helospectin-i and Diabetes-Mellitus

Radiolabeled exendin is used for non-invasive quantification of beta cells in the islets of Langerhans in vivo. High accumulation of radiolabeled exendin in the islets raised concerns about possible radiation-induced damage to these islets in man. In this work, islet absorbed doses resulting from exendin-imaging were calculated by combining whole organ dosimetry with small scale dosimetry for the islets. Our model contains the tissues with high accumulation of radiolabeled exendin: kidneys, pancreas and islets. As input for the model, data from a clinical study (radiolabeled exendin distribution in the human body) and from a preclinical study with Biobreeding Diabetes Prone (BBDP) rats (islet-to-exocrine uptake ratio, beta cell mass) were used. We simulated

Topics: Adult; Animals; Cell Count; Diabetes Mellitus; Disease Models, Animal; Female; Gallium Radioisotopes; Humans; Indium Radioisotopes; Insulin-Secreting Cells; Intercellular Signaling Peptides and Proteins; Islets of Langerhans; Kidney; Male; Middle Aged; Peptides; Radiation; Radiation Dosage; Radiation Injuries; Radiometry; Rats; Rats, Mutant Strains; Young Adult