Page last updated: 2024-08-23

heme and Colonic Neoplasms

heme has been researched along with Colonic Neoplasms in 28 studies

Research

Studies (28)

TimeframeStudies, this research(%)All Research%
pre-19900 (0.00)18.7374
1990's1 (3.57)18.2507
2000's10 (35.71)29.6817
2010's15 (53.57)24.3611
2020's2 (7.14)2.80

Authors

AuthorsStudies
Aktar, S; Cheng, T; Dissabandara, L; Gamage, SMK; Gopalan, V; Hewage, D; Islam, F; Lam, AK; Lu, CT; Macfarlane, L; Nanayakkara, S1
Cheng, T; Dissabandara, L; Gopalan, V; Kodagoda Gamage, SM; Lam, AK; Lee, KT1
Dissabandara, L; Gamage, SMK; Gopalan, V; Lam, AK1
Attaix, D; Blas-Y-Estrada, F; Blot, A; Chantelauze, C; Chevolleau, S; Corpet, DE; Debrauwer, L; Dupuy, J; Durand, D; Guéraud, F; Kuhnle, GGC; Martin, OCB; Meunier, N; Naud, N; Pierre, FHF; Pujos-Guillot, E; Santé-Lhoutellier, V; Sayd, T; Schlich, P; Scislowski, V; Taché, S; Urbano, C; Viala, D1
Chenni, FZ; Corpet, DE; Guéraud, F; Hobbs, DA; Kunhle, GG; Naud, N; Pierre, FH; Taché, S1
Anwar, MM; Corpet, DE; Guéraud, F; Mirvish, SS; Naud, N; Pierre, FH; Santarelli, RL; Taché, S; Vendeuvre, JL; Zhou, L1
Conlon, MA; Gratz, SW; Hu, Y; Le Leu, RK; Winter, J; Young, GP1
Chen, CS; Kazanjian, K; Mirshahidi, S; Senthil, M; Tang, H; Zhang, K1
Corpet, DE; Lin, C; Martin, OC; Naud, N; Pierre, FH; Raymond-Letron, I; Tache, S1
Audebert, M; Baradat, M; Bastide, NM; Chenni, F; Corpet, DE; Gueraud, F; Hobbs, DA; Jouanin, I; Kuhnle, GG; Naud, N; Pierre, FH; Raymond-Letron, I; Santarelli, RL; Surya, R; Taché, S1
Borovic-Sunjic, S; Gaultier, E; Guéraud, F; Héliès-Toussaint, C; Milkovic, L; Naud, N; Pierre, F; Priymenko, N; Steghens, JP; Taché, S; Zarkovic, N1
Lloyd, SK; Turner, ND1
Arihara, K; Ishikawa, S; Itoh, M; Ohata, M; Tamaki, S1
Corpet, DE; Genot, C; Guéraud, F; Naud, N; Pierre, FH; Santarelli, RL; Taché, S; Vendeuvre, JL; Viau, M1
Allam, O; Bahuaud, D; Corpet, DE; Naud, N; Pierre, FH; Taché, S1
de Wit, N; Dekker, J; IJssennagger, N; Jonker-Termont, D; Müller, M; Rijnierse, A; van der Meer, R1
de Wit, N; Ijssennagger, N; Müller, M; van der Meer, R1
Belobrajdic, DP; McIntosh, GH; Owens, JA1
Corpet, DE; Freeman, A; Pierre, F; Taché, S; Van der Meer, R1
de Vogel, J; Jonker-Termont, DS; Katan, MB; van der Meer, R; van Lieshout, EM1
Oates, PS; West, AR1
Tappel, A1
Bingham, SA; Corpet, DE; Cross, AJ; Gasc, N; Gottardi, G; Guéraud, F; Peiro, G; Pierre, F; Taché, S1
Hogg, N1
Ebert, B; Kemmner, W; Klamm, U; Macdonald, R; Moesta, KT; Rüttinger, S; Wan, K1
Kleibeuker, JH; Sesink, AL; Termont, DS; Van der Meer, R3

Reviews

3 review(s) available for heme and Colonic Neoplasms

ArticleYear
The role of heme iron molecules derived from red and processed meat in the pathogenesis of colorectal carcinoma.
    Critical reviews in oncology/hematology, 2018, Volume: 126

    Topics: Animals; Carcinogenesis; Colonic Neoplasms; Colorectal Neoplasms; Diet; Food Handling; Heme; Humans; Iron; Meat; Risk Factors

2018
Association between red meat consumption and colon cancer: A systematic review of experimental results.
    Experimental biology and medicine (Maywood, N.J.), 2017, Volume: 242, Issue:8

    Topics: Animals; Colonic Neoplasms; Cooking; Diet, Western; Heme; Humans; Iron; Meat; Mutagens; Observational Studies as Topic

2017
Heme in intestinal epithelial cell turnover, differentiation, detoxification, inflammation, carcinogenesis, absorption and motility.
    World journal of gastroenterology, 2006, Jul-21, Volume: 12, Issue:27

    Topics: Animals; Cell Cycle; Cell Differentiation; Colonic Neoplasms; Gastrointestinal Motility; Heme; Heme Oxygenase (Decyclizing); Humans; Inactivation, Metabolic; Inflammation; Intestinal Absorption; Intestinal Mucosa; Iron

2006

Trials

2 trial(s) available for heme and Colonic Neoplasms

ArticleYear
Targeting Colon Luminal Lipid Peroxidation Limits Colon Carcinogenesis Associated with Red Meat Consumption.
    Cancer prevention research (Philadelphia, Pa.), 2018, Volume: 11, Issue:9

    Topics: Adult; Animals; Azoxymethane; Biomarkers; Carcinogenesis; Carcinogens; Colonic Neoplasms; Cooking; Cross-Over Studies; Feces; Female; Healthy Volunteers; Heme; Humans; Lipid Peroxidation; Male; Mice; Middle Aged; Neoplasms, Experimental; Rats; Rats, Inbred F344; Red Meat

2018
New marker of colon cancer risk associated with heme intake: 1,4-dihydroxynonane mercapturic acid.
    Cancer epidemiology, biomarkers & prevention : a publication of the American Association for Cancer Research, cosponsored by the American Society of Preventive Oncology, 2006, Volume: 15, Issue:11

    Topics: Acetylcysteine; Adult; Aged; Animal Feed; Animals; Biomarkers, Tumor; Colonic Neoplasms; Diet; Female; Heme; Humans; Iron; Male; Middle Aged; Oxidative Stress; Rats; Rats, Inbred F344; Risk

2006

Other Studies

23 other study(ies) available for heme and Colonic Neoplasms

ArticleYear
Heme oxygenase-1 & 2 and their potential contribution in heme induced colorectal carcinogenesis.
    Pathology, research and practice, 2022, Volume: 233

    Topics: Carcinogenesis; Colonic Neoplasms; Colorectal Neoplasms; Heme; Heme Oxygenase (Decyclizing); Heme Oxygenase-1; Hemin; Humans

2022
Hemin, a major heme molecule, induced cellular and genetic alterations in normal colonic and colon cancer cells.
    Pathology, research and practice, 2021, Volume: 224

    Topics: Carcinogenesis; Carcinogens; Colon; Colonic Neoplasms; Epithelial Cells; Heme; Hemin; Humans; Mutation

2021
Heme-induced biomarkers associated with red meat promotion of colon cancer are not modulated by the intake of nitrite.
    Nutrition and cancer, 2013, Volume: 65, Issue:2

    Topics: Acetylcysteine; Animals; Biomarkers; Body Weight; Colonic Neoplasms; Disease Models, Animal; Drinking Water; Eating; Feces; Heme; Lipid Peroxidation; Male; Meat; Nitrites; Nitroso Compounds; Rats, Inbred F344; Saliva; Sodium Nitrite; Thiobarbituric Acid Reactive Substances

2013
Calcium inhibits promotion by hot dog of 1,2-dimethylhydrazine-induced mucin-depleted foci in rat colon.
    International journal of cancer, 2013, Dec-01, Volume: 133, Issue:11

    Topics: 1,2-Dimethylhydrazine; Animals; Calcium; Carcinogenicity Tests; Colon; Colonic Neoplasms; Heme; Meat; Mucins; Rats

2013
Accumulation of promutagenic DNA adducts in the mouse distal colon after consumption of heme does not induce colonic neoplasms in the western diet model of spontaneous colorectal cancer.
    Molecular nutrition & food research, 2014, Volume: 58, Issue:3

    Topics: Animals; Body Weight; Colonic Neoplasms; Colorectal Neoplasms; Diet, Western; DNA Adducts; Feces; Heme; Humans; Male; Mice, Inbred C57BL; Mutagens; Starch

2014
Down-regulation of LXR/RXR activation and negative acute phase response pathways in colon adenocarcinoma revealed by proteomics and bioinformatics analysis.
    Cancer biomarkers : section A of Disease markers, 2014, Volume: 14, Issue:5

    Topics: Acute-Phase Reaction; Adenocarcinoma; Aged; Biomarkers, Tumor; Case-Control Studies; Colonic Neoplasms; Computational Biology; Down-Regulation; Female; Gene Expression Profiling; Heme; Humans; Iron; Lipid Metabolism; Male; Middle Aged; Proteomics; Retinoid X Receptors; Vitamin D; Vitamin E

2014
Antibiotic suppression of intestinal microbiota reduces heme-induced lipoperoxidation associated with colon carcinogenesis in rats.
    Nutrition and cancer, 2015, Volume: 67, Issue:1

    Topics: Animals; Anti-Bacterial Agents; Anticarcinogenic Agents; Biomarkers; Carcinogenesis; Cecum; Cell Proliferation; Colon; Colonic Neoplasms; Colony Count, Microbial; Drug Therapy, Combination; Feces; Heme; Intestinal Mucosa; Lipid Peroxidation; Male; Microbiota; Random Allocation; Rats, Inbred F344; Thiobarbituric Acid Reactive Substances

2015
A central role for heme iron in colon carcinogenesis associated with red meat intake.
    Cancer research, 2015, Mar-01, Volume: 75, Issue:5

    Topics: Animals; Carcinogenesis; Cell Line, Tumor; Colonic Neoplasms; Heme; Iron; Male; Meat; Mice; Mice, Inbred C57BL; Rats; Rats, Inbred F344; Risk Factors

2015
Dietary polyunsaturated fatty acids and heme iron induce oxidative stress biomarkers and a cancer promoting environment in the colon of rats.
    Free radical biology & medicine, 2015, Volume: 83

    Topics: Animals; Antioxidants; Biomarkers; Colon; Colonic Neoplasms; Diet; Fatty Acids, Unsaturated; Female; Heme; Iron; Lipid Peroxidation; Malondialdehyde; Mice; Oxidative Stress; Rats; Rats, Inbred F344; Reactive Oxygen Species; Rectal Neoplasms; Thiobarbituric Acid Reactive Substances; Tumor Cells, Cultured; Tumor Microenvironment

2015
Heme induces DNA damage and hyperproliferation of colonic epithelial cells via hydrogen peroxide produced by heme oxygenase: a possible mechanism of heme-induced colon cancer.
    Molecular nutrition & food research, 2010, Volume: 54, Issue:8

    Topics: Caco-2 Cells; Catalase; Cell Proliferation; Cell Survival; Colonic Neoplasms; DNA Damage; Enzyme Inhibitors; Epithelial Cells; Gene Expression Regulation, Neoplastic; Heme; Heme Oxygenase (Decyclizing); Humans; Hydrogen Peroxide; Interleukin-8; Meat; Osmolar Concentration; Oxidative Stress; Protoporphyrins; Risk Factors; RNA, Messenger

2010
Meat processing and colon carcinogenesis: cooked, nitrite-treated, and oxidized high-heme cured meat promotes mucin-depleted foci in rats.
    Cancer prevention research (Philadelphia, Pa.), 2010, Volume: 3, Issue:7

    Topics: Animals; Biomarkers; Colonic Neoplasms; Cooking; Diet; Feces; Female; Heme; Meat; Meat-Packing Industry; Models, Animal; Mucins; Nitrites; Precancerous Conditions; Rats; Rats, Inbred F344

2010
Calcium carbonate suppresses haem toxicity markers without calcium phosphate side effects on colon carcinogenesis.
    The British journal of nutrition, 2011, Volume: 105, Issue:3

    Topics: Animals; Biomarkers; Calcium Carbonate; Calcium Phosphates; Colon; Colonic Neoplasms; Diet; Dietary Supplements; Feces; Female; Heme; Meat; Rats; Rats, Inbred F344

2011
Dietary haem stimulates epithelial cell turnover by downregulating feedback inhibitors of proliferation in murine colon.
    Gut, 2012, Volume: 61, Issue:7

    Topics: Animals; Cell Proliferation; Colon; Colonic Neoplasms; Dietary Supplements; Down-Regulation; Epithelial Cells; Feedback, Physiological; Gene Expression; Gene Expression Profiling; Heme; Intestinal Mucosa; Laser Capture Microdissection; Male; Mice; Mice, Inbred C57BL; Oligonucleotide Array Sequence Analysis; Signal Transduction; Transcriptome

2012
Dietary heme-mediated PPARα activation does not affect the heme-induced epithelial hyperproliferation and hyperplasia in mouse colon.
    PloS one, 2012, Volume: 7, Issue:8

    Topics: Animal Feed; Animals; Antioxidants; Cell Proliferation; Colon; Colonic Neoplasms; Heme; Immunohistochemistry; Lipid Metabolism; Male; Meat; Mice; Mice, Knockout; Mucous Membrane; Oligonucleotide Array Sequence Analysis; Oxidative Stress; PPAR alpha; Reactive Oxygen Species; Risk

2012
Whey proteins protect more than red meat against azoxymethane induced ACF in Wistar rats.
    Cancer letters, 2003, Jul-30, Volume: 198, Issue:1

    Topics: Animals; Azoxymethane; Colonic Neoplasms; Diet; Heme; Meat; Milk Proteins; Precancerous Conditions; Rats; Rats, Wistar; Whey Proteins

2003
Beef meat and blood sausage promote the formation of azoxymethane-induced mucin-depleted foci and aberrant crypt foci in rat colons.
    The Journal of nutrition, 2004, Volume: 134, Issue:10

    Topics: Animals; Azoxymethane; Carcinogens; Cattle; Chickens; Colonic Neoplasms; Diet; Female; Heme; Lipid Peroxidation; Meat; Mucins; Rats; Rats, Inbred F344

2004
Green vegetables, red meat and colon cancer: chlorophyll prevents the cytotoxic and hyperproliferative effects of haem in rat colon.
    Carcinogenesis, 2005, Volume: 26, Issue:2

    Topics: Animals; Cell Division; Cells, Cultured; Chlorophyll; Colon; Colonic Neoplasms; Diet; Epithelial Cells; Feces; Heme; Male; Meat; Rats; Rats, Wistar; Spinacia oleracea

2005
Heme of consumed red meat can act as a catalyst of oxidative damage and could initiate colon, breast and prostate cancers, heart disease and other diseases.
    Medical hypotheses, 2007, Volume: 68, Issue:3

    Topics: Animals; Breast Neoplasms; Colonic Neoplasms; Female; Heart Diseases; Heme; Humans; Male; Meat; Oxidative Stress; Prostatic Neoplasms

2007
Red meat and colon cancer: heme proteins and nitrite in the gut. A commentary on "diet-induced endogenous formation of nitroso compounds in the GI tract".
    Free radical biology & medicine, 2007, Oct-01, Volume: 43, Issue:7

    Topics: Colonic Neoplasms; Diet; Gastrointestinal Tract; Heme; Hemeproteins; Humans; Meat; Nitrites; Nitroso Compounds

2007
Silencing of human ferrochelatase causes abundant protoporphyrin-IX accumulation in colon cancer.
    FASEB journal : official publication of the Federation of American Societies for Experimental Biology, 2008, Volume: 22, Issue:2

    Topics: Aminolevulinic Acid; Cell Line, Tumor; Colonic Neoplasms; Ferrochelatase; Gene Expression Regulation, Enzymologic; Heme; Heme Oxygenase (Decyclizing); Humans; Protoporphyrins; RNA, Messenger; RNA, Small Interfering; Stomach Neoplasms

2008
Red meat and colon cancer: the cytotoxic and hyperproliferative effects of dietary heme.
    Cancer research, 1999, Nov-15, Volume: 59, Issue:22

    Topics: Animals; Bilirubin; Cell Division; Colon; Colonic Neoplasms; Feces; Ferric Compounds; Heme; Hemin; Intestinal Absorption; Intestinal Mucosa; Iron; Male; Protoporphyrins; Rats; Rats, Wistar; Specific Pathogen-Free Organisms

1999
Red meat and colon cancer: dietary haem, but not fat, has cytotoxic and hyperproliferative effects on rat colonic epithelium.
    Carcinogenesis, 2000, Volume: 21, Issue:10

    Topics: Animals; Cations, Monovalent; Cattle; Cell Division; Colon; Colonic Neoplasms; Diet; Dietary Fats; Epithelium; Feces; Heme; Male; Meat; Rats; Rats, Wistar; Water

2000
Red meat and colon cancer: dietary haem-induced colonic cytotoxicity and epithelial hyperproliferation are inhibited by calcium.
    Carcinogenesis, 2001, Volume: 22, Issue:10

    Topics: Animals; Calcium Phosphates; Cell Division; Colon; Colonic Neoplasms; Diet; Feces; Heme; Intestinal Mucosa; Male; Meat; Rats; Rats, Wistar; Water

2001