helium-3-atom has been researched along with Cystic-Fibrosis* in 4 studies
1 review(s) available for helium-3-atom and Cystic-Fibrosis
| Article | Year |
|---|---|
Hyperpolarized Gas Magnetic Resonance Imaging of Pediatric Cystic Fibrosis Lung Disease.
Conventional pulmonary function tests appear normal in early cystic fibrosis (CF) lung disease. Therefore, new diagnostic approaches are required that can detect CF lung disease in children and monitor treatment response. Hyperpolarized (HP) gas ( Topics: Adolescent; Child; Cystic Fibrosis; Disease Progression; Female; Helium; Humans; Isotopes; Magnetic Resonance Imaging; Male; Reproducibility of Results; Respiratory Function Tests; Workflow; Xenon Isotopes | 2019 |
1 trial(s) available for helium-3-atom and Cystic-Fibrosis
| Article | Year |
|---|---|
Use of hyperpolarized helium-3 MRI to assess response to ivacaftor treatment in patients with cystic fibrosis.
This pilot study evaluated the effect of short- and long-term ivacaftor treatment on hyperpolarized. Part A (single-blind) comprised 4weeks of ivacaftor treatment; Part B (open-label) comprised 48weeks of treatment. The primary outcome was change from baseline in total ventilation defect (TVD; total defect volume:total lung volume ratio).. Mean change in TVD ranged from -8.2% (p=0.0547) to -12.8% (p=0.0078) in Part A (n=8) and -6.3% (p=0.1953) to -9.0% (p=0.0547) in Part B (n=8) as assessed by human reader and computer algorithm, respectively.. TVD responded to ivacaftor therapy. Topics: Adult; Aminophenols; Chloride Channel Agonists; Cystic Fibrosis; Cystic Fibrosis Transmembrane Conductance Regulator; Drug Administration Schedule; Drug Monitoring; Female; Forced Expiratory Volume; Helium; Humans; Isotopes; Magnetic Resonance Imaging; Male; Middle Aged; Mutation; Outcome Assessment, Health Care; Pilot Projects; Pulmonary Ventilation; Quinolones; Single-Blind Method | 2017 |
2 other study(ies) available for helium-3-atom and Cystic-Fibrosis
| Article | Year |
|---|---|
Three-dimensional Isotropic Functional Imaging of Cystic Fibrosis Using Oxygen-enhanced MRI: Comparison with Hyperpolarized
Purpose To compare the performance of three-dimensional radial ultrashort echo time (UTE) oxygen-enhanced (OE) MRI with that of hyperpolarized helium 3 ( Topics: Adolescent; Adult; Child; Cystic Fibrosis; Female; Helium; Humans; Imaging, Three-Dimensional; Isotopes; Lung; Magnetic Resonance Imaging; Male; Middle Aged; Oxygen; Prospective Studies; Reproducibility of Results; Young Adult | 2019 |
MRI accelerating progress in functional assessment of cystic fibrosis lung disease.
Topics: Aminophenols; Cystic Fibrosis; Helium; Humans; Isotopes; Magnetic Resonance Imaging; Quinolones | 2017 |