treatment with imidazole.
Topics: Animals; Cell Differentiation; Cell Division; Cell Line; Chromosomal Proteins, Non-Histone; Cytidine Deaminase; Dimethyl Sulfoxide; Erythropoiesis; Gene Expression Regulation; Globins; Heme; Hemoglobins; Imidazoles; Leukemia, Erythroblastic, Acute; Mice; Neoplasms, Experimental | 1982 |
Effects of 3'-azido-3'-deoxythymidine on erythroid inducible gene expression in human K-562 leukemia cells.
Topics: 5-Aminolevulinate Synthetase; Base Sequence; Down-Regulation; Erythropoiesis; Gene Expression; Globins; Heme; Humans; Hydroxymethylbilane Synthase; Leukemia, Erythroblastic, Acute; Molecular Sequence Data; Oligonucleotide Probes; Porphobilinogen Synthase; RNA, Messenger; Tumor Cells, Cultured; Zidovudine | 1995 |
Generation of resistance to the diphenyl ether herbicide acifluorfen by MEL cells.
Topics: Animals; Cell Death; Cytochrome P-450 Enzyme System; Drug Resistance; Enzyme Induction; Flavoproteins; Heme; Herbicides; Leukemia, Erythroblastic, Acute; Mice; Mitochondrial Proteins; Nitrobenzoates; Oxidoreductases; Oxidoreductases Acting on CH-CH Group Donors; Porphyrins; Protoporphyrinogen Oxidase; Tumor Cells, Cultured | 1995 |
Induction of terminal enzymes for heme biosynthesis during differentiation of mouse erythroleukemia cells.
Topics: Amino Acid Sequence; Animals; Base Sequence; Cattle; Coproporphyrinogen Oxidase; DNA, Complementary; Enzyme Induction; Erythrocytes; Erythropoiesis; Ferrochelatase; Flavoproteins; Heme; Leukemia, Erythroblastic, Acute; Mice; Mitochondrial Proteins; Molecular Sequence Data; Oxidoreductases; Oxidoreductases Acting on CH-CH Group Donors; Protoporphyrinogen Oxidase; RNA, Messenger; Sequence Homology, Amino Acid; Tumor Cells, Cultured | 1995 |
Haem is necessary for a continued increase in ferrochelatase mRNA in murine erythroleukaemia cells during erythroid differentiation.
Topics: Animals; Blotting, Northern; Cell Differentiation; Dimethyl Sulfoxide; Drug Resistance; Erythroid Precursor Cells; Ferrochelatase; Heme; Leukemia, Erythroblastic, Acute; Leukemia, Experimental; Mice; RNA, Messenger; Tumor Cells, Cultured | 1993 |
Regulation of beta-globin mRNA accumulation by heme in dimethyl sulfoxide (DMSO)-sensitive and DMSO-resistant murine erythroleukemia cells.
Topics: 5-Aminolevulinate Synthetase; Animals; Base Sequence; Dimethyl Sulfoxide; Globins; Heme; Heme Oxygenase (Decyclizing); Hemin; Hemoglobins; Leukemia, Erythroblastic, Acute; Mice; Molecular Sequence Data; RNA, Messenger; Tumor Cells, Cultured | 1994 |
Induction of peripheral-type benzodiazepine receptors during differentiation of mouse erythroleukemia cells. A possible involvement of these receptors in heme biosynthesis.
Topics: Amino Acid Sequence; Animals; Base Sequence; Binding Sites; Blotting, Western; Cloning, Molecular; Coproporphyrinogen Oxidase; DNA, Complementary; Ferrochelatase; Hematopoiesis; Heme; Isoquinolines; Leukemia, Erythroblastic, Acute; Mice; Molecular Sequence Data; Receptors, GABA-A; RNA, Messenger; Tumor Cells, Cultured | 1994 |
Ferrochelatase, glutathione peroxidase and transferrin receptor mRNA synthesis and levels in mouse erythroleukemia cells.
Topics: Animals; Cell Differentiation; Chromatography, Gel; Ferrochelatase; Gene Expression Regulation, Enzymologic; Glutathione Peroxidase; Heme; Humans; Iron; Leukemia, Erythroblastic, Acute; Mice; Receptors, Transferrin; RNA, Messenger; Tumor Cells, Cultured | 1993 |
Impaired erythroid-specific gene expression in cAMP-dependent protein kinase-deficient murine erythroleukemia cells.
Topics: 5-Aminolevulinate Synthetase; Acetamides; Aminolevulinic Acid; Animals; Blotting, Northern; Cell Differentiation; Cell Nucleus; Ferritins; Gene Expression; Genes, myc; Globins; Hematinics; Heme; Hemin; Hemoglobins; Hydroxymethylbilane Synthase; Leukemia, Erythroblastic, Acute; Leukemia, Experimental; Mice; Oncogenes; Protein Kinases; RNA, Messenger; Transcription, Genetic; Transfection; Tumor Cells, Cultured | 1993 |
Wortmannin, a specific inhibitor of phosphatidylinositol-3-kinase, inhibits erythropoietin-induced erythroid differentiation of K562 cells.
Topics: Androstadienes; Cell Differentiation; Cell Line; Enzyme Inhibitors; Erythropoietin; Gene Expression; Glycophorins; Heme; Hemoglobins; Humans; Kinetics; Leukemia, Erythroblastic, Acute; Phosphatidylinositol 3-Kinases; Phosphotransferases (Alcohol Group Acceptor); Recombinant Proteins; Time Factors; Tumor Cells, Cultured; Wortmannin | 1996 |
Effect of the R569W missense mutation on the biosynthesis of myeloperoxidase.
Topics: Amino Acid Sequence; Base Sequence; Blood Bactericidal Activity; Cell Line; DNA Primers; DNA, Complementary; Heme; Humans; Leukemia, Erythroblastic, Acute; Molecular Sequence Data; Mutagenesis, Site-Directed; Neutrophils; Peroxidase; Point Mutation; Polymerase Chain Reaction; Protein Processing, Post-Translational; Recombinant Proteins; Transfection | 1996 |
Overexpression of the ferritin H subunit in cultured erythroid cells changes the intracellular iron distribution.
Topics: Acetamides; Aminolevulinic Acid; Animals; Base Sequence; Cell Compartmentation; Cell Differentiation; Cells, Cultured; Erythroid Precursor Cells; Ferritins; Gene Expression Regulation; Globins; Heme; Hemin; Hemoglobins; Intracellular Fluid; Iron; Iron-Regulatory Proteins; Iron-Sulfur Proteins; Leukemia, Erythroblastic, Acute; Mice; Molecular Sequence Data; Protein Conformation; Recombinant Fusion Proteins; RNA; RNA-Binding Proteins; Transfection; Tumor Cells, Cultured | 1996 |
Inhibition of hemoglobin expression by heterologous production of nitric oxide synthase in the K562 erythroleukemic cell line.
Topics: 5-Aminolevulinate Synthetase; Aminolevulinic Acid; Base Sequence; Butyrates; Butyric Acid; Gene Expression Regulation, Enzymologic; Gene Expression Regulation, Leukemic; Globins; Heme; Hemin; Hemoglobins; Humans; Iron-Sulfur Proteins; Leukemia, Erythroblastic, Acute; Leukemia, Myelogenous, Chronic, BCR-ABL Positive; Molecular Sequence Data; Neoplasm Proteins; Nitric Oxide; Nitric Oxide Synthase; Protein Biosynthesis; Recombinant Proteins; Transfection; Tumor Cells, Cultured | 1996 |
Nitric oxide prevents oxidative damage produced by tert-butyl hydroperoxide in erythroleukemia cells via nitrosylation of heme and non-heme iron. Electron paramagnetic resonance evidence.
Topics: Cell Survival; Electron Spin Resonance Spectroscopy; Free Radicals; Heme; Hemoglobins; Humans; Kinetics; Leukemia, Erythroblastic, Acute; Nitric Oxide; Oxidative Stress; Peroxides; Reactive Oxygen Species; tert-Butylhydroperoxide; Tumor Cells, Cultured | 1997 |
Regulation of NF-E2 activity in erythroleukemia cell differentiation.
Topics: 5-Aminolevulinate Synthetase; Animals; Calcium-Calmodulin-Dependent Protein Kinases; Cell Differentiation; Dimethyl Sulfoxide; DNA-Binding Proteins; Drug Resistance; Enhancer Elements, Genetic; Erythroid-Specific DNA-Binding Factors; Erythropoiesis; Gene Expression Regulation, Developmental; Gene Expression Regulation, Leukemic; Globins; Heme; Leukemia, Erythroblastic, Acute; MafK Transcription Factor; Mice; Models, Genetic; NF-E2 Transcription Factor; NF-E2 Transcription Factor, p45 Subunit; Nuclear Proteins; Phosphorylation; Protein Binding; Protein Serine-Threonine Kinases; Proto-Oncogene Proteins c-raf; ras Proteins; RNA, Messenger; Signal Transduction; Transcription Factors; Transcriptional Activation; Zinc Fingers | 1998 |
Control of hemoglobin synthesis in erythroid differentiating K562 cells. II. Studies of iron mobilization in erythroid cells by high-performance liquid chromatography-electrochemical detection.
Topics: Cell Differentiation; Chromatography, High Pressure Liquid; Electrochemistry; Erythroid Precursor Cells; Heme; Hemoglobins; Humans; Iron; Leukemia, Erythroblastic, Acute; Molecular Weight; Receptors, Transferrin; Transferrin; Tumor Cells, Cultured | 1998 |
Differential regulation of coproporphyrinogen oxidase gene between erythroid and nonerythroid cells.
Topics: 3T3 Cells; Animals; Base Sequence; Cloning, Molecular; Coproporphyrinogen Oxidase; Enzyme Induction; Erythroid Precursor Cells; Exons; Gene Expression Regulation, Enzymologic; Heme; Humans; Leukemia, Erythroblastic, Acute; Mice; Molecular Sequence Data; Neoplastic Stem Cells; Organ Specificity; Promoter Regions, Genetic; Recombinant Fusion Proteins; Regulatory Sequences, Nucleic Acid; Species Specificity; Transcription Factors; Transfection; Tumor Cells, Cultured | 1998 |
Molecular characterization of a newly identified heme-binding protein induced during differentiation of urine erythroleukemia cells.
Topics: Amino Acid Sequence; Animals; Base Sequence; Carrier Proteins; Cell Differentiation; Cloning, Molecular; Coproporphyrins; Dimethyl Sulfoxide; DNA, Complementary; Erythrocytes; Ferrochelatase; Gene Expression Regulation, Neoplastic; Heat-Shock Proteins; Heme; Heme-Binding Proteins; Hemeproteins; Hemin; Leukemia, Erythroblastic, Acute; Mice; Molecular Sequence Data; Peroxidases; Peroxiredoxins; Protoporphyrins; Recombinant Proteins; Sequence Analysis; Sequence Homology, Amino Acid; Urine | 1998 |
ABC-me: a novel mitochondrial transporter induced by GATA-1 during erythroid differentiation.
Topics: Amino Acid Sequence; Animals; ATP-Binding Cassette Transporters; Carrier Proteins; Cell Differentiation; Cell Line; DNA-Binding Proteins; DNA, Complementary; Erythroid Precursor Cells; Erythroid-Specific DNA-Binding Factors; Erythropoiesis; Fetal Proteins; GATA1 Transcription Factor; Gene Expression Regulation, Developmental; Genes, Reporter; Hematopoietic System; Heme; Hemoglobins; Intracellular Membranes; Leukemia, Erythroblastic, Acute; Membrane Proteins; Mice; Mitochondria; Models, Molecular; Molecular Sequence Data; Polymerase Chain Reaction; Promoter Regions, Genetic; Rats; Recombinant Fusion Proteins; Sequence Alignment; Sequence Homology, Amino Acid; Transcription Factors; Transcription, Genetic; Tumor Cells, Cultured | 2000 |
Regulation of hemoglobin synthesis and proliferation of differentiating erythroid cells by heme-regulated eIF-2alpha kinase.
Topics: 3T3 Cells; Animals; Cell Differentiation; Cell Division; Cell Line; Dimethyl Sulfoxide; eIF-2 Kinase; Enzyme Activation; Heme; Hemoglobins; Homeostasis; Leukemia, Erythroblastic, Acute; Mice; Recombinant Proteins; Transfection; Tumor Cells, Cultured | 2000 |
Multiple regulatory steps in erythroid heme biosynthesis.
Topics: Aminolevulinic Acid; Animals; Enzyme Inhibitors; Erythroid Precursor Cells; Erythropoiesis; Heme; Heptanoates; Iron; Kinetics; Leukemia, Erythroblastic, Acute; Mice; Porphyrins; Tumor Cells, Cultured | 2000 |
Disturbance of cellular iron uptake and utilisation by aluminium.
Topics: Aluminum; Apoproteins; Barbiturates; Biological Transport; Cell Differentiation; Heme; Hemin; Hemoglobins; Humans; Iron; K562 Cells; Leukemia, Erythroblastic, Acute; Radioisotopes; Transferrin | 2001 |
Characterization of the iron transporter DMT1 (NRAMP2/DCT1) in red blood cells of normal and anemic mk/mk mice.
Topics: Anemia; Animals; Biological Transport; Cation Transport Proteins; CHO Cells; Cricetinae; Endosomes; Erythrocyte Membrane; Erythrocytes; Erythroid Precursor Cells; Erythropoietin; Fluorescent Antibody Technique; Heme; Hemoglobins; Homozygote; Iron; Iron-Binding Proteins; Leukemia, Erythroblastic, Acute; Mice; Mice, Mutant Strains; Microscopy, Confocal; Mutation; Phenylhydrazines; Protein Isoforms; Reticulocyte Count; Reticulocytes; Spleen; Transferrin; Tumor Cells, Cultured | 2001 |
Differentiation of erythroleukemic cells in vitro: irreversible induction by dimethyl sulfoxide (DMSO).
Topics: Benzidines; Cell Count; Cell Differentiation; Clone Cells; Dimethyl Sulfoxide; Heme; Kinetics; Leukemia, Erythroblastic, Acute; Staining and Labeling; Vacuoles | 1975 |
Evidence for multiple sites of regulation of heme synthesis in murine erythroleukemia cells.
Topics: Animals; Butyrates; Cell Differentiation; Clone Cells; Dimethyl Sulfoxide; Heme; Hemoglobins; Leukemia, Erythroblastic, Acute; Leukemia, Experimental; Mice; Plicamycin; Porphyrins; Procaine | 1979 |
Increase in globin chains and globin mRNA in erythroleukemia cells in response to hemin.
Topics: Animals; Cell Line; Globins; Heme; Hemin; Leukemia, Erythroblastic, Acute; Mice; Nucleic Acid Hybridization; Protein Biosynthesis; Reticulocytes; RNA, Messenger | 1977 |
Inhibition of transcription and translation of globin messenger RNA in dimethyl sulfoxide-stimulated Friend erythroleukemic cells treated with interferon.
Topics: Animals; Cell Line; Cell Nucleus; Cytoplasm; Dimethyl Sulfoxide; Friend murine leukemia virus; Globins; Heme; Hemoglobins; Interferons; Leukemia, Erythroblastic, Acute; Leukemia, Experimental; Neoplasm Proteins; Protein Biosynthesis; RNA, Messenger; Transcription, Genetic | 1977 |
The effect of hemin on the expression of beta globin genes in friend cells.
Topics: Animals; Cell Differentiation; Clone Cells; Electrophoresis, Polyacrylamide Gel; Friend murine leukemia virus; Genes; Globins; Heme; Hemin; Hemoglobins; Leukemia, Erythroblastic, Acute; Mice | 1977 |
Allylisopropylacetamide restricts expression of beta minor globin gene in Friend cells.
Topics: Acetamides; Allylisopropylacetamide; Animals; Cell Line; Dimethyl Sulfoxide; Erythropoiesis; Friend murine leukemia virus; Genes; Globins; Heme; Leukemia, Erythroblastic, Acute; Leukemia, Experimental; Macromolecular Substances | 1978 |
Transferrin receptors, iron transport and ferritin metabolism in Friend erythroleukemia cells.
Topics: Animals; Cell Line; Dimethyl Sulfoxide; Erythropoiesis; Ferritins; Friend murine leukemia virus; Heme; Iron; Iron Radioisotopes; Leukemia, Erythroblastic, Acute; Leukemia, Experimental; Receptors, Drug; Transferrin; Tumor Virus Infections | 1978 |
Hemin control of heme biosynthesis in mouse Friend virus-transformed erythroleukemia cells in culture.
Topics: Animals; Cell Transformation, Viral; Cells, Cultured; Friend murine leukemia virus; Heme; Hemin; Hemoglobins; Hydroxymethylbilane Synthase; Leukemia, Erythroblastic, Acute; Mice; Porphobilinogen Synthase | 1978 |
Inhibition of dimethyl sulfoxide-stimulated Friend cell erythrodifferentiation by hydrocortisone and other steroids.
Topics: Aldosterone; Animals; Anti-Inflammatory Agents; Cell Differentiation; Clone Cells; Corticosterone; Desoxycorticosterone; Dexamethasone; Dimethyl Sulfoxide; Erythrocytes; Friend murine leukemia virus; Globins; Heme; Hemoglobins; Hydrocortisone; Leukemia, Erythroblastic, Acute; Leukemia, Experimental; RNA, Messenger | 1978 |
Stimulation of protein synthesis by hemin in extracts of Friend erythroleukemia cells.
Topics: Cell Line; Globins; Heme; Hemin; Kinetics; Leukemia, Erythroblastic, Acute; Neoplasm Proteins; Protein Biosynthesis; RNA, Messenger | 1978 |
Negative control of hemoglobin production in somatic cell hybrids due to heme deficiency.
Topics: Aminolevulinic Acid; Bone Marrow; Cell Line; Dimethyl Sulfoxide; Female; Genetic Linkage; Heme; Hemin; Hemoglobins; Hybrid Cells; Leukemia, Erythroblastic, Acute; RNA, Messenger; X Chromosome | 1978 |
Heme biosynthesis in Friend erythroleukemia cells: control by ferrochelatase.
Topics: 5-Aminolevulinate Synthetase; Animals; Cells, Cultured; Dimethyl Sulfoxide; Enzyme Induction; Erythropoiesis; Ferrochelatase; Friend murine leukemia virus; Heme; Hemin; Leukemia, Erythroblastic, Acute; Leukemia, Experimental; Lyases; Porphyrins | 1979 |
Terminal erythroid differentiation in normal and leukemic mouse cells.
Topics: Analysis of Variance; Animals; Cell Differentiation; Chromatin; Dimethyl Sulfoxide; Erythrocytes; Erythropoietin; Friend murine leukemia virus; Genes; Heme; Leukemia, Erythroblastic, Acute; Liver; Mice; Mice, Inbred DBA; Spectrin | 1978 |
Tumor promoter-mediated inhibition of cell differentiation: suppression of the expression of erythroid functions in murine erythroleukemia cells.
Topics: Cell Differentiation; Cell Division; Cell Line; Globins; Heme; Kinetics; Leukemia, Erythroblastic, Acute; Phorbols; Protein Biosynthesis; RNA, Messenger; Spectrin; Tetradecanoylphorbol Acetate | 1979 |
Deficient heme synthesis as the cause of noninducibility of hemoglobin synthesis in a Friend erythroleukemia cell line.
Topics: Animals; Cell Line; Erythropoiesis; Friend murine leukemia virus; Globins; Heme; Hemin; Hemoglobins; Leukemia, Erythroblastic, Acute; Leukemia, Experimental; Lyases; Mice; Protein Biosynthesis; Protoporphyria, Erythropoietic; RNA, Messenger | 1979 |
Regulation of hemoglobin synthesis, iron metabolism, and maturation of Friend leukemic cells by 5-amino levulinic acid and hemin.
Topics: Aminolevulinic Acid; Animals; Cell Differentiation; Culture Media; Heme; Hemin; Hemoglobins; Iron; Leukemia, Erythroblastic, Acute; Leukemia, Experimental; Levulinic Acids; Mice | 1979 |
Succinylacetone, a potent inhibitor of heme biosynthesis: effect on cell growth, heme content and delta-aminolevulinic acid dehydratase activity of malignant murine erythroleukemia cells.
Topics: Animals; Cell Division; Cells, Cultured; Heme; Hemoglobins; Heptanoates; Heptanoic Acids; Keto Acids; Leukemia, Erythroblastic, Acute; Leukemia, Experimental; Mice; Porphobilinogen Synthase | 1979 |
Synthesis and turnover of globin mRNA in murine erythroleukemia cells induced with hemin.
Topics: Animals; Cell Line; Dimethyl Sulfoxide; Globins; Heme; Hemin; Kinetics; Leukemia, Erythroblastic, Acute; Mice; Protein Biosynthesis; RNA; RNA, Messenger; Transcription, Genetic | 1979 |
Globin synthesis and erythroid differentiation in a Friend cell variant deficient in heme synthesis.
Topics: Animals; Cell Differentiation; Cell Line; Dimethyl Sulfoxide; Erythropoiesis; Globins; Heme; Hemin; Leukemia, Erythroblastic, Acute; Leukemia, Experimental; Mice; Spectrin | 1979 |
Synthesis of erythrocyte-specific proteins in cultured friend leukemia cells.
Topics: Agglutination; Animals; Blood Proteins; Carbonic Anhydrases; Cell Line; Cell Transformation, Neoplastic; Chromatography; Clone Cells; Dimethyl Sulfoxide; Diphosphoglyceric Acids; Electrophoresis, Cellulose Acetate; Erythrocytes; Friend murine leukemia virus; Globins; Heme; Hemoglobins; Kinetics; Lectins; Leukemia, Erythroblastic, Acute; Mice; Mice, Inbred DBA | 1975 |
Differentiation of erythroleukemia cells in vitro: properties of chemical inducers.
Topics: Acetamides; Acetone; Animals; Blood; Cell Differentiation; Cell Line; Cryoprotective Agents; Culture Media; Dialysis; Dimethyl Sulfoxide; Drug Interactions; Drug Synergism; Ethylene Glycols; Formamides; Heme; Leukemia, Erythroblastic, Acute; Mice; Molecular Weight; Pharmaceutical Preparations; Pyridines; Urea | 1975 |
Cryoprotective agents as inducers of erythroleukemic cell differentiation in vitro.
Topics: Acetamides; Animals; Cell Differentiation; Cell Line; Dimethyl Sulfoxide; Heme; Leukemia, Erythroblastic, Acute; Leukemia, Experimental; Urea | 1976 |
Erythroid cell differentiation.
Topics: Anemia, Hemolytic; Animals; Blood Cell Count; Cell Differentiation; Cell Division; Erythrocytes; Erythropoiesis; Erythropoietin; Female; Fetal Hemoglobin; Genes; Globins; Hematopoietic Stem Cells; Heme; Hemoglobin H; Humans; Leukemia; Leukemia, Erythroblastic, Acute; Mice; Phenylhydrazines; RNA, Messenger; Time Factors | 1976 |
The role of transferrin in heme transport.
Topics: Animals; Binding Sites; Biological Transport; Heme; Iodine Radioisotopes; Iron Radioisotopes; Kinetics; Leukemia, Erythroblastic, Acute; Mice; Porphyrins; Receptors, Transferrin; Spectrometry, Fluorescence; Transferrin; Tumor Cells, Cultured | 1992 |
Reciprocal control of RNA-binding and aconitase activity in the regulation of the iron-responsive element binding protein: role of the iron-sulfur cluster.
Topics: Aconitate Hydratase; Animals; Cell Line; Deferoxamine; Dithiothreitol; Edetic Acid; Heme; Humans; Iron; Iron-Regulatory Proteins; Iron-Sulfur Proteins; Kinetics; Leukemia, Erythroblastic, Acute; Mice; Recombinant Proteins; RNA-Binding Proteins | 1992 |
c-myb effects on kinetic events during MEL cell differentiation.
Topics: Animals; Blotting, Northern; Cell Differentiation; Cell Line; Cyclins; Dimethyl Sulfoxide; DNA Polymerase II; Gene Expression; Heme; Histones; Leukemia, Erythroblastic, Acute; Mice; Oncogenes; Plasmids; Proto-Oncogene Proteins; Proto-Oncogene Proteins c-myb; Restriction Mapping; Transfection | 1992 |
Serum-free, defined medium for the growth and differentiation of murine erythroleukemia cells.
Topics: Animals; Cell Count; Cell Differentiation; Cell Division; Culture Media, Serum-Free; Dimethyl Sulfoxide; Heme; Leukemia, Erythroblastic, Acute; Mice; Tumor Cells, Cultured | 1992 |
Inhibition of heme synthesis decreases transferrin receptor expression in mouse erythroleukemia cells.
Topics: Animals; Gene Expression; Glutathione Peroxidase; Glycine; Heme; Heptanoates; Iron; Leukemia, Erythroblastic, Acute; Mice; Receptors, Transferrin; RNA, Messenger; Tumor Cells, Cultured | 1992 |
Regulation of Cu,Zn superoxide dismutase with copper. Caeruloplasmin maintains levels of functional enzyme activity during differentiation of K562 cells.
Topics: Biological Transport; Cell Differentiation; Cell Line; Ceruloplasmin; Copper; DNA Replication; Heme; Humans; Kinetics; Leukemia, Erythroblastic, Acute; Lysine; Neoplasm Proteins; Subcellular Fractions; Superoxide Dismutase | 1991 |
Intracellular heme coordinately modulates globin chain synthesis, transferrin receptor number, and ferritin content in differentiating Friend erythroleukemia cells.
Topics: Cell Differentiation; Dimethyl Sulfoxide; Ferritins; Globins; Heme; Heptanoates; Humans; Leukemia, Erythroblastic, Acute; Receptors, Transferrin | 1991 |
Sequential activation of genes for heme pathway enzymes during erythroid differentiation of mouse Friend virus-transformed erythroleukemia cells.
Topics: Animals; Blotting, Northern; Cell Differentiation; Cell Transformation, Viral; Erythrocytes; Friend murine leukemia virus; Gene Expression Regulation, Enzymologic; Heme; Kinetics; Leukemia, Erythroblastic, Acute; Mice; RNA, Messenger; Transcription, Genetic; Tumor Cells, Cultured | 1991 |
2-Aminobenzamide, an inhibitor of ADP-ribosylation, antagonizes induced DNA hypomethylation during differentiation of murine Friend erythroleukemia cells by N'-methylnicotinamide.
Topics: Adenosine Diphosphate Ribose; Animals; Cell Differentiation; Cell Line; DNA, Neoplasm; Friend murine leukemia virus; Heme; Leukemia, Erythroblastic, Acute; Methylation; Mice; Niacinamide; ortho-Aminobenzoates | 1990 |
Pteridine modulation of lead inhibition of uroporphyrinogen synthesis in erythroid precursor cells.
Topics: Animals; Cell Line; Dialysis; Folic Acid; Hematopoietic Stem Cells; Heme; Lead; Leukemia, Erythroblastic, Acute; Mice; Porphyrinogens; Pteridines; Uroporphyrinogens | 1990 |
The relationship between heme synthesis and iron uptake in erythroid cells.
Topics: Animals; Friend murine leukemia virus; Heme; Hemin; Iron; Leukemia, Erythroblastic, Acute; Mice; Transferrin; Tumor Cells, Cultured | 1990 |
Inhibition of hemoglobin accumulation by monoclonal antibodies to the human transferrin receptor is reversed by hemin.
Topics: Animals; Antibodies, Monoclonal; Azacitidine; Cell Differentiation; Cell Line; Heme; Hemoglobins; Humans; Kinetics; Leukemia, Erythroblastic, Acute; Leukemia, Experimental; Mice; Receptors, Transferrin | 1987 |
Hemin and cyclic AMP stimulate message-dependent translation in lysates from Friend erythroleukemia cells.
Topics: Acetamides; Animals; Cell Line, Transformed; Cell-Free System; Cyclic AMP; Friend murine leukemia virus; Heme; Hemin; Leukemia, Erythroblastic, Acute; Protein Biosynthesis | 1989 |
Inhibition of cellular iron uptake by haem in mouse erythroleukaemia cells.
Topics: Acetamides; Aminolevulinic Acid; Animals; Cell Differentiation; Cells, Cultured; Glycine; Heme; Hemin; Iron; Iron Radioisotopes; Leukemia, Erythroblastic, Acute; Mice; Time Factors; Transferrin | 1989 |
Cytosine arabinoside plus hemin treatment of a human erythroid cell line, KMOE, strongly induces embryonic, fetal, and adult beta-like globin genes.
Topics: Aminolevulinic Acid; Cytarabine; Dimethyl Sulfoxide; Drug Synergism; Erythroid Precursor Cells; Erythropoietin; Gene Expression Regulation; Globins; Heme; Hemin; Humans; Leukemia, Erythroblastic, Acute; RNA, Messenger; Stimulation, Chemical; Tumor Cells, Cultured | 1989 |
Can glutathione-S-transferases function as intracellular heme carriers?
Topics: Animals; Biological Transport, Active; Carrier Proteins; Dimethyl Sulfoxide; Globins; Glutathione Transferase; Heme; Hemin; Humans; Leukemia, Erythroblastic, Acute; Mice; Substrate Specificity; Tumor Cells, Cultured | 1989 |
c-myb but not c-myc suppresses the hemin-induced nonterminal expression of hemoglobin by murine erythroleukemia cells.
Topics: Animals; Blotting, Northern; Cell Differentiation; Dimethyl Sulfoxide; Erythropoiesis; Gene Expression Regulation; Globins; Heme; Hemin; Hemoglobins; Leukemia, Erythroblastic, Acute; Mice; Proto-Oncogene Proteins; Proto-Oncogene Proteins c-myb; Proto-Oncogene Proteins c-myc; RNA, Messenger; Tumor Cells, Cultured | 1989 |
In K562 leukemia cells treated with doxorubicin and hemin, a decrease in c-myc mRNA expression correlates with loss of self-renewal capability but not with erythroid differentiation.
Topics: Blotting, Northern; Cell Cycle; Cell Differentiation; Cell Division; Cell Line; Doxorubicin; Erythropoiesis; Heme; Hemin; Hemoglobins; Humans; Leukemia, Erythroblastic, Acute; Proto-Oncogene Proteins; Proto-Oncogene Proteins c-myc; RNA, Messenger | 1989 |
Differential effect of hemin-controlled eIF-2 alpha kinases from mouse erythroleukemia cells on protein synthesis.
Topics: Animals; Cell Line; eIF-2 Kinase; Globins; Heme; Hemin; Hemoglobins; Leukemia, Erythroblastic, Acute; Mice; Phosphorylation; Protein Biosynthesis; Protein Kinases; Rabbits; Reticulocytes; RNA, Messenger | 1989 |
Expression of messenger RNA species coding for a Mr 43,000 peptide associated with ferritin in human leukemia-K562 cells and its down regulation during differentiation.
Topics: Cell Line; Deferoxamine; Ferritins; Heme; Humans; Leukemia, Erythroblastic, Acute; Molecular Weight; Neoplasm Proteins; RNA, Messenger; Transcription, Genetic | 1989 |
Hemin increase production of beta-like globin RNA transcripts in human erythroleukemia K-562 cells.
Topics: Blotting, Northern; Cytoplasm; Globins; Heme; Hemin; Humans; Leukemia, Erythroblastic, Acute; RNA, Messenger; Transcription, Genetic; Tumor Cells, Cultured | 1989 |
Hemoglobin induction by Ara-C in human erythroleukemic cells (K562) is cell-cycle dependent.
Topics: Cell Cycle; Cell Line; Cytarabine; Heme; Hemoglobins; Humans; Hydroxyurea; Interphase; Kinetics; Leukemia, Erythroblastic, Acute | 1989 |
Hemin-induced transcriptional activation of the HSP70 gene during erythroid maturation in K562 cells is due to a heat shock factor-mediated stress response.
Topics: Carrier Proteins; Cell Differentiation; Chloramphenicol O-Acetyltransferase; DNA-Binding Proteins; DNA, Recombinant; Endoplasmic Reticulum Chaperone BiP; Gene Expression Regulation; Genes, Regulator; Heat-Shock Proteins; Heme; Hemin; Humans; Leukemia, Erythroblastic, Acute; Molecular Chaperones; Transcription Factors; Transfection; Tumor Cells, Cultured | 1989 |
Iron metabolism in K562 erythroleukemic cells.
Topics: Cell Line; Deferoxamine; Heme; Heptanoates; Humans; Iron; Leukemia, Erythroblastic, Acute; Receptors, Cell Surface; Receptors, Transferrin; Transferrin | 1985 |
A soluble ATP-dependent system for protein degradation from murine erythroleukemia cells. Evidence for a protease which requires ATP hydrolysis but not ubiquitin.
Topics: Adenosine Triphosphate; Adenylyl Imidodiphosphate; Animals; Cell Line; Ethylmaleimide; Heme; High Mobility Group Proteins; Isoflurophate; Kinetics; Leukemia, Erythroblastic, Acute; Leukemia, Experimental; Mice; Peptide Hydrolases; Proteins; Rabbits; Reticulocytes; Ubiquitins | 1985 |
Heme binding to murine erythroleukemia cells. Evidence for a heme receptor.
Topics: Animals; Binding, Competitive; Cell Line; Heme; Kinetics; Leukemia, Erythroblastic, Acute; Leukemia, Experimental; Mice; Receptors, Cell Surface; Sulfuric Acid Esters | 1985 |
Inhibitory effects of theophylline and dibutyryl cAMP on murine erythroleukemia cell differentiation.
Topics: Animals; Bucladesine; Caffeine; Cell Differentiation; Cell Line; Cyclic AMP; Dimethyl Sulfoxide; Dose-Response Relationship, Drug; Drug Synergism; Erythropoiesis; Heme; Hemoglobins; Leukemia, Erythroblastic, Acute; Mice; Theophylline | 1986 |
Receptor-mediated heme uptake from hemopexin by human erythroleukemia K562 cells.
Topics: Cell Line; Heme; Hemopexin; Humans; Kinetics; Leukemia, Erythroblastic, Acute; Leukemia, Myeloid; Receptors, Cell Surface | 1986 |
A rosette receptor assay with haem-microbeads. Demonstration of a haem receptor on K562 cells.
Topics: Cell Line; Erythrocytes; Heme; Humans; Leukemia, Erythroblastic, Acute; Microspheres; Receptors, Cell Surface; Receptors, Transferrin; Rosette Formation; Transferrin | 1987 |
Regulation of the activity of heme degradative enzymes in K562 erythroleukemic cells: induction by thymidine.
Topics: Bromobenzenes; Cell Line; Cobalt; Enzyme Induction; Heme; Heme Oxygenase (Decyclizing); Hemin; Humans; Hypoxanthine; Hypoxanthines; Leukemia, Erythroblastic, Acute; NADPH-Ferrihemoprotein Reductase; Oxidoreductases; Oxidoreductases Acting on CH-CH Group Donors; Thymidine | 1987 |
Changes in chemosensitivity of K 562 leukemia cells after induction of erythroid differentiation by hemin.
Topics: Antineoplastic Agents; Cell Cycle; Cell Differentiation; Drug Resistance; Heme; Hemin; Humans; Leukemia, Erythroblastic, Acute; Leukemia, Myeloid; Tumor Cells, Cultured | 1988 |
Induction to erythroid differentiation of K562 cells by 1-beta-D-arabinofuranosylcytosine is inhibited by iron chelators: reversion by treatment with hemin.
Topics: Cell Differentiation; Cell Line; Cytarabine; Deferoxamine; Erythropoiesis; Growth Inhibitors; Heme; Hemin; Hemoglobins; Humans; Kinetics; Leukemia, Erythroblastic, Acute | 1988 |
Surface antigenic profile and globin phenotype of two new human erythroleukemia lines: characterization and interpretations.
Topics: Antigens, Surface; Cell Line; Clone Cells; Culture Media; Globins; Growth Substances; Hematopoietic Stem Cells; Heme; Histocytochemistry; Humans; Leukemia, Erythroblastic, Acute; Male; Middle Aged; Phenotype; Tetradecanoylphorbol Acetate; Tumor Cells, Cultured | 1988 |
A possible effect of heme on the fate of DNA ligase activity extracted from differentiating mouse erythroleukemia cells.
Topics: Acetamides; Adenosine Triphosphate; Animals; Cell Differentiation; Dimethyl Sulfoxide; DNA Ligases; Heme; Hemin; Imidazoles; Leukemia, Erythroblastic, Acute; Mice; Molecular Weight; Polynucleotide Ligases; Tumor Cells, Cultured | 1988 |
Tin-protoporphyrin inhibits heme oxygenase and prevents the decline in hepatic heme and cytochrome P-450 contents produced in nude mice by tumor transplantation.
Topics: Animals; Carcinoma; Cytochrome P-450 Enzyme System; Female; Heme; Heme Oxygenase (Decyclizing); Humans; Leukemia, Erythroblastic, Acute; Leukemia, Experimental; Male; Metalloporphyrins; Mice; Mice, Nude; Microsomes, Liver; Mixed Function Oxygenases; Neoplasm Transplantation; Porphyrins; Protoporphyrins; Reference Values | 1988 |
Control of heme synthesis during Friend cell differentiation: role of iron and transferrin.
Topics: Aminolevulinic Acid; Animals; Cell Differentiation; Friend murine leukemia virus; Glycine; Heme; Humans; Iron; Leukemia, Erythroblastic, Acute; Mice; Transferrin | 1986 |
Differential hemoglobin synthesis in murine erythroleukemic cells: hemin effects.
Topics: Animals; Butyrates; Butyric Acid; Cell Differentiation; Clone Cells; Friend murine leukemia virus; Heme; Hemin; Hemoglobins; Isoniazid; Leukemia, Erythroblastic, Acute; Leukemia, Experimental; Mice | 1987 |
Effect of extracellular hemin on hemoglobin and ferritin content of erythroleukemia cells.
Topics: Animals; Cell Line; Ferritins; Heme; Hemoglobins; Humans; Iron; Kinetics; Leukemia, Erythroblastic, Acute; Leukemia, Experimental; Leukemia, Myeloid; Mice; Spectrum Analysis | 1987 |
Inhibition of ferrochelatase during differentiation of murine erythroleukaemia cells.
Topics: Animals; Cations, Divalent; Cell Differentiation; Dicarbethoxydihydrocollidine; Dimethyl Sulfoxide; Ferrochelatase; Heme; Leukemia, Erythroblastic, Acute; Lyases; Mice; Organometallic Compounds; Protoporphyrins | 1987 |
Precommitted erythroid cells enriched in cultures of suboptimally induced Friend erythroleukemia cells.
Topics: Acetamides; Animals; Cell Differentiation; Cell Line; Dimethyl Sulfoxide; Heme; Kinetics; Leukemia, Erythroblastic, Acute; Leukemia, Experimental; Mice | 1987 |
Hemin uptake by erythroleukemic cells treated with iron chelators: effects on the induced expression of differentiated functions.
Topics: Cell Line; Cytarabine; Deferoxamine; Heme; Hemin; Hemoglobins; Humans; Leukemia, Erythroblastic, Acute | 1987 |
Cytologic evidence for increased rRNA gene activity in hemin-induced K562(S) cells.
Topics: Cell Differentiation; Cell Division; Cell Line; DNA, Ribosomal; Erythroblasts; Heme; Hemin; Humans; Karyotyping; Leukemia, Erythroblastic, Acute; RNA, Ribosomal | 1985 |
Effects of 1-beta-D-arabinofuranosylcytosine and phorbol ester on differentiation of human K562 erythroleukemia cells.
Topics: Cell Differentiation; Cell Line; Cytarabine; DNA Replication; Globins; Glycophorins; Heme; Humans; Kinetics; Leukemia, Erythroblastic, Acute; Leukemia, Myeloid; Nucleic Acid Hybridization; Phorbols; RNA, Messenger; Tetradecanoylphorbol Acetate; Transcription, Genetic | 1985 |
Accumulation of porphobilinogen deaminase, uroporphyrinogen decarboxylase, and alpha- and beta-globin mRNAs during differentiation of mouse erythroleukemic cells. Effects of succinylacetone.
Topics: Ammonia-Lyases; Animals; Carboxy-Lyases; Cell Differentiation; Electrophoresis, Agar Gel; Friend murine leukemia virus; Globins; Heme; Heptanoates; Heptanoic Acids; Hydroxymethylbilane Synthase; Leukemia, Erythroblastic, Acute; Mice; Nucleic Acid Hybridization; RNA, Messenger; Time Factors; Uroporphyrinogen Decarboxylase | 1985 |
Requirement of spermidine for induction of both heme synthesis and globin transcription in murine erythroleukemia cells.
Topics: Animals; Cell Division; Dexamethasone; Dimethyl Sulfoxide; Eflornithine; Globins; Heme; Leukemia, Erythroblastic, Acute; Mice; Ornithine; Spermidine; Tetradecanoylphorbol Acetate; Transcription, Genetic | 1985 |
The relationship of erythromonocytic leukemia to other myeloproliferative disorders.
Topics: Aged; Bone Marrow Cells; Bone Marrow Examination; Chromosomes; Clone Cells; Erythropoiesis; Female; Heme; Hemoglobinuria, Paroxysmal; Humans; Leukemia, Erythroblastic, Acute; Leukemia, Myeloid; Male; Middle Aged; Myeloproliferative Disorders; Periodic Acid; Polycythemia Vera; Primary Myelofibrosis; Syndrome | 1973 |
Distinctions between idiopathic ineffective erythropoiesis and di Guglielmo's disease: clinical and biochemical differences.
Topics: 5-Aminolevulinate Synthetase; Adult; Aged; Anemia, Hemolytic; Blood Cell Count; Blood Platelets; Bone Marrow; Bone Marrow Cells; Carbon Isotopes; Cells, Cultured; Erythrocytes, Abnormal; Erythropoiesis; Female; Globins; Glycine; Hematopoiesis; Heme; Humans; Isoelectric Focusing; Karyotyping; Leukemia, Erythroblastic, Acute; Leukemia, Myeloid, Acute; Levulinic Acids; Male; Middle Aged; Reticulocytes; Valine | 1972 |
Depression of bone marrow delta-aminolaevulic acid synthetase activity in erythroleukaemia.
Topics: 5-Aminolevulinate Synthetase; Adolescent; Blood Cell Count; Blood Transfusion; Bone Marrow; Bone Marrow Cells; Carbon Radioisotopes; Glycine; Heme; Humans; Iron; L-Lactate Dehydrogenase; Leukemia, Erythroblastic, Acute; Levulinic Acids; Male; Middle Aged | 1973 |
Erythropoietin responsiveness of differentiating Friend leukaemia cells.
Topics: Animals; Cell Differentiation; Cell Division; Cell Transformation, Neoplastic; Clone Cells; Depression, Chemical; Dimethyl Sulfoxide; DNA, Neoplasm; Erythropoietin; Friend murine leukemia virus; Heme; Leukemia, Erythroblastic, Acute; Leukemia, Experimental; Mice; Neoplasm Proteins; RNA, Neoplasm; Stimulation, Chemical | 1974 |
The Di Guglielmo syndrome: studies in hemoglobin synthesis.
Topics: Blood Cell Count; Blood Proteins; Bone Marrow; Bone Marrow Cells; Culture Techniques; Globins; Heme; Humans; Leukemia, Erythroblastic, Acute | 1967 |
Accumulation of iron in mitochondria of erythroblasts.
Topics: Anemia, Hemolytic; Anemia, Sideroblastic; Bone Marrow Examination; Chloramphenicol; Erythrocytes; Globins; Heme; Humans; Iron; Lead Poisoning; Leukemia, Erythroblastic, Acute; Microscopy, Electron; Mitochondria; Porphyrias; Thalassemia | 1967 |
The DiGuglielmo syndrome revisited.
Topics: Bone Marrow Cells; Chromosome Aberrations; Cytarabine; DNA Replication; Friend murine leukemia virus; Heme; Humans; Iron; Leukemia, Erythroblastic, Acute; Terminology as Topic | 1969 |