helvolic-acid and Mycoses

helvolic-acid has been researched along with Mycoses* in 1 studies

Other Studies

1 other study(ies) available for helvolic-acid and Mycoses

Article	Year
Production of Helvolic Acid in Metarhizium Contributes to Fungal Infection of Insects by Bacteriostatic Inhibition of the Host Cuticular Microbiomes. Microbiology spectrum, 2022, 10-26, Volume: 10, Issue:5 The nortriterpenoid helvolic acid (HA) has potent antibiotic activities and can be produced by different fungi, yet HA function remains elusive. Here, we report the chemical biology of HA production in the insect pathogen Metarhizium robertsii. After deletion of the core oxidosqualene cyclase gene in Metarhizium, insect survival rates were significantly increased compared to those of insects treated with the wild type and the gene-rescued strain during topical infections but not during injection assays to bypass insect cuticles. Further gnotobiotic infection of axenic Topics: Animals; Anti-Bacterial Agents; Drosophila; Fungal Proteins; Insecta; Metarhizium; Microbiota; Mycoses; Spores, Fungal	2022

Article

Year

Production of Helvolic Acid in Metarhizium Contributes to Fungal Infection of Insects by Bacteriostatic Inhibition of the Host Cuticular Microbiomes.

Microbiology spectrum, 2022, 10-26, Volume: 10, Issue:5

The nortriterpenoid helvolic acid (HA) has potent antibiotic activities and can be produced by different fungi, yet HA function remains elusive. Here, we report the chemical biology of HA production in the insect pathogen Metarhizium robertsii. After deletion of the core oxidosqualene cyclase gene in Metarhizium, insect survival rates were significantly increased compared to those of insects treated with the wild type and the gene-rescued strain during topical infections but not during injection assays to bypass insect cuticles. Further gnotobiotic infection of axenic

Topics: Animals; Anti-Bacterial Agents; Drosophila; Fungal Proteins; Insecta; Metarhizium; Microbiota; Mycoses; Spores, Fungal

2022